Clinical and Translational Neuroscience最新文献_第7页

From Diagnosis to Satisfaction in Multiple Sclerosis: A Swiss Patient Survey Highlighting the Importance of the First Diagnostic Consultation 从多发性硬化症的诊断到满意度:一项瑞士患者调查强调了首次诊断咨询的重要性

Clinical and Translational Neuroscience Pub Date : 2022-01-31 DOI: 10.3390/ctn6010004

C. Kamm, Praveen Manjakunnel, Dirk Lehnick, M. Welter, A. Chan, N. Kamber, T. Vanbellingen

{"title":"From Diagnosis to Satisfaction in Multiple Sclerosis: A Swiss Patient Survey Highlighting the Importance of the First Diagnostic Consultation","authors":"C. Kamm, Praveen Manjakunnel, Dirk Lehnick, M. Welter, A. Chan, N. Kamber, T. Vanbellingen","doi":"10.3390/ctn6010004","DOIUrl":"https://doi.org/10.3390/ctn6010004","url":null,"abstract":"Background: An early treatment start with disease modifying therapies (DMT) and long-term adherence is crucial in the treatment of people with multiple sclerosis (PwMS) to prevent future disability. Objectives: To gain information on the diagnostic process, decision making, treatment start and adherence with regard to DMT as well as satisfaction in PwMS in Switzerland to optimize management of PwMS. Methods: A survey was conducted between June 2017 and March 2018 in six hospital-based MS centres and eight private practices in Switzerland. PwMS according to the 2010 McDonald criteria, aged 18–60 years, having a clinical isolated syndrome, relapsing remitting MS, or secondary progressive MS were eligible. The survey contained 40 questions, covering participants’ background and circumstances, treatment decisions, therapy start, treatment adherence, and satisfaction (EKNZ Req-2016-00701). Results: 212 questionnaires were returned for analysis. Of these, 125 (59.0%) were answered by patients treated by practice-based neurologists and 85 (40.1%) by patients treated in hospitals. That PwMS were satisfied overall with current medical care, that they were free of relapses and disease progression, and that they were able to live independently were the main goals of patients. Satisfaction was reflected by an early therapy start and a high adherence to DMT in our cohort. The treating neurologist played a major role in this regard. Furthermore, a satisfactory first diagnostic consultation (FDC) was crucial for successful long-term patient care positively influencing an early treatment start, longer duration of the initial therapy, as well as adherence to treatments and general satisfaction. Conclusion: The treating neurologist and especially a satisfactory FDC play a major role for the successful long-term treatment of PwMS. Detailed information on various aspects of the disease and time with the treating neurologist seems to be of major importance.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"699 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115131118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurologic Complications in Adult and Pediatric Patients with SARS-CoV-2 Infection 成人和儿童SARS-CoV-2感染患者的神经系统并发症

Clinical and Translational Neuroscience Pub Date : 2021-12-23 DOI: 10.3390/ctn6010001

Kendall Howard, Taylor Williams, Elizabeth Fitch, Heather D. Ots, Esther Pototskiy, Jay Hawkshead, Zelda J. Ghersin, A. Musto

{"title":"Neurologic Complications in Adult and Pediatric Patients with SARS-CoV-2 Infection","authors":"Kendall Howard, Taylor Williams, Elizabeth Fitch, Heather D. Ots, Esther Pototskiy, Jay Hawkshead, Zelda J. Ghersin, A. Musto","doi":"10.3390/ctn6010001","DOIUrl":"https://doi.org/10.3390/ctn6010001","url":null,"abstract":"SARS-CoV-2 has an impact on the nervous system as a result of pathological cellular and molecular events at the level of vascular and neural tissue. Severe neurologic manifestations including stroke, ataxia, seizure, and depressed level of consciousness are prevalent in patients with SARS-CoV-2 infection. Although the mechanism is still unclear, SARS-CoV-2 has been associated with the pathogenesis of intravascular coagulation and angiotensin-converting enzyme-I, both exacerbating systemic inflammation and contributing to hypercoagulation or blood–brain barrier leakage, resulting in ischemic or hemorrhagic stroke. On the other hand, the SARS-CoV-2 spike protein in neural tissue and within the cerebrospinal fluid may induce neural dysfunction, resulting in neuroinflammation, which is exacerbated by peripheral and neural hypercytokinemia that can lead to neuronal damage and subsequent neuroinflammation. A deeper understanding of the fundamental biological mechanisms of neurologic manifestations in SARS-CoV-2 infection can pave the way to identifying a single biomarker or network of biomarkers to help target neuroprotective therapy in patients at risk for developing neurological complications.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116633675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technology-Based Neurorehabilitation in Parkinson’s Disease—A Narrative Review 以技术为基础的帕金森病神经康复研究综述

