Clinical and Translational Neuroscience最新文献_第2页

Hyperbaric Oxygen in Post-Stroke Patients: A Feasibility Study 中风后患者的高压氧治疗：可行性研究

Clinical and Translational Neuroscience Pub Date : 2023-11-28 DOI: 10.3390/ctn7040041

Jörg Schmutz, S. Engelter, Nils Peters, Patrick Schmucki, Marco Gelsomino

{"title":"Hyperbaric Oxygen in Post-Stroke Patients: A Feasibility Study","authors":"Jörg Schmutz, S. Engelter, Nils Peters, Patrick Schmucki, Marco Gelsomino","doi":"10.3390/ctn7040041","DOIUrl":"https://doi.org/10.3390/ctn7040041","url":null,"abstract":"Background: Hyperbaric oxygen therapy (HBOT) has been shown to improve the outcomes of certain stroke patients. Our objective was to assess the feasibility of employing HBOT in daily practice in unselected stroke patients with mild-to-moderate residual post-stroke symptoms, considering their ability to commute our center. Methods: This was an exploratory, interventional, prospective monocentric study on post-stroke patients who have completed their in-hospital stroke rehabilitation. We aimed to include 10 participants who were able to complete 40 daily HBOT sessions (2.0 ATA). Effectiveness was assessed using the National Institutes of Health Stroke Score (NIHSS) pre- and post-HBOT. Results: We recruited 13 patients (12 males) with a mean age of 61 years. Three patients dropped out (two never started HBOT and one withdrew after five sessions because of traveling distance). Post-stroke time was 4–251 months. Among the 10 patients completing the HBOT program, 8 improved their NIHSS by a mean of 1,3 (1–4), while 2 patients’ NIHSS remained unchanged. There were no serious adverse events and no side effects. Conclusions: HBOT was shown to be feasible for mobile post-stroke patients who have completed standard rehabilitation. In the absence of major safety concerns, HBOT seems to be an interesting option post-stroke, with the potential to further improve residual stroke severity.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"3 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139216809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of the 2023 Joint Annual Meeting of the Swiss Neurological Society and Swiss Society of Neurosurgery Guest Society: Swiss Society of Behavioural Neurology, Kongresshaus Zurich, Switzerland, November 23–24, 2023 瑞士神经学会和瑞士神经外科学会客座学会 2023 年联合年会摘要：瑞士行为神经学会，2023 年 11 月 23-24 日，瑞士苏黎世孔格雷斯豪斯会议中心

Clinical and Translational Neuroscience Pub Date : 2023-11-15 DOI: 10.3390/ctn7040039

引用次数: 0

Unilateral Posterior Spinal Cord Ischemia Due to a Floating Aortic Thrombus: A Case Report 漂浮主动脉血栓所致单侧后脊髓缺血1例报告

Clinical and Translational Neuroscience Pub Date : 2023-09-06 DOI: 10.3390/ctn7030026

Fabrizio Giammello, Anna Gardin, T. Brizzi, C. Casella, M. C. Fazio, Karol Galletta, E. Mormina, S. Vinci, R. Musolino, P. La Spina, Antonio Toscano

