World Journal of Gastrointestinal Endoscopy最新文献

{"title":"Advances in gastrointestinal endoscopy: A comprehensive review of innovations in cancer diagnosis and management.","authors":"Mohammed Abusuliman, Taher Jamali, Tobias E Zuchelli","doi":"10.4253/wjge.v17.i5.105468","DOIUrl":"10.4253/wjge.v17.i5.105468","url":null,"abstract":"<p><p>The field of gastroenterology has experienced revolutionary advances over the past years, as flexible endoscopes have become widely accessible. In addition to enabling faster, less invasive, and more affordable treatment, flexible endoscopes have greatly improved the detection and endoscopic screening of malignancies and prevented many cancer-related deaths. The development and clinical application of new diagnostic endoscopic technologies, such as magnification endoscopy, narrow-band imaging, endoscopic ultrasound with biopsy, and more recently, artificial intelligence enhanced technologies, have made the recognition and detection of various neoplasms and sub-epithelial tumors more possible. This review demonstrates the latest advancements in endoscopic procedures, techniques, and devices applied in the diagnosis and management of gastrointestinal cancer.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 5","pages":"105468"},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing trends in upper gastrointestinal endoscopic findings in Ethiopia: A comparison of eighteen thousand exams across two periods.","authors":"Guda M Roro, Rodas T Annose, Odd H Gilja","doi":"10.4253/wjge.v17.i5.106690","DOIUrl":"10.4253/wjge.v17.i5.106690","url":null,"abstract":"<p><strong>Background: </strong>Relative changes in the prevalence of gastrointestinal (GI) diseases have been reported worldwide over the past decades. However, data on changing trends of upper GI diseases remain scarce in sub-Saharan Africa. This study examines the shifting patterns of upper GI endoscopic findings over 35 years in Ethiopia.</p><p><strong>Aim: </strong>To analyze trends in upper GI endoscopic findings over two distinct time periods, 35 years apart, in Ethiopia.</p><p><strong>Methods: </strong>We extracted findings from 8412 upper GI endoscopies performed between 2016 and 2024 at a tertiary referral center in Addis Ababa, Ethiopia. Patient characteristics, indications, and endoscopic findings were analyzed using descriptive statistics and presented in tables, map and graphs. These findings were compared to 10000 procedures conducted between 1979 and 1994. Key endoscopic findings were identified, and percentage changes in disease prevalence were calculated.</p><p><strong>Results: </strong>Between the two study periods, the male-to-female ratio of patients undergoing upper GI endoscopy shifted from 2:1 to 1.4:1, while the median patient age increased from 36 to 40 years. The proportion of patients older than 50 years doubled (14.6% to 30.2%), and referrals from outside Addis Ababa increased from 33% to 57%. The prevalence of peptic ulcer disease and its complications decreased from 46.2% to 9.5%. Conversely, gastroesophageal varices increased from 9.5% to 21.8%, and upper GI malignancies rose from 3.6% to 18.8%.</p><p><strong>Conclusion: </strong>This study sheds light on critical epidemiological shifts in upper GI diseases in Ethiopia, with a decline in peptic ulcer disease and a rise in portal hypertensive lesions and malignancies which have important public health implications. These findings underscore the need for increased awareness, improved clinical practices, enhanced resource allocation, and expanded access to early diagnosis and treatment of prevailing conditions. Preventive strategies targeting immunization and treatment of viral hepatitis, schistosomiasis, and <i>Helicobacter pylori</i> infection are urgently needed.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 5","pages":"106690"},"PeriodicalIF":1.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12110153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective randomized study comparing Franseen 22-gauge <i>vs</i> standard 22-gauge needle for endoscopic ultrasound guided sampling of pancreatic solid lesions.","authors":"Gabriela F Paduani, Leika M Felipe, Gustavo A De Paulo, Luciano Lenz, Bruno C Martins, Sergio E Matuguma, Adriana V Safatle-Ribeiro, Evandro S De Mello, Fauze Maluf-Filho","doi":"10.4253/wjge.v17.i4.101998","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.101998","url":null,"abstract":"<p><strong>Background: </strong>This is a randomized study to compare the diagnostic accuracy of endoscopic ultrasound (EUS)-guided sampling of pancreatic solid lesions obtained with the 22-gauge Franseen (EUS-fine needle biopsy) <i>vs</i> the 22-gauge standard needle (EUS-fine needle aspiration) without rapid onsite evaluation (ROSE), since, in most endoscopy units around the world ROSE is not routinely available.</p><p><strong>Aim: </strong>To investigate the accuracy of EUS-guided sampling of pancreatic solid lesions obtained between two different needles without ROSE.