肝脏异种移植的研究与应用进展

Q3 Medicine
Y Xie, D Wang, W T Jiang
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引用次数: 0

摘要

肝移植是许多终末期肝病的有效治疗方法;然而,供体肝脏的短缺是影响其发展的主要障碍之一。因此,异种器官移植有望成为解决器官短缺的一种潜在途径。利用基因编辑技术改良动物基因,增强其与人的生理相容性,结合新型免疫抑制药物,减少排斥反应的发生,延长移植物的存活时间。异种肝脏移植比心脏或肾脏移植更为突出,由于肝脏的结构和生理功能更为复杂,其相关的异种排斥反应、术后凝血障碍等分子机制有待进一步研究。本文结合国内外最新研究进展,对异种肝脏移植的历史发展、当前存在的主要问题及临床应用进行综述,旨在提高临床医生对异种肝脏移植的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Research and application progress for liver xenotransplantation].

Liver transplantation is an effective treatment method for many end-stage liver diseases; however, the shortage of donor livers is one of the main obstacles affecting its development. Thus, xenotransplantation is expected to be a potential way to solve the shortage of organs. Gene editing technology has been used to improve animal genes so they can enhance their physiological compatibility with humans, and new immunosuppressive drugs are combined to reduce the occurrence of rejection so as to prolong the survival time of grafts. Liver xenotransplantation is more prominent than that of the heart or kidney transplants, and the related molecular mechanisms, such as xenogeneic rejection and coagulation disorders after surgery, need to be further studied due to the more complex structure and physiological functions of the liver. This paper reviews the historical development, current main problems, and clinical applications based on the latest research progress at home and abroad, with aim to improve clinicians' understanding of liver xenotransplantation.

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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
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