{"title":"Unilateral Posterior Spinal Cord Ischemia Due to a Floating Aortic Thrombus: A Case Report","authors":"Fabrizio Giammello, Anna Gardin, T. Brizzi, C. Casella, M. C. Fazio, Karol Galletta, E. Mormina, S. Vinci, R. Musolino, P. La Spina, Antonio Toscano","doi":"10.3390/ctn7030026","DOIUrl":"https://doi.org/10.3390/ctn7030026","url":null,"abstract":"Introduction. Spinal cord ischemia (SCI) accounts for less than 1% of all strokes, and mostly affects the anterior cord. The ascending aorta (AA) is the rarest site of localization for aortic thrombi (5%). We report a singular case of posterior SCI due to a floating thrombus in the AA. Case presentation. A 75-year-old male with acute left hemiparesis and left tactile and proprioceptive sensory loss below the C5 dermatome (NIHSS 3) is presented. Spinal cord MRI showed a C4–C6 ischemic lesion, involving the left lateral posterior hemi-cord. CT angiography showed a 6 mm floating thrombus in the AA. According to cardiovascular surgeons, dual antiplatelet therapy and high-dose statin were started. After seven days, the patient was discharged with mild left distal hemiparesis and an unchanged sensory deficit. Conclusions. Posterior SCI is rarer than anterior ischemia and potentially unilateral. Its clinical presentation is mainly sensory with possible, but not systematic, weakness of the homolateral limbs. SCI is often caused by aortic pathologies in the elderly, but the incidence rate of non-aneurysmal aortic mural thrombus is about 0.45% and the AA represents a very rare location. In similar cases, conservative medical treatment is preferred despite the high-risk rates of embolic recurrences.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"1970 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130062866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anton Valavanis, a Leader in Swiss Neuroscience Anton Valavanis，瑞士神经科学的领导者

Clinical and Translational Neuroscience Pub Date : 2023-09-01 DOI: 10.3390/ctn7030025

Luca Remonda, Isabel Wanke, K. Lövblad, Harald Grossmann, Claudio L. A. Bassetti

引用次数: 0

Cognitive Neuroimaging Studies on Poverty and Socioeconomic Status Differences in Children and Families across the World: Translational Insights for Next Decade’s Policy, Health, and Education 世界各地儿童和家庭贫困和社会经济地位差异的认知神经影像学研究:对未来十年政策、健康和教育的转化见解

Clinical and Translational Neuroscience Pub Date : 2023-08-25 DOI: 10.3390/ctn7030024

Shanine Kamgang, Meghan Lord, Aanchal Mishra, A. D’Angiulli

{"title":"Cognitive Neuroimaging Studies on Poverty and Socioeconomic Status Differences in Children and Families across the World: Translational Insights for Next Decade’s Policy, Health, and Education","authors":"Shanine Kamgang, Meghan Lord, Aanchal Mishra, A. D’Angiulli","doi":"10.3390/ctn7030024","DOIUrl":"https://doi.org/10.3390/ctn7030024","url":null,"abstract":"This systematic review and meta-analysis of global peer-reviewed neuroimaging findings preliminarily assessed the magnitude of effect sizes (ES) of the influences of family poverty/low socioeconomic status (SES) on children’s neurocognition and whether these were consistently detrimental. The literature search (Web of Science; PUBMED; MEDLINE: PSYCNET; GOOGLE SCHOLAR; SCIENCEDIRECT) included 66 studies from 1988 to 2022; 85% of the studies included were conducted in Western, high-income nations. Bayesian models, corrected by study sizes and variances, revealed ESs were heterogeneous across countries and measurements. Bayesian and standard hypothesis testing indicated high and low SES groups showed similar behavioral performances in neuroimaging-concurrent tasks. Except for Magnetic Resonance Imaging studies, ESs were small-to-intermediate with modest reliability. The strongest ESs were found for attention, mathematical performance, language, and cortical volume, followed by intermediate ESs for reading and socioemotional processes. Differentials in resting activity and connectivity, working memory, and executive functions yielded small effects. A bibliometric analysis showed a significant proportion of the literature attributed neurocognitive deficits to low SES, despite overlooking the under-representativity of non-Western and low-income countries, potential influences of racial/ethnic differences, and measurement sensitivity/specificity discrepancies. To reach United Nations Sustainable Development Goals, policies and interventions should consider regional, structural, or environmental ecologies beyond the individual, critically probing implicit deficit attributions.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129667179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Disorders in Neuromuscular Diseases: A Narrative Review 神经肌肉疾病的睡眠障碍:叙述性综述

Clinical and Translational Neuroscience Pub Date : 2023-08-18 DOI: 10.3390/ctn7030023

M. Boentert

引用次数: 0

Sleep and Stroke-Related Delirium: A Systematic Review 睡眠和中风相关谵妄:系统综述

Clinical and Translational Neuroscience Pub Date : 2023-08-15 DOI: 10.3390/ctn7030022

