World Journal of Gastrointestinal Endoscopy最新文献

{"title":"Stricture prevention after circumferential endoscopic submucosal dissection of the esophagus: Proactive <i>vs</i> reactive strategies.","authors":"Giulio Calabrese, Sandro Sferrazza, Daryl Ramai, Marcello Maida","doi":"10.4253/wjge.v17.i3.101428","DOIUrl":"10.4253/wjge.v17.i3.101428","url":null,"abstract":"<p><p>In this editorial, we explored currently available strategies for reducing the occurrence of esophageal strictures following circumferential endoscopic submucosal dissection. This manuscript provided a comprehensive overview of the various strategies including recent insights from Wang <i>et al</i>. To this end, stenosis-related symptoms such as dysphagia and vomiting can severely affect a patient's quality of life. Therefore, we assess the efficacy of both reactive and proactive measures, ranging from traditional approaches like endoscopic balloon dilation and steroid administration to more advanced techniques, including tissue engineering and polyglycolic acid sheet placement. However, no single treatment has shown high efficacy, particularly for resections involving the entire circumference. Despite these shortcomings, the combination of different strategies may improve patient outcomes, although further large-scale studies are needed for validation.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"101428"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing and popularizing a standard pathological diagnostic model of endoscopic submucosal dissection specimens in China.","authors":"Chun Xu, Ling Chen, An-Ning Feng, Ling Nie, Yao Fu, Lin Li, Wei Li, Qi Sun","doi":"10.4253/wjge.v17.i3.101525","DOIUrl":"10.4253/wjge.v17.i3.101525","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic submucosal dissection (ESD) is a standardized therapeutic approach for early carcinoma of the digestive tracts. In this regard, the process of histopathological diagnosis requires standardization. However, the uneven development of healthcare in China, especially in eastern and western China, creates challenges for sharing a standardized diagnostic process.</p><p><strong>Aim: </strong>To optimize the process of ESD specimen sampling, embedding and slide production, and to provide complete and accurate pathological reports.</p><p><strong>Methods: </strong>We established a practical process of specimen sampling, created standardized reporting templates, and trained pathologists from neighboring hospitals and those in the western region. A training effectiveness survey was conducted, and the collected data were assessed by the corresponding percentages.</p><p><strong>Results: </strong>A total of 111 valid feedback forms have been received, among which 58% of the participants obtained photographs during specimen collection, whereas the percentage increased to 79% after training. Only 58% and 62% of the respondents ensured the mucosal tissue strips were flat and their order remained unchanged; after training, these two proportions increased to 95% and 92%, respectively. Approximately half the participants measured the depth of the submucosal infiltration, which significantly increased to 95% after training. The percentage of pathologists who did not evaluate lymphovascular invasion effectively reduced. Only 22% of the participants had fixed clinic-pathological meetings before training, which increased to 49% after training. The number of participants who had a thorough understanding of endoscopic diagnosis also significantly increased.</p><p><strong>Conclusion: </strong>There have been significant improvements in the process of specimen collection, section quality, and pathology reporting in trained hospitals. Therefore, our study provides valuable insights for others facing similar challenges.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"101525"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities related to metachronous recurrence for early gastric cancer in elderly patients.","authors":"Ying Xiang, Ying Yuan, Zhen-Yu Wang, Yan-Mei Zhu, Wen-Ying Li, Qian-Ge Ye, Ya-Nan Wang, Qi Sun, Xi-Wei Ding, Faraz Longi, De-Hua Tang, Gui-Fang Xu","doi":"10.4253/wjge.v17.i3.99540","DOIUrl":"10.4253/wjge.v17.i3.99540","url":null,"abstract":"<p><strong>Background: </strong>A significant association between increased age and an increased risk of metachronous gastric cancer (MGC) following curative endoscopic submucosal dissection (ESD) has previously been reported.