World Journal of Gastrointestinal Endoscopy最新文献

{"title":"Pancreato-hepatobiliary neuroendocrine tumors diagnosed through endoscopic ultrasound: Clinical characteristics and factors associated with high-grade lesions.","authors":"Abbas A Tasneem, Nasir H Luck, Muhammed Mubarak","doi":"10.4253/wjge.v17.i6.105904","DOIUrl":"10.4253/wjge.v17.i6.105904","url":null,"abstract":"<p><strong>Background: </strong>Neuroendocrine tumors (NETs) are an important type of neoplastic disease of the digestive tract. There is little data on NETs originating from the pancreato-hepatobiliary region of the digestive tract in Pakistan.</p><p><strong>Aim: </strong>To evaluate different types of pancreato-hepatobiliary NETs (PHB-NET) diagnosed with endoscopic ultrasound (EUS) and to identify factors associated with high-grade NETs.</p><p><strong>Methods: </strong>All patients diagnosed with PHB-NET through EUS-guided biopsy were included in the study. The site of origin, histology, and grade of PHB-NETs were noted and factors associated with high-grade lesions were analyzed. SPSS, version 20.0 was used for statistical analysis.</p><p><strong>Results: </strong>A total of 36 patients with PHB-NET were included. Males and females were equal in numbers, <i>i.e.</i>, 18 (50%) each. The mean age was 48 ± 15.7 years with an age range of 17-70 years. The most common sites of origin of PHB-NET were: Pancreas 20 (55.6%), porta hepatis mass 8 (22.2%), perigastric mass 3 (8.3%) and others 5 (13.9%). The mean size of the PHB-NETs was 34.7 ± 22.5 mm. Among pancreatic NETs, the most commonly affected areas were body 9, tail 5, and head 5. Only 4 (11.1%) PHB-NETs were functioning, all of which were insulinomas originating from the body or tail of the pancreas. Two-thirds of PHB-NETs, 24 (66.6%), were benign (WHO grade I: 19; grade 2: 5) while one-third 12 (33.3%) were neuroendocrine cancers (NEC) (WHO grade III). Histological types were large cell 17 (47.2%), small cell 8 (22.2%), mixed 1 (2.8%), and undetermined 10 (27.8%). Factors associated with NECs were age > 40 years (<i>P</i> = 0.016), extra-pancreatic origin of the lesion (<i>P</i> = 0.014), and small cell histologic type (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The most common site of PHB-NET detected through EUS was the pancreas. Although most were benign, about one-third were high-grade cancers. Insulinoma was the most common functioning tumor. NECs were associated with advanced age, extra-pancreatic origin, and small-cell histology.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"105904"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical guide to duodenal stenting for gastric outlet obstruction: Clinical outcomes, selection criteria, placement techniques, and management strategies.","authors":"Sakue Masuda, Chikamasa Ichita, Kazuya Koizumi","doi":"10.4253/wjge.v17.i6.107189","DOIUrl":"10.4253/wjge.v17.i6.107189","url":null,"abstract":"<p><p>Duodenal stenting is a widely used palliative treatment for gastric outlet obstruction (GOO) caused by unresectable malignancies. Compared to surgical gastrojejunostomy, duodenal stenting allows for earlier oral intake, shorter hospitalization, and earlier chemotherapy initiation. However, its long-term efficacy is limited by stent occlusion, which typically occurs 2-4 months post-procedure, due to tumor ingrowth, overgrowth, or food impaction. Covered stents can reduce tumor ingrowth but increase the migration risk, particularly in patients receiving chemotherapy. This review provides a comprehensive comparison of duodenal stenting, surgical gastrojejunostomy, and endoscopic ultrasound-guided gastroenterostomy, by discussing their clinical outcomes, advantages, and limitations. We further explore stent selection based on stricture characteristics, optimal placement techniques, post-procedural management, and for handling complications including occlusion, migration, bleeding, and perforation. Additionally, we address technical challenges and troubleshooting strategies, including management of guidewire-induced perforation, incomplete stent expansion, and bile duct obstruction for overlapping biliary and duodenal stricture cases. Despite its widespread clinical use, no prior review has comprehensively covered both the technical and clinical aspects of duodenal stenting so extensively. By providing a clinically oriented, practical guide, this review serves as a valuable resource for endoscopists and gastroenterologists, facilitating optimized decision-making and improved outcomes for patients with GOO in real-world practice.