中华肝脏病杂志最新文献

{"title":"[Advances in the application of exhaled breath analysis technology in the detection and diagnosis of liver failure].","authors":"S T Zhang, Y S Liu, Y L He","doi":"10.3760/cma.j.cn501113-20250831-00355","DOIUrl":"10.3760/cma.j.cn501113-20250831-00355","url":null,"abstract":"<p><p>In recent years, exhaled breath analysis technology has shown significant potential for the detection and diagnosis of liver diseases as an innovative noninvasive diagnostic method. This paper systematically reviews the recent relevant literature on the application progress of exhaled breath analysis in the field of liver failure at home and abroad, including the correlation between volatile organic compounds and liver pathology, the principles and advantages and disadvantages of present mainstream technologies (mass spectrometry, electronic nose, and spectroscopy analysis), the development and application in warning early-stage conditions and prognostic assessment following treatment, as well as the facing challenges and future application status.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"386-391"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interferon-α induces disulfidptosis occurrence in human liver cancer cells].","authors":"X Y Bi, J Zhang, L H Xu, X R Chu, S S Liu, Y N Xin","doi":"10.3760/cma.j.cn501113-20250612-00233","DOIUrl":"10.3760/cma.j.cn501113-20250612-00233","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the potential molecular regulatory mechanism of interferon-α (IFN-α)-induced disulfidptosis occurrence in human liver cancer cells. <b>Methods:</b> Glucose starvation and IFN-α treatment models were constructed using human hepatocellular carcinoma cell lines HepG2 and Huh7, respectively. Western blotting (WB), NADPH content measurement, and immunofluorescence staining were employed to evaluate disulfidptosis-related phenotypes, such as intracellular disulfide bond accumulation, NADPH depletion, and filamentous actin (F-actin) skeleton collapse. The reversibility of the phenotypes was validated by combining the disulfidptosis inhibitor D-penicillamine (D-Pen). The expression of solute carrier family 7 member 11 (SLC7A11) was downregulated using siRNA interference to evaluate the dependence of IFN-α-induced disulfidptosis on the SLC7A11 pathway. Furthermore, the GEO transcriptome dataset was employed to conduct differential gene analysis for screening candidate molecules involved in the regulation of IFN-α-induced disulfidptosis. Quantitative data are presented as mean ± standard deviation (SD). Comparisons between two groups were performed using the independent-samples <i>t</i> test, while comparisons among multiple groups were analyzed by one-way analysis of variance (ANOVA), followed by Dunnett's t test for pairwise comparisons. <b>Results:</b> Compared with the control group, glucose starvation and IFN-α treatment both induced disulfidptosis-related phenotypes in HepG2 and Huh7 cells, characterized by increased intracellular disulfide bond levels, decreased NADPH content, and F-actin cytoskeleton collapse. Following IFN-α treatment, the accumulation of high-molecular-weight protein aggregates increased in a time- and dose-dependent manner. Compared with IFN-α treatment alone, combined D-Pen intervention partially alleviated intracellular disulfide accumulation, NADPH depletion, and F-actin cytoskeletal collapse. Under conditions of SLC7A11 knockdown, IFN-α-induced high-molecular-weight protein aggregation was further aggravated, suggesting that regulatory mechanisms independent of SLC7A11 may also be involved in this process. Transcriptomic differential expression analysis revealed that β2-microglobulin (B2M), ubiquitin-specific peptidase 18 (USP18) and proteasome activator subunit 1 (PSME1) were upregulated following IFN-α stimulation, among which PSME1 also showed increased protein expression after IFN-α treatment. <b>Conclusion:</b> IFN-α can induce disulfidptosis-related phenotypic changes in HepG2 and Huh7 human hepatocellular carcinoma cells. The upregulation of B2M, USP18, and PSME1 suggests that these molecules may be involved in this process; however, the specific underlying mechanisms require further investigation.