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Abstracts of the Meeting of the Austrian Stroke Society (ÖGSF) and the Swiss Stroke Society (SHG), June 14–15, 2022, Innsbruck/Austria 奥地利中风学会(ÖGSF)和瑞士中风学会(SHG)会议摘要，2022年6月14-15日，奥地利因斯布鲁克
Clinical and Translational Neuroscience Pub Date : 2022-06-10 DOI: 10.3390/ctn6020014
Patrik Michel
{"title":"Abstracts of the Meeting of the Austrian Stroke Society (ÖGSF) and the Swiss Stroke Society (SHG), June 14–15, 2022, Innsbruck/Austria","authors":"Patrik Michel","doi":"10.3390/ctn6020014","DOIUrl":"https://doi.org/10.3390/ctn6020014","url":null,"abstract":"On behalf of Society ÖGSF and the Swiss Stroke Society SHG, we are pleased to present the Abstracts of the Annual Meeting that was held from 14–15 June 2022 in Innsbruck/Austria. Twenty (20) abstracts were selected for presentation as oral presentations and sixteen (16) abstracts were selected as poster presentations. We congratulate all the presenters on their research work and contribution.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120977904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Just Breathe: Improving LEP Outcomes through Long Interval Breathing 只要呼吸:通过长时间间歇呼吸改善LEP结果
Clinical and Translational Neuroscience Pub Date : 2022-06-01 DOI: 10.3390/ctn6020013
A. Wold, Rebecca Boehme, M. Thordstein
{"title":"Just Breathe: Improving LEP Outcomes through Long Interval Breathing","authors":"A. Wold, Rebecca Boehme, M. Thordstein","doi":"10.3390/ctn6020013","DOIUrl":"https://doi.org/10.3390/ctn6020013","url":null,"abstract":"Background: Laser-evoked potentials (LEPs) constitute an objective clinical diagnostic method used to investigate the functioning of the nociceptor system, including signaling in thin peripheral nerve fibers: Aδ and C fibers. There is preliminary evidence that phase locking LEPs with the breathing cycle can improve the parameters used to evaluate LEPs. Methods: We tested a simple breathing protocol as a low-cost improvement to LEP testing of the hands. Twenty healthy participants all underwent three variants of LEP protocols: following a video-guided twelve-second breathing instruction, watching a nature video, or using the classic LEP method of focusing on the hand being stimulated. Results: The breath protocol produced significantly shorter latencies as compared with the nature or classic protocol. It was also the least prone to artifacts and was deemed most acceptable by the subjects. There was no difference between the protocols regarding LEP amplitudes. Conclusions: Using a breathing video can be a simple, low-cost improvement for LEP testing in research and clinical diagnostics.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125971619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Loneliness of Migraine Scale: A Development and Validation Study 偏头痛孤独感量表:开发与验证研究
Clinical and Translational Neuroscience Pub Date : 2022-04-12 DOI: 10.3390/ctn6020012
M. Neumeier, Evdokia Efthymiou, A. Gantenbein, Miranda Stattmann, H. Pohl
{"title":"The Loneliness of Migraine Scale: A Development and Validation Study","authors":"M. Neumeier, Evdokia Efthymiou, A. Gantenbein, Miranda Stattmann, H. Pohl","doi":"10.3390/ctn6020012","DOIUrl":"https://doi.org/10.3390/ctn6020012","url":null,"abstract":"Patients with migraine often isolate themselves during their attacks. This disease-related loneliness seems to reverberate interictal, as some patients report failing relationships, losing jobs, or suffering from reduced social contacts. We developed a 10-item self-report questionnaire, the loneliness of migraine scale (LMS), and conducted an online survey. The questionnaire comprised diagnostic questions for migraine, the loneliness of migraine scale, the Generalized Anxiety Disorder Scale (GAD-7), the Patient Health Questionnaire (PHQ-8), and the Headache Attributed Lost Time Index (HALT-90). We computed item statistics, the psychometric properties of the LMS and assessed correlations between loneliness, migraine days, anxiety, and depression. We included 223 participants with (probable) migraine, reporting 8 ± 6 headache days with a disease duration of 11 ± 11 years. The mean scores of the HALT were 88 ± 52, of the GAD-7 10 ± 5, for PHQ-8 11 ± 6, and of the LMS 28.79 ± 9.72. Cronbach’s alpha for all ten items was 0.929. The loneliness scale correlated with the GAD-7 (r = 0.713, p < 0.001), with the PHQ-8 scale (r = 0.777, p < 0.001) and with migraine days (r = 0.338, p < 0.001). The LMS is a reliable and valid questionnaire measuring the loneliness of migraine patients. Feelings of loneliness were common and correlated highly with migraine days, anxiety, and depression.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124711965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral Venous Sinus Thrombosis Associated with Vaccine-Induced Thrombotic Thrombocytopenia—A Narrative Review 脑静脉窦血栓形成与疫苗诱导的血栓性血小板减少相关——一篇叙述性综述
Clinical and Translational Neuroscience Pub Date : 2022-04-11 DOI: 10.3390/ctn6020011
A. Scutelnic, J. Brodard, J. K. Kremer Hovinga, M. Arnold, M. Heldner
