World Journal of Gastrointestinal Endoscopy最新文献

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Endoscopic ultrasound guided gastroenterostomy: Technical details updates, clinical outcomes, and adverse events 内镜下超声引导胃肠造口术:技术细节更新,临床结果和不良事件
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-11-16 DOI: 10.4253/wjge.v15.i11.634
Jian Wang, Jin-Long Hu, Si-Yu Sun
{"title":"Endoscopic ultrasound guided gastroenterostomy: Technical details updates, clinical outcomes, and adverse events","authors":"Jian Wang, Jin-Long Hu, Si-Yu Sun","doi":"10.4253/wjge.v15.i11.634","DOIUrl":"https://doi.org/10.4253/wjge.v15.i11.634","url":null,"abstract":"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has been transformed from an innovative technique, into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet obstruction. Even EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed, giving patients more less invasive options. However, EUS-GE is still a technically challenging procedure. In order to improve EUS-GE, several techniques have been reported to improve the technical details. With EUS-GE widely performed, more data about EUS-GE’s clinical outcomes have been reported. The aim of the current review is to describe technical details updates, clinical outcomes, and adverse events of EUS-GE.","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"6 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions 经口内镜下上消化道粘膜下病变切除术中气体相关并发症的影像学预测
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-11-16 DOI: 10.4253/wjge.v15.i11.649
Jia Yang, Zhi-Guo Chen, Xing-Lin Yi, Jing Chen, Lei Chen
{"title":"Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions","authors":"Jia Yang, Zhi-Guo Chen, Xing-Lin Yi, Jing Chen, Lei Chen","doi":"10.4253/wjge.v15.i11.649","DOIUrl":"https://doi.org/10.4253/wjge.v15.i11.649","url":null,"abstract":"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has been transformed from an innovative technique, into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet obstruction. Even EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed, giving patients more less invasive options. However, EUS-GE is still a technically challenging procedure. In order to improve EUS-GE, several techniques have been reported to improve the technical details. With EUS-GE widely performed, more data about EUS-GE’s clinical outcomes have been reported. The aim of the current review is to describe technical details updates, clinical outcomes, and adverse events of EUS-GE.","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"6 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General anesthesia with endotracheal intubation ensures the quick removal of magnetic foreign bodies: A case report 气管插管全麻可快速清除磁性异物1例
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-11-16 DOI: 10.4253/wjge.v15.i11.676
Qi-Fei Tian, Ai-Xiang Zhao, Ni Du, Zeng-Juan Wang, Ling-Ling Ma, Fang-Li Men
{"title":"General anesthesia with endotracheal intubation ensures the quick removal of magnetic foreign bodies: A case report","authors":"Qi-Fei Tian, Ai-Xiang Zhao, Ni Du, Zeng-Juan Wang, Ling-Ling Ma, Fang-Li Men","doi":"10.4253/wjge.v15.i11.676","DOIUrl":"https://doi.org/10.4253/wjge.v15.i11.676","url":null,"abstract":"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has been transformed from an innovative technique, into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet obstruction. Even EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed, giving patients more less invasive options. However, EUS-GE is still a technically challenging procedure. In order to improve EUS-GE, several techniques have been reported to improve the technical details. With EUS-GE widely performed, more data about EUS-GE’s clinical outcomes have been reported. The aim of the current review is to describe technical details updates, clinical outcomes, and adverse events of EUS-GE.","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"6 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic retrograde cholangiopancreatography-related early perforations: A study of effects of procedure duration, complexity, and endoscopist experience 内镜逆行胰胆管造影相关的早期穿孔:手术时间、复杂性和内镜医师经验的影响研究
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-11-16 DOI: 10.4253/wjge.v15.i11.641
Mark Aloysius, Hemant Goyal, Tejas Nikumbh, Niraj James Shah, Ghassan M Hammoud, Pritesh Mutha, Mairin Joseph-Talreja, Savio John, Ganesh Aswath, Vaibhav Wadhwa, Nirav Thosani