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"312-322"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Global differences and challenges in the definition of acute liver failure].","authors":"Y Ren, M Kong, M M Xu, Y Chen","doi":"10.3760/cma.j.cn501113-20250903-00364","DOIUrl":"10.3760/cma.j.cn501113-20250903-00364","url":null,"abstract":"<p><p>Acute liver failure (ALF) is a critical syndrome characterized by sudden deterioration of liver function, coagulopathy, and hepatic encephalopathy, with a very high mortality rate. However, the global ALF diagnostic criteria exhibit significant heterogeneity, with remarkable differences among countries in terms of disease course duration, grading requirements for hepatic encephalopathy, exclusion principles for basic liver disease, and accompanied symptoms. This inconsistency hinders accurate determination of liver transplantation timing, epidemiological comparisons, prognostic assessments, and cross-border research. This article systematically analyzes the core differences in ALF definitions among liver disease-related associations in China, Japan, Europe, and America; explores their impact on clinical practice and scientific research; and proposes strategies such as multicenter collaboration and molecular typing to promote global integration and research advancement for ALF definitions.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"371-375"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic value and clinical significance of matrix metalloproteinase-7, gamma-glutamate transferase, and liver stiffness measurement with ultrasound elastography in children with biliary atresia].","authors":"J M Zhang, Y L Sun, Q Z Li, Y Y Peng, D Qin, Q J Liu, C Fan, Y M Wang, L Zhu","doi":"10.3760/cma.j.cn501113-20250805-00315","DOIUrl":"10.3760/cma.j.cn501113-20250805-00315","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the diagnostic value and clinical significance of matrix metalloproteinase-7 (MMP-7), gamma-glutamyl transferase (GGT), and liver stiffness measurement (LSM) with ultrasound elastography in children with biliary atresia (BA). <b>Methods:</b> A retrospective study was conducted. Forty-five children diagnosed with cholestasis at the Guiyang Maternal and Child Health Hospital between January 2022 and February 2025 were selected as the study subjects. All subjects underwent clinical examination. Pre-enrollment diagnoses were thoroughly documented. The children were divided into a BA group (<i>n</i>=20) and a non-BA group (<i>n</i>=25) based on intraoperative cholangiography and follow-up results. The levels of MMP-7, GGT, direct bilirubin (DBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, total bile acids, and LSM were compared between the two groups. Indicators with statistically significant differences were used to plot and calculate receiver operating characteristic (ROC) curves. The model's stability was internally validated by the bootstrap method. Continuous variables were compared using <i>t</i>-tests or rank-sum tests. Categorical variables were analyzed using <i>χ</i>² tests. The highest observed effect size among all indicators, matrix metalloproteinase-7 (effect size <i>d</i>≈2.5), with an α error probability set at 0.05 was determined using the G*Power 3.1 software. The statistical reliability of the present sample size (BA group <i>n</i>=20, non-BA group <i>n</i>=25) was analyzed using the efficacy calculation model of the Mann-Whitney U test (two independent samples). <b>Results:</b> The levels of MMP-7 [38.95 (17.50, 58.75) μg/L <i>vs</i>. 6.00 (6.00, 7.00) μg/L], GGT [492.04 (237.92, 611.25) U/L <i>vs</i>. 166.00 (86.95, 220.00) U/L], DBil [139.16 (122.62, 164.45) µmol/L <i>vs</i>. 100.90 (62.90, 149.90) µmol/L], and LSM [12.0 (10.0, 17.5) kPa <i>vs</i>. 7.0 (6.0, 8.0) kPa] were significantly higher in the BA group than those in the non-BA group, and the differences were statistically significant (<i>P</i><0.05). MMP-7 as a single indicator demonstrated extremely high diagnostic efficacy in BA diagnosis, with an area under the ROC curve of 0.987. Combining MMP-7 with DBil and LSM further enhanced diagnostic efficacy, achieving a combined AUC of 0.990. The bootstrap method had validated the model as stable and reliable. The statistical power analysis indicated that with the present study sample size, key diagnostic indicators, such as MMP-7, were >0.99. <b>Conclusion:</b> MMP-7, GGT, DBil, and LSM have significant value in the diagnosis of BA. Among them, MMP-7 serves as an independent biomarker with the highest diagnostic efficacy, while combining it with LSM and DBil further improves diagnostic efficacy.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"332-339"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research advances on hepatocyte zonal changes in metabolic associated fatty liver disease].","authors":"Y Li, Z W Huang, J T Gan, Q F Zhang, W W Fu","doi":"10.3760/cma.j.cn501113-20251219-00543","DOIUrl":"10.3760/cma.j.cn501113-20251219-00543","url":null,"abstract":"<p><p>Hepatocyte zonation is a core feature of the spatial heterogeneity of liver function, which is driven by the process of gradients of oxygen and nutrients from the portal vein to the central vein and is precisely regulated by signaling pathways such as Wnt/β-catenin, thereby forming distinct metabolic functional zones. This zonation mechanism is crucial to preserving hepatic metabolic