V. Brunetti, Eleonora Rollo, I. Scala, J. Marotta, A. Callea, C. Imperatori, G. Della Marca

{"title":"Sleep and Stroke-Related Delirium: A Systematic Review","authors":"V. Brunetti, Eleonora Rollo, I. Scala, J. Marotta, A. Callea, C. Imperatori, G. Della Marca","doi":"10.3390/ctn7030022","DOIUrl":"https://doi.org/10.3390/ctn7030022","url":null,"abstract":"Study objectives: Sleep and circadian rhythms disorders are frequent in the acute stroke. Sleep modifications are likely to contribute to the development of stroke-related delirium, a common neuropsychiatric complication of acute stroke. This systematic review aimed to clarify the association between sleep modifications and the occurrence of delirium in patients with acute stroke. Methods: The current systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The search was performed on PubMed and Scopus databases. Only studies that provided data concerning sleep, or pre-existing sleep disorders, in acute stroke and performed a formal evaluation of delirium were included. Results: The literature search enabled the identification of 15 studies, which exhibited high heterogeneity in terms of study design, settings, sleep assessments, delirium measures, and types of sleep intervention. In the study quality assessment, the majority of the studies were rated as weak or moderate. In most of the cases, sleep was subjectively assessed by the patients or rated by clinicians. None of the studies performed polysomnography for the evaluation of sleep. Only four of the studies assessed the impact of a sleep intervention on delirium, suggesting the potentially protective role of sleep promotion in reducing the prevalence and severity of stroke-related delirium. Conclusions: The evidence arising from the present systematic review supports that sleep disruption is a potential promoting factor for stroke-related delirium. We suggest that a formal sleep assessment and sleep promotion should be included in routine stroke care.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127370067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and Therapeutic Approaches in Neurorehabilitation after Traumatic Brain Injury and Disorders of Consciousness 创伤性脑损伤及意识障碍后神经康复的诊断与治疗方法

Clinical and Translational Neuroscience Pub Date : 2023-08-09 DOI: 10.3390/ctn7030021

Julian Lippert, A. Guggisberg

{"title":"Diagnostic and Therapeutic Approaches in Neurorehabilitation after Traumatic Brain Injury and Disorders of Consciousness","authors":"Julian Lippert, A. Guggisberg","doi":"10.3390/ctn7030021","DOIUrl":"https://doi.org/10.3390/ctn7030021","url":null,"abstract":"Severe traumatic brain injury (TBI) may cause disorders of consciousness (DoC) in the form of coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS). Despite significant advancements made over the last two decades in detecting, predicting, and promoting the recovery of consciousness in TBI patients with DoC, the available diagnostic and treatment choices remain limited. In cases of severe TBI, the dissolution of consciousness both in the acute and post-acute phases constitutes one of the major clinical findings and challenges. In clinical settings, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate, and inappropriate care. Recent studies refer to network-based mechanisms of consciousness as a more promising method to predict outcomes and functional recovery. A further goal is the modulation of neural networks underlying awareness and arousal as the main components of consciousness. This review centers on the difficulties in characterizing individuals experiencing post-traumatic DoC and on the recent advancements made in the identification and prognostication of consciousness recovery through the utilization of advanced neuroimaging and electrophysiological techniques as well as biomarkers. Moreover, we discuss new treatment approaches and summarize recent therapeutic recommendations.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124995038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Nap or to Rest? The Influence of a Sixty-Minute Intervention on Verbal and Figural Convergent and Divergent Thinking 小睡还是休息?60分钟干预对语言和图形趋同和发散思维的影响

Clinical and Translational Neuroscience Pub Date : 2023-08-01 DOI: 10.3390/ctn7030020

