World Journal of Gastrointestinal Endoscopy最新文献

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Prevention and treatment of recurrence after endoscopic resection of large non-pedunculated colorectal polyps. 内镜下无带蒂大结肠息肉切除术后复发的预防与治疗。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107746
Samantha Pang, Pedram Tavakoli, Neal Shahidi
{"title":"Prevention and treatment of recurrence after endoscopic resection of large non-pedunculated colorectal polyps.","authors":"Samantha Pang, Pedram Tavakoli, Neal Shahidi","doi":"10.4253/wjge.v17.i7.107746","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107746","url":null,"abstract":"<p><p>Minimally invasive endoscopic resection techniques are the recommended first-line treatment strategy for the majority of large non-pedunculated colorectal polyps, with endoscopic mucosal resection (EMR) as a predominant resection modality due to its efficacy, efficiency, safety, and cost-effectiveness. A limitation of EMR is recurrence, which has historically occurred in 15%-20% of lesions. In the past 10 years, a number of effective mitigating strategies have been developed, including margin thermal ablation using snare-tip soft coagulation, argon plasma coagulation (APC), and hybrid-APC, alongside margin marking pre-resection. Moreover, techniques for effective recurrence management have also been developed. Herein, we appraise existing evidence on the frequency of recurrence, reasonings behind recurrence formation, as well as recurrence mitigating strategies and the effectiveness of recurrence management.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107746"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis. 在溃疡性结肠炎的组织和内镜活动的实时评估内吞镜。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.108082
Thanaboon Chaemsupaphan, Mohammad Shir Ali, Caroline Fung, Sudarshan Paramsothy, Rupert W Leong
{"title":"Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis.","authors":"Thanaboon Chaemsupaphan, Mohammad Shir Ali, Caroline Fung, Sudarshan Paramsothy, Rupert W Leong","doi":"10.4253/wjge.v17.i7.108082","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.108082","url":null,"abstract":"<p><strong>Background: </strong>Endocytoscopy is an advanced imaging modality that provides real-time, ultra-high magnification views of the intestinal mucosa. In ulcerative colitis (UC), the combined assessment of endoscopic and histological remission is now becoming a standard practice. However, histological evaluation typically falls outside the scope of the endoscopist. By offering <i>in vivo</i> microscopic imaging, endocytoscopy has the potential to streamline workflow and enhance efficiency in assessing UC activity.</p><p><strong>Aim: </strong>To evaluate the utility of real-time endocytoscopy in assessing endoscopic and histological disease activity in UC, and to validate endocytoscopic scoring systems.</p><p><strong>Methods: </strong>This study was conducted at Concord Hospital. Patients with UC who consented to undergo colonoscopy with endocytoscopy were enrolled. Data collected included patient demographics, clinical disease activity, Mayo endoscopic score (MES), and endocytoscopic features such as crypt architecture, intercrypt distance and cellular infiltration. Correlation between endocytoscopic findings were evaluated against MES and the Nancy histological index. Agreement and validation were assessed using the ErLangen Endocytoscopy in ColiTis (ELECT) score and the endocytoscopy score (ECSS), applying Kappa (<i>κ</i>) statistics and Spearman's correlation coefficient (<i>r</i>).</p><p><strong>Results: </strong>A total of 61 colonic segments from 15 patients were assessed, with 187 analyzable endocytoscopic images. Endocytoscopy showed significant correlation with the MES using both the ECSS (<i>κ</i> = 0.60, <i>P</i> < 0.001; <i>r</i> = 0.78, <i>P</i> < 0.001) and ELECT (<i>κ</i> = 0.88, <i>P</i> < 0.001; <i>r</i> = 0.81, <i>P</i> < 0.001) scoring systems. Similarly, correlations with the Nancy histological index were significant for both ECSS (<i>κ</i> = 0.47, <i>P</i> < 0.001; <i>r</i> = 0.69, <i>P</i> < 0.001) and ELECT (<i>κ</i> = 0.88, <i>P</i> < 0.001; <i>r</i> = 0.74, <i>P</i> < 0.001). The ELECT score demonstrated superior diagnostic accuracy in identifying histological remission, with a sensitivity of 100%, specificity of 85%, and an area under the receiver operating characteristic curve of 0.90 (95% confidence interval: 0.78-1.00), compared to 68.3%, 85%, and an area under the receiver operating characteristic curve of 0.88 (95% confidence interval: 0.75-1.00) for the ECSS. No serious adverse events occurred, except for transient urinary discoloration due to methylene blue excretion.