World journal of Pharmacy and pharmaceutical sciences最新文献_第4页

Stability Indicating Method Development and Validation for Determination of Daunorubicin and Cytarabine in Bulk and Pharmaceutical Dosage Form by RP-HPLC 反相高效液相色谱法测定原料药和制剂中柔红霉素和阿糖胞苷含量的稳定性指示方法的建立与验证

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100104

Uma Maheswari Katari, M. Ajitha

{"title":"Stability Indicating Method Development and Validation for Determination of Daunorubicin and Cytarabine in Bulk and Pharmaceutical Dosage Form by RP-HPLC","authors":"Uma Maheswari Katari, M. Ajitha","doi":"10.54037/wjps.2022.100104","DOIUrl":"https://doi.org/10.54037/wjps.2022.100104","url":null,"abstract":"A Simple, Accurate and Precise method was developed for the simultaneous estimation of Daunorubicin and Cytarabine in bulk and pharmaceutical dosage form by RPHPLC technique. Chromatogram was run through standard Zorbax C18 (150mm x 4.6 mm, 5μ particle size). Mobile phase containing buffer 0.01N KH2PO4: Acetonitrile taken in the ratio of 60:40 was pumped through column at a flow rate of 1.0 ml/min. Buffer used in this method was 0.01N KH2PO4 buffer. Temperature was set to 30C. Optimized wavelength selected was 240.0 nm. Retention time of Cytarabine and Daunorubicin were found to be 2.325 min and 3.208 nm. % RSD of Daunorubicin and Cytarabine were found to be 0.6 and 0.6 respectively. %Recovery was obtained as 100.30% and 100.33% for Daunorubicin and Cytarabine respectively. LOD, LOQ values obtained from regression equation of Daunorubicin and Cytarabine were 0.09, 0.28 and 0.32, 0.97 respectively. The regression equation of Daunorubicin and Cytarabine is y=39589X+28710 and y=32928X+12457 respectively Retention times were decreased and that run was decreased, so the method was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78537662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Demographic, EtiologicandCo-morbidity Status AmongCOPD Patients copd患者的人口统计学、病因学和合并症评估

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100702

Saurabh Saklani, Shivam Bisht, Yogesh Joshi

引用次数: 0

Variation in the efficacy of organic extrants for the phytochemical validation of Sauropus androgynus – a multivitamin plant 多维生素植物——雌雄同体龙的有机萃取物对其植物化学有效性的影响

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100302

L. S.

引用次数: 0

Effects of citrus fruit and their bioactive components on immunity 柑橘类水果及其生物活性成分对免疫的影响

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100404

Rakhi Sahu, Anurag Pandey, M. Tiwari, N. Mishra, A. Varshney

{"title":"Effects of citrus fruit and their bioactive components on immunity","authors":"Rakhi Sahu, Anurag Pandey, M. Tiwari, N. Mishra, A. Varshney","doi":"10.54037/wjps.2022.100404","DOIUrl":"https://doi.org/10.54037/wjps.2022.100404","url":null,"abstract":"The genus Citrus contains a vast range of antioxidant metabolites, dietary metabolites and antioxidant polyphenols that protect plants from unfavourable environmental conditions, enhance their tolerance to abiotic and biotic stresses and possess multiple health-promoting effects in humans along with specifically Immunity boosting. Immunity is described as a condition of being able to resist a particular disease especially through preventing the development of a pathogenic microorganism or by counteracting the effects of its products. The immune system is a bodily system that produces the immune response to defend your body from foreign substances, cells and tissues. The immune system includes various parts of the body including the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (such as those in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells and antibodies. This review summarizes various citrus fruit and their bioactive components having a positive effect to promote immunity responses in humans body. Additionally, we highlight the health-promoting properties along with Pharmacodynamic and Phytochemical properties of Citrus fruit described in Ayurveda and their potential usage.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89912417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Pyrogenic Meningitis 热原性脑膜炎1例报告

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100207

Kanikella Sivaji, A. Sai, M. Prasad, Sundaresh Ram, N. Vamsi, N. Rahul

引用次数: 0

Nutraceuticals aid in managing COVID-19 营养保健品有助于管理COVID-19

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100204

Sweta Sharma, P. Patel, A. Yadav

引用次数: 1

Stability Indicating Method Development and Validation for Simultaneous Estimation of the Netupitant and Palonosetron in Bulk and Pharmaceutical Dosage Form by RP-HPLC 反相高效液相色谱法同时测定尼妥吡坦和帕洛诺司琼原料药和制剂的稳定性指示方法的建立与验证