</p><p><strong>Methods: </strong>Patients with a solid pancreatic were included. Patients were biopsied in a randomized order. The primary endpoint was the diagnostic sensitivity for pancreatic malignancy (PM). Secondary outcomes were adequacy of the sample, the mean tissue area, the mean tumor area, and the adverse event rate.</p><p><strong>Results: </strong>The final diagnosis was pancreatic adenocarcinoma in 38 (76%), neuroendocrine tumor in 4 (8%), chronic pancreatitis in 3 (6%) patients. The sensitivity for PM with Franseen needle was 0.91 [95% confidence interval (CI): 0.80-0.98], <i>vs</i> 0.8 (95%CI: 0.67-0.91) (<i>P</i> = 0.025) with standard needle. The specificity for PM did not differentiate. The accuracy of the standard needle for PM was 0.80 (95%CI: 0.66-0.90), and the Franseen group was 0.90 (95%CI: 0.78-0.97) (<i>P</i> = 0.074). The technical success rates for the standard and Franseen needle groups were 94% (95%CI: 0.83-0.99) and 100% (95%CI: 0.92-1.00), respectively. The mean total tissue area in mm² (SD) was greater in the Franseen group, 2.07 (0.22) <i>vs</i> 1.16 (0.17) (<i>P</i> < 0.01). The mean tumor area in mm² (SD) was not different in Franseen group <i>vs</i> standard group, 0.42 (0.09) <i>vs</i> 0.47 (0.09) (<i>P</i> = 0.80). There were no adverse events.</p><p><strong>Conclusion: </strong>The sensitivity for PM and mean total tissue area, was greater in the as compared with standard needle. The mean tumor area did not differ between the groups.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"101998"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in the diagnosis of biliopancreatic diseases: A comparative review and study on future insights.","authors":"Eyad Gadour, Bogdan Miutescu, Zeinab Hassan, Emad S Aljahdli, Khurram Raees","doi":"10.4253/wjge.v17.i4.103391","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.103391","url":null,"abstract":"<p><p>Owing to the complex and often asymptomatic presentations, the diagnosis of biliopancreatic diseases, including pancreatic and biliary malignancies, remains challenging. Recent technological advancements have remarkably improved the diagnostic accuracy and patient outcomes in these diseases. This review explores key advancements in diagnostic modalities, including biomarkers, imaging techniques, and artificial intelligence (AI)-based technologies. Biomarkers, such as cancer antigen 19-9, <i>KRAS</i> mutations, and inflammatory markers, provide crucial insights into disease progression and treatment responses. Advanced imaging modalities include enhanced computed tomography (CT), positron emission tomography-CT, magnetic resonance cholangiopancreatography, and endoscopic ultrasound. AI integration in imaging and pathology has enhanced diagnostic precision through deep learning algorithms that analyze medical images, automate routine diagnostic tasks, and provide predictive analytics for personalized treatment strategies. The applications of these technologies are diverse, ranging from early cancer detection to therapeutic guidance and real-time imaging. Biomarker-based liquid biopsies and AI-assisted imaging tools are essential for non-invasive diagnostics and individualized patient management. Furthermore, AI-driven models are transforming disease stratification, thus enhancing risk assessment and decision-making. Future studies should explore standardizing biomarker validation, improving AI-driven diagnostics, and expanding the accessibility of advanced imaging technologies in resource-limited settings. The continued development of non-invasive diagnostic techniques and precision medicine approaches is crucial for optimizing the detection and management of biliopancreatic diseases. Collaborative efforts between clinicians, researchers, and industry stakeholders will be pivotal in applying these advancements in clinical practice.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"103391"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing endoscopic remission in small bowel Crohn's disease: Are markers enough?","authors":"Iyad A Issa, Taly Issa","doi":"10.4253/wjge.v17.i4.106083","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.106083","url":null,"abstract":"<p><p>Mucosal healing in Crohn's disease (CD) has been established as a crucial target of treatment, leading to long term remission and decrease in complication rates. Endoscopy still serves as the gold standard for assessment, particularly in the small bowel where balloon or capsule enteroscopy is frequently needed. However, these modalities are often unavailable, expensive, and invasive, posing risks to patients. Consequently, the identification of accessible and reliable biomarkers, especially in small intestinal CD, remains a challenge. The study by Ohno <i>et al</i>, published in this issue, further illuminates this field. It confirms the potential role of fecal biomarker leucine-rich α2 glycoprotein (LRG) and validates findings from previous smaller trials. Comparing to other markers LRG showed a much higher predictive value for mucosal healing of the small bowel, making it a useful option for small intestinal CD follow up. In this editorial, we explore the optimal marker of inflammation or mucosal healing in CD, particularly in the small bowel. We provide an overview of available conventional biomarkers and introduce several novel biomarkers, including an update on emerging technologies and innovations.