中华口腔医学杂志最新文献

{"title":"[Effect of triply periodic minimal surfaces structure and ceramic volume fraction on mechanical properties of polymer-infiltrated ceramic network composites fabricated by additive manufactured zirconia and resin].","authors":"C C Ye, X Tong, S W Liu, Y Huang, Q Z Zhou, L Zhu, J X Lin, C E Wen, J F Ma","doi":"10.3760/cma.j.cn112144-20250331-00105","DOIUrl":"10.3760/cma.j.cn112144-20250331-00105","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effect of triply periodic minimal surfaces (TPMS) structure and ceramic volume fraction on the mechanical properties of polymer-infiltrated ceramic network (PICN) composite and reveal its strengthening and toughening mechanism. <b>Methods:</b> In this study, TPMS structures with gyroid (G), primitive (P), diamond (D), and ceramic volume fraction (40%, 55%, 70%, 85%) were designed. Porous zirconia scaffolds were prepared using stereolithography technology, and resin was infiltrated into the scaffolds through a vacuum. Then, the PICN composites were obtained after curing. The bending strength, elastic modulus and fracture toughness of PICN were tested using an electronic universal testing machine, with commercial PICN as the control group. The micromorphology of PICN was observed through stereomicroscope and scanning electron microscope. The cytocompatibility of PICN was verified by using cell counting kit, live/dead cell staining and phalloidin staining. <b>Results:</b> The bending strength values of PICN with different ceramic volume fractions ranged from 82.0 MPa to 376.0 MPa, and they gradually increased as the ceramic volume fraction rised. The elastic modulus values of PICN with different ceramic volume fractions ranged from 12.1 GPa to 56.1 GPa. The fracture toughness values of PICN with different ceramic volume fractions ranged from 1.7 MPa·m^1/2 to 6.5 MPa·m^1/2. The bending strength of 85G PICN reached 306.0 MPa, and it had the highest fracture toughness (6.5 MPa·m^1/2) and an appropriate elastic modulus between that of the control group and that of enamel. Under scanning electron microscopy, it could be observed that the cracks branch and deflect at the interface and eventually terminate within the resin phase. After co-culture with PICN, the survival rate of mouse fibroblasts exceeded 80%, indicating that PICN had no cytotoxicity. <b>Conclusions:</b> The PICN composite with TPMS structure can satisfy the mechanical properties and cytocompatibility of dental prosthesis.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"626-634"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vulvovaginal-gingival syndrome: a case report].","authors":"B W Li, Q Wang, J Liu, J Q Jin","doi":"10.3760/cma.j.cn112144-20241110-00423","DOIUrl":"10.3760/cma.j.cn112144-20241110-00423","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"652-655"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress in mitochondrial regulation of osteogenic and odontogenic differentiation of dental-derived mesenchymal stem cells].","authors":"L J Wang, J Zhou, C C Zhou","doi":"10.3760/cma.j.cn112144-20250116-00022","DOIUrl":"10.3760/cma.j.cn112144-20250116-00022","url":null,"abstract":"<p><p>Dental-derived mesenchymal stem cells (DMSC), owing to their self-renewal capacity and multi-lineage differentiation potential, have demonstrated significant promise in the field of oral tissue regeneration. Mitochondria, as essential organelles within cells, can not only be responsible for energy metabolism but also influence the maintenance of stem cell stemness and the direction of differentiation by regulating cellular metabolic processes, apoptosis, and signal transduction pathways. In recent years, the mechanisms by which mitochondria participating in the osteogenic and odontogenic differentiation of DMSC have gradually become a research focus. This paper reviews the regulatory mechanisms of mitochondria in the osteogenic and odontogenic differentiation of DMSC, with emphasis on how mitochondrial energy metabolism (oxidative phosphorylation and glycolysis) and quality control processes (namely biogenesis, dynamics as fission and fusion, and autophagy) modulate the differentiation of DMSC. The aim is to provide a theoretical basis and reference for the research and application of dental pulp regeneration, periodontal tissue regeneration, and other aspects of oral tissue engineering.