</p><p><strong>Aim: </strong>To determine risk factors for the metachronous occurrence of early gastric cancer (EGC) in elderly individuals.</p><p><strong>Methods: </strong>This retrospective cohort study comprised 653 elderly patients (aged ≥ 65 years) who underwent curative ESD for EGC between January 2014 and June 2020 at Nanjing Drum Tower Hospital. Comprehensive analyses were conducted to compare lifestyle habits, comorbidities, and <i>Helicobacter pylori (H. pylori</i>) infections as potential indicators.</p><p><strong>Results: </strong>During a median follow-up of 38 months, 46 patients (7.0%, 20.46/1000 person-years) developed MGC in the elderly cohort. The cumulative incidences of MGC at 2, 3, and 5 years were 3.3%, 5.3%, and 11.5%, respectively. In multivariate Cox regression analyses, the independent risk factors for MGC included metabolic dysfunction-associated steatotic liver disease (MASLD) [hazard ratio (HR) = 2.44, 95% confidence interval (CI): 1.15-5.17], persistent <i>H. pylori</i> infection (HR = 10.38, 95%CI: 3.36-32.07), severe mucosal atrophy (HR = 2.71, 95%CI: 1.45-5.08), and pathological differentiation of EGC (well/moderately differentiated <i>vs</i> poorly differentiated: HR = 10.18, 95%CI: 1.30-79.65). Based on these risk factors, a risk stratification system was developed to categorize individuals into low (0-1 point), intermediate (2-3 points), and high (4-8 points) risk categories for MGC, with cumulative incidence rates of 12.3%, 21.6%, and 45%, respectively.</p><p><strong>Conclusion: </strong>Among elderly individuals, MASLD, persistent <i>H. pylori</i> infection, severe mucosal atrophy, and well/moderately differentiated EGC were associated with an increased risk of MGC. Elderly patients are recommended to adopt healthy lifestyle practices, and undergo regular endoscopic screening and <i>H. pylori</i> testing after curative ESD for EGC.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"99540"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a training system that tracks the operator's gaze pattern during endoscopic submucosal dissection on hemostasis.","authors":"Takao Tonishi, Fumiaki Ishibashi, Kosuke Okusa, Kentaro Mochida, Sho Suzuki","doi":"10.4253/wjge.v17.i3.104315","DOIUrl":"10.4253/wjge.v17.i3.104315","url":null,"abstract":"<p><strong>Background: </strong>The early acquisition of skills required to perform hemostasis during endoscopy may be hindered by the lack of tools that allow assessments of the operator's viewpoint. Understanding the operator's viewpoint may facilitate the skills.</p><p><strong>Aim: </strong>To evaluate the effects of a training system using operator gaze patterns during gastric endoscopic submucosal dissection (ESD) on hemostasis.</p><p><strong>Methods: </strong>An eye-tracking system was developed to record the operator's viewpoints during gastric ESD, displaying the viewpoint as a circle. In phase 1, videos of three trainees' viewpoints were recorded. After reviewing these, trainees were recorded again in phase 2. The videos from both phases were retrospectively reviewed, and short clips were created to evaluate the hemostasis skills. Outcome measures included the time to recognize the bleeding point, the time to complete hemostasis, and the number of coagulation attempts.</p><p><strong>Results: </strong>Eight cases treated with ESD were reviewed, and 10 video clips of hemostasis were created. The time required to recognize the bleeding point during phase 2 was significantly shorter than that during phase 1 (8.3 ± 4.1 seconds <i>vs</i> 23.1 ± 19.2 seconds; <i>P</i> = 0.049). The time required to complete hemostasis during phase 1 and that during phase 2 were not significantly different (15.4 ± 6.8 seconds <i>vs</i> 31.9 ± 21.7 seconds; <i>P</i> = 0.056). Significantly fewer coagulation attempts were performed during phase 2 (1.8 ± 0.7 <i>vs</i> 3.2 ± 1.0; <i>P</i> = 0.004).</p><p><strong>Conclusion: </strong>Short-term training did not reduce hemostasis completion time but significantly improved bleeding point recognition and reduced coagulation attempts. Learning from the operator's viewpoint can facilitate acquiring hemostasis skills during ESD.