Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences最新文献

{"title":"Facial expression recognition ability and its neuropsychological mechanisms in children with attention deficit and hyperactive disorder.","authors":"Yi Chen, Ye Ma, Xiaoli Fan, Jiamin Lyu, Rongwang Yang","doi":"10.3724/zdxbyxb-2023-0390","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2023-0390","url":null,"abstract":"Attention deficit and hyperactive disorder (ADHD) is a chronic neurodevelopmental disorder characterized by inattention, hyperactivity-impulsivity, and working memory deficits. Social dysfunction is one of the major challenges faced by children with ADHD. It's found that children with ADHD perform less well than typically developing children on facial expression recognition (FER) tasks. Generally, children with ADHD have some difficulties in FER, while some researches suggest that they have no significant differences in accuracy of specific emotion recognition with typically developing children. The neuropsychological mechanisms underlying these difficulties are as follows: 1. neuroanatomically, compared to typically developing children, children with ADHD show smaller gray matter volume and surface area in the amygdala and medial prefrontal cortex regions, as well as reduced density and volume of axons/cells in certain frontal white matter fiber tracts; 2. neurophysiologically, children with ADHD exhibit increased slow-wave activity in their electroencephalogram, and event-related potential studies reveal abnormalities in emotional regulation and responses to angry faces when facing facial stimuli; 3. psychologically, psychosocial stressors may influence FER abilities in children with ADHD, and sleep deprivation in ADHD children may significantly increase their recognition threshold for negative expressions such as sadness and anger. This article reviews research progress on the FER abilities of children with ADHD over the past three years, analyzing the FER deficit in children with ADHD from three dimensions: neuroanatomy, neurophysiology and psychology, aiming to provide new perspectives for further research and clinical treatment of ADHD.","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" 12","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance in applications of artificial intelligence algorithms in cancer-related miRNA research.","authors":"Hongyu Lu, Jia Zhang, Yixing Cao, Shuming Wu, Xingyan Wang, Yurong Bai, Chang Zhao, Jun Zhu, Yuan Wei, Runting Yin","doi":"10.3724/zdxbyxb-2023-0511","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2023-0511","url":null,"abstract":"MiRNAs are a class of small non-coding RNAs, which regulate gene expression post-transcriptionally by partial complementary base pairing. Aberrant miRNA expressions have been reported in tumor tissues and peripheral blood of cancer patients. Bioinformatic tools could improve efficiency of miRNA research, while current bioinformatic tools are in lack of sufficient accuracy. In recent years, artificial intelligence algorithms such as machine learning and deep learning have been widely used in the bioinformatical tools. MiRNA target prediction tools based on artificial intelligence algorithms have higher accuracy than traditional target prediction tools. Bioinformatic tools based on artificial intelligence algorithms successfully predicted miRNA subcellular localization and redistribution, which advanced researchers' understanding of miRNAs. Additionally, the clinical application of artificial intelligence algorithms improved the development of miRNA biomarkers. In this article, we summarized recently developed miRNA bioinformatic tools based on artificial intelligence algorithms. And the potential of machine learning and deep learning in the miRNA research was also highlighted.","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":"83 7","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and genetic analysis of six children with carnitine palmitoyltransferase 2 deficiency.","authors":"Yan Zhang, W. Qiu, Huiwen Zhang, Ting Chen, Feng Xu, Suhong Yang, Jianmei Zhang, Xuefan Gu, Lianshu Han","doi":"10.3724/zdxbyxb-2023-0611","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2023-0611","url":null,"abstract":"OBJECTIVES\u0000To investigate the clinical characteristic and genetic variants of children with carnitine palmitoyltransferase 2 (CPT2) deficiency.\u0000\u0000\u0000METHODS\u0000The clinical and genetic data of 6 children with CPT2 deficiency were retrospectively analyzed. The blood acylcarnitines and genetic variants were detected with tandem mass spectrometry and whole-exon gene sequencing, respectively.