Clinical and Translational Neuroscience Pub Date : 2021-11-29 DOI: 10.3390/ctn5030023

J. C. Möller, D. Zutter, R. Riener

引用次数: 3

Abstracts of the 113th Annual Meeting of the Swiss Neurological Society, Congress Centre Kursaal Interlaken, Interlaken, Switzerland, 18–19 November 2021 第113届瑞士神经学会年会摘要，会议中心Kursaal Interlaken，因特拉肯，瑞士，2021年11月18日至19日

Clinical and Translational Neuroscience Pub Date : 2021-11-15 DOI: 10.3390/ctn5030022

Hans Jung, U. Fischer

引用次数: 2

Prediction of Tissue Damage Using a User-Independent Machine Learning Algorithm vs. Tmax Threshold Maps 使用用户独立机器学习算法与Tmax阈值图预测组织损伤

Clinical and Translational Neuroscience Pub Date : 2021-11-12 DOI: 10.3390/ctn5030021

A. Hakim, Benjamin Messerli, Raphael Meier, T. Dobrocky, Sebastian Bellwald, Simon Jung, Richard McKinley, R. Wiest

{"title":"Prediction of Tissue Damage Using a User-Independent Machine Learning Algorithm vs. Tmax Threshold Maps","authors":"A. Hakim, Benjamin Messerli, Raphael Meier, T. Dobrocky, Sebastian Bellwald, Simon Jung, Richard McKinley, R. Wiest","doi":"10.3390/ctn5030021","DOIUrl":"https://doi.org/10.3390/ctn5030021","url":null,"abstract":"(1) Background: To test the accuracy of a fully automated stroke tissue estimation algorithm (FASTER) to predict final lesion volumes in an independent dataset in patients with acute stroke; (2) Methods: Tissue-at-risk prediction was performed in 31 stroke patients presenting with a proximal middle cerebral artery occlusion. FDA-cleared perfusion software using the AHA recommendation for the Tmax threshold delay was tested against a prediction algorithm trained on an independent perfusion software using artificial intelligence (FASTER). Following our endovascular strategy to consequently achieve TICI 3 outcome, we compared patients with complete reperfusion (TICI 3) vs. no reperfusion (TICI 0) after mechanical thrombectomy. Final infarct volume was determined on a routine follow-up MRI or CT at 90 days after the stroke; (3) Results: Compared to the reference standard (infarct volume after 90 days), the decision forest algorithm overestimated the final infarct volume in patients without reperfusion. Underestimation was observed if patients were completely reperfused. In cases where the FDA-cleared segmentation was not interpretable due to improper definitions of the arterial input function, the decision forest provided reliable results; (4) Conclusions: The prediction accuracy of automated tissue estimation depends on (i) success of reperfusion, (ii) infarct size, and (iii) software-related factors introduced by the training sample. A principal advantage of machine learning algorithms is their improved robustness to artifacts in comparison to solely threshold-based model-dependent software. Validation on independent datasets remains a crucial condition for clinical implementations of decision support systems in stroke imaging.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122340912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Case of Polyautoimmunity with Concomitant Presentation of Postural Tachycardia Syndrome, Antiphospholipid Syndrome and Hashimoto’s Thyroiditis 多自身免疫并发体位性心动过速综合征、抗磷脂综合征和桥本甲状腺炎1例

Clinical and Translational Neuroscience Pub Date : 2021-10-29 DOI: 10.3390/ctn5030020