homeostasis. However, zonation stability is disrupted in metabolic associated fatty liver disease (MAFLD). The pericentral venous zone (Zone 3) is the initial site of steatosis and oxidative stress due to lipid metabolism imbalance and hypoxic sensitivity, while the periportal venous zone (Zone 1) exhibits metabolic abnormalities associated with insulin resistance. Furthermore, the dissemination of inflammatory activation and fibrosis from Zone 3 to the entire lobule with zonation disruption facilitates disease progression. Therefore, an in-depth understanding of the hepatocyte zonation mechanism is of enormous significance for revealing the pathogenesis, pathological evolution, and treatment strategies of MAFLD. This article systematically explains that the homeostasis of hepatocyte zonation is fundamental to maintaining a healthy liver, whereas zonation disorders are a central factor driving MAFLD progression, providing a theoretical basis for understanding pathogenesis from a spatial metabolism perspective and exploring new therapeutic strategies based on recent research findings.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"400-408"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A real-world study of clinical cure in children with HBeAg-positive chronic hepatitis B from the Guangxi region].","authors":"R Y Lyu, J H Tian, S M Huang, M L Meng, W Y Xiang, P Y Fan, J Li, S X Li","doi":"10.3760/cma.j.cn501113-20251125-00506","DOIUrl":"10.3760/cma.j.cn501113-20251125-00506","url":null,"abstract":"","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"363-370"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exploring the protective effects and mechanisms of HYX1-derived exosomes on acute liver failure based on disulfidptosis signaling].","authors":"Q Yang, H X Tang, X X Liu, Y Chen, L Bai","doi":"10.3760/cma.j.cn501113-20250610-00227","DOIUrl":"10.3760/cma.j.cn501113-20250610-00227","url":null,"abstract":"<p><p><b>Objective:</b> To explore the protective effect and molecular mechanism of human liver stem cell line HYX1-derived exosomes (HYX1-Exos) on acute liver failure (ALF) based on disulfidptosis signaling. <b>Methods:</b> Healthy male BALB/c mice were intraperitoneally injected with D-galactosamine/lipopolysaccharide (D-GalN/LPS) to induce ALF. Mice were divided into a normal control group, an acute liver failure group (ALF group), a disulfidptosis inhibitor tris (2-carboxyethyl) phosphine (TCEP) intervention group (TCEP+ALF group), a HYX1-Exos intervention group (HYX1-Exos+ALF group), and a SLC7A11-IN-1 intervention group (SLC7A11-IN-1+ALF group), with five mice per group. Blood and liver tissue samples were collected. The degree of liver tissue damage was assessed based on serum transaminase levels and hematoxylin-eosin staining results. Quantitative PCR was used to analyze the gene expression levels of disulfidptosis markers SLC7A11, GLUT1, and WAVE2 in liver tissues of each group. Cell Counting Kit-8 (CCK-8) was used to evaluate hepatocyte viability. Statistical analysis was performed using the independent samples <i>t</i>-test and one-way ANOVA. <b>Results:</b> TCEP treatment had significantly alleviated liver damage in ALF mice, as indicated by a marked reduction in transaminase levels [alanine aminotransferase: (312.01±19.46) U/L <i>vs</i>. (1 512.09±229.34) U/L, <i>t</i>=10.38, <i>P</i><0.001; aspartate aminotransferase: (76.30±39.63) U/L <i>vs</i>. (324.17±78.27) U/L, <i>t</i>=5.75, <i>P</i><0.001] and a notable improvement in liver histology. HYX1-Exos treatment had significantly reduced liver injury and disulfidptosis levels in ALF mice. Liver injury and disulfidptosis levels were significantly reduced with inhibition of SLC7A11 in ALF mice. <i>In vitro</i> experiments showed that HYX1-Exos protected hepatocytes from disulfidptosis induced by high SLC7A11 under glucose starvation. <b>Conclusion:</b> Disulfidptosis plays an important role in the development of ALF, and HYX1-Exos likely have a hepatoprotective effect on ALF by inhibiting SLC7A11-mediated disulfidptosis.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"348-355"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Precise clinical classification of metabolic associated fatty liver disease].","authors":"W R Su, J J Ding, Q Pan, J Chai","doi":"10.3760/cma.j.cn501113-20251205-00519","DOIUrl":"10.3760/cma.j.cn501113-20251205-00519","url":null,"abstract":"<p><p>Metabolic associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide, and its significant clinical and pathophysiological heterogeneity poses a serious challenge to traditional \"one-size-fits-all\" diagnostic and therapeutic approaches. Therefore, constructing a precise clinical classification system to identify patient subgroups with varying risks and treatment responses has become a core frontier in this field. This