World Journal of Gastrointestinal Endoscopy最新文献

{"title":"Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report.","authors":"Mayuko Kinoshita, Tetsuro Maruyama, Shutaro Hike, Takuya Hirosuna, Shunsuke Kainuma, Kazuya Kinoshita, Akira Nakano, Gaku Ohira, Masaya Uesato, Hisahiro Matsubara","doi":"10.4253/wjge.v17.i1.101119","DOIUrl":"10.4253/wjge.v17.i1.101119","url":null,"abstract":"<p><strong>Background: </strong>Early anal canal cancer is frequently treated with endoscopic submucosal dissection (ESD) to preserve anal function. However, if the lesion is in the anal canal, then significant difficulties such as bleeding and challenges associated with scope manipulation can arise.</p><p><strong>Case summary: </strong>A 70-year-old woman undergoing follow-up after transverse colon cancer surgery was diagnosed with anal canal cancer extending to the dentate line. The patient underwent a combination of ESD and transanal resection (TAR). The specimen was excised in pieces, which resulted in difficulty performing the pathological evaluation of the margins, especially on the anal side where TAR was performed and severe crushing was observed. Careful follow-up was performed, and local recurrence was observed 3 years postoperatively. Because the patient had superficial cancer without lymph node metastasis, local resection was performed again. The second treatment attempt was improved as follows: (1) TAR and ESD were performed appropriately based on the situation by the same physician; (2) A needle scalpel was used during TAR to prevent tissue crushing; and (3) The lesion borders were marked using ESD techniques before treatment. Complete resection was performed without complications.</p><p><strong>Conclusion: </strong>Anal canal lesions can be safely and reliably removed when ESD and TAR are used appropriately.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"101119"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting malignant gastric outlet obstruction: Where do we stand?","authors":"Krishna Kumar Govindarajan","doi":"10.4253/wjge.v17.i1.100472","DOIUrl":"10.4253/wjge.v17.i1.100472","url":null,"abstract":"<p><p>The scope of management of malignant gastric outlet obstruction is ever-expanding. The therapeutic use of endoscopy is gaining popularity not just owing to its technical advancement and satisfactory patient outcomes. With technical success rates close to 96%, stent placement for palliating gastric obstruction has ensured a median survival of about 2 months post-deployment of gastro-duodenal stents. Understanding the correct concept of palliation is the need of the hour in management. Identifying the right patient for palliation, selecting the appropriate intervention and auditing the outcome are vital in delivering optimal care. Also, newer procedures such as endoscopic gastro-enterostomy offer promising outcomes in palliative care.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"100472"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study.","authors":"Toru Kaneko, Mitsuhiro Kida, Takahiro Kurosu, Gen Kitahara, Shiori Koyama, Nao Nomura, Kumiko Tahara, Chika Kusano","doi":"10.4253/wjge.v17.i1.97840","DOIUrl":"10.4253/wjge.v17.i1.97840","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic retrograde cholangiopancreatography is a challenging procedure involving bile duct cannulation. Despite the development of several cannulation devices, none have effectively facilitated the procedure.</p><p><strong>Aim: </strong>To evaluate the efficacy of a recently developed catheter for bile duct cannulation.</p><p><strong>Methods: </strong>We retrospectively examined 342 patients who underwent initial cholangiopancreatography. We compared the success rate of bile duct cannulation and the incidence of complications between the groups using existing and novel catheters.</p><p><strong>Results: </strong>The overall success rates of bile duct cannulation were 98.3% and 99.1% in the existing and novel catheter groups, respectively (<i>P</i> = 0.47). The bile duct cannulation rate using the standard technique was 73.0% and 82.1% in the existing and novel catheter groups, respectively (<i>P</i> = 0.042). Furthermore, when catheterization was performed by expert physicians, the bile duct cannulation rate was significantly higher in the novel catheter group (81.3%) than in the existing catheter group (65.2%) (<i>P</i> = 0.017). The incidence of difficult cannulation was also significantly lower in the novel catheter group (17.4%) than in the existing catheter group (33.0%) (<i>P</i> = 0.019).