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"106083"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopists and endoscopic assistants' qualifications, but not their biopsy rates, improve gastric precancerous lesions detection rate.","authors":"Yao Shen, Xiao-Juan Gao, Xiao-Xue Zhang, Jia-Min Zhao, Fei-Fan Hu, Jing-Lue Han, Wen-Ying Tian, Mei Yang, Yun-Fei Wang, Jia-Le Lv, Qiang Zhan, Fang-Mei An","doi":"10.4253/wjge.v17.i4.104097","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.104097","url":null,"abstract":"<p><strong>Background: </strong>Detecting gastric precancerous lesions (GPLs) is critical for the early diagnosis and treatment of gastric cancer. Endoscopy combined with tissue examination is an important method for detecting GPLs. However, negative biopsy results often increase patients' risks, economic burdens, and lead to additional healthcare costs. Improving the detection rate of GPLs and reducing the rate of negative biopsies is currently a key focus in endoscopic quality control.</p><p><strong>Aim: </strong>To explore the relationships between the endoscopist biopsy rate (EBR), qualifications of endoscopists and endoscopic assistants, and detection rate of GPLs.</p><p><strong>Methods: </strong>EBR, endoscopists, and endoscopic assistants were divided into four groups: Low, moderate, high, and very high levels. Multivariable logistic regression analysis was used to analyze the relationships between EBR and the qualifications of endoscopists with respect to the detection rate of positive lesions. Pearson and Spearman correlation analyses were used to evaluate the correlation between EBR, endoscopist or endoscopic assistant qualifications, and the detection rate of positive lesions.</p><p><strong>Results: </strong>Compared with those in the low EBR group, the odds ratio (OR) values for detecting positive lesions in the moderate, high, and very high EBR groups were 1.12 [95% confidence interval (CI): 1.06-1.19, <i>P</i> < 0.001], 1.22 (95%CI: 1.14-1.31, <i>P</i> < 0.001), and 1.38 (95%CI: 1.29-1.47, <i>P</i> < 0.001), respectively. EBR was positively correlated with the detection rate of gastric precancerous conditions (atrophic gastritis/intestinal metaplasia) (<i>ρ</i> = 0.465, <i>P</i> = 0.004). In contrast, the qualifications of the endoscopists were positively correlated with GPLs detection (<i>ρ</i> = 0.448, <i>P</i> = 0.005). Compared to endoscopists with low qualification levels, those with moderate, high, and very high qualification levels endoscopists demonstrated increased detection rates of GPLs by 13% (OR = 1.13, 95%CI: 0.98-1.31), 20% (OR = 1.20, 95%CI: 1.03-1.39), and 32% (OR = 1.32, 95%CI: 1.15-1.52), respectively. Further analysis revealed that the qualifications of endoscopists were positively correlated with the detection rates of GPLs in the cardia (<i>ρ</i> = 0.350, <i>P</i> = 0.034), angularis (<i>ρ</i> = 0.396, <i>P</i> = 0.015) and gastric body (<i>ρ</i> = 0.453, <i>P</i> = 0.005) but not in the antrum (<i>ρ</i> = 0.292, <i>P</i> = 0.079). Moreover, the experience of endoscopic assistants was positively correlated with the detection rate of precancerous lesions by endoscopists with low or moderate qualifications (<i>ρ</i> = 0.427, <i>P</i> = 0.015).</p><p><strong>Conclusion: </strong>Endoscopists and endoscopic assistants with high/very high qualifications, but not EBR, can improve the detection rate of GPLs. These results provide reliable evidence for the development of gastroscopic quality control indicators.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"104097"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intricacy of Crohn's disease: Incongruity between diagnostic modalities and histopathologic assessment.","authors":"Hai-Ming Fang","doi":"10.4253/wjge.v17.i4.103979","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.103979","url":null,"abstract":"<p><p>Crohn's disease (CD) is a chronic and recurrent inflammatory condition. Histologic healing is associated with better outcomes in CD, while less is known regarding the assessment of histological condition. Recently, a study has examined the discordance between endoscopic and histopathologic assessment in ileal CD, revealing a poor correlation between endoscopic and histologic evaluations in assessing mucosal inflammation and disease activity. However, the involvement of CD can span the entire gastrointestinal tract, as well as numerous clinical manifestations and extraintestinal complications, and the patchy nature of transmural inflammation is a well-established characteristic of this disease. The diagnosis of CD relies on a comprehensive evaluation that includes clinical, biochemical, stool, endoscopic, cross-sectional imaging, and histological investigations due to the incomplete understanding of its etiology and pathogenesis. Upon diagnosis, complimentary investigations should focus on markers of disease activity. Since transmural inflammation can only be assessed in resections, therefore, we primarily focused on the evaluation value of clinical aspects, histological scoring systems, particular <i>in vivo</i> imaging evaluation such as computed tomography enterography, magnetic resonance elastography, scintigraphy, sonographically measurement, endoscopic ultrasonography, and advanced endoscopic imaging techniques.