{"title":"Cerebral Venous Sinus Thrombosis Associated with Vaccine-Induced Thrombotic Thrombocytopenia—A Narrative Review","authors":"A. Scutelnic, J. Brodard, J. K. Kremer Hovinga, M. Arnold, M. Heldner","doi":"10.3390/ctn6020011","DOIUrl":"https://doi.org/10.3390/ctn6020011","url":null,"abstract":"In March 2021, cerebral venous sinus thrombosis and thrombocytopenia after vaccination with adenovirus-based vaccine against SARS-CoV-2 were first reported. The underlining condition has been termed vaccine-induced immune thrombocytopenia (VITT). Anti-platelet factor 4 antibodies have been proposed as a central component of the pathomechanism. Treatment recommendations entailed immunomodulation with intravenous immunoglobulins, avoidance of heparins and avoidance of platelet transfusions. Although mortality from VITT-associated cerebral venous sinus thrombosis has decreased over time, it remains high. The aim of this narrative review is to describe different aspects of this disease according to the current state of knowledge.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115122521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NeuroCOVID: Insights into Neuroinvasion and Pathophysiology NeuroCOVID:神经侵袭和病理生理学的见解
Clinical and Translational Neuroscience Pub Date : 2022-04-05 DOI: 10.3390/ctn6020010
J. Matschke, S. Krasemann, H. Altmeppen, M. Shafiq, M. Glatzel
{"title":"NeuroCOVID: Insights into Neuroinvasion and Pathophysiology","authors":"J. Matschke, S. Krasemann, H. Altmeppen, M. Shafiq, M. Glatzel","doi":"10.3390/ctn6020010","DOIUrl":"https://doi.org/10.3390/ctn6020010","url":null,"abstract":"Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may lead to acute and chronic neurological symptoms (NeuroCOVID-19). SARS-CoV-2 may spread from the respiratory tract to the central nervous system as the central nervous system (CNS) of certain patients dying from COVID-19 shows virus-related neuropathological changes. Moreover, a syndrome found in many patients having passed a SARS-CoV-2 infection, which is termed long COVID and characterized by lasting fatigue and other diverse clinical features, may well have some of its pathological correlates inside the CNS. Although knowledge on the routes of SARS-CoV-2 neuroinvasion and the pathophysiology of NeuroCOVID have increased, the molecular mechanisms are not yet fully understood. This includes the key question: to understand if observed CNS damage is a direct cause of viral damage or indirectly mediated by an overshooting neuroimmune response.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127198930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Waning Humoral Immune Response to SARS-CoV-2 Vaccination with Symptomatic Infection after Initiation of Anti-CD20 Treatment in a Patient with Multiple Sclerosis 在多发性硬化症患者开始抗cd20治疗后，对SARS-CoV-2疫苗接种和症状性感染的体液免疫反应减弱
Clinical and Translational Neuroscience Pub Date : 2022-03-18 DOI: 10.3390/ctn6010008
R. Hoepner, A. Salmen
{"title":"Waning Humoral Immune Response to SARS-CoV-2 Vaccination with Symptomatic Infection after Initiation of Anti-CD20 Treatment in a Patient with Multiple Sclerosis","authors":"R. Hoepner, A. Salmen","doi":"10.3390/ctn6010008","DOIUrl":"https://doi.org/10.3390/ctn6010008","url":null,"abstract":"Waning humoral responses to SARS-CoV-2 vaccination have been reported arguing for booster vaccinations even in healthy populations. Multiple sclerosis (MS) immunotherapy with anti-CD20 monoclonal antibodies may negatively influence morbidity and mortality of COVID-19. The opportunity to treat patients at risk for a severe COVID-19 course with specific monoclonal antibodies targeting SARS-CoV-2 represents an important novel measure for patient safety. We report a patient with waning humoral vaccination response around five months after two mRNA vaccination doses upon initiation of ocrelizumab treatment. Symptomatic COVID-19 infection was treated with casirivimab/imdevimab with rapid symptom recovery.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134388708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hot Topics on COVID-19 and Its Possible Association with Guillain-Barré Syndrome 2019冠状病毒病及其与格林-巴-罗综合征的关系
Clinical and Translational Neuroscience Pub Date : 2022-03-15 DOI: 10.3390/ctn6010007
A. Dietmann, P. Ripellino, A. Humm, T. Hundsberger, B. Schreiner, M. Théaudin, O. Scheidegger
{"title":"Hot Topics on COVID-19 and Its Possible Association with Guillain-Barré Syndrome","authors":"A. Dietmann, P. Ripellino, A. Humm, T. Hundsberger, B. Schreiner, M. Théaudin, O. Scheidegger","doi":"10.3390/ctn6010007","DOIUrl":"https://doi.org/10.3390/ctn6010007","url":null,"abstract":"As the COVID-19 pandemic progresses, reports of neurological manifestations are increasing. However, despite a high number of case reports and case series on COVID-19 and Guillain-Barré-Syndrome (GBS), a causal association is still highly debated, due to the lack of case-control studies. In this opinion paper, we focus on a few clinically relevant questions regarding the possible link between GBS and SARS-CoV-2 infection or vaccination based on our personal clinical experience and literature review.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131970184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
