中风后患者的高压氧治疗:可行性研究

Jörg Schmutz, S. Engelter, Nils Peters, Patrick Schmucki, Marco Gelsomino
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摘要

背景:高压氧疗法(HBOT)已被证明可改善某些中风患者的预后。我们的目的是评估在日常实践中对轻度至中度中风后残留症状的非选择性中风患者采用高压氧治疗的可行性,同时考虑到他们往返本中心的能力。方法:这是一项探索性、介入性、前瞻性的单中心研究,对象是已完成院内中风康复治疗的中风后患者。我们的目标是纳入 10 名能够完成每天 40 次 HBOT 治疗(2.0 ATA)的参与者。采用美国国立卫生研究院卒中评分(NIHSS)评估HBOT前后的疗效。结果:我们招募了 13 名患者(12 名男性),平均年龄 61 岁。三名患者退出(两名从未开始 HBOT,一名因路途遥远在五次治疗后退出)。中风后时间为 4-251 个月。在完成 HBOT 计划的 10 名患者中,8 名患者的 NIHSS 平均改善了 1.3(1-4),2 名患者的 NIHSS 保持不变。没有出现严重不良事件和副作用。结论:对于已完成标准康复治疗的脑卒中后移动患者来说,HBOT 是可行的。在没有重大安全问题的情况下,HBOT 似乎是脑卒中后的一种有趣选择,有可能进一步改善脑卒中的残余严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperbaric Oxygen in Post-Stroke Patients: A Feasibility Study
Background: Hyperbaric oxygen therapy (HBOT) has been shown to improve the outcomes of certain stroke patients. Our objective was to assess the feasibility of employing HBOT in daily practice in unselected stroke patients with mild-to-moderate residual post-stroke symptoms, considering their ability to commute our center. Methods: This was an exploratory, interventional, prospective monocentric study on post-stroke patients who have completed their in-hospital stroke rehabilitation. We aimed to include 10 participants who were able to complete 40 daily HBOT sessions (2.0 ATA). Effectiveness was assessed using the National Institutes of Health Stroke Score (NIHSS) pre- and post-HBOT. Results: We recruited 13 patients (12 males) with a mean age of 61 years. Three patients dropped out (two never started HBOT and one withdrew after five sessions because of traveling distance). Post-stroke time was 4–251 months. Among the 10 patients completing the HBOT program, 8 improved their NIHSS by a mean of 1,3 (1–4), while 2 patients’ NIHSS remained unchanged. There were no serious adverse events and no side effects. Conclusions: HBOT was shown to be feasible for mobile post-stroke patients who have completed standard rehabilitation. In the absence of major safety concerns, HBOT seems to be an interesting option post-stroke, with the potential to further improve residual stroke severity.
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