Zhongguo yao li xue bao = Acta pharmacologica Sinica最新文献_第2页

Effect of artemether on phosphorylase, lactate dehydrogenase, adenosine triphosphatase, and glucosephosphate dehydrogenase of Schistosoma japonicum harbored in mice. 蒿甲醚对小鼠日本血吸虫磷酸化酶、乳酸脱氢酶、腺苷三磷酸酶和葡萄糖磷酸脱氢酶的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

S H Xiao, J Q You, H F Guo, J Y Mei, P Y Jiao, M Y Yao, Z N Zhuang, Z Feng

{"title":"Effect of artemether on phosphorylase, lactate dehydrogenase, adenosine triphosphatase, and glucosephosphate dehydrogenase of Schistosoma japonicum harbored in mice.","authors":"S H Xiao, J Q You, H F Guo, J Y Mei, P Y Jiao, M Y Yao, Z N Zhuang, Z Feng","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To study the effect of artemether (Art) on phosphorylase (PP), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), and adenosine triphosphatase (ATPase) of S japonicum.Methods: Mice infected with S. japonicum cercariae for 32-38 d were treated i.g. with Art 100-300 mg.kg-1 and killed 24-72 h after treatment for collection of schistosomes. The activities of PP, LDH, and G-6-PDH were measured by the formation of NADH or NADPH. The activity of ATPase was measured by the rate of release of inorganic phosphate (Pi) from ATP at 37 degrees C.Results: After infected mice were treated i.g. with Art 300 mg.kg-1 for 24-48 h, the activities of total PP and PPa (active form) increased markedly in both male and female worms, while PPb (inactive form) showed no or only a slight increase. At 24-72 h after the above-mentioned mice were treated i.g. with Art 100-300 mg.kg-1, the inhibitory rates of LDH and G-6-PDH were 9%-59% (male) and 41%-75% (female) as well as 22%-42% (male) and 74%-89% (female), respectively. When Art 300 mg.kg-1 was given to infected mice for 24 h, only the activity of Mg(2+)-ATPase showed marked inhibition in both male and female worms. At 48 h, the Ca(2+)-ATPase, Mg(2+)-ATPase, and Na(+)-K(+)-ATPase were all inhibited, the inhibitory rates of 17% (male) and 19% (female), 32% (male) and 48% (female) as well as 29% (male) and 44% (female), respectively.Conclusion: In schistosomes, the increase in the activity of AMP-independent PPa induced by Art may enhance the decomposition of glycogen and the inhibition of LDH by Art could reduce the formation of lactate. Moreover, Art exerts a potent inhibition on the G-6-PDH activity of the female S japonicum.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects. CYP2D6表型决定了16名汉族人群普罗帕酮对映体的药代动力学变异性。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

W M Cai, B Chen, M H Cai, Y D Zhang

{"title":"CYP2D6 phenotype determines pharmacokinetic variability of propafenone enantiomers in 16 HAN Chinese subjects.","authors":"W M Cai, B Chen, M H Cai, Y D Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To determine the role of the CYP2D6 phenotype in the metabolism of propafenone (Pro) enantiomers in 16 HAN Chinese subjects.Methods: Seven very extensive metabolizers (VEM) and nine intermediate metabolizers (IM) were enrolled from a Chinese population whose phenotype had been previously assessed with a dextromethorphan metabolic phenotyping. The blood samples (0-15 h) were taken after oral administration of a single dose (400 mg) of rac-Pro hydrochloride. Enantiomeric concentrations of propafenone in plasma were measured by a reverse-phase HPLC with precolumn derivatization.Results: S-Pro was less metabolized and had higher plasma concentrations than R-Pro in both CYP2D6 phenotypes. Besides, the T1/2 of R-Pro was longer than that of S-Pro in IM, but not in VEM. However, there were significant differences in the metabolism of Pro enantiomers between VEM and IM. The Cmax and AUC of both isomers in the IM group were higher than those in the VEM group (P < 0.01). The Cl of Pro enantiomers in IM group was only about half of that in VEM group [(67 +/- 17) vs (133 +/- 28) L.h-1 for S-Pro, (90 +/- 24) vs (200 +/- 87) L.h-1 for R-Pro, P < 0.01]. The S/R ratios of T1/2, Tmax, Cmax, Cl, and AUC were not significantly different (P > 0.05).Conclusion: CYP2D6 phenotype determines the pharmacokinetic variability of propafenone enantiomers and existence of IM may be relevant to diminished capacity of CYP2D6 enzyme in Chinese subjects.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21531417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of effects of surfactant and inhaled nitric oxide in rabbits with surfactant-depleted respiratory failure. 表面活性剂与吸入型一氧化氮对表面活性剂衰竭家兔的影响比较。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