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"104315"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of endoscopic submucosal dissection for gastric dysplasia and early neoplasia in a United Kingdom Caucasian population.","authors":"Sammi X Y Lim, Elizabeth Ratcliffe, Ryan Wiltshire, James G S Whiteway, Stephen McGrath, Javed Sultan, Neeraj Prasad, Arash Assadsangabi, James Britton, Yeng S Ang","doi":"10.4253/wjge.v17.i3.102694","DOIUrl":"10.4253/wjge.v17.i3.102694","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic submucosal dissection (ESD) is increasingly used to treat gastric dysplasia and early neoplasia in the West. Unlike Eastern countries, data for Caucasian patients in the United Kingdom is limited due to its limited implementation in a few tertiary centres.</p><p><strong>Aim: </strong>To evaluate the outcomes of ESD on gastric dysplasia and neoplasia in Caucasian patients.</p><p><strong>Methods: </strong>Our ten-year retrospective study at a single tertiary centre included data spanning from May 2012 to July 2023. The efficacy of ESD on gastric dysplasia and early neoplasia was measured using parameters set out by the National Institute for Health and Care Excellence, which include <i>en-bloc</i> and curative resection (CR) rates, local recurrence and survival rates.</p><p><strong>Results: </strong>ESD was attempted on 111 lesions in 93 patients. 95.0% of completed procedures achieved endoscopic clearance. 74.3% were <i>en-bloc</i> resections and the rest were hybrid ESD with piecemeal resections. In all, 34.7% achieved histological CR. Overall, disease recurrence was 10.9% at latest follow-up (63 months, median follow-up). Importantly 100% of lesions in the CR group showed no disease recurrence at subsequent and latest follow-up. In the Indeterminate and Non-CR group, 18.8% of lesions showed disease recurrence at subsequent endoscopic follow-ups. ESD changed the histological staging of 44.5% of lesions. Immediate complications were observed in 9.9% of all ESD procedures. The median survival time was 69 months post-ESD. The mean age at death is 82.2 years old.</p><p><strong>Conclusion: </strong>The study affirms the long-term efficacy and safety of ESD for gastric dysplasia and early neoplasia in Caucasian patients.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"102694"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When ectopic bone forms in the abdomen: The diagnostic and management challenges of heterotopic mesenteric ossification.","authors":"Uchenna Esther Okpete, Haewon Byeon","doi":"10.4253/wjge.v17.i3.100253","DOIUrl":"10.4253/wjge.v17.i3.100253","url":null,"abstract":"<p><p>Heterotopic mesenteric ossification (HMO) is a rare medical condition, with < 100 cases reported globally by 2024. This disorder is characterized by abnormal bone tissue formation within the mesentery, often following abdominal trauma, ischemia, or infection. This editorial reviews the case presented by Zhang <i>et al</i>, involving a 34-year-old male who developed persistent left lower abdominal pain after sustaining blunt trauma to the abdomen. Diagnostic challenges arose due to the rarity and nonspecific presentation of HMO, which shares histopathological features with conditions such as myositis ossificans and necessitates differentiation from malignancies like sarcomas. Advanced imaging revealed calcifications suggestive of HMO, but definitive diagnosis was achieved only through surgical resection and histopathological analysis, which confirmed the presence of ectopic bone formation. Although benign, HMO can result in severe complications, such as bowel perforation or obstruction. Therefore, awareness of HMO is crucial for clinicians to ensure timely and appropriate treatment.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"100253"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment.","authors":"Lei Zhang, Jing Chen, Yu-Ying Zhang, Lei Liu, Han-Dan Wang, Ya-Fei Zhang, Jun Sheng, Qiu-Shi Hu, Ming-Liang Liu, Yi-Lin Yuan","doi":"10.4253/wjge.v17.i3.104966","DOIUrl":"10.4253/wjge.v17.i3.104966","url":null,"abstract":"<p><strong>Background: </strong>Inguinal hernias are common after surgery. Tension-free repair is widely accepted as the main method for managing inguinal hernias. Adequate exposure, coverage, and repair of the myopectineal orifice (MPO) are necessary. However, due to differences in race and sex, people's body shapes vary. According to European guidelines, the patch should measure 10 cm × 15 cm. If any part of the MPO is dissected, injury to the nerves, vascular network, or organs may occur during surgery, thereby leading to inguinal discomfort, pain, and seroma formation after surgery. Therefore, accurate localization and measurement of the boundary of the MPO are crucial for selecting the optimal patch for inguinal hernia repair.