Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-08-01

Z F Wang, C S Xue, Q X Zhou, Z B Wan, Q S Luo

引用次数: 0

Abstract

Aim: To study the effects of tetrandrine (Tet) on the changes of NMDA receptor channels in cortical neurons induced by anoxia.

Methods: Cell-attached configuration of patch-clamp techniques. Anoxia was produced by perfused cells with 95% N2 + 5% CO2 gassed bath solution.

Results: During anoxia, the open time constant (tau 2), open probability (Po) of 35-pS and 100-pS channels increased. Tet 7.5 mumol.L-1 reduced the Po of 35-pS and 100-pS channels, 15 and 30 mumol.L-1 inhibited open of 100-pS channel fully, and changed the open time constant of 35-pS from two to single exponential distribution.

Conclusion: Tet inhibition of the open of NMDA receptor channels induced by anoxia was one of its protective mechanisms.

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粉防己碱对缺氧大鼠皮质神经元NMDA受体通道变化的影响。

目的:研究粉防己碱(Tet)对缺氧诱导的皮质神经元NMDA受体通道变化的影响。方法:细胞贴壁膜片钳技术。用95% N2 + 5% CO2的气浴液灌注细胞产生缺氧。结果:缺氧时，35-pS和100-pS通道的开放时间常数(tau 2)和开放概率(Po)增加。Tet 7.5 mumol。L-1使35-pS和100-pS通道Po分别降低15和30 μ mol。L-1完全抑制了100-pS通道的开放，使35-pS通道的开放时间常数由2指数分布变为单指数分布。结论:Tet抑制缺氧诱导的NMDA受体通道开放是其保护机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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