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"662-668"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Centennial ode to the Chinese Medical Association].","authors":"X Y Cai","doi":"10.3760/cma.j.cn112144-20250304-00064","DOIUrl":"10.3760/cma.j.cn112144-20250304-00064","url":null,"abstract":"","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"587-588"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of photodynamic therapy in the treatment of oral diseases].","authors":"R L Ding, Z H Zhao","doi":"10.3760/cma.j.cn112144-20250115-00015","DOIUrl":"10.3760/cma.j.cn112144-20250115-00015","url":null,"abstract":"<p><p>The problem of bacterial resistance caused by antibiotics is becoming increasingly serious worldwide, which poses a great challenge to the treatment of infectious diseases. Photodynamic therapy (PDT) was initially used for cancer treatment. In recent years, PDT has developed into a novel antibacterial strategy to achieve efficient pathogen clearance through mechanisms such as reactive oxygen species(ROS)-mediated damage and immune activation. Due to its advantages of non-invasiveness, high targeting and no drug resistance, PDT has attracted extensive attention in the field of antibacterial medicine. However, PDT still faces limitations such as insufficient permeability, small range of ROS release, short duration, and poor vector stability. In response to these problems, researchers have improved photosensitizers and light sources, and achieved synergistic effects by combining antibiotics, chemotherapy drugs, and photothermal therapy, which has significantly enhanced the antibacterial effect. This article reviews the progress of PDT in the field of oral medicine, introduces the development and characteristics of three generations of photosensitizers, discusses the limitations and optimization strategies of different photosensitizers, and summarizes the advantages and disadvantages of PDT in the treatment of related infectious diseases. Subsequently, the mechanism and therapeutic potential of PDT in oral cancer, periodontitis, peri-implantitis and pulpal and apical diseases were reviewed.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"669-677"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Incidence trends and age-period-cohort analysis of lip and oral cancer in China, 1990-2021].","authors":"P Lyu, J J Guo, W Wu, C T Xu, L N Xun","doi":"10.3760/cma.j.cn112144-20241204-00456","DOIUrl":"10.3760/cma.j.cn112144-20241204-00456","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the incidence trend of lip and oral cancer in China from 1990 to 2021. <b>Methods:</b> The incidence data of lip and oral cancer in China from 1990 to 2021 were obtained through the Global Health Data Exchange (GHDx) database, including incidence rates by gender and age-standardized incidence rates. Joinpoint regression was used to analyze the trend of lip and oral cancer incidence rate. Age-period-cohort (APC) model was adopted to estimate the effects of Age, Period and Cohort on the incidence of lip and oral cancer in China. <b>Results:</b> The crude and age-standardized incidence rates of lip and oral cancer in China from 1990 to 2021 showed an increasing trend, and the crude incidence rates of the whole population, male and female in the year 2021 increased by 216.8%, 266.7% and 130.4%, respectively, compared with 1990. The age effect, period effect and birth cohort effect of the incidence risk of lip and oral cancer in China were statistically significant (all <i>P</i><0.05). People of older the age and the more recent the birth cohort, the higher the incidence risk. <b>Conclusions:</b> The incidence of lip and oral cancer is on the rise in China from 1990 to 2021. Age, period and birth cohort are all the factors affecting the incidence of lip and oral cancer.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"644-651"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dental esthetic restoration for cleft lip and palate patients].","authors":"C Huang, W J Yuan, H H Zhang","doi":"10.3760/cma.j.cn112144-20250323-00096","DOIUrl":"10.3760/cma.j.cn112144-20250323-00096","url":null,"abstract":"<p><p>Cleft lip and palate, as one of the most common congenital deformities of the oral and maxillofacial region, not only affects the physiological functions of patients, but also has a profound impact on their psychological well-being. Traditional sequential treatment for cleft lip and palate aims to restore primary functions and typically concludes intervention after orthodontic treatment. However, this management protocol often fails to meet patients' expectations for esthetic outcomes. In the process of dental esthetic