</p><p><strong>Aim: </strong>To compare the size of the MPO measured on three-dimensional multislice spiral computed tomography (CT) with that measured <i>via</i> laparoscopy and explore the relevant factors influencing the size of the MPO.</p><p><strong>Methods: </strong>Clinical data from 74 patients who underwent laparoscopic tension-free inguinal hernia repair at the General Surgery Department of the First Affiliated Hospital of Anhui University of Science and Technology between September 2022 and July 2024 were collected and analyzed retrospectively. Transabdominal preperitoneal was performed. Sixty-four males and 10 females, with an average age of 58.30 ± 12.32 years, were included. The clinical data of the patients were collected. The boundary of the MPO was measured on three-dimensional CT images before surgery and then again during transabdominal preperitoneal. All the preoperative and intraoperative data were analyzed <i>via</i> paired <i>t</i>-tests. A <i>t</i>-test was used for comparisons of age, body mass index, and sex between the groups. In the comparative analysis, a <i>P</i> value less than 0.05 indicated a significant difference.</p><p><strong>Results: </strong>The boundaries of the MPO on 3-dimensional CT images measured 7.05 ± 0.47 cm and 6.27 ± 0.61 cm, and the area of the MPO was 19.54 ± 3.33 cm². The boundaries of the MPO during surgery were 7.18 ± 0.51 cm and 6.17 ± 0.40 cm. The errors were not statistically significant. However, the intraoperative BD (the width of the MPO, <i>P</i> = 0.024, <i>P</i> < 0.05) and preoperative AC (the length of the MPO, <i>P</i> = 0.045, <i>P</i> < 0.05) significantly differed according to sex. The AC and BD measurements before and during surgery were not significantly different according to age, body mass index, hernia side or hernia type (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The application of this technology can aid in determining the most appropriate dissection range and patch size.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"104966"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and applications for PuraStat^® use in the management of unselected gastrointestinal bleeding: A retrospective observational study.","authors":"Raquel Ballester, Conor Costigan, Aoife Mary O'Sullivan, Shreyashee Sengupta, Deirdre McNamara","doi":"10.4253/wjge.v17.i3.98021","DOIUrl":"10.4253/wjge.v17.i3.98021","url":null,"abstract":"<p><strong>Background: </strong>Hemostatic powders have been used as primary or salvage therapy to control gastrointestinal bleeding in a number of scenarios. PuraStat^® is a novel, self-assembling peptide gel that has properties that differ from hemostatic powders. It is transparent, can be used in narrow spaces and combined with other modalities. Also, it is pre-filled in a syringe ready to use and easy to handle and deliver. PuraStat^® has been shown to be effective and safe in treating gastrointestinal bleeding lesions. But, its role as a hemostatic agent in all bleeding indications remains to be clarified.</p><p><strong>Aim: </strong>To evaluate PuraStat^® efficacy and its applications, feasibility and safety in treating gastrointestinal bleeding lesions.</p><p><strong>Methods: </strong>We performed a retrospective single-centre analysis of all consecutive patients with gastrointestinal bleeding, that required endoscopic treatment and where PuraStat^® was applied, from June 2020 to October 2022. Demographics, biochemical, endoscopic, endoscopist assessment and outcome data were collected. We analysed the whole cohort and the subgroup with upper gastrointestinal bleeding. The primary outcome was to evaluate the efficacy of PuraStat^® at achieving initial hemostasis. The patients were followed-up for 30 days after the episode of bleeding.