R. Müri, Magdalena Camenzind, Kathrin Chiffi, Isabel Stuber, A. K. Eberhard-Moscicka

{"title":"To Nap or to Rest? The Influence of a Sixty-Minute Intervention on Verbal and Figural Convergent and Divergent Thinking","authors":"R. Müri, Magdalena Camenzind, Kathrin Chiffi, Isabel Stuber, A. K. Eberhard-Moscicka","doi":"10.3390/ctn7030020","DOIUrl":"https://doi.org/10.3390/ctn7030020","url":null,"abstract":"Background: The relationship between sleep and creativity is a topic of much controversy. General benefits of napping have been described not only in sleep-deprived individuals and in shift workers, but also in people with sufficient night sleep. However, only few studies have investigated the relationship between nap and creativity. Methods: Forty-two native German speakers (29 females, mean age = 24 years, SD = 3.3 years) took part in two experimental sessions (i.e., baseline and intervention). In both sessions, divergent and convergent verbal and figural creativity tasks were administered at the same time of the day. While the baseline session was identical for all the participants, in the second session participants were randomized into either a sixty-minute nap or a sixty-minute rest group. Results: No significant group differences were found for neither divergent nor convergent creativity thinking tasks, suggesting that the interventions had similar effects in both groups. Interestingly, the analysis of the pooled data (i.e., pooled nap and rest groups) indicated differential effects of figural versus verbal creativity tasks, such that significant post-intervention improvements were found for the figural, but not for the verbal divergent and convergent thinking tasks. Conclusions: While further studies are needed to confirm these findings, to the best of our knowledge, such a dissociation between performance of verbal and figural creativity tasks after nap/rest interventions has not been described to date.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115326647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on Rapid-Eye-Movement Sleep Behavior Disorder (RBD): Focus on Its Strong Association with α-Synucleinopathies 快速眼动睡眠行为障碍(RBD)的最新进展:关注其与α-突触核蛋白病的密切联系

Clinical and Translational Neuroscience Pub Date : 2023-07-28 DOI: 10.3390/ctn7030019

C. Schenck

{"title":"Update on Rapid-Eye-Movement Sleep Behavior Disorder (RBD): Focus on Its Strong Association with α-Synucleinopathies","authors":"C. Schenck","doi":"10.3390/ctn7030019","DOIUrl":"https://doi.org/10.3390/ctn7030019","url":null,"abstract":"REM sleep behavior disorder (RBD) is a parasomnia in which the customary generalized skeletal muscle atonia of REM sleep, “REM-atonia”, is compromised, allowing for the injurious acting-out of dreams. RBD can be idiopathic/isolated (iRBD) or symptomatic of neurological disorders, and can be triggered by most antidepressants. RBD mainly affects middle-aged and older adults, and is strongly linked with alpha-synucleinopathies, mainly Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). iRBD is now known to be the earliest and strongest predictor of future PD/DLB, which has stimulated a major international clinical and basic science research effort to enroll iRBD patients for upcoming neuroprotective/disease-modifying trials and to identify the most promising interventions to test in these cohorts. This review will provide the latest pertinent information on the rapidly expanding field of RBD. The methods included a PubMed literature search that included PubCrawlers, which utilizes the NCBI (National Center for Biotechnology Information) E-utils tools for publication retrieval, using the keywords “REM sleep behavior disorder” and “RBD”. The results yielded the latest updates on iRBD as prodromal PD/DLB, with the most promising biomarkers for phenoconversion provided, along with a presentation of three clinical research consortiums that are systematically gathering patients in preparation for enrollment in upcoming clinical trials: (i) The International RBD Study Group; (ii) The North American Prodromal Synucleinopathy (NAPS and NAPS2) Consortium; and (iii) The FARPRESTO Italian multicenter RBD research consortium. In addition, updates on the Parasomnia Overlap Disorder (RBD + NREM parasomnia) and on narcolepsy-RBD are provided, along with new epidemiologic data, the latest RBD management guidelines, and updates on animal models of RBD. Emerging areas of critical RBD research are also highlighted. In conclusion, RBD is a notable example of clinical and translational neuroscience research.","PeriodicalId":242430,"journal":{"name":"Clinical and Translational Neuroscience","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127301791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0