restoration, it is essential to adhere to the principles of comprehensive planning, sequential treatment, and tooth preservation, while formulating individualized treatment strategies. This article delves into the main challenges and corresponding therapeutic measures in dental esthetic restoration following sequential treatment for cleft lip and palate patients. It systematically analyzes the causes, clinical manifestations, and treatment methods for esthetic defects in dental arch space, dental hard tissues, and periodontal soft tissues. The study proposes that dental esthetic restoration can be implemented during three critical phases of sequential treatment: the mixed dentition stage, early permanent dentition stage, and adulthood stage to reduce the complexity of subsequent treatments, thereby preserving more dental and periodontal tissues. Through multidisciplinary collaboration and the application of digital technology, not only has the efficiency and predictability of treatment been enhanced, but more economical and effective treatment options have also been provided for patients. The aim is to offer clinicians comprehensive treatment insights, promoting a shift in the treatment philosophy for cleft lip and palate patients from \"function-oriented\" to a multidimensional approach that equally emphasizes\" function-aesthetics-psychosocial aspects\", ultimately achieving a comprehensive improvement in patients' quality of life.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"603-610"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development and preliminary clinical evaluation of an optical digital border molding technique for soft tissue movement boundary in edentulous jaws].","authors":"X K Xu, K H Deng, S K Tian, H Chen, W W Li, X Su, X B Zhao, X J Chen, C Ma, Y J Jia, S J Xiao, Y C Sun","doi":"10.3760/cma.j.cn112144-20250407-00124","DOIUrl":"10.3760/cma.j.cn112144-20250407-00124","url":null,"abstract":"<p><p><b>Objective:</b> To address the critical issue of missing dynamic border molding information in edentulous direct digital impression technology, this study explores innovative digital solutions and conducts preliminary application validation. <b>Methods:</b> Based on the myostatic line theory, a methodology was established: intraoral scanner (IOS) high-frequency video was utilized to dynamically capture functional molding data of soft tissues, integrated with a self-developed mobility gradient recognition algorithm to achieve dynamic threshold segmentation between the muscle dynamic zone and myostatic zone, termed \"optical digital molding technology\". Ten edentulous patients with well-fitting complete dentures, treated at the Department of Prosthodontics, Peking University School and Hospital of Stomatology from January 2024 to December 2024, were enrolled. The standard deviation between the muscle static line (generated by mobility gradient algorithm with thresholds of 0.3-0.7 mm) and the denture border curve was analyzed to optimize the dynamic threshold, followed by single-case clinical validation. <b>Results:</b> Among the mobility thresholds of 0.3-0.7 mm, the 0.5 mm threshold yielded the smallest standard deviation between the myostatic line and denture border. Clinical validation demonstrated that dentures designed with this threshold exhibited no displacement during dynamic functional tests, with marginal sealing meeting clinical standards. <b>Conclusions:</b> The optical digital border molding technique for edentulous soft tissue boundaries translates the myostatic line theory into quantifiable parameters for the first time. Based on data from 10 cases, a mobility threshold of 0.5 mm is recommended for clinical application.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 6","pages":"611-617"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artificial intelligence-based multimodal fusion diagnosis: advances in precision diagnosis of periodontitis].","authors":"Z Chai, Y Li, M L You, H N Song, F Xu, A Li","doi":"10.3760/cma.j.cn112144-20250110-00009","DOIUrl":"10.3760/cma.j.cn112144-20250110-00009","url":null,"abstract":"<p><p>Periodontitis is a globally prevalent inflammatory oral disease, affecting approximately 50% of the population worldwide and imposing a substantial burden on patients' health and quality of life. Early and accurate diagnosis is critical for preventing disease progression; however, conventional diagnostic approaches often rely on subjective clinical assessments, which only primarily evaluate the cumulative state of