Eyad Gadour, Bogdan Miutescu, Hussein Hassan Okasha, Ana Maria Ghiuchici, Mohammed S AlQahtani
{"title":"Diagnostic yield of video capsule endoscopy <i>vs</i> simple balloon enteroscopy in small intestinal disorders: A systematic review.","authors":"Eyad Gadour, Bogdan Miutescu, Hussein Hassan Okasha, Ana Maria Ghiuchici, Mohammed S AlQahtani","doi":"10.4253/wjge.v17.i7.108264","DOIUrl":"10.4253/wjge.v17.i7.108264","url":null,"abstract":"<p><strong>Background: </strong>Small-bowel disorders, including obscure gastrointestinal bleeding (OGIB), Crohn's disease, and tumors, require accurate diagnostic approaches for effective treatment. Video capsule endoscopy (VCE) and simple balloon enteroscopy (SBE) are widely used; however, each modality has limitations, particularly regarding therapeutic intervention and diagnostic yield.</p><p><strong>Aim: </strong>To evaluate diagnostic yields of various modalities for small bowel bleeding, analyze factors affecting heterogeneity, and improve understanding of clinical outcomes associated with different diagnostic approaches.</p><p><strong>Methods: </strong>A comprehensive search of four databases (PubMed, Embase, Cochrane Library, and Scopus) revealed over 600 citations related to the use of capsule endoscopy and balloon enteroscopy for diagnosing small intestine disorders with wall thickening. Based on predetermined eligibility criteria, seven moderate-to-high-quality retrospective studies were analyzed to evaluate the diagnostic performance of VCE and SBE in patients with small bowel disorders. Quality Assessment of Diagnostic Accuracy Studies was applied to evaluate the risk of bias and overall methodological quality.</p><p><strong>Results: </strong>Analysis of seven moderate-to-high-quality retrospective studies revealed comparable overall detection rates for small bowel lesions between VCE and SBE. VCE demonstrated superior performance in detecting vascular lesions. Conversely, SBE exhibited a higher efficacy in detecting ulcerative lesions. The overall diagnostic yield varied across studies, with VCE showing a range of 32%-83% for small bowel bleeding, whereas SBE demonstrated a higher overall detection rate of 69.7% compared to 57.6% for VCE (<i>P</i> < 0.05). Notably, SBE showed superior performance in diagnosing Crohn's disease, with a detection rate of 35%, compared to 11.3% for VCE (<i>P</i> < 0.001). The diagnostic concordance between VCE and SBE was influenced by the lesion type. Strong agreement was observed for inflammatory lesions (κ = 0.82, 95%CI: 0.75-0.89), whereas moderate agreement was noted for tumors (κ = 0.61, 95%CI: 0.52-0.70) and angiectasias (κ = 0.58, 95%CI: 0.49-0.67). SBE demonstrated significant advantages in therapeutic interventions, particularly in overt bleeding. Patient tolerability was generally higher for VCE, with a completion rate of 95% (95%CI: 92%-98%), compared to 85% for SBE (95%CI: 80%-90%). However, the capsule retention rate for VCE was 1.4% (95%CI: 0.8%-2.0%), necessitating subsequent intervention.</p><p><strong>Conclusion: </strong>VCE and SBE are complementary techniques for evaluating small intestinal disorders. Although VCE remains the initial test of choice for patients with stable OGIB, SBE should be considered in patients requiring therapeutic intervention. Thus, combining both modalities enhances diagnostic accuracy and patient management.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108264"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic management of biliary leaks: Where are we now?","authors":"Alberto Tringali, Deborah Costa, Daryl Ramai","doi":"10.4253/wjge.v17.i7.107587","DOIUrl":"10.4253/wjge.v17.i7.107587","url":null,"abstract":"<p><p>Biliary leaks can arise as a consequence of cholecystectomy, liver surgery, liver transplant, or, less frequently, trauma. Early identification and characterization of these leaks are crucial, as they can significantly enhance patient outcomes by reducing morbidity and mortality. Traditionally, surgical repair has been the standard treatment; however, advancements in endoscopic techniques and tools have established endoscopic retrograde cholangiopancreatography (ERCP) as the primary approach for managing these often-complicated cases. Interventions such as sphincterotomy, nasobiliary drainage, and stent placement aim to alleviate the pressure within the bile duct, facilitating depressurization and promoting leak healing. Alongside ERCP, endoscopic ultrasound is playing an increasingly vital role in addressing challenging cases. Ongoing improvements in endoscopic technologies and methodologies offer promising prospects, often minimizing the need for invasive surgical interventions. Nonetheless, the management of biliary leaks continues to pose significant challenges for clinicians. An optimal approach for patients experiencing bile leakage should be determined on a case-by-case basis and discussed within a multidisciplinary team involving radiologists, endoscopists, and surgeons. This comprehensive review aims to elucidate the role of endoscopy in the management of various types of biliary leaks, providing clinicians with practical insights to navigate this complex field.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107587"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