</p><p><strong>Conclusion: </strong>The novel catheter improved the bile duct cannulation rate using the standard technique and reduced the frequency of difficult cannulation cases, valuable tool in endoscopic retrograde cholangiopancreatography procedures performed by experts.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"97840"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy.","authors":"Jing Sui, Jian-Sheng Luo, Chao Xiong, Chun-Yong Tang, Yan-Hua Peng, Rui Zhou","doi":"10.4253/wjge.v17.i1.100219","DOIUrl":"10.4253/wjge.v17.i1.100219","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal endoscopy has been widely used in the diagnosis and treatment of gastrointestinal diseases. A great many of studies on gastrointestinal endoscopy have been done.</p><p><strong>Aim: </strong>To analyze the characteristics of top 100 cited articles on gastrointestinal endoscopy.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted. The publications and their features were extracted from the Web of Science Core Collection, Science Citation Index-Expanded database. Excel, Web of Science database and SPSS software were used to perform the statistical description and analysis. VOSviewer software and MapChart were responsible for the visualizations.</p><p><strong>Results: </strong>The top 100 cited articles were published between 1976 and 2022. The guidelines (52%) and clinical trials (37%) are the main article types, and average publication year of the guidelines is much later than that of the clinical trials (2015 <i>vs</i> 1998). Among the clinical trials, diagnostic study (27.0%), cohort study (21.6%), case series (13.5%) and cross-sectional study (10.8%) account for a large proportion. Average citations of different study types and designs of the enrolled studies are of no significant differences. Most of the 100 articles were published by European authors and recorded by the endoscopic journals (65%). Top journals in medicine, such as the <i>Lancet</i>, <i>New England Journal of Medicine</i> and <i>JAMA</i>, also reported studies in this field. The hot spots of involved diseases include neoplasm or cancer-related diseases, inflammatory diseases, obstructive diseases, gastrointestinal hemorrhage and ulcer. Endoscopic surgery, endoscopic therapy and stent placement are frequently studied.</p><p><strong>Conclusion: </strong>Our research contributes to delineating the field and identifying the characteristics of the most highly cited articles. It is noteworthy that there is a significantly smaller number of clinical trials included compared to guidelines, indicating potential areas for future high-quality clinical trials.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"100219"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel approach to managing two enormous bezoars with successive snare-tip electrocautery: A case report.","authors":"Cherng Harng Lim, Cherng Jyr Lim, Chih-Ta Yao, Chi-Chun Chang","doi":"10.4253/wjge.v17.i1.102185","DOIUrl":"10.4253/wjge.v17.i1.102185","url":null,"abstract":"<p><strong>Background: </strong>Gastric bezoars are indigestible masses that can lead to gastrointestinal obstruction and ulceration. Standard treatments include endoscopic mechanical lithotripsy with a polypectomy snare and Coca-Cola dissolution therapy or a combination of both approaches. However, giant bezoars frequently require multiple treatment sessions and extended hospital stays. Additionally, snare-based mechanical fragmentation may be limited by factors such as bezoar size, shape, density, slipperiness, and restricted working space. In cases where refractory giant bezoars are unresponsive to traditional methods, surgical intervention is often necessary.</p><p><strong>Case summary: </strong>A 57-year-old male with a history of type 2 diabetes presented with severe epigastric pain and vomiting. Endoscopy revealed two large phytobezoars and a gastric ulcer. Initial attempts at mechanical fragmentation with a polypectomy snare and Coca-Cola ingestion for dissolution were unsuccessful due to the large size and complex structure of the bezoars. An innovative approach using snare-tip electrocautery was then employed. It successfully penetrated the slippery, hard surface of the bezoars and fragmented them into smaller pieces. The patient was subsequently treated with Coca-Cola ingestion, enzyme supplements, and proton pump inhibitors. He was discharged without complications following the endoscopic sessions.</p><p><strong>Conclusion: </strong>Snare-tip electrocautery is a safe, cost-effective, and minimally invasive alternative for managing large, refractory gastric bezoars. This is a valuable option in resource-limited settings.