{"title":"Endoscopic retrograde cholangiopancreatography-related early perforations: A study of effects of procedure duration, complexity, and endoscopist experience","authors":"Mark Aloysius, Hemant Goyal, Tejas Nikumbh, Niraj James Shah, Ghassan M Hammoud, Pritesh Mutha, Mairin Joseph-Talreja, Savio John, Ganesh Aswath, Vaibhav Wadhwa, Nirav Thosani","doi":"10.4253/wjge.v15.i11.641","DOIUrl":"https://doi.org/10.4253/wjge.v15.i11.641","url":null,"abstract":"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has been transformed from an innovative technique, into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet obstruction. Even EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed, giving patients more less invasive options. However, EUS-GE is still a technically challenging procedure. In order to improve EUS-GE, several techniques have been reported to improve the technical details. With EUS-GE widely performed, more data about EUS-GE’s clinical outcomes have been reported. The aim of the current review is to describe technical details updates, clinical outcomes, and adverse events of EUS-GE.","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"6 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid laparo-endoscopic access: New approach to surgical treatment for giant fibrovascular polyp of esophagus: A case report and review of literature 腹腔镜-内镜混合入路:食管巨大纤维血管息肉手术治疗的新途径:1例报告及文献复习
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-11-16 DOI: 10.4253/wjge.v15.i11.666
Seda Dzhantukhanova, Lyudmila Grigori Avetisyan, Amina Badakhova, Yury Starkov, Andrey Glotov
{"title":"Hybrid laparo-endoscopic access: New approach to surgical treatment for giant fibrovascular polyp of esophagus: A case report and review of literature","authors":"Seda Dzhantukhanova, Lyudmila Grigori Avetisyan, Amina Badakhova, Yury Starkov, Andrey Glotov","doi":"10.4253/wjge.v15.i11.666","DOIUrl":"https://doi.org/10.4253/wjge.v15.i11.666","url":null,"abstract":"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has been transformed from an innovative technique, into a viable alternative to enteral stenting and surgical gastrointestinal anastomosis for patients with gastric outlet obstruction. Even EUS-GE guided ERCP and EUS-guided gastrointestinal anastomosis for the treatment of afferent loop syndrome have been performed, giving patients more less invasive options. However, EUS-GE is still a technically challenging procedure. In order to improve EUS-GE, several techniques have been reported to improve the technical details. With EUS-GE widely performed, more data about EUS-GE’s clinical outcomes have been reported. The aim of the current review is to describe technical details updates, clinical outcomes, and adverse events of EUS-GE.","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"6 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct cost variance analysis of peroral endoscopic myotomy vs heller myotomy for management of achalasia: A tertiary referral center experience. 经口内镜肌切开术与heller肌切开术治疗贲门失弛缓症的直接成本方差分析:三级转诊中心经验。
IF 2
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-10-16 DOI: 10.4253/wjge.v15.i10.593
Syedreza Ali Haider, Gregory S Bills, C Prakash Gyawali, Passisd Laoveeravat, Jordan Miller, Samir Softic, Mihir S Wagh, Moamen Gabr
{"title":"Direct cost variance analysis of peroral endoscopic myotomy <i>vs</i> heller myotomy for management of achalasia: A tertiary referral center experience.","authors":"Syedreza Ali Haider,&nbsp;Gregory S Bills,&nbsp;C Prakash Gyawali,&nbsp;Passisd Laoveeravat,&nbsp;Jordan Miller,&nbsp;Samir Softic,&nbsp;Mihir S Wagh,&nbsp;Moamen Gabr","doi":"10.4253/wjge.v15.i10.593","DOIUrl":"https://doi.org/10.4253/wjge.v15.i10.593","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic Heller myotomy (LHM) has been the traditional surgical treatment for achalasia. Recently, peroral endoscopic myotomy (POEM) has demonstrated similar clinical outcomes with shorter procedure times. Studies comparing the direct cost-effectiveness of POEM <i>vs</i> LHM are limited.</p><p><strong>Aim: </strong>To compare costs of POEM <i>vs</i> LHM.</p><p><strong>Methods: </strong>This retrospective chart review aimed to compare the outcomes and cost of clinical care between patients who underwent POEM and LHM procedures for achalasia. The study was conducted at a tertiary academic center from January 2019 to December 2020. Clinical outcomes, including post-operative Eckardt scores and adverse events, were assessed and compared between the two groups. Direct cost variance analysis was utilized to evaluate the cost of clinical care incurred by patients undergoing POEM in the year preceding the procedure, during the index admission, and one year post-procedure, in comparison to patients undergoing LHM.</p><p><strong>Results: </strong>Of 30 patients were included (15 POEM and 15 LHM) in the study. Patients in the POEM group had a mean Eckardt score of 0.5 ± 0.5 post-procedure, which was no different from patients in the LHM group (0.7 ± 0.6, <i>P</i> = 0.17) indicating comparative efficacy. However, the total costs of the admission for the procedure in the LHM group were on average $1827 more expensive than in the POEM group (<i>P</i> < 0.01). Total healthcare costs one year prior to index procedure were $7777 higher in the LHM group, but not statistically different (<i>P</i> = 0.34). The patients in the LHM group one year after the index procedure had accrued $19730.24 larger total cost, although this was not statistically different from POEM group (<i>P</i> = 0.68).</p><p><strong>Conclusion: </strong>Despite similar clinical outcomes, the cost of the index procedure admission for POEM was significantly lower than for LHM. The difference was primarily related to shorter time increments utilized in the operating room during the index procedure, and shorter length of hospital stay following POEM.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"15 10","pages":"593-601"},"PeriodicalIF":2.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis. 内镜逆行胰胆管造影治疗儿童天冬酰胺酶相关性胰腺炎复发性胰腺炎的疗效和安全性。