So Young Shin, Hee Jin Yeon, Sang On Lee, Jeong Rim Lee, Galam Leem, Seok Joo Han
{"title":"Fatal air embolism during intestinal endoscopy in Kasai portoenterostomy for biliary atresia: A case report.","authors":"So Young Shin, Hee Jin Yeon, Sang On Lee, Jeong Rim Lee, Galam Leem, Seok Joo Han","doi":"10.4253/wjge.v17.i7.105773","DOIUrl":"10.4253/wjge.v17.i7.105773","url":null,"abstract":"<p><strong>Background: </strong>Air embolism (AE) is a rare but potentially fatal complication of intestinal endoscopy (IE).</p><p><strong>Case summary: </strong>Herein, we report the case of an 18-year-old woman who underwent a successful Kasai portoenterostomy (KPE) for biliary atresia but died of AE during intraoperative IE for stone removal at the portoenterostomy site. Our review of the English literature identified only four similar cases of fatal AE during IE in patients undergoing KPE. The common clinical setting in the five patients, including our case, was high-pressure air insufflation into the blind closed afferent loop of the KPE to secure visibility. We hypothesize that the highly pressurized air injected into the closed loop entered the bile canaliculi-previously opened by KPE for bile drainage-passed through the tiny, microscopic pores of the fenestrated liver sinusoid endothelial cells, and finally entered the bloodstream with ease, resulting in fatal AE.</p><p><strong>Conclusion: </strong>Meticulous performance of IE, especially on the KPE blind loop, is warranted owing to the risk of AE.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"105773"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative schemes of colonoscopy bowel preparation with oral lactulose: Optimizing traditional standards to improve colonoscopy quality.","authors":"Josué Aliaga Ramos, Danilo Carvalho, Vitor Nunes Arantes","doi":"10.4253/wjge.v17.i7.107168","DOIUrl":"10.4253/wjge.v17.i7.107168","url":null,"abstract":"<p><p>The bowel preparation is a crucial step to achieve an optimal quality in colonoscopy. The major clinical impact of an adequate colonic cleansing is to allow a more detailed and thorough inspection reducing the rates of missing lesions during the procedure and consequently reducing the incidence of interval colorectal carcinomas. Currently there are different colonoscopic preparation schemes, being the polyethylene glycol (PEG) based regimen one of the most used and recommended by the main international clinical guidelines. Nevertheless, PEG preparation requires the ingestion of considerably large volumes to achieve an optimal colonic cleansing, leading to poor tolerability in may patients, particularly in an elderly population. Other aspects that make accessibility to most colonoscopy preparation regimens difficult is their high cost and low availability. New options of colonoscopic preparation schemes based on oral lactulose are emerging with promising results, showing excellent efficacy-safety profiles and high tolerability indexes. Lactulose regimens present other benefits such as low cost and wide availability. The aim of this review is to analyze the scientific evidence to date and the current status of colonoscopy bowel preparation utilizing lactulose-based regimens, in order to consolidate this agent as a feasible \"new player\" in the field of colonoscopic preparation.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107168"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-endoscopic retrograde cholangiopancreatography cholecystitis: A review of incidence, risk factors, prevention, and management.","authors":"Suprabhat Giri, Shivaraj Afzalpurkar, Prasanna Gore, Gaurav Khatana, Saroj Kanta Sahu, Dibya Lochan Praharaj, Bipadabhanjan Mallick, Preetam Nath, Sridhar Sundaram, Manoj Kumar Sahu","doi":"10.4253/wjge.v17.i7.108030","DOIUrl":"10.4253/wjge.v17.i7.108030","url":null,"abstract":"<p><p>Post-endoscopic retrograde cholangiopancreatography (ERCP) cholecystitis (PEC) is a recognized adverse event associated with ERCP. The incidence of PEC is low in patients undergoing ERCP, but is high in specific subgroups, such as those receiving fully-covered self-expandable metallic stents (SEMS). Several risk factors contribute to PEC, including gallbladder (GB)-related factors like tumor involvement of the orifice of the cystic duct (OCD) or feeding artery, and associated gallstones. Stent-related factors, such as covered stent placement and high axial force stents, and procedure-related factors, including stent placement across the OCD and contrast injection into the GB, further elevate the risk. Prevention strategies focus on modifying techniques, such as careful contrast administration and stent selection (uncovered or low axial force SEMS), and considering prophylactic GB drainage through endoscopic transpapillary GB drainage (ETGBD) or endoscopic ultrasound-guided GB drainage (EUS-GBD), especially in high-risk patients. Treatment options for PEC range from conservative management with antibiotics to more invasive interventions like percutaneous transhepatic GB aspiration or drainage, endoscopic techniques (ETGBD, EUS-GBD), and cholecystectomy. The choice of treatment depends on the severity of cholecystitis, the patient's condition, and other factors. The present review summarizes the currently available literature on the incidence, predictors, prevention, and management of PEC.