</p><p><strong>Results: </strong>In total 45 patients were included, and 17/45 (37.8%) females. The mean age was 65.8 years. Charlson score was > 2 in 27/45 (60%) and 26/45 (57.8%) required transfusion. The procedures were gastroscopy (77.8%), colonoscopy (15.5%), endoscopic retrograde cholangiopancreatography (4.4%) and enteroscopy (2.2%). The most common bleeding lesion was peptic ulcer (33.3%). PuraStat^® was used alone in 36% of the cases. One hundred percent achieved initial hemostasis and no complications were documented. There were no significant differences between the use of PuraStat^® alone or in combination in terms of re-bleeding (<i>P</i> = 0.64) or mortality (<i>P</i> = 0.69). In 46.6% of cases, the reason for applying PuraStat^® was as addition to standard of care, in 35.5% as an alternative because standard of care was not possible and in 17.8% as a rescue therapy.</p><p><strong>Conclusion: </strong>PuraStat^® is an effective therapy for multiple etiologies and is considered very easy to use in the majority. Its role as front line agent should be considered in the future.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"98021"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive monitoring of inflammatory bowel disease using intestinal ultrasound.","authors":"Hakima Abid, Hajar Cherkaoui, Fatima Benahsine, Asmae Lamine, Maria Lahlali, Ismail Chaouche, Fatima Bartal, Nada Lahmidani, Amine Elmekkaoui, Dafr Allah Benajah, Mohammed Abkari, Sidi Adil Ibrahimi, Karima Elghazi, Mustapha Maaroufi, Mounia Elyousfi","doi":"10.4253/wjge.v17.i3.97016","DOIUrl":"10.4253/wjge.v17.i3.97016","url":null,"abstract":"<p><strong>Background: </strong>Intestinal ultrasound (IUS) is a safe and effective way for the diagnosis and surveillance of patients with inflammatory bowel disease (IBD). It allows a noninvasive and reproducible follow-up for patients with IBD.</p><p><strong>Aim: </strong>To compare the outcomes of colonoscopy and IUS in diagnosing and monitoring patients with IBD.</p><p><strong>Methods: </strong>A prospective study was conducted over a three-year period (January 2021 to April 2024) comparing endoscopic and IUS findings. A total of 101 patients were included in the study (68 with Crohn's disease and 33 with ulcerative colitis). All patients underwent both IUS and colonoscopy within a 10-day period.</p><p><strong>Results: </strong>The study found a strong correlation between bowel thickening on IUS and inflammatory activity (<i>P</i> = 0.004), IUS remission and endoscopic remission (<i>P</i> = 0.03), IUS and endoscopic location (<i>P</i> = 0.04), as well as IUS and computed tomography scan findings for collection diagnosis (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>The study's findings demonstrated excellent results for using IUS in the diagnosis and follow-up of IBD patients.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"97016"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and limitations in assessing mucosal healing in Crohn's disease: Discrepancies between endoscopic and histologic evaluations.","authors":"Arunkumar Krishnan, Diptasree Mukherjee","doi":"10.4253/wjge.v17.i3.103834","DOIUrl":"10.4253/wjge.v17.i3.103834","url":null,"abstract":"<p><p>The recent study published by Lee <i>et al</i> examined the discrepancies between endoscopic and histologic evaluations of mucosal inflammation in active ileal Crohn's disease (CD). While this research contributes to our understanding of the limitations of current biopsy protocols, it raises several concerns about the generalizability of its findings, sample size, and methodology. One major limitation was the exclusion of patients with ileal strictures, ileostomies, or J-pouches, which reduced the applicability of the results to the wider CD population. Furthermore, the biopsy protocol's focus on single biopsies from specific locations may inadequately capture the patchy inflammation characteristic of CD. The study also uses histologic indices primarily developed for ulcerative colitis, which may not be suitable for assessing CD. It is recommended that multi-center studies be conducted and histologic indices specific to CD be developed to improve the relevance of future research. Additionally, researchers should consider the influence of treatment regimens on the findings. Addressing these limitations would enhance the clinical significance of the study and inform better diagnostic and therapeutic approaches for CD.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 3","pages":"103834"},"PeriodicalIF":1.4,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}