\u0000\u0000\u0000RESULTS\u0000There were 4 males and 2 females and the mean age at diagnosis was 32 months (15 d~9 y). One case was asymptomatic, 2 had delayed onset, and 3 were of infantile type. Three cases were diagnosed at neonatal screening, and 3 cases presented with clinical manifestations of fever, muscle weakness, and increased muscle enzymes. Five children presented with decreased free carnitine and elevated levels of palmitoyl and octadecenoyl carnitines. CPT2 gene variants were detected at 8 loci in 6 children (4 harboring biallelic mutations and 2 harboring single locus mutations), including 3 known variants (p.R631C, p.T589M, and p.D255G) and 5 newly reported variants (p.F352L, p.R498L, p.F434S, p.A515P, and c.153-2A>G). It was predicted by PolyPhen2 and SIFT software that c.153-2A>G and p.F352L were suspected pathogenic variants, and p.R498L, p.F434S and p.A515P were variants of unknown clinical significance.\u0000\u0000\u0000CONCLUSIONS\u0000The clinical phenotypes of CPT2 deficiency are diverse. The early diagnosis can be facilitated by neonatal blood tandem mass spectrometry screening and genetic testing, and most of them have good prognosis after timely diagnosis and treatment.","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":"83 10","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombus composition and regulatory T cell expression are associated with clinical outcomes in acute ischemic stroke patients with thrombectomy.","authors":"Jia Luo, Jun Ma","doi":"10.3724/zdxbyxb-2023-0424","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2023-0424","url":null,"abstract":"OBJECTIVES\u0000To analyze the relationship between thrombus composition and regulatory T cell expression with clinical outcome in acute ischemic stroke (AIS) patients with thrombectomy.\u0000\u0000\u0000METHODS\u0000We consecutively enrolled AIS patients with thrombectomy in the Department of Neurology, Shaoxing Hospital of China Medical University from June 2021 to October 2022. All thrombus specimens were subjected to hematoxylin-eosin staining and immunohistochemistry. Semi-quantitative analysis was performed to determine the content of red blood cells, fibrinogen/platelets, and regulatory T cells. Clinical data, vascular recanalization status, and neurologic outcomes at 3 months were collected. A modified Rankin Scale score of 0-2 was defined as a favorable outcome.\u0000\u0000\u0000RESULTS\u0000A total of 44 patients with complete thrombus data were included, including 15 patients with red cell type, 11 patients with mixed type, and 18 patients with fibrin/platelet type. The TOAST etiological classification among the three groups had statistical significance (P=0.001), while no significant difference was found in other general clinical data and surgical data (P>0.05). According to the TOAST etiology, 28 cases were classified into large atherosclerosis type and 16 cases were cardioembolic type. The proportion of red blood cells in thrombus was significantly higher in patients with large atherosclerosis than in those with cardiogenic embolism [58.00%(44.25%, 72.50%) and 24.00%(12.75%, 48.00%), respectively, P<0.01]. The ratio of fibrin to platelet in patients with cardiogenic embolism was significantly higher than that in patients with large atherosclerosis (73%(49.25%, 84.50%) and 40% (25.25%, 54.50%), respectively, P<0.01). Among the 44 patients, 19 had good neurological outcomes and 25 had poor outcomes. Univariate logistic regression analysis was performed on the relevant data of the patients, and it was found that age, operation time, CD4+CD25+T cell number were correlated with the functional outcomes of the patients (P<0.05). However, other clinical and surgical data were not correlated with clinical outcomes (P>0.05). Multivariate logistic regression analysis was performed, including age, operation time, CD4+CD25+T cell count and other variables, and it was found that thrombus CD4+CD25+T cell count was an independent factor affecting the functional outcome of patients (OR=1.369, 95%CI: 1.101-1.701, P=0.005).