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108030"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Revolutionizing upper gastrointestinal disease diagnosis: The transformative role of artificial intelligence in endoscopy.","authors":"Xin-Rui Li, Mo-Wei Kong, Xiang-Feng Guan, Yu Gao","doi":"10.4253/wjge.v17.i7.108293","DOIUrl":"10.4253/wjge.v17.i7.108293","url":null,"abstract":"<p><p>With the rapid advancement of technology, artificial intelligence (AI) has emerged as a transformative force in gastroenterology, particularly in diagnosing upper gastrointestinal diseases such as Barrett's esophagus (BE), esophageal cancer, gastroesophageal reflux disease (GERD), and esophagogastric varices. AI's capabilities in image analysis, classification, detection, and segmentation have significantly improved diagnostic accuracy and efficiency. For BE, AI models achieve high sensitivity and specificity in detecting early neoplastic changes and guiding targeted biopsies. In esophageal cancer, AI enhances early lesion detection, improving intervention success rates. For GERD, AI classifies disease severity based on the Los Angeles grading system and accurately segments lesions. Additionally, AI detects esophagogastric varices and predicts bleeding risks more effectively than traditional methods. Despite these advancements, challenges remain, including the need for high-quality data, multi-center validation, and ensuring AI model interpretability. Future research should address these issues and further integrate AI into clinical practice to optimize patient outcomes. This review highlights AI's transformative impact on upper gastrointestinal disease diagnosis, emphasizing its potential to revolutionize endoscopic practice and improve patient care.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108293"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing-Rui Wu, Chang-Cheng Wang, Bo-Yang Li, Jia-Hang Li, Tao Zhang, Zi-Yao Li
{"title":"Concomitant functional gallbladder disorder and left-sided gallbladder: A case report.","authors":"Jing-Rui Wu, Chang-Cheng Wang, Bo-Yang Li, Jia-Hang Li, Tao Zhang, Zi-Yao Li","doi":"10.4253/wjge.v17.i7.107059","DOIUrl":"10.4253/wjge.v17.i7.107059","url":null,"abstract":"<p><strong>Background: </strong>Ectopic gallbladder, occurring in 0.1% to 0.7% of the population, is rarely found in the left liver lobe without situs inversus totalis. Functional gallbladder disorder (FGBD), characterized by biliary pain without stones or sludge, affects 8% of men and 21% of women. No prior cases of concomitant FGBD and left-sided gallbladder have been reported, posing diagnostic and surgical challenges.</p><p><strong>Case summary: </strong>A 73-year-old woman with a 20-year history of epigastric pain was diagnosed with a left-sided gallbladder and FGBD based on imaging findings and impaired gallbladder contraction. Laparoscopic cholecystectomy was performed and confirmed the ectopic gallbladder adherent to the left liver lobe. Postoperative pathology revealed no abnormalities, and the patient achieved complete symptom resolution at three-month follow-up.</p><p><strong>Conclusion: </strong>This is the first reported case of FGBD with a left-sided gallbladder. Preoperative imaging, such as magnetic resonance cholangiopancreatography or computed tomography, is crucial for identifying anatomical variations of the gallbladder. Laparoscopic cholecystectomy is feasible but requires careful planning to avoid complications.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107059"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Construction and validation of a machine learning algorithm-based predictive model for difficult colonoscopy insertion.","authors":"Ren-Xuan Gao, Xin-Lei Wang, Ming-Jie Tian, Xiao-Ming Li, Jia-Jia Zhang, Jun-Jing Wang, Jing Gao, Chao Zhang, Zhi-Ting Li","doi":"10.4253/wjge.v17.i7.108307","DOIUrl":"10.4253/wjge.v17.i7.108307","url":null,"abstract":"<p><strong>Background: </strong>Difficulty of colonoscopy insertion (DCI) significantly affects colonoscopy effectiveness and serves as a key quality indicator. Predicting and evaluating DCI risk preoperatively is crucial for optimizing intraoperative strategies.</p><p><strong>Aim: </strong>To evaluate the predictive performance of machine learning (ML) algorithms for DCI by comparing three modeling approaches, identify factors influencing DCI, and develop a preoperative prediction model using ML algorithms to enhance colonoscopy quality and efficiency.