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"107189"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of endoscopic treatment for esophageal diverticulum based on diverticular peroral endoscopic myotomy.","authors":"Guo-Yao Sun, Yong Sun, Xue-Zhu Wang, Wen Jia, Jiao Liu, Zhuo Yang, Jiang-Ning Gu","doi":"10.4253/wjge.v17.i6.106799","DOIUrl":"10.4253/wjge.v17.i6.106799","url":null,"abstract":"<p><p>Esophageal diverticulum can be broadly classified into three main types: Pharyngoesophageal diverticulum located near the upper esophageal sphincter (including Zenker's diverticulum, Killian-Jamieson diverticulum, and Laimer's diverticulum); Mid-esophageal diverticulum, and epiphrenic diverticulum located just above the lower esophageal sphincter. Most asymptomatic esophageal diverticulum are incidentally detected during routine imaging studies, such as barium swallow, computed tomography scans, or esophagogastroduodenoscopy. For these patients, regular follow-up is typically sufficient. However, a small subset may experience persistent symptoms such as dysphagia and acid reflux. Patients with symptomatic diverticulum should be assessed for the potential need for surgical intervention to prevent serious complications, including aspiration pneumonia and malnutrition. The treatment options for symptomatic esophageal diverticulum encompass both endoscopic and surgical approaches. Due to the technical complexity and significant risks associated with surgical intervention, endoscopic treatment has gained increasing preference, achieving remarkable results with the advancements in endoscopic instruments and techniques. Given the anatomical location and pathophysiological differences among esophageal diverticulum, a personalized endoscopic strategy is essential to achieve optimal results. This review provides an overview of the characteristics of esophageal diverticulum and offers a comprehensive discussion of diverticular peroral endoscopic myotomy and its related variations as the primary endoscopic treatment strategy.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"106799"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of single use duodenoscopes in comparison to reusable duodenoscopes for endoscopic retrograde cholangiopancreatography: A single center experience.","authors":"Iyiad Alabdul Razzak, Maram Alenzi, Butros Fakhoury, Xin-Yuan Zhang, Krishnan Sandeep, Syed Kashif Mahmood","doi":"10.4253/wjge.v17.i6.105298","DOIUrl":"10.4253/wjge.v17.i6.105298","url":null,"abstract":"<p><strong>Background: </strong>Single-use duodenoscopes (SDs) were introduced to eliminate exogenous infection risks post-endoscopic retrograde cholangiopancreatography (ERCP).</p><p><strong>Aim: </strong>To evaluate their efficacy and safety against reusable duodenoscopes (RDs).</p><p><strong>Methods: </strong>This was a single-center case control study. All consecutive patients undergoing ERCP using SD between 2020 and 2023 were enrolled. A similar number of patients undergoing ERCP using RD were randomly selected and enrolled. In case of ERCP failure using SD, operators switched to a RD if judged appropriate. The primary outcome was successful ERCP completion rates. The secondary outcomes were rate of difficult biliary cannulation, incidence of crossover from SD to RD, procedure related adverse events, 30-day re-admission rate, and endoscopists' assessment of SD's performance.