\u0000\u0000\u0000CONCLUSIONS\u0000There was no significant correlation between erythrocyte and fibrin/platelet components in thrombus and functional outcome, but increased expression of regulatory T cells was associated with good functional outcome.","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":"110 6","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of preclinical research on induced pluripotent stem cell therapy for acute myocardial infarction.","authors":"Songyan Cai, Qingyuan Dai","doi":"10.3724/zdxbyxb-2023-0402","DOIUrl":"https://doi.org/10.3724/zdxbyxb-2023-0402","url":null,"abstract":"Induced pluripotent stem cells (iPSCs) are obtained by introducing exogenous genes or adding chemicals to the culture medium to induce somatic cell differentiation. iPSCs have the ability to differentiate into all three embryonic cell lines, similar to embryonic stem cells. iPSCs can differentiate into cardiac muscle cells through two-dimensional differentiation methods such as monolayer cell culture and co-culture, or through embryoid body and scaffold-based three-dimensional differentiation methods. In addition, the process of iPSCs differentiation into cardiac muscle cells also requires activation or inhibition of specific signaling pathways,such as Wnt, BMP, Notch signaling pathways to mimic the development of the heart in vivo. In recent years, cell suspension culture by bioreactors has been able to produce large number of iPSCs derived cardiac muscle cells (iPSC-CMs). Before transplantation it is necessary to purify iPSC-CMs through metabolic regulation or cell sorting to eliminate undifferentiated iPSCs, which may lead to teratoma formation. The transplantation methods for iPSC-CMs are mainly injection of cell suspension and transplantation of cell patches into the infarcted myocardium. Animal studies have shown that transplantation of iPSC-CMs into the infarcted myocardium can improve cardiac function. This article reviews the progress of preclinical studies on iPSC-CMs therapy for acute myocardial infarction and discusses the limitations and challenges of its clinical application to provide references for further clinical research and application.","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":"1992 2","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on mechanism of follicle injury after ovarian tissue transplantation and protective strategies.","authors":"Hanqi Ying, Libing Shi, Songying Zhang","doi":"10.3724/zdxbyxb-2023-0566","DOIUrl":"10.3724/zdxbyxb-2023-0566","url":null,"abstract":"<p><p>Ovarian tissue cryopreservation and transplantation is the only way to preserve fertility for female cancer patients in prepubertal ages and those who cannot delay radiotherapy or chemotherapy. However, the success rate of cryopreservation and transplantation of ovarian tissue is still low at present due to the risk of ischemia and hypoxia of the grafted tissues. Abnormal activation of primordial follicles and ischemia-reperfusion injury after blood supply recovery also cause massive loss of follicles in grafted ovarian tissues. Various studies have explored the use of different drugs to reduce the damage of follicles during freezing and transplantation as well as to extend the duration of endocrine and reproductive function in patients with ovarian transplantation. For example, melatonin, <i>N</i>-acetylcysteine, erythropoietin or other antioxidants have been used to reduce oxidative stress; mesenchymal stem cells derived from different tissues, basic fibroblast growth factor, vascular endothelial growth factor, angiopoietin 2 and gonadotropin have been used to promote revascularization; anti-Müllerian hormone and rapamycin have been used to reduce abnormal activation of primordial follicles. This article reviews the research progress on the main mechanisms of follicle loss after ovarian tissue transplantation, including hypoxia, ischemia-reperfusion injury and associated cell death, and abnormal activation of follicles. The methods for reducing follicle loss in grafted ovarian tissues are further explored to provide a reference for improving the efficiency of ovarian tissue cryopreservation and transplantation.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"321-330"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cesarean scar defect on reproductive outcomes after assisted reproductive technology.","authors":"Ling Wang, Chenhan Zhao, Qin Zhang","doi":"10.3724/zdxbyxb-2023-0539","DOIUrl":"10.3724/zdxbyxb-2023-0539","url":null,"abstract":"<p><p>In the last twenty years, the cesarean section rate has been rising in China, leading to an increased prevalence of cesarean scar defect (CSD) and secondary infertility. CSD decreases receptivity of endometrium, induces adenomyosis and endometriosis, disrupts uterine micro-environment and causes difficulties in embryo transplant operation as well as has further pregnancy complications. For women undergoing assisted reproductive technology (ART), CSD significantly reduces live birth rate, clinical pregnancy rate and embryo implantation rate. CSD can be effectively treated by hysteroscopic surgery, laparoscopic surgery and transvaginal surgery to increase the pregnancy rate. This article reviews the research progress on the impact of CSD on the reproductive outcomes of ART, the potential factors and related treatments, and provides a reference for the management of CSD patients undergoing ART.