</p><p><strong>Conclusion: </strong>Endocytoscopy allows for real-time, simultaneous assessment of endoscopic and histological activity in UC and has been proven to be accurate, safe, and well-tolerated. Compared with the ECSS, the ELECT score showed superior concordance with histological findings.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108082"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic techniques and factors for complications in pediatric esophageal foreign body removal. 儿童食管异物取出术的内镜技术及并发症因素。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.106352
Lucas Dourado Mapurunga Pereira, Márcio Alencar Barreira, Thiago Nepomuceno de Saboia Mont'Alverne, Marina Marques Maia, Marcela Alina Jereissati de Castro, Joao Wallace Carvalho de Oliveira, Mariana Marques Maia, Paulo Roberto Cavalcante de Vasconcelos, Alessandrino Terceiro de Oliveira
{"title":"Endoscopic techniques and factors for complications in pediatric esophageal foreign body removal.","authors":"Lucas Dourado Mapurunga Pereira, Márcio Alencar Barreira, Thiago Nepomuceno de Saboia Mont'Alverne, Marina Marques Maia, Marcela Alina Jereissati de Castro, Joao Wallace Carvalho de Oliveira, Mariana Marques Maia, Paulo Roberto Cavalcante de Vasconcelos, Alessandrino Terceiro de Oliveira","doi":"10.4253/wjge.v17.i7.106352","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.106352","url":null,"abstract":"<p><strong>Background: </strong>Foreign body (FB) ingestion is one of the most challenging clinical situations faced by endoscopists. Most esophageal FB impaction emergencies occur in children. It is important to study the epidemiological profile and endoscopic methods for treating FB impacted in the esophagus of children, as it can help in the development of more effective, safe and personalized preventive and therapeutic strategies.</p><p><strong>Aim: </strong>To define the profile of children seeking emergency care due to FB impaction in the esophagus, analyze factors associated with complications, and evaluate the effectiveness of rigid (RE) and flexible endoscopes (FE).</p><p><strong>Methods: </strong>A retrospective cohort study of 166 children with impacted FB in the esophagus who underwent an endoscopy (FE = 84 <i>vs</i> RE = 82) at the Dr. José Frota Institute was performed. The primary outcomes were to assess the efficacy of the endoscopic technique and factors associated with complications. The secondary outcomes were age group, gender, symptoms, length of hospital stay, and location of the FB.</p><p><strong>Results: </strong>Boys (66.9%), preschoolers (43.4%), FB > 24 hours (62.7%), cervical esophagus (60.8%), coin ingestion (57.2%) and complaints of dysphagia (24.9%) and sialorrhea (23.1%) were the predominant findings. Endoscopy was successful (90.4%) with sedation (89.1%). A total of 97% of patients were discharged from the hospital, while 3% died. The average hospital stay length was 2.6 days. Most patients did not experience complications predominated (64.5%). Esophageal perforations were more frequent after RE (11% <i>vs</i> 4.8%), while FE was more effective (95.2% <i>vs</i> 85.4%). The <i>χ</i> <sup>2</sup> test or Fisher's exact test was used to compare categorical variables. For continuous variables, the Kruskal-Wallis test or analysis of variance was used. Statistical analyses were performed in R<sup>®</sup> software (version 1.3.1093).</p><p><strong>Conclusion: </strong>Coins were the most frequent FBs and were mainly lodged in the upper esophagus of preschool boys. Risk factors for complications due to esophageal FB include battery ingestion, delayed removal (> 48 hours) and lodging in the thoracic esophagus. FE was generally more effective than RE for removing FBs; both procedures are safe.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"106352"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is endoscopic treatment a useful therapeutic option for esophageal gastrointestinal stromal tumors? 内镜治疗是食管胃肠道间质瘤的有效治疗选择吗?