</p><p><strong>Results: </strong>A total of 133 patients were enrolled (<i>n</i> = 53 for SD, <i>n</i> = 80 for RD). Baseline characteristics and American Society for Gastrointestinal Endoscopy ERCP complexity grades were comparable between both groups. Successful ERCP completion rates were 88.7% for SD and 95% for RD (<i>P</i> = 0.3). In cases of unsuccessful ERCP with SD, crossover to RD occurred in 3 out of 6 instances, with 2 subsequently succeeding with RD. Rates of adverse events and 30-day readmission were comparable: (1) 13.2% <i>vs</i> 11.2% (<i>P</i> = 0.19); and (2) 15.4% <i>vs</i> 8.9% (<i>P</i> = 0.25), respectively. Median overall endoscopists' satisfaction with SD was 8 out of 10.</p><p><strong>Conclusion: </strong>The novel SDs demonstrated no difference in efficacy and safety compared to conventional RDs when used to perform a wide range of ERCPs. Nevertheless, further development and study of SDs' financial and environmental effectiveness is warranted.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"105298"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic retrograde cholangiopancreatography treatment of cholangitis stone in a patient with total situs inversus: A case report.","authors":"Ke-Rui Gong, Zhuo-Lin Zheng, Guo-Fu Li, Jun-Mao Chen","doi":"10.4253/wjge.v17.i6.106347","DOIUrl":"10.4253/wjge.v17.i6.106347","url":null,"abstract":"<p><strong>Background: </strong>Situs inversus viscerum (SIV) is a rare autosomal recessive genetic disorder characterized a complete mirror-image organ reversal in the thoracic and abdominal cavities. Its low incidence presents considerable challenges in clinical diagnosis and treatment, especially concerning gastrointestinal endoscopic procedures.</p><p><strong>Case summary: </strong>Herein, we report a case of an 80-year-old male with choledocholithiasis and acute obstructive empyematous cholangitis. Imaging revealed total visceral inversion in the patient. Endoscopic retrograde cholangiopancreatography (ERCP) was successfully performed to remove the stones, resulting to substantial relief of clinical symptoms and gradual improvement of the patient's condition, leading to successful recovery and discharge.</p><p><strong>Conclusion: </strong>Therapeutic ERCP is a safe and effective surgical option for patients with SIV. The main focus for successful ERCP in patients with SIV includes positioning adjustments during the surgical process and using the dual-guidewire technique for biliary cannulation.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"106347"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing laparoscopic inguinal hernia repair with three-dimensional computed tomography reconstruction.","authors":"Yoshinori Kagawa, Katsuya Ota","doi":"10.4253/wjge.v17.i6.107391","DOIUrl":"10.4253/wjge.v17.i6.107391","url":null,"abstract":"<p><p>Zhang <i>et al</i> highlighted the importance of three-dimensional computed tomography reconstruction and myopectineal orifice measurement in laparoscopic inguinal hernia repair. Their findings indicated that preoperative three-dimensional computed tomography provides precise anatomical mapping, allowing surgeons to optimize mesh selection and reduce recurrence rates. Recent studies have corroborated these results, demonstrating that a personalized mesh size based on myopectineal orifice dimensions leads to superior patient outcomes. This article discusses the clinical significance of these advancements in hernia surgery, and emphasises their impact on improving precision, reducing complications, and optimizing surgical planning.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"107391"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of post-transplant biliary anastomotic strictures: Endoscopic therapy with plastic and metal stents.","authors":"Larissa Wermelinger Pinheiro, Fernanda Prata Martins, Angelo Paulo Ferrari, Edmar Tafner, Gustavo Andrade De Paulo, Ermelindo Della Libera","doi":"10.4253/wjge.v17.i6.103183","DOIUrl":"10.4253/wjge.v17.i6.103183","url":null,"abstract":"<p><strong>Background: </strong>Biliary anastomotic stricture (BAS) occurs in approximately 14%-20% of patients post-orthotopic liver transplantation (post-OLT). Endoscopic retrograde cholangiopancreatography (ERCP) using multiple plastic stents (MPSs) or fully covered self-expandable metal stents (cSEMSs) represent the standard treatment for BAS post-OLT. Recently, cSEMSs have emerged as the primary option for managing BAS post-OLT.