IF 2
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-10-16 DOI: 10.4253/wjge.v15.i10.614
Kai-Hua Yang, Jing-Qing Zeng, Sheng Ding, Tian-Ao Zhang, Wen-Yu Wang, Jia-Yu Zhang, Lan Wang, Jian Xiao, Biao Gong, Zhao-Hui Deng
{"title":"Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis.","authors":"Kai-Hua Yang,&nbsp;Jing-Qing Zeng,&nbsp;Sheng Ding,&nbsp;Tian-Ao Zhang,&nbsp;Wen-Yu Wang,&nbsp;Jia-Yu Zhang,&nbsp;Lan Wang,&nbsp;Jian Xiao,&nbsp;Biao Gong,&nbsp;Zhao-Hui Deng","doi":"10.4253/wjge.v15.i10.614","DOIUrl":"https://doi.org/10.4253/wjge.v15.i10.614","url":null,"abstract":"<p><strong>Background: </strong>Asparaginase (ASP) is an important drug in combined chemotherapy regimens for pediatric acute lymphoblastic leukemia (ALL); ASP-associated pancreatitis (AAP) is the main adverse reaction of ASP. Recurrent pancreatitis is a complication of AAP, for which medication is ineffective.</p><p><strong>Aim: </strong>To evaluate the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in treating recurrent pancreatitis due to AAP.</p><p><strong>Methods: </strong>From May 2018 to August 2021, ten children (five males and five females; age range: 4-13 years) with AAP were treated using ERCP due to recurrent pancreatitis. Clinical data of the ten children were collected, including their sex, age, weight, ALL risk grading, clinical symptoms at the onset of pancreatitis, time from the first pancreatitis onset to ERCP, ERCP operation status, and postoperative complications. The symptomatic relief, weight change, and number of pancreatitis onsets before and after ERCP were compared.</p><p><strong>Results: </strong>The preoperative symptoms were abdominal pain, vomiting, inability to eat, weight loss of 2-7 kg, and 2-9 pancreatitis onsets. After the operation, nine of ten patients did not develop pancreatitis, had no abdominal pain, could eat normally; the remaining patient developed three pancreatitis onsets due to the continuous administration of ASP, but eating was not affected. The postoperative weight gain was 1.5-8 kg. There was one case of post ERCP pancreatitis and two cases of postoperative infections; all recovered after medication.</p><p><strong>Conclusion: </strong>ERCP improved clinical symptoms and reduced the incidence of pancreatitis, and was shown to be a safe and effective method for improving the management of recurrent pancreatitis due to AAP.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"15 10","pages":"614-622"},"PeriodicalIF":2.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic anchor technique assisted endoscopic submucosal dissection for early esophageal cancer. 磁锚技术辅助内镜下黏膜下剥离术治疗早期食管癌症。
IF 2
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-10-16 DOI: 10.4253/wjge.v15.i10.584
Min Pan, Miao-Miao Zhang, Shu-Qin Xu, Yi Lyu, Xiao-Peng Yan
{"title":"Magnetic anchor technique assisted endoscopic submucosal dissection for early esophageal cancer.","authors":"Min Pan,&nbsp;Miao-Miao Zhang,&nbsp;Shu-Qin Xu,&nbsp;Yi Lyu,&nbsp;Xiao-Peng Yan","doi":"10.4253/wjge.v15.i10.584","DOIUrl":"https://doi.org/10.4253/wjge.v15.i10.584","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Esophageal cancer has high incidence globally and is often diagnosed at an advanced stage. With the widespread application of endoscopic technologies, the need for early detection and diagnosis of esophageal cancer has gradually been realized. Endoscopic submucosal dissection (ESD) has become the standard of care for managing early tumors of the esophagus, stomach, and colon. However, due to the steep learning curve, difficult operation, and technically demanding nature of the procedure, ESD has currently been committed to the development of various assistive technologies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To explore the feasibility and applicability of magnetic anchor technique (MAT)-assisted ESD for early esophageal cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Isolated pig esophagi were used as the experimental model, and the magnetic anchor device was designed by us. The esophagi used were divided into two groups, namely the operational and control groups, and 10 endoscopists completed the procedure. The two groups were evaluated for the following aspects: The total operative time, perforation rate, rate of whole mucosal resection, diameter of the peering mucosa, and