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"102185"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic retrograde cholangiopancreatography for patients aged ninety and older with choledocholithiasis: A single-center experience in south China.","authors":"Lei Wang, Zi-Ye Li, Fan Wu, Guo-Qian Tan, Bai-Lin Wang","doi":"10.4253/wjge.v17.i1.102010","DOIUrl":"10.4253/wjge.v17.i1.102010","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic retrograde cholangiopancreatography (ERCP) serves an essential role in treating biliary diseases, especially in choledocholithiasis. However, due to the limited human lifespan, there remains a paucity of clinical investigations on ERCP treatment in patients over 90 years old.</p><p><strong>Aim: </strong>To explore the effectiveness and safety of ERCP in super-older patients aged ≥ 90 years with choledochal stones.</p><p><strong>Methods: </strong>This study retrospectively analyzed data from patients (aged ≥ 65 years) with choledocholithiasis who received ERCP treatment in our hospital from 2011 to 2023. Among them, patients ≥ 90 years old were in the super-older group, and patients aged 65-89 years were in the older group. Baseline data, including gender, number of stones, stone size, gallbladder stones, periampullary diverticulum, and common bile duct intubation of patients in the two groups, were matched by adopting the 1:1 propensity score matching method.</p><p><strong>Results: </strong>After matching, 44 patients were included in both the super-older group and the older group. The incidence of stroke in the super-older group was markedly higher than that in the older group [34.1% (15/44) <i>vs</i> 6.8% (3/44), <i>P</i> = 0.008]. The success rate of the ERCP procedure in the super-older group was 90.9% (40/44), compared to that in the older group [93.2% (41/44), <i>P</i> = 1.000]. Although endoscopic papillary balloon dilation was more frequently used in the super-older group than in the older group [61.4% (27/44) <i>vs</i> 18.2% (8/44), <i>P</i> < 0.001], there was no significant difference in terms of stone removal rate, the incidence of complications, mortality, recurrence, and length of hospitalization between the two groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>ERCP is safe and effective in super-older patients ≥ 90 years old with choledocholithiasis.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"102010"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early esophageal cancer with mucosal bridging in the resting room: A case report.","authors":"Ying-Ling Liu, Jie Liu, Ye-Tao Wang","doi":"10.4253/wjge.v17.i1.103404","DOIUrl":"10.4253/wjge.v17.i1.103404","url":null,"abstract":"<p><strong>Background: </strong>Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia, which pose considerable challenges for endoscopic surgical interventions.</p><p><strong>Case summary: </strong>We present a case involving early-stage esophageal cancer discovered in a resting room, notable for the rare manifestation of esophageal mucosal bridging. Following a comprehensive multidisciplinary discussion and the development of a treatment strategy, we proceeded with endoscopic submucosal dissection for the patient. During the procedure, we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria. To facilitate the retraction of a portion of the resected specimen, we utilized dental floss. Ultimately, we successfully excised the entire lesion. After a three-day period of fasting with a water-only diet, subsequent iodine water cholangiography did not indicate any perforations, and the patient was advised to transition to a liquid diet. The patient was discharged five days post-operation. A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus, with the patient reporting no significant discomfort.</p><p><strong>Conclusion: </strong>In summary, although esophageal mucosal bridges are rarely documented, they should be considered in the differential diagnosis of mechanical dysphagia. Furthermore, endoscopic therapy represents a feasible approach for their management.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"103404"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study.","authors":"Gang Wang, Biao Zhen, Jia-Jun Li, Chun-Nv Jin, Jun Jia, Bo-Hai Liu, Yan-Hui Bai","doi":"10.4253/wjge.v17.i1.101382","DOIUrl":"10.4253/wjge.v17.i1.101382","url":null,"abstract":"<p><strong>Background: </strong>Administering anesthesia to elderly patients undergoing gastroenteroscopy necessitates careful attention due to age-related physiological changes and an increased risk of complications.</p><p><strong>Aim: </strong>To analyze the research trends in anesthesia management for elderly patients undergoing gastroenteroscopy.