article systematically summarizes the main current MAFLD classification methods, covering content from simple classification based on clinical phenotypes (e.g., body mass index) to non-invasive risk stratification via serology and imaging markers, and further extending to deep molecular subtyping driven by cutting-edge multi-omics technologies and artificial intelligence. In addition, it analyzes and points out the limitations of single-dimensional classification approaches. The future development trend is to construct a multi-dimensional, dynamic assessment system that integrates clinical, non-invasive biomarkers and deep molecular features, providing a comprehensive framework for laying a scientific foundation for elucidating the origins of disease heterogeneity, achieving personalized risk assessment, precision-targeted interventions, and innovative clinical trial designs, ultimately propelling MAFLD into the era of precision medicine.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"307-311"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the effects of time-restricted eating on metabolic associated fatty liver disease].","authors":"Z Q Jiang, T J Wei, G X Li","doi":"10.3760/cma.j.cn501113-20250529-00204","DOIUrl":"10.3760/cma.j.cn501113-20250529-00204","url":null,"abstract":"<p><p>Metabolic-associated fatty liver disease (MAFLD) is a common chronic liver disease closely related to metabolic disorders. Currently, the effective pharmacological treatments are scarce. In recent years, time-restricted eating (TRE), as an emerging dietary intervention strategy, has been shown in studies to have significant preventive and therapeutic potential for diseases related to metabolic dysfunction. However, the effects of TRE on MAFLD and the underlying mechanisms remain not fully elucidated. This review briefly summarizes the present research progress of this field in terms of the effects, improvement, and mechanistic role of TRE on MAFLD.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"380-385"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[ATPase H⁺ transporter expression with prognosis in hepatocellular carcinoma].","authors":"Q Yuan, Y Q Jin, Y X Cao, L J Cheng, H M Fan, Y Liu, L Yang","doi":"10.3760/cma.j.cn501113-20250709-00269","DOIUrl":"10.3760/cma.j.cn501113-20250709-00269","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the expression level of ATPase H⁺ transporting accessory protein 1 (ATP6AP1) in hepatocellular carcinoma (HCC) lines and its effect on cell proliferation and migration, providing a new target for the treatment of HCC. <b>Methods:</b> Real-time quantitative polymerase chain reaction (RT-PCR) was used to detect the differential expression of ATP6AP1 in normal hepatocyte line L02 and hepatocellular carcinoma line HepG2. An ATP6AP1 knockdown group (KD group) and a negative control group (NC group) were constructed by lentiviral infection. The proliferation and migration abilities were detected by CCK8 cell proliferation and cell scratch assay between the two groups. Independent samples <i>t</i>-test was used to analyze the differences between groups. Bioinformatics analysis was performed on the Cancer Genome Atlas (TCGA) databases using Kaplan-Meier Plotter, UALCAN, and GEPIA to explore the differential expression of ATP6AP1 in HCC patients and its impact on prognosis. <b>Results:</b> Bioinformatics results showed that the expression level of ATP6AP1 was significantly higher in HCC tissues than that in normal liver tissues (<i>P</i><0.05). Functional enrichment analysis indicated that ATP6AP1 regulated lysosomal function, intracellular acidification, and the immune microenvironment in HCC progression. RT-PCR results showed that ATP6AP1 mRNA expression was significantly higher in HepG2 liver cancer cells than that in normal hepatocytes L02 (<i>P</i><0.05). The relative expression level of ATP6AP1 mRNA was significantly lower in the KD group (0.18±0.01) than that in the NC group (1.00±0.08) (<i>P</i><0.001). CCK assays showed that the profileration capacity was significantly higher in KD group than that in the NC group from day 3 to day 5 (<i>P</i><0.05), with a significant time-effect relationship (<i>P</i><0.001). Cell scratch assay results showed that the migration rate was significantly higher in the NC group than that of the KD group over time, with a slower scratch repair rate. <b>Conclusion:</b> High expression of ATP6AP1 plays a pro-cancerous role in HCC progression and may serve as a potential biomarker for predicting prognosis and a potential therapeutic target.Therefore, further validation of its mechanism of action in animal models and clinical samples is needed in the future.</p>","PeriodicalId":24006,"journal":{"name":"中华肝脏病杂志","volume":"34 4","pages":"323-331"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}