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107790
Beata Jabłońska
{"title":"Is endoscopic treatment a useful therapeutic option for esophageal gastrointestinal stromal tumors?","authors":"Beata Jabłońska","doi":"10.4253/wjge.v17.i7.107790","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107790","url":null,"abstract":"<p><p>Decisions regarding the management of patients with esophageal gastrointestinal tumors (EGISTs) are very challenging, as there are still no clear guidelines on the treatment of these tumors due to their rarity. Surgery remains the standard treatment, but it is known that surgical procedures performed on the esophagus are related to a high risk of serious postoperative complications and impaired quality of life. Endoscopic resection is both safe and effective for patients with low-risk EGISTs. This article presents the current therapeutic options in patients with EGISTs, including both the endoscopic and surgical approach, and discusses the results, strengths and limitations of the recent article by Xu <i>et al</i> regarding the endoscopic treatment outcome of EGISTs.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107790"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for achieving successful cannulation in endoscopic retrograde cholangiopancreatography: A technical overview. 在内窥镜逆行胆管造影中成功插管的策略:技术概述。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107810
Alaa Ismail, Maya M Abdelwahab, Mubin Ozercan, Osama Elnahas, Ibrahim H Bahcecioglu, Mehmet Yalniz, Ahmed Tawheed
{"title":"Strategies for achieving successful cannulation in endoscopic retrograde cholangiopancreatography: A technical overview.","authors":"Alaa Ismail, Maya M Abdelwahab, Mubin Ozercan, Osama Elnahas, Ibrahim H Bahcecioglu, Mehmet Yalniz, Ahmed Tawheed","doi":"10.4253/wjge.v17.i7.107810","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107810","url":null,"abstract":"<p><p>Endoscopic retrograde cholangiopancreatography (ERCP) is a vital diagnostic and therapeutic technique in evaluating and treating biliary and pancreatic disorders. Since its inception in the late 20<sup>th</sup> century, ERCP has transitioned from a mostly diagnostic instrument to a chiefly interventional procedure, owing to the emergence of less invasive imaging techniques like magnetic resonance cholangiopancreatography and endoscopic ultrasonography. Successful biliary cannulation is the most important and difficult step of the procedure. However, there are many challenges associated with cannulation, such as the anatomy of the major duodenal papilla, the direction of the common bile duct and pancreatic duct in the ampulla of Vater, the presence of periampullary diverticula, and scope position. Advanced techniques for cannulation are necessary when basic techniques fail. Double guidewire, precut methods, and transpancreatic sphincterotomy are examples of these advanced techniques. This review aims to summarize the challenges of biliary cannulation and tips for performing cannulation techniques.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107810"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of gastric neoplasms location on clinical outcome of patients treated by endoscopic submucosal dissection. 胃肿瘤位置对内镜下粘膜下剥离患者临床疗效的影响。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107911
Josué Aliaga Ramos, Vitor Nunes Arantes
{"title":"Impact of gastric neoplasms location on clinical outcome of patients treated by endoscopic submucosal dissection.","authors":"Josué Aliaga Ramos, Vitor Nunes Arantes","doi":"10.4253/wjge.v17.i7.107911","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107911","url":null,"abstract":"<p><strong>Background: </strong>The location of gastric neoplasms can influence the level of technical difficulty and performance of endoscopic submucosal dissection (ESD). There are few studies that analyze the influence of tumor location in the stomach on ESD outcomes.</p><p><strong>Aim: </strong>To compare the clinical efficacy and safety of ESD in the proximal <i>vs</i> distal stomach.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients admitted in chronological order who received gastric ESD between 2009 and 2024. Patients were stratified into two groups based on tumor location: Group 1 included patients with tumors in the lower third of the stomach, while Group 2 included those with tumors in the middle or upper third. The following parameters were evaluated for each group: procedure duration, curative resection rate, <i>en bloc</i> resection rate, complete resection rate, incidence of complications, and depth of neoplastic invasion.