COVID-19 in a Neuroimmunological Outpatient Cohort: The Bernese Experience 神经免疫学门诊队列中的COVID-19:伯尔尼经验
Clinical and Translational Neuroscience Pub Date : 2022-02-16 DOI: 10.3390/ctn6010006
M. Pistor, A. Salmen, A. Chan, R. Hoepner
{"title":"COVID-19 in a Neuroimmunological Outpatient Cohort: The Bernese Experience","authors":"M. Pistor, A. Salmen, A. Chan, R. Hoepner","doi":"10.3390/ctn6010006","DOIUrl":"https://doi.org/10.3390/ctn6010006","url":null,"abstract":"The COVID-19 pandemic specifically affects the management and treatment of patients with autoimmune neurological disorders. Major concerns include potentially higher risks of infection or severe disease course under certain immunotherapies used to treat those disorders and the influence of COVID-19 on the underlying disease. We present data of the neuroimmunological outpatient department of the University Hospital of Bern (Switzerland). 24 cases were analyzed, 19 of them suffered from Multiple Sclerosis. Of these 24 patients, 6 were hospitalized, 2/6 were treated in the Intensive Care Unit. Possible risk factors for severe course (defined as need for hospitalization) observed in our cohort included cardiovascular risk factors, treatment with B-cell depleting agents, Sphingosine-1 Phosphate Receptor Modulators, and oral steroid therapies. These data are based on a small, retrospective observational cohort and should be interpreted with caution, although they are in line with several other cohort studies.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114586394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical Hyperexcitability in the Driver’s Seat in ALS ALS患者驾驶座的皮质过度兴奋性
Clinical and Translational Neuroscience Pub Date : 2022-02-10 DOI: 10.3390/ctn6010005
Zeynep I. Gunes, Vanessa W. Y. Kan, Shenyi Jiang, Evgeny Logunov, Xiaoqian Ye, S. Liebscher
{"title":"Cortical Hyperexcitability in the Driver’s Seat in ALS","authors":"Zeynep I. Gunes, Vanessa W. Y. Kan, Shenyi Jiang, Evgeny Logunov, Xiaoqian Ye, S. Liebscher","doi":"10.3390/ctn6010005","DOIUrl":"https://doi.org/10.3390/ctn6010005","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration of cortical and spinal motor neurons. With no effective treatment available to date, patients face progressive paralysis and eventually succumb to the disease due to respiratory failure within only a few years. Recent research has revealed the multifaceted nature of the mechanisms and cell types involved in motor neuron degeneration, thereby opening up new therapeutic avenues. Intriguingly, two key features present in both ALS patients and rodent models of the disease are cortical hyperexcitability and hyperconnectivity, the mechanisms of which are still not fully understood. We here recapitulate current findings arguing for cell autonomous and non-cell autonomous mechanisms causing cortical excitation and inhibition imbalance, which is involved in the degeneration of motor neurons in ALS. Moreover, we will highlight recent evidence that strongly indicates a cardinal role for the motor cortex as a main driver and source of the disease, thus arguing for a corticofugal trajectory of the pathology.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"106-108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121191487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Parasomnias and Sleep Related Movement Disorders—A Look Back at Six Decades of Scientific Studies 睡眠异常和睡眠相关的运动障碍——六十年科学研究的回顾
Clinical and Translational Neuroscience Pub Date : 2022-01-31 DOI: 10.3390/ctn6010003
R. Broughton
{"title":"The Parasomnias and Sleep Related Movement Disorders—A Look Back at Six Decades of Scientific Studies","authors":"R. Broughton","doi":"10.3390/ctn6010003","DOIUrl":"https://doi.org/10.3390/ctn6010003","url":null,"abstract":"The objective of this article is to provide a comprehensive personal survey of all the major parasomnias with coverage of their clinical presentation, investigation, physiopathogenesis and treatment. These include the four major members of the slow-wave sleep arousal parasomnias which are enuresis nocturna (bedwetting), somnambulism (sleepwalking), sleep terrors (pavor nocturnus in children, incubus attacks in adults) and confusional arousals (sleep drunkenness). Other parasomnias covered are sleep-related aggression, hypnagogic and hypnopompic terrifying hallucinations, REM sleep terrifying dreams, nocturnal anxiety attacks, sleep paralysis, sleep talking (somniloquy), sexsomnia, REM sleep behavior disorder (RBD), nocturnal paroxysmal dystonia, sleep starts (hypnic jerks), jactatio capitis nocturna (head and total body rocking), periodic limb movement disorder (PLMs), hypnagogic foot tremor, restless leg syndrome (Ekbom syndrome), exploding head syndrome, excessive fragmentary myoclonus, nocturnal cramps, and sleep-related epileptic seizures. There is interest in the possibility of relationships between sleep/wake states and creativity.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123583269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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