</p><p><strong>Methods: </strong>We performed a literature search using the Web of Science database to identify articles published between 2004 and 2023. Bibliometric and visual analyses were conducted using CiteSpace, R, and VOSviewer to explore the current research landscape of anesthesia administration in painless gastroenteroscopy for elderly patients and to identify future research directions by examining trends and emerging hotspots in this domain.</p><p><strong>Results: </strong>A total of 800 articles were examined, revealing a rising trend in annual publication counts. The United States led with 181 articles, followed by China with 112, collectively contributing over 35% of the studies among the top ten countries. The majority of publications appeared in the United States journals, with the top three being <i>Gastrointestinal Endoscopy</i> [impact factor (IF) = 7.7, H-index = 26], <i>Digestive Diseases and Sciences</i> (IF = 3.1), and <i>Endoscopy</i> (IF = 9.3). Six primary research clusters were identified: Obstructive sleep apnea and airway management, surveillance and risk factors, colorectal cancer examination and treatment, sedation and safety of propofol and midazolam, patient satisfaction, and mortality and complications. These findings underscore the pivotal focus areas in anesthesia for elderly patients undergoing gastroenteroscopy.</p><p><strong>Conclusion: </strong>A comprehensive understanding of current research trends and hotspots will aid anesthesiologists in developing more evidence-based practices, thereby improving the safety and outcomes for elderly patients undergoing gastroenteroscopy.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"101382"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecystogastric fistula presenting as pyloric obstruction - a Bouveret's syndrome: A case report.","authors":"Yi Yang, Ding-Fu Zhong","doi":"10.4253/wjge.v17.i1.101534","DOIUrl":"10.4253/wjge.v17.i1.101534","url":null,"abstract":"<p><strong>Background: </strong>Bouveret's syndrome is a rare (1%-4%) form of cholelithiasis characterized by gastric outlet obstruction. It presents mainly in elderly women with nausea, vomiting, and abdominal pain. On physical examination, common findings include dehydration signs such as tachycardia, decreased urine output, abdominal discomfort, and distention. Diagnosis relies on computed tomography (CT) and magnetic resonance imaging, with Rigler's triad (pneumobilia, ectopic gallstone, gastric distension) being highly specific. This report aims to improve understanding of Bouveret's syndrome and inform better management and treatment strategies.</p><p><strong>Case summary: </strong>A 60-year-old male patient presented with a three-day history of nausea, vomiting, upper abdominal pain, and loss of appetite. An upright abdominal X-ray revealed a gas shadow in the intrahepatic and extrahepatic bile ducts. Endoscopy revealed a brown and black stone measuring approximately 3030 mm in diameter in the gastric pylorus, incompletely obstructing the gastric outlet. The diagnosis of Bouveret's syndrome was accurately confirmed <i>via</i> an abdominal CT scan. Endoscopic removal of the stone was successful, owing to the stone being fragmented and extracted in pieces using a crushing basket. Three weeks later, laparoscopy was attempted but failed because of severe tissue adhesions. Consequently, the procedure was converted to a laparotomy, and fistula repair and cholecystectomy were performed. He returned to the outpatient clinic for follow-up, and no further concerns were noted.</p><p><strong>Conclusion: </strong>This case highlights the importance of timely diagnosis and adaptable endoscopic and surgical approaches for effectively managing Bouveret's syndrome.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"101534"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of spray flushing in the reprocessing of flexible endoscopes.","authors":"Harendra Kumar, Arkadeep Dhali, Rick Maity, Jyotirmoy Biswas","doi":"10.4253/wjge.v17.i1.100298","DOIUrl":"10.4253/wjge.v17.i1.100298","url":null,"abstract":"<p><p>This article comments on the article by Du <i>et al</i>, who conducted a randomized controlled trial aiming at evaluating the effectiveness of a novel spray flushing system in cleaning flexible endoscopes while minimizing damage to the working channels. We share our perspective on the importance of improving endoscope reprocessing methods. The findings highlight the spray flushing system's capacity to improve cleaning efficacy while minimizing damage, suggesting that it might be important in enhancing endoscope reprocessing procedures.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 1","pages":"100298"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}