</p><p><strong>Aim: </strong>To compare the resolution and recurrence of BAS rates in these patients.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted in a single tertiary care center (Hospital Israelita Albert Einstein, São Paulo, Brazil). We reported the results of endoscopic therapy in patients with post-OLT BAS between 2012 and 2022. Patients were stratified into two groups according to therapy: (1) MPSs; and (2) cSEMSs. Primary endpoints were to compare stricture resolution and recurrence among the groups. The secondary endpoint was to identify predictive factors for stricture recurrence.</p><p><strong>Results: </strong>A total of 104 patients were included. Overall stricture resolution was 101/104 (97.1%). Stricture resolution was achieved in 83/84 patients (99%) in the cSEMS group and 18/20 patients (90%) in the MPS group (<i>P</i> = 0.094). Failure occurred in 3/104 patients (2.8%). Stricture recurrence occurred in 9/104 patients (8.7%). Kaplan-Meier analysis showed there was no difference in recurrence-free time among the groups (<i>P</i> = 0.201). A multivariate analysis identified the number of ERCP procedures (hazard ratio = 1.4; 95% confidence interval: 1.194-1.619; <i>P</i> < 0.001] and complications (hazard ratio = 2.8; 95% confidence interval: 1.008-7.724; <i>P</i> = 0.048) as predictors of stricture recurrence.</p><p><strong>Conclusion: </strong>cSEMSs and MPSs were effective and comparable regarding BAS post-OLT resolution and recurrence. The number of ERCP procedures and complications were predictors of stricture recurrence.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"103183"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern endoscopist's toolbox: Innovations in foreign body removal.","authors":"Yumna Shahid","doi":"10.4253/wjge.v17.i6.106099","DOIUrl":"10.4253/wjge.v17.i6.106099","url":null,"abstract":"<p><p>Foreign body ingestion is a common gastrointestinal emergency, particularly in children, who account for 80% of cases. While most ingested objects pass spontaneously, around 20% require medical intervention. In adults, incidents often occur accidentally during meals, leading to impactions, especially in individuals with underlying esophageal conditions. Endoscopy remains the gold standard for foreign body retrieval, with a success rate exceeding 95%. The type, shape, and location of the foreign body determine the clinical presentation and management approach. Sharp objects, batteries, and large items pose the highest risk of complications, including perforation, obstruction, and chemical injury. Prompt endoscopic removal is guided by established protocols, with emergent intervention required for complete esophageal obstruction and high-risk objects. Various retrieval devices, including forceps, snares, baskets, and overtubes, are used based on the nature of the foreign body. Technological advancements, such as artificial intelligence-assisted imaging and endoscopic ultrasound, are improving diagnostic precision and procedural outcomes. Despite these advances, foreign body ingestion can still lead to severe complications if not managed in a timely manner. Public awareness, preventive measures, and rapid medical response are essential in reducing morbidity and mortality associated with foreign body ingestion.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 6","pages":"106099"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse phenotypic manifestations of small intestinal mucosa in non-infectious common variable immunodeficiency bowel disease: A case report.","authors":"Tian He, Min-Min Fan, Peng-Qiong Zhang, Wen Zhang, Dong Fan, Liu-Suo Du, Ming Tang, Ping Wan, Zheng-Ji Song","doi":"10.4253/wjge.v17.i5.101618","DOIUrl":"10.4253/wjge.v17.i5.101618","url":null,"abstract":"<p><strong>Background: </strong>Common variable immunodeficiency (CVID) is a primary antibody immunodeficiency disorder characterized by diminished IgG levels. Despite ongoing research, the precise pathogenesis of CVID remains unclear. Genetic factors account for only 10%-20% of cases, with an estimated incidence of 1 in 10000 to 1 in 100000, affecting individuals across all age groups.