scores of endoscopists' feelings with the procedure, including the convenience, mucosal surface exposure degree, and tissue tension. In addition, in the operational group, the soft tissue clip and the target magnet (TM) were connected by a thin wire through a small hole at the tail end of the TM. Under gastroscopic guidance, the soft tissue clip was clamped to the edge of the lesioned mucosa, which was marked in advance. By changing the position of the anchor magnet (AM) outside the esophagus, the pulling force and pulling direction of the TM could be changed, thus exposing the mucosal peeling surface and assisting the ESD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Herein, each of the two groups comprised 10 isolated esophageal putative mucosal lesions. The diameter of the peering mucosa did not significantly differ between the two groups (2.13 ± 0.06 &lt;i&gt;vs&lt;/i&gt; 2.15 ± 0.06, &lt;i&gt;P&lt;/i&gt; = 0.882). The total operative time was shorter in the operational group than in the control group (17.04 ± 0.22 min &lt;i&gt;vs&lt;/i&gt; 21.94 ± 0.23 min, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). During the entire experiment, the TM remained firmly connected with the soft tissue clip and did not affect the opening, closing, and release of the soft tissue clip. The interaction between the TM and AM could provide sufficient tissue tension and completely expose the mucosa, which greatly assists the surgeon with the operation. There was no avulsion of the mucosa, and mucosal lesions were intact when peeled. Therefore, the scores of endoscopists' feelings were higher in the operational group than in the control group in terms of the convenience (9.22 ± 0.19 &lt;i&gt;vs&lt;/i&gt; 8.34 ± 0.15, &lt;i&gt;P&lt;/i&gt; = 0.002), mucosal surface exposure degree (9.11 ± 0.15 &lt;i&gt;vs&lt;/i&gt; 8.25 ± 0.12, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and tissue tension (9.35 ± 0.13 &lt;i&gt;vs&lt;/i&gt; 8.0","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"15 10","pages":"584-592"},"PeriodicalIF":2.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyposis found on index colonoscopy in a 56-year-old female - BMPR1A variant in juvenile polyposis syndrome: A case report. 一名56岁女性在指数结肠镜检查中发现息肉病——幼年息肉病综合征中的BMPR1A变体:一例报告。
IF 2
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-10-16 DOI: 10.4253/wjge.v15.i10.623
Michael Yulong Wu, Christopher Toon, Michael Field, May Wong
{"title":"Polyposis found on index colonoscopy in a 56-year-old female - <i>BMPR1A</i> variant in juvenile polyposis syndrome: A case report.","authors":"Michael Yulong Wu,&nbsp;Christopher Toon,&nbsp;Michael Field,&nbsp;May Wong","doi":"10.4253/wjge.v15.i10.623","DOIUrl":"https://doi.org/10.4253/wjge.v15.i10.623","url":null,"abstract":"<p><strong>Background: </strong>Juvenile polyposis syndrome (JPS) is a rare hereditary polyposis disease frequently associated with an autosomal-dominant variant of the <i>SMAD4</i> or <i>BMPR1A</i> gene. It often manifests with symptoms in children and adolescents and is infrequently diagnosed in asymptomatic adults. Establishing the diagnosis is important as patients with JPS have a high risk of developing gastrointestinal cancer and require genetic counselling and close routine follow-up.</p><p><strong>Case summary: </strong>We report on the case of a 56-year-old female diagnosed with JPS after genetic testing revealed a rare variant of the <i>BMPR1A</i> gene <i>BMPR1A c.1409T>C</i> (p.Met470Thr). She was initially referred for colonoscopy by her general practitioner after testing positive on a screening faecal immunochemical test and subsequently found to have polyposis throughout the entire colorectum on her index screening colonoscopy. The patient was asymptomatic with a normal physical examination and no related medical or family history. Blood tests revealed only mild iron deficiency without anemia. To date, there has only been one other reported case of JPS with the same genetic variant. Subsequent colonoscopies were organised for complete polyp clearance and the patient was returned for surveillance follow-up.</p><p><strong>Conclusion: </strong>JPS patients can present with no prior symptoms or family history. Genetic testing plays an important diagnostic role guiding management.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"15 10","pages":"623-628"},"PeriodicalIF":2.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71414286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transoral outlet reduction: Outcomes of endoscopic Roux-en-Y gastric bypass revision in 284 patients at a community practice. 经口胃出口减少:284名社区诊所患者经内镜Roux-en-Y胃旁路翻修术的结果。
IF 2
World Journal of Gastrointestinal Endoscopy Pub Date : 2023-10-16 DOI: 10.4253/wjge.v15.i10.602
Daniel B Maselli, Vibhu Chittajallu, Chase Wooley, Areebah Waseem, Daniel Lee, Michelle Secic, Lauren L Donnangelo, Brian Coan, Christopher E McGowan
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