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 712 patients who underwent colonoscopy at a tertiary hospital between June 2020 and May 2021. Demographic data, past medical history, medication use, and psychological status were collected. The endoscopist assessed DCI using the visual analogue scale. After univariate screening, predictive models were developed using multivariable logistic regression, least absolute shrinkage and selection operator (LASSO) regression, and random forest (RF) algorithms. Model performance was evaluated based on discrimination, calibration, and decision curve analysis (DCA), and results were visualized using nomograms.</p><p><strong>Results: </strong>A total of 712 patients (53.8% male; mean age 54.5 years ± 12.9 years) were included. Logistic regression analysis identified constipation [odds ratio (OR) = 2.254, 95% confidence interval (CI): 1.289-3.931], abdominal circumference (AC) (77.5-91.9 cm, OR = 1.895, 95%CI: 1.065-3.350; AC ≥ 92 cm, OR = 1.271, 95%CI: 0.730-2.188), and anxiety (OR = 1.071, 95%CI: 1.044-1.100) as predictive factors for DCI, validated by LASSO and RF methods. Model performance revealed training/validation sensitivities of 0.826/0.925, 0.924/0.868, and 1.000/0.981; specificities of 0.602/0.511, 0.510/0.562, and 0.977/0.526; and corresponding area under the receiver operating characteristic curves (AUCs) of 0.780 (0.737-0.823)/0.726 (0.654-0.799), 0.754 (0.710-0.798)/0.723 (0.656-0.791), and 1.000 (1.000-1.000)/0.754 (0.688-0.820), respectively. DCA indicated optimal net benefit within probability thresholds of 0-0.9 and 0.05-0.37. The RF model demonstrated superior diagnostic accuracy, reflected by perfect training sensitivity (1.000) and highest validation AUC (0.754), outperforming other methods in clinical applicability.</p><p><strong>Conclusion: </strong>The RF-based model exhibited superior predictive accuracy for DCI compared to multivariable logistic and LASSO regression models. This approach supports individualized preoperative optimization, enhancing colonoscopy quality through targeted risk stratification.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108307"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic resection for esophageal gastrointestinal stromal tumors: Balancing R0 resection and long-term outcomes.","authors":"Shinichiro Kobayashi, Yuki Muta, Shunsuke Murakami, Kengo Kanetaka","doi":"10.4253/wjge.v17.i7.108289","DOIUrl":"10.4253/wjge.v17.i7.108289","url":null,"abstract":"<p><p>Xu <i>et al</i> retrospectively assessed endoscopic resection (ER) for esophageal gastrointestinal stromal tumors (E-GISTs) and reported excellent 5-year survival rates. Although ER shows promise as a minimally invasive procedure, the 75% R0 resection rate with recurrence observed even after R0 resection warrants further discussion. We highlight the need for careful patient selection based on tumor size, location, and risk, considering endoscopic and thoracoscopic approaches. Future studies should refine ER techniques, optimize patient selection, and establish long-term follow-up to guide E-GIST management.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108289"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Delgado Galan, Elvira Quintanilla Lazaro, Luis Ramon Rabago Torre
{"title":"Postcolonoscopy colorectal cancer: What we need to know in the age of screening and magnifying endoscopy techniques.","authors":"Maria Delgado Galan, Elvira Quintanilla Lazaro, Luis Ramon Rabago Torre","doi":"10.4253/wjge.v17.i7.107430","DOIUrl":"10.4253/wjge.v17.i7.107430","url":null,"abstract":"<p><p>Post-colonoscopic colorectal cancer (PCCRC), also known as interval CRC, is defined as CRC diagnosed more than six months after a colonoscopy in which no cancer was detected. It typically arises from missed lesions or incomplete resections and is now recognized as one of the most reliable quality indicators for assessing colonoscopy performance. With an incidence rate of 3.6% to 9.3%, PCCRC remains a significant concern, highlighting the limitations of colonoscopy in CRC screening-not only in terms of diagnostic accuracy but also in its preventive role and effectiveness in treating lesions. A range of clinical, endoscopic, and biological factors has been associated with an increased risk of PCCRC. Identifying these factors can help stratify high-risk patients, enabling earlier detection and improving preventive strategies for interval CRC. Reducing PCCRC should be a top priority for every endoscopy unit. While technological advancements will enhance polyp detection, minimize missed lesions, prevent incomplete resections, and improve overall procedural quality, the most impactful strategy remains internal self-assessment within each unit. This review should evaluate key performance metrics, including cecal intubation rate, adenoma detection rate, withdrawal time, PCCRC incidence, and incomplete resections-both at the individual endoscopist level and across the entire unit.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107430"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}