</p><p><strong>Case summary: </strong>We report the case of a 32-year-old man with CVID who presented with a chief complaint of \"recurrent diarrhea and significant weight loss over the past 2 years\". Laboratory tests on admission showed fat droplets in stool, while other parameters were within normal ranges. Gastroscopy revealed a smooth gastric mucosa without bile retention or signs of <i>Helicobacter pylori</i> infection; however, the mucosa of the descending segment of the duodenum appeared rough. Further evaluation of the small intestine using computed tomography indicated no abnormalities. Finally, the whole-small bowel double-balloon enteroscopy (DBE) was performed, which revealed various phenotypic changes in the small intestinal mucosa. The patient was diagnosed with CVID, which improved after immunoglobulin therapy, with favorable follow-up outcomes.</p><p><strong>Conclusion: </strong>Non-infectious enteropathy in CVID is rare. Therefore, DBE is essential for diagnosing small intestinal involvement in such cases.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 5","pages":"101618"},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colon capsule endoscopy is an effective filter test for colonic polyp surveillance.","authors":"Serhiy Semenov, Mohd Syafiq Ismail, Sandeep Sihag, Thilagaraj Manoharan, Phyllis Reilly, Gerard Boran, Barbara Ryan, Niall Breslin, Anthony O'Connor, Sarah O'Donnell, Deirdre McNamara","doi":"10.4253/wjge.v17.i5.101322","DOIUrl":"10.4253/wjge.v17.i5.101322","url":null,"abstract":"<p><strong>Background: </strong>Surveillance colonoscopies are predominantly normal, identifying patients for potential polypectomy is advantageous.</p><p><strong>Aim: </strong>To assess colon capsule endoscopy (CCE) and/or faecal immunochemical test (FIT) as filters in surveillance.</p><p><strong>Methods: </strong>Patients aged ≥ 18 due for polyp surveillance were invited for CCE and FIT. Identifying polyps or colorectal cancer resulted in a positive CCE. Significant lesions (≥ 3 polyps or ≥ 6 mm polyps), incomplete studies and positive FITs (≥ 225 ng/mL) were referred for endoscopy. CCE and endoscopy results, FIT accuracy and patient preference were assessed.</p><p><strong>Results: </strong>From a total of 126 CCEs [mean age 64 (31-80), 67 (53.2%) males), 70.6% (89/126) were excreted, 86.5% (109/126) had adequate image quality. CCE positivity was 70.6% (89/126), 42.9% (54/126) having significant polyps with 63.5% (80/126) referred for endoscopy (19 sigmoidoscopies, 61 colonoscopies). CCE reduced endoscopy need by 36.5% (46/126) and 51.6% (65/126) were spared a colonoscopy. CCE positive predictive value was 88.2% (45/51). Significant extracolonic findings were reported in 3.2% (4/126). Patients with positive CCEs were older > 65 [odds ratio (OR) = 2.5, 95% confidence interval (CI): 1.1517-5.5787, <i>P</i> = 0.0159], with personal history of polyps (OR = 2.3, 95%CI: 0.9734-5.4066, <i>P</i> = 0.045), with high/intermediate polyp surveillance risk (OR = 5.4, 95%CI: 1.1979-24.3824, <i>P</i> = 0.0156). Overall, 5/114 (4.4%) FITs were positive (range: 0-1394 ng/mL, mean: 54 ng/mL). Sensitivity (9.6%) and negative predictive values (20.3%) were inadequate. Receiver operating curve analysis gave a sensitivity and specificity of 26.9% and 91.7%, for FIT of 43 ng/mL. Patients preferred CCE 63.3% (76/120), with less impact on daily activities (21.7% <i>vs</i> 93.2%) and time off work (average days 0.9 <i>vs</i> 1.2, <i>P</i> = 0.0201).</p><p><strong>Conclusion: </strong>CCE appears effective in low-risk polyp surveillance. FIT does not appear to be of benefit in surveillance.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 5","pages":"101322"},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}