</p><p><strong>Results: </strong>The mean procedure time was 97.07 minutes for lesions located in the distal stomach and 129.08 minutes for those in the proximal stomach (<i>P</i> = 0.0011). <i>En bloc</i> resection rates for ESD in the distal and proximal stomach were 97.9% and 85.7%, respectively (<i>P</i> = 0.0016), while complete resection rates were 93.9% and 73.4%, respectively (<i>P</i> = 0.0002). Curative resection was achieved in 90.9% of distal lesions compared to 65.3% of proximal lesions (<i>P</i> = 0.0001). Submucosal invasion was identified in 4.0% of distal lesions and 14.2% of proximal lesions (<i>P</i> = 0.013).</p><p><strong>Conclusion: </strong>ESD performed in the proximal stomach requires a longer procedural time compared to ESD in the distal stomach, independent of lesion size and histopathological characteristics. Additionally, proximal gastric ESD is associated with reduced clinical efficacy and increased incidence of submucosal invasion.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107911"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatoscopy in the evaluation and management of pancreatic disorders. 胰腺镜检查在胰腺疾病的评估和治疗中的应用。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107645
Rodrigo Mansilla-Vivar, Eduardo Segovia-Vergara, Vicente Pons-Beltrán
{"title":"Pancreatoscopy in the evaluation and management of pancreatic disorders.","authors":"Rodrigo Mansilla-Vivar, Eduardo Segovia-Vergara, Vicente Pons-Beltrán","doi":"10.4253/wjge.v17.i7.107645","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107645","url":null,"abstract":"<p><p>Pancreatoscopy is an advanced endoscopic technique that enables high-resolution imaging of the main pancreatic duct. Its relevance has grown in recent years with the introduction of novel technologies, allowing for both diagnosis and treatment within a single procedure. In therapeutic applications, it facilitates interventions such as stone fragmentation, stone retrieval, and tumor-related obstruction management. In diagnostic applications, it improves the accuracy of biopsies for suspicious lesions, particularly in cases of cystic neoplasms, indeterminate strictures, and pancreatic fistula assessments. The most common complications include post-procedural pancreatitis and self-limited abdominal pain, with their incidence mitigated by prophylactic anti-inflammatory drugs and pancreatic stent placement. Despite being limited by the need for specialized equipment and trained personnel, technological advancements may position pancreatoscopy as a first-line tool in modern clinical practice.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107645"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report. 难治性慢性腹泻合并视神经炎1例。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.106208
Chao-Nan Chen, Xin-Yu Fan, Chong-Mei Yang, Xiao-Hua Zhang, Jin Liu
{"title":"Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report.","authors":"Chao-Nan Chen, Xin-Yu Fan, Chong-Mei Yang, Xiao-Hua Zhang, Jin Liu","doi":"10.4253/wjge.v17.i7.106208","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.106208","url":null,"abstract":"<p><strong>Background: </strong>Collagenous sprue is a serious intestinal malabsorption disorder characterized by dull and flattened intestinal villi with subepithelial collagen deposition. At present, fewer than 100 cases have been reported in the literature. Owing to the rarity of this disease, clinicians and pathologists have insufficient understanding of it.</p><p><strong>Case summary: </strong>The authors present a case of a 34-year-old female patient who presented with severe watery diarrhea with significant weight loss. She also experienced blurred binocular vision. The intestinal lesions were located mainly in the small intestine, which presented flat and dull intestinal villi with subepithelial collagen deposition. Masson staining was positive. Glucocorticoids were effective for this patient, but there seemed to be glucocorticoid dependence.</p><p><strong>Conclusion: </strong>Collagenous stomatitis diarrhea is a rare intestinal malabsorption disease that needs to be diagnosed in combination with special clinical manifestations and unique histological features.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"106208"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic insights into digestive-related adverse effects of immune checkpoint inhibitors: A narrative review. 内镜下观察免疫检查点抑制剂与消化相关的不良反应:一篇叙述性综述。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.107798