the disease, thus limiting their ability to achieve precise early detection. In recent years, the rapid advancement of artificial intelligence (AI) in medical diagnostics has demonstrated significant promise, particularly through the integration of multimodal data to enable more comprehensive information capture and analysis. Multimodal data fusion, which combines diverse inputs such as imaging, clinical parameters, and biomarkers, offers transformative potential for AI-powered periodontitis diagnostics. This innovative approach aims to overcome the limitations of traditional methods, significantly enhancing diagnostic accuracy and predictive capabilities. This manuscript reviews the primary diagnostic techniques for periodontitis, explores recent advances in AI applications within this domain, and emphasizes the potential of multimodal data in facilitating precision diagnosis. Furthermore, it provides new insights and supports for personalized treatment strategies.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"558-566"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on injury of vascular intima with hemostatic clamp and optimization of protective strategy].","authors":"L Z Ren, Q Q Wang, D Wang, Z P Zhang, X F Wu, R Sun","doi":"10.3760/cma.j.cn112144-20241231-00510","DOIUrl":"10.3760/cma.j.cn112144-20241231-00510","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the intimal injury of two kinds of hemostatic clips under different clamping forces, and to optimize and verify the calculation formula of minimum occlusion force (MOF), so as to provide theoretical basis for selecting appropriate hemostatic clips to reduce vascular injury. &lt;b&gt;Methods:&lt;/b&gt; A total of 96 male SD rats with body weight ranging from 280 to 300 g (Animal Experimental Center of Shanxi Medical University) were randomly assigned to metal hemostatic clip group (&lt;i&gt;n&lt;/i&gt;=48) and disposable hemostatic clip group (&lt;i&gt;n&lt;/i&gt;=48) by random number table method. Each group was further divided into four subgroups with clamping forces of 0.3, 0.6, 0.9 and 1.2 N for abdominal aortic injury experiments. The damage to the vascular intima was observed under a scanning electron microscope. A vascular closure model was established for mathematical analysis to derive the theoretical calculation formula of the arterial blood management factor (MOF). According to blood pressure (BP), blood vessel diameter (D) and hemostatic clamp width (W), the average values of theoretical and actual MOF data were analyzed by paired &lt;i&gt;t&lt;/i&gt; test to verify the accuracy of the formula. From January 2021 to December 2022, six patients (with 12 branch arteries) who presented with oral and maxillofacial malignancies at the Department of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, were included to validate the accuracy of the MOF formula. &lt;b&gt;Results:&lt;/b&gt; Under electron microscopy, when the clamping force was 0.3 N, the one-time hemostatic clip caused very little damage to the vascular intima (grade 1 injury), with only a few folds being flattened. When the clamping force was 0.6 N, both types of hemostatic clips caused partial peeling of the intima surface (grade 2-3 injury). However, when the clamping force was adjusted to 0.9 and 1.2 N, the damage caused by both types of hemostatic clips was more severe (grade 3-4 injury), with large areas of intima peeling or even disappearance. In some specimens of the metal hemostatic clip group, the damage even reached the muscular layer. Vascular closure model analysis showed that MOF=2×(1/2×π×D×W×BP), the mean diameter of abdominal aorta of 24 SD rats was (1.41±0.07) mm, the blood pressure was (83.29±11.56) mmHg (1 mmHg=0.133 kPa). The theoretical MOF value was (0.096±0.015) N, the actual clamping force (ACF) was (0.095±0.012) N, there was no statistical significance between the two groups (&lt;i&gt;t&lt;/i&gt;=-0.35, &lt;i&gt;P&lt;/i&gt;=0.725). In clinical application, the MOF calculation formula was used to select the appropriate hemostatic clip for 12 arteries, successfully blocking the blood flow, verifying the accuracy of the formula. &lt;b&gt;Conclusions:&lt;/b&gt; Hemostatic clips can cause damage to the inner membrane of blood vessels, and the greater the clamping force, the more severe the damage. Disposable hemostatic clips have certain advantages in avoiding excessive damage t","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"60 5","pages":"501-508"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}