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"313-320"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"He<b>'</b>s Yangchao recipe improves premature ovarian insufficiency by regulating mitochondrial biogenesis of granulose cells via ER<b>β</b>/PGC1<b>α</b>/TFAM pathway.","authors":"Chenyun Miao, Ying Zhao, Yun Chen, Ruye Wang, Ning Ren, Qing Liu, Xiaobing Dou, Qin Zhang","doi":"10.3724/zdxbyxb-2023-0521","DOIUrl":"10.3724/zdxbyxb-2023-0521","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of Chinese medicine He's Yangchao recipe on premature ovarian insufficiency (POI) and its relationship with mitochondrial function of ovarian granulose cells in an animal model.</p><p><strong>Methods: </strong>Thirty-six female C57BL/6J mice were randomly divided into blank control group, model group, low-, medium- and high-dose He's Yangchao recipe treatment group and coenzyme Q10 (Q10) treatment group (positive control). The POI model was induced by a single intraperitoneal injection of cyclophosphamide (90 mg/kg). The animals were sacrificed after 21 days. Primary granulose cells were obtained from POI mice and treated with He's Yangchao recipe, ERβ inhibitor PHTPP, and He's Yangchao recipe+PHTPP <i>in vitro</i> for 24 h, respectively. Ovarian histopathological changes were observed by hematoxylin-eosin (HE) staining, ATP levels were detected by luciferase assay, mtDNA copy numbers were detected by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), mitochondrial structure changes were observed by transmission electron microscopy, protein and mRNA expression levels of estrogen receptor β (ERβ), peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α), mitochondrial transcription factor A (TFAM), and superoxide dismutase 2 (SOD2) were detected by Western blotting and qRT-PCR.</p><p><strong>Results: </strong>The ovarian tissue in model group exhibited few secondary and tertiary follicles, whereas the He's Yangchao recipe groups and Q10 group had abundant secondary and tertiary follicles. Compared with the blank control group, ATP and mtDNA levels in model group decreased (<i>P</i><0.01), mitochondrial crista disappeared or abnormal vacuolated structure increased; the protein and mRNA levels of ERβ, PGC1α, TFAM, and SOD2 decreased (all <i>P</i><0.01). ATP production increased in granulose cells of high-dose He's Yangchao recipe group and Q10 group; mtDNA copy numbers increased (<i>P</i><0.05 or <i>P</i><0.01); abnormal mitochondrial structure was reduced; the protein and mRNA expressions of ERβ, PGC1α, TFAM, and SOD2 increased (<i>P</i><0.05 or <i>P</i><0.01). Compared with the PHTPP intervention group, the proportion of normal mitochondrial structure in the granulose cells of He's Yangchao recipe + PHTPP group was higher; ATP content increased (<i>P</i><0.05 or <i>P</i><0.01); mtDNA copy numbers increased (<i>P</i><0.05 or <i>P</i><0.01); the protein and mRNA expression of ERβ, PGC1α, TFAM and SOD2 increased (<i>P</i><0.05 or <i>P</i><0.01).</p><p><strong>Conclusions: </strong>He's Yangchao recipe can regulate mitochondrial biogenesis through ERβ/PGC1α/TFAM pathway to improve ovarian function in POI mice.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":"53 3","pages":"358-367"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of serum alpha-fetoprotein, PIVKA-Ⅱ and glypican-3 in diagnosis of hepatocellular carcinoma: a meta-analysis.","authors":"Hongliang Song, Jianguo Wang, Hui Zhang, Yongfeng Wu, Kai Wang, Xiaobo Wang, Xiao Xu","doi":"10.3724/zdxbyxb-2023-0483","DOIUrl":"10.3724/zdxbyxb-2023-0483","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the value of serum alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist-Ⅱ (PIVKA-Ⅱ) and glypican-3 (GPC-3) in the diagnosis of hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>Studies of AFP, PIVKA-Ⅱ, GPC-3 or in combination for the diagnosis of HCC since 2002 were searched in PubMed, Web of Science and Embase databases. The literature was screened according to the inclusion and exclusion