Grigorios Petrousis, Sylwester Szczegielniak, Haider Sabhan, Peter Elbe, Gülden Bilican, Hans Strid, Francesca Bresso, Charlotte Hedin, Stephan L Haas
{"title":"Endoscopic insights into digestive-related adverse effects of immune checkpoint inhibitors: A narrative review.","authors":"Grigorios Petrousis, Sylwester Szczegielniak, Haider Sabhan, Peter Elbe, Gülden Bilican, Hans Strid, Francesca Bresso, Charlotte Hedin, Stephan L Haas","doi":"10.4253/wjge.v17.i7.107798","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.107798","url":null,"abstract":"<p><p>Treatment with immune checkpoint inhibitors (ICIs) is an innovative therapy for managing certain types of malignancy and has the potential to improve overall patient survival significantly. The most widely used ICIs selectively target different receptors comprising programmed cell death-1 receptor, programmed cell death-ligand 1 receptor, and cytotoxic T lymphocyte antigen 4 receptor. The widespread utilization of ICIs over the past several years, however, is frequently accompanied by immune-related adverse events (irAEs) that substantially impact the patient's quality of life, particularly those affecting the digestive system, including both the upper and lower gastrointestinal tract. Based on a literature search covering databases such as PubMed, Web of Science, Embase, and the Cochrane Library, we present an insight into primary gastrointestinal irAEs, with a special focus on endoscopic manifestations. Additionally, we analyze data regarding the pathogenetic mechanisms, diagnostic approaches, histological characteristics, and proposed therapeutic interventions for managing irAEs involving the gastrointestinal tract.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"107798"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review. 内镜超声在胆道狭窄治疗中的作用:荟萃分析和系统回顾。
IF 1.4
World Journal of Gastrointestinal Endoscopy Pub Date : 2025-07-16 DOI: 10.4253/wjge.v17.i7.108541
Eyad Gadour, Bogdan Miutescu, Hussein H Okasha, Mohammed Albeshir, Turki Alamri, Elsayed Ghoneem, Călin Burciu, Alexandru Popa, Oana Koppandi, Mohammed S AlQahtani
{"title":"Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review.","authors":"Eyad Gadour, Bogdan Miutescu, Hussein H Okasha, Mohammed Albeshir, Turki Alamri, Elsayed Ghoneem, Călin Burciu, Alexandru Popa, Oana Koppandi, Mohammed S AlQahtani","doi":"10.4253/wjge.v17.i7.108541","DOIUrl":"https://doi.org/10.4253/wjge.v17.i7.108541","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic ultrasound (EUS) has evolved from a diagnostic tool to a management technique for various gastroenterological conditions, including biliary strictures.</p><p><strong>Aim: </strong>To summarize the current evidence on EUS's role in diagnosing and managing biliary strictures.</p><p><strong>Methods: </strong>Two independent reviewers searched five electronic databases (PubMed, CENTRAL, Science Direct, Google Scholar, and EMBASE) for articles published up to January 2025. Included articles met specific criteria, and statistical software was used to analyze reported outcomes.</p><p><strong>Results: </strong>Of 935 articles, 19 met the inclusion criteria. Ten articles focused on diagnostic EUS, while nine focused on EUS-guided therapeutic interventions. EUS fine-needle aspiration demonstrated superior sensitivity [0.43-1.00; 95% confidence interval (CI): 0.24-1.00] compared to conventional techniques (0.36-0.96; 95%CI: 0.19-0.99) for diagnosing malignant biliary strictures. Both EUS-fine-needle aspiration and conventional methods exhibited high specificity, with most achieving 100% specificity. EUS-guided interventions showed significantly higher clinical success rates than control interventions (odds ratio = 2.89; 95%CI: 1.22-6.84; <i>P</i> = 0.02). No significant difference was observed in technical success rates (odds ratio = 0.97; 95%CI: 0.30-3.16; <i>P</i> = 0.96).</p><p><strong>Conclusion: </strong>EUS is a promising tool for diagnosing and managing biliary strictures. Combining EUS-guided and conventional interventions improves diagnostic performance. Further research is needed to investigate the feasibility and use of EUS-guided interventions in this field.</p>","PeriodicalId":23953,"journal":{"name":"World Journal of Gastrointestinal Endoscopy","volume":"17 7","pages":"108541"},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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