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100112

Harshini Gandla, M. Ajitha

{"title":"Stability Indicating Method Development and Validation for Simultaneous Estimation of the Netupitant and Palonosetron in Bulk and Pharmaceutical Dosage Form by RP-HPLC","authors":"Harshini Gandla, M. Ajitha","doi":"10.54037/wjps.2022.100112","DOIUrl":"https://doi.org/10.54037/wjps.2022.100112","url":null,"abstract":"A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palonosetron in Pharmaceutical dosage form. Chromatogram was run through Phenomenex C18 150 mm (4.6 x 150mm, 5μm) Mobile phase containing Buffer 60% 0.01N KH2PO4: 40% Acetonitrile was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was 230.0 nm. Retention time of Palonosetron and Netupitant were found to be 2.266 min and 2.945 min. %RSD of the Netupitant and Palonosetron were and found to be 0.8 and 0.8 respectively. %Recovery was obtained as 101.08% and 100.35%for Netupitant and Palonosetron respectively. LOD, LOQ values obtained from regression equations of Netupitant and Palonosetron were 1.27, 3.86 and 0.002, 0.006. respectively. Regression equation of Netupitant is y =18431x + 50471.and y = 13091x + 11.98. of Palonosetron. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91337348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of anti-arthritic activity of Spathodea Campanulata of root bark extract on freund’s adjuvant induced arthritis in rats models 鸡血藤根皮提取物对freund佐剂性关节炎大鼠模型的抗关节炎活性评价

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100701

Sankari M, Thamizharasi S, Mariyammal A, Meghana K, Parvatha Raja Kumaran V.S, Chetan A

{"title":"Evaluation of anti-arthritic activity of Spathodea Campanulata of root bark extract on freund’s adjuvant induced arthritis in rats models","authors":"Sankari M, Thamizharasi S, Mariyammal A, Meghana K, Parvatha Raja Kumaran V.S, Chetan A","doi":"10.54037/wjps.2022.100701","DOIUrl":"https://doi.org/10.54037/wjps.2022.100701","url":null,"abstract":"Rheumatoid arthritis is a chronic systemic inflammation of the synovial joint and progressive destruction of cartilage and bone that may affect many tissues and organs-skin, blood vessels, heart, lungs and muscles but principally attacks the joints, producing a non-suppurative proliferative andinflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. Angiogenesis and microvascular lesions are common features of RA inflammation, which leads to abnormal serum protein infiltration into the synovium. The objective of the study was to determine the preliminary phytochemical constituents, to evaluate acute toxicity studies, In-vitroanti-oxidant studies, In vitroand In-vivoanti-arthritic activity of theroot bark of Spathodea campanulata.. Paw edema was induced in rats by intra plantar injection of 0.1ml of Complete Freund’s Adjuvant (CFA) in left hind paw. The ethanolic extract of Spathodea campanulata (150mg/Kg & 300mg/Kg) and Diclofenac Sodium were orally administered for 28 consecutive days.Percentage inhibition was determined by Protein denaturation method and Membrane Stabilizing Activity Hematological, Histopathology, Radiological Analysis of CFA-induced arthritis in rat was performed. Statisticalsignificant was analyzed by one-way ANOVA followed by Tukey test. Our study concluded that ethanolic extract at the dose of 300 mg/kg showed significant anti-arthritic activity when compared to Diclofenac sodium","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88078440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wilt-Causing Fungal Pathogens of Banana 香蕉致枯萎真菌病原体

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2022.100206

P. Kumari, Ngangbam Sushma, Lourembam Saaya Devi, Samreen Taj, Neha Jit, Jayarama Reddy

引用次数: 0

Analytical method development and validation for simultaneous estimation of sitagliptin and etruglifloxin in bulk and pharmaceutical dosage form by RP-HPLC 反相高效液相色谱法同时测定西格列汀和依曲格列辛原料药和制剂的分析方法的建立与验证

World journal of Pharmacy and pharmaceutical sciences Pub Date : 2022-01-01 DOI: 10.54037/wjps.2021.91210

C. Parthiban, Aneesa, M. Sudhakar

{"title":"Analytical method development and validation for simultaneous estimation of sitagliptin and etruglifloxin in bulk and pharmaceutical dosage form by RP-HPLC","authors":"C. Parthiban, Aneesa, M. Sudhakar","doi":"10.54037/wjps.2021.91210","DOIUrl":"https://doi.org/10.54037/wjps.2021.91210","url":null,"abstract":"A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination Sitagliptinand Etruglifloxinin pharmaceutical dosage form. The column used was Discovery C18(250mm x 4.6 mm, 5m)in isocratic mode, with mobile phase containing phosphatebufferandacetonitrile (45:55v/v). The buffer is prepared by adding accurately weighed 1.36gm of PotassiumdihyrogenOrtho phosphate in a 1000ml of Volumetric flask add about 900ml of milli-Q water added and degas to sonicate and finally make up the volume with water then pH adjusted to 5.4with dil. Orthophosphoric acid solution.The flow rate was 1.0ml/ min and effluents were monitored at 260nm. The retention times of Sitagliptinand Etruglifloxinwere found to be 2.381min and 3.429min, respectively. The linearity for Sitagliptinand Etruglifloxinwere in the range of 25-150μg/mland 3.75-22.5μg/ml respectively. The recoveries of Sitagliptinand Etruglifloxinwere found to be 99.46to 101.19% and 99.36to 100.99%, respectively. The proposed method was validated and successfully applied to the estimation of Sitagliptinand Etruglifloxinin combined tablet dosage forms.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80567380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1