criteria, the quality of the included articles was evaluated by QUADAS checklist, and relevant data were extracted by Meta DiSc, Review Manager 5.4 and Stata 15.1. The diagnostic values of AFP, PIVKA-Ⅱ and GPC-3 alone or in combination for HCC were assessed with receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>A total of 32 articles were included in the study. Meta-analysis showed that when a single marker was used to diagnose HCC, the area under the ROC curve (AUC) of PIVKA-Ⅱ was the highest (0.88, 95%<i>CI</i>: 0.85-0.91), followed by GPC-3 and AFP. The AUC of combination of serum markers was higher than that of a single marker, and the AUC of PIVKA-Ⅱ combined with GPC-3 was the highest (0.90, 95%<i>CI</i>: 0.87-0.92). When a single marker was used for diagnosis, the sensitivity of PIVKA-Ⅱ and GPC-3 were relatively high (0.75 and 0.76), while the specificity of PIVKA-Ⅱ (0.88) and AFP (0.87) were higher than that of GPC-3 (0.81). The sensitivity of the combination of serum markers was higher than that of a single marker, while the specificity was not significantly improved. When a single marker is used to diagnose HCC, the diagnostic odds ratio (DOR) of PIVKA-Ⅱ was the highest (22, 95%<i>CI</i>: 13-36), followed by GPC-3 and AFP. The DOR of the combination of two markers in the diagnosis of HCC was higher than that of a single marker, and the DOR of AFP combined with GPC-3 was the highest (25, 95%<i>CI</i>: 9-67). The DOR of the combination of the three markers was significantly reduced to 10 (95%<i>CI</i>: 7-45).</p><p><strong>Conclusions: </strong>When a single marker is used, PIVKA-Ⅱ has a higher diagnostic value for HCC. The combination of two markers can significantly improve the diagnostic sensitivity, and AFP combined with PIVKA-Ⅱ is recommended for the diagnosis of HCC. The combination of all three markers failed to further improve the diagnostic value.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"131-139"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online mindfulness-based stress reduction improves anxiety and depression status and quality of life in caregivers of patients with severe mental disorders.","authors":"Deng'ai Duan, Haiming Wang, Liang Tong, Jingying Ruan, Qizhu Wang, Zhixiang Chen, Ye Ruan, Tianhao Bao","doi":"10.3724/zdxbyxb-2023-0555","DOIUrl":"10.3724/zdxbyxb-2023-0555","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the effects of online mindfulness-based stress reduction (MBSR) on the anxiety and depression status, and quality of life in the caregivers of patients with severe mental disorders.</p><p><strong>Methods: </strong>Ninety-three caregivers for patients with schizophrenia or bipolar disorder, who were hospitalized in Yunnan Provincial Mental Hospital in March 2021, were enrolled and randomly divided into control group (<i>n</i>=47) and MBSR intervention group (<i>n</i>=46). Both groups received basic health education and rehabilitation skill training, while the intervention group received additional online MBSR for 8 weeks. The anxiety and depression status, and the quality of life of the caregivers were evaluated by Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS) and the 36-item Short Form Health Survey (SF-36) before and 8 weeks after intervention, respectively.</p><p><strong>Results: </strong>Thirteen caregivers dropped out of the study, and 80 subjects (40 in each group) were included in the final analysis. At the baseline, there were no significant differences in SAS, SDS and SF-36 scores between two groups (all <i>P</i>>0.05). Compared with the baseline, SAS and SDS scores in the intervention group significantly decreased after 8 weeks of intervention (both <i>P</i><0.01) and were significantly lower than those in the control group (both <i>P</i><0.01). There were no significant changes in the control group (all <i>P</i>>0.05). Except the physiological function dimension, the total score and the scores of each dimension of SF-36 in the intervention group were significantly increased after 8-week intervention (all <i>P</i><0.05), and were significantly higher than those in the control group (all <i>P</i><0.01). There were no significant changes in the control group before and after intervention (all <i>P</i>>0.05).</p><p><strong>Conclusions: </strong>Online MBSR can reduce the anxiety and depression levels, improve the quality of life in the caregivers of patients with severe mental disorders.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"108-115"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}