E. Edwards, W. Z’Graggen, C. Bassetti

{"title":"An Unusual Case of Polyautoimmunity with Concomitant Presentation of Postural Tachycardia Syndrome, Antiphospholipid Syndrome and Hashimoto’s Thyroiditis","authors":"E. Edwards, W. Z’Graggen, C. Bassetti","doi":"10.3390/ctn5030020","DOIUrl":"https://doi.org/10.3390/ctn5030020","url":null,"abstract":"Introduction: Postural tachycardia syndrome (POTS) is a chronic form of autonomic dysfunction characterized by symptoms of orthostatic intolerance, often accompanied by sudomotor dysfunction and gastrointestinal dysmotility. In a subgroup of patients with POTS, autoantibodies against adrenergic or cholinergic receptors suggest an immune-mediated etiology. Antiphospholipid syndrome (APS) is a hypercoagulative autoimmune disorder associated with anti-phospholipid-antibodies that causes arterial and venous thromboses. Concurrent occurrence of APS and immune-mediated POTS is rare. Methods and Results: Here, we report a 28-year-old female that experiences symptoms of orthostatic intolerance, vasovagal syncopes, gastrointestinal dysmotility and sudomotor dysfunction. She fulfills the formal diagnostic criteria of POTS showing a heart rate increment of ≥30 beats per minute (bpm) within 10 m of head-up tilt in the absence of orthostatic hypotension, accompanied by symptoms of orthostatic intolerance. The thermoregulatory sweat test reveals severe patchy anhidrotic areas. Gastric emptying scintigraphy shows an impaired gastrointestinal motility. Plasma norepinephrine levels and a skin biopsy appear normal. Finally, serological persistence of anti-alpha-1-adrenergic autoantibodies suggest an immune-mediated pathogenesis. Several years after initial presentation of POTS symptoms, the patient develops APS with recurrent venous emboli and persistent anti-phospholipid-antibodies. Recently the patient is diagnosed with Hashimoto’s thyroiditis (HT) expressing high levels of thyroid-stimulating hormone and high titers of anti-thyroid antibodies. Conclusion: To our knowledge, this is the first report of consecutive immune-mediated POTS, APS and HT in a young woman, possibly displaying a unique combination of three disorders of autoimmune etiology.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"32 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114114463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Abstracts of the 2021 Annual Virtual Meeting of the Swiss Society of Neurosurgery, September 16–17, 2021 瑞士神经外科学会2021年年度虚拟会议摘要，2021年9月16-17日

Clinical and Translational Neuroscience Pub Date : 2021-09-15 DOI: 10.3390/ctn5020019

R. Guzman

引用次数: 0

Could New Generations of Sensors Reshape the Management of Parkinson’s Disease? 新一代传感器能否重塑帕金森病的治疗?

Clinical and Translational Neuroscience Pub Date : 2021-09-13 DOI: 10.3390/ctn5020018

O. Levin, O. Iakovleva, I. I. Coloman, A. V. Kuzmina

引用次数: 2

Intracerebral Hemorrhage, Visual Hallucination and COVID-19: What Is the Connection? A Case-Related Review of the Literature on Peduncular Hallucinosis Following Intracerebral Hemorrhage 脑出血、视幻觉与COVID-19:有什么联系?脑出血后幻脚症的病例相关文献综述

Clinical and Translational Neuroscience Pub Date : 2021-08-12 DOI: 10.3390/ctn5020015

Nicolas M. Nagysomkuti Mertse, Lisa Zenorini, R. Müri

{"title":"Intracerebral Hemorrhage, Visual Hallucination and COVID-19: What Is the Connection? A Case-Related Review of the Literature on Peduncular Hallucinosis Following Intracerebral Hemorrhage","authors":"Nicolas M. Nagysomkuti Mertse, Lisa Zenorini, R. Müri","doi":"10.3390/ctn5020015","DOIUrl":"https://doi.org/10.3390/ctn5020015","url":null,"abstract":"Previous publications have discussed the occurrence of intracerebral hemorrhages, hallucinations and psychosis in COVID-19 patients. In this article, we have reviewed the literature on the subject while depicting the case of a 63-year-old female patient who suffered from an intracerebral hemorrhage in the right basal ganglia and thalamus two weeks after a COVID-19 diagnosis and who developed a visual hallucinosis shortly after. We concluded that, while there may be a correlation between COVID-19 and hallucinations according to current literature, more research is yet needed to clarify. In our case, we rather interpreted the hallucinations in the context of a peduncular hallucinosis related to the intracerebral hemorrhage. We compared our patient’s lesion localization to other 15 reported cases of peduncular hallucinations following intracerebral hemorrhages reported on Pubmed. In summary, the lesions were localized in the pons in 52.9% of the cases, 17.7% were in the thalamus and/or the basal ganglia, 17.7% in the mesencephalon and respectively 5.8% in the temporal and occipital lobe. The distribution pattern we found is consistent with the previously proposed mechanism behind peduncular hallucinations.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127781147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Position Statement on Anti-Dementia Medication for Alzheimer’s Disease by Swiss Stakeholders 瑞士利益相关者对阿尔茨海默病抗痴呆药物的立场声明

Clinical and Translational Neuroscience Pub Date : 2021-08-10 DOI: 10.3390/ctn5020014

G. Frisoni, J. Annoni, S. Becker, T. Brockmann, Markus Buerge, J. Démonet, D. Georgescu, A. Gietl, U. Hemmeter, S. Klöppel, T. Leyhe, A. Monsch, F. Rogantini, Delphine Roulet Schwab, E. Savaskan, K. Schaller, A. von Gunten, G. Gold

引用次数: 0