B H Zhou, B Sun, Z H Zhou, L W Zhu, S Z Fan, R Lindwall

{"title":"Comparison of effects of surfactant and inhaled nitric oxide in rabbits with surfactant-depleted respiratory failure.","authors":"B H Zhou, B Sun, Z H Zhou, L W Zhu, S Z Fan, R Lindwall","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare effects of pulmonary surfactant and inhaled nitric oxide (iNO) in improvement of survival and blood oxygenation in ventilated rabbits with acute hypoxic respiratory failure induced by repeated bronchoalveolar lavage (BAL).Methods: After BAL all the rabbits had more than 50% reduction of dynamic lung compliance (Cdya), 50% increment of resistance of respiratory system (Rrs), and an increase of mean oxygenation index (OI) from 1 to 22. The rabbits were then randomly allocated to groups receiving (1) mechanical ventilation only (Control), (2) iNO 0.8 mumol.L-1 (20 ppm) (NO), (3) intratracheal bolus surfactant phospholipids at 100 mg.kg-1 (Surf), and (4) combined surfactant at 100 mg.kg-1 with inhaled NO at 0.8 mumol.L-1 (Surf + NO). All the rabbits were ventilated with standardized tidal volume (8-10 mL.kg-1) for another 8 h or until early death.Results: The rabbits in both control and NO groups had the lowest survival rate, deterioration of lung mechanics and OI, whereas those in the Surf and Surf + NO groups had modestly improved Cdyn, Rrs, and OI. Only rabbits in the Surf + NO group had significantly improved survival rate and alveolar expansion.Conclusion: Surfactant with or without iNO is more effective compared to the control and iNO groups in rabbit, suggesting that iNO is not effective unless a method to recruit alveoli is applied.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21532054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrolysis of extracellular adenine nucleotides by cultured bovine endocardial endothelial cells. 体外培养的牛心内膜内皮细胞对胞外腺嘌呤核苷酸的水解。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

F X Yi, W L Liu, L W Chen, S Zeng, Z G Guo

引用次数: 0

Anti-inflammatory and nitric oxide-inhibiting properties of granulocyte colony-stimulating factor. 粒细胞集落刺激因子的抗炎和抑制一氧化氮的特性。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

G Hoffmann, W Schobersberger

引用次数: 0

Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia. 鞘内注射促肾上腺皮质激素抑制福尔马林致痛觉过敏大鼠脊髓一氧化氮合酶阳性神经元的增加。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

H J Zhou, H D Li, X C Li, H Z Ruan, B Y Zhao

引用次数: 0

Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia. 粉防己碱对缺氧大鼠皮质神经元NMDA受体通道变化的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

Z F Wang, C S Xue, Q X Zhou, Z B Wan, Q S Luo

引用次数: 0

Antagonistic effects of shikimic acid against focal cerebral ischemia injury in rats subjected to middle cerebral artery thrombosis. 莽草酸对脑中动脉血栓形成大鼠局灶性脑缺血损伤的拮抗作用。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

Y Ma, Q P Xu, J N Sun, L M Bai, Y J Guo, J Z Niu

引用次数: 0

Vascular effects of estrogens: rapid actions, novel mechanisms, and potential therapeutic implications. 雌激素对血管的作用:快速作用、新机制和潜在的治疗意义。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

M Barton

{"title":"Vascular effects of estrogens: rapid actions, novel mechanisms, and potential therapeutic implications.","authors":"M Barton","doi":"","DOIUrl":"","url":null,"abstract":"Although estrogen-dependent effects on the vasculature were first observed more than a century ago, many of the mechanisms by which estrogens interact with the vascular wall have been identified only in the past 15 years. Estrogens bind to vascular estrogen receptors (ER), including the ER alpha, the novel ER beta as well as to membrane-bound receptors. Estrogens have direct effects in human coronary and internal mammary arteries by inducing rapid, endothelium-independent relaxation, enhancement of endothelial function and inhibition of vasoconstriction by vasoactive agonists. Furthermore, estrogens contribute to vascular homeostasis through modulation of gene expression, changes in membrane potentials, as well as expression and function of receptors. In addition, estrogens interfere with the activity of vasoactive peptides and vascular enzymes and act as natural antioxidants. Some of these effects have also been observed for phyto-estrogens, which are important dietary components in Asian countries. In the vasculature, the sum of these actions of estrogens results in vasodilatation and inhibition of vascular cell growth. Accordingly, estrogens have been shown to improve vascular function of animals and humans and to inhibit the response to injury after balloon angioplasty and the progression of atherosclerosis. Prospective clinical studies are ongoing to determine whether replacement therapy with estrogen or derivatives provides an alternative to lower cardiovascular mortality in postmenopausal women.","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21532053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics of 2-hydroxyflutamide, a major metabolite of flutamide, in normal and CCl4-poisoned rats. 氟他胺的主要代谢物- 2-羟基氟他胺在正常和ccl4中毒大鼠体内的药代动力学

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-07-01

C J Xu, D Li

引用次数: 0