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"103979"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia: Methodological concerns, clinical implications, and future research directions.","authors":"Arunkumar Krishnan","doi":"10.4253/wjge.v17.i4.105630","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.105630","url":null,"abstract":"<p><p>Gastrointestinal bleeding (GIB) presents a significant challenge for patients with hematologic malignancies, especially those with severe thrombocytopenia. Although endoscopic intervention is frequently used in managing GIB, its safety and effectiveness in this high-risk group remain unclear. A recent study by Alhumayyd <i>et al</i> provided insight into this issue. However, it has notable limitations, including its retrospective nature, small sample size, and failure to adjust for important confounding factors such as disease severity, hemodynamic status, and platelet function. The study's findings indicated that urgent endoscopy may help decrease the incidence of recurrent bleeding; however, it did not show a clear benefit in terms of mortality. Future research ought to prioritize prospective, multicenter studies that employ standardized protocols and incorporate risk stratification models to better understand the impact of endoscopic treatment for GIB in these patients. Additionally, integrating platelet function assays could improve clinical decision-making. Addressing these research gaps is essential for improving patient outcomes and developing effective guidelines for managing GIB in individuals with thrombocytopenia.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"105630"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn's disease: A critical review and the path forward.","authors":"Arunkumar Krishnan","doi":"10.4253/wjge.v17.i4.106671","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.106671","url":null,"abstract":"<p><p>The study by Ohno <i>et al</i> provides valuable insights into the role of leucine-rich alpha-2-glycoprotein (LRG) as a potential biomarker for identifying small bowel lesions in Crohn's disease (CD). However, several methodological challenges hinder its immediate use in clinical practice. Notably, the current research was retrospective, lacks comparative studies with fecal calprotectin, and did not provide long-term predictive data. Further prospective studies are needed to improve the applicability of LRG. Moreover, integrating LRG with additional biomarkers and employing artificial intelligence techniques may improve its effectiveness in disease monitoring. Future research should address interobserver variability, assess LRG's cost-effectiveness, and standardize endoscopic healing definitions to ensure broader applicability. Advancing these areas is vital for establishing LRG's role in precision medicine strategies for the management of CD.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"106671"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, endoscopic and histopathological observation of a rare case of esophageal submucosal gland duct adenoma: A case report.","authors":"Ting Lu, Jun-Xing Liu, Yin Xia, Yan Zhao","doi":"10.4253/wjge.v17.i4.105238","DOIUrl":"https://doi.org/10.4253/wjge.v17.i4.105238","url":null,"abstract":"<p><strong>Background: </strong>Esophageal submucosal gland duct adenoma (ESGDA) is very rare, and easily diagnosed as adenocarcinoma.</p><p><strong>Case summary: </strong>A 70-year-old man presented with abdominal discomfort and intermittent dull pain during swallowing for 10 days. Digestive endoscopy revealed a polypoid bulge at the esophago-gastric junction, which was resected by endoscopic submucosal dissection (ESD). Routine pathological examination showed intestinal metaplasia of the glandular epithelium on the mucosal surface, with serous tumor-like complex glands in the submucosa which showing significant hyperplasia. This initially diagnosis was early gastric adenocarcinoma. However, we still observed a few points that did not meet the criteria for cancer such as lack of malignant features. Following multidisciplinary discussion and consultation with the experienced specialist pathologists, we finally diagnosed the lesion as a rare ESGDA by further immunohistochemistry. The follow-up examination results for the patient were satisfactory, with no evidence of tumor recurrence. And we summarize the ESGDAs reported in the literature, aiming to enhance understanding of this tumor type.</p><p><strong>Conclusion: </strong>ESGDA is a benign tumor that can be cured by ESD. Accurate diagnosis can prevent unnecessary extensive therapeutic interventions.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 4","pages":"105238"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12019125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}