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Zeitschrift fur Immunitatsforschung. Immunobiology最新文献

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Activation of lymphocyte subpopulations in patients with chronic lymphocytic leukemia. 慢性淋巴细胞白血病患者淋巴细胞亚群的激活。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-01-01
H Rühl, H Scholle, G Bochert, W Vogt
{"title":"Activation of lymphocyte subpopulations in patients with chronic lymphocytic leukemia.","authors":"H Rühl,&nbsp;H Scholle,&nbsp;G Bochert,&nbsp;W Vogt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T lymphocytes from the peripheral blood of normal donors and patients with CLL were isolated by nylon wool filtration or E-rosette separation and tested for functional activities. Unseparated CLL lymphocytes showed a poor response to phytomitogens and to allogeneic cells. Subpopulations enriched in E-RFC showed an increased PHA- and a normal MLC-reactivity; the Con A responses, however, were markedly reduced in all experiments. Subpopulations which were T cell depleted showed no reactivity to all mitogens. Purified T cells from normal donors showed a decreased reactivity to PHA, Con A and PWM. The Con A responses were completely abolished in almost all experiments. These diminished responses could be restored by unseparated cells or by small numbers of syngeneic, mitomycin-treated monocytes. The data suggest that mitogen-induced T lymphocyte stimulation in vitro in general depends on the presence of monocytes.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 1","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11364941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on lymphocytotoxicity in acute and chronic liver disease. 急慢性肝病的淋巴细胞毒性研究。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
H Warnatz, W Gutmann, W Rösch, G Hommel
{"title":"Studies on lymphocytotoxicity in acute and chronic liver disease.","authors":"H Warnatz,&nbsp;W Gutmann,&nbsp;W Rösch,&nbsp;G Hommel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cytotoxicity of lymphocytes from patients with chronic active hepatitis, chronic persistent hepatitis, acute hepatitis B and rheumatoid arthritis as well as from normal controls was studied in a microcytotoxicity assay according to COHEN et al. using 125I-iododeoxyuridine labeled embryonal liver cells and Chang cells as target cells. Unfractionated lymphocytes of the peripheral blood from patients with chronic active hepatitis and rheumatoid arthritis showed a high frequency of cytotoxic activity. The lymphocytotoxicity in chronic active hepatitis was significantly increased in comparison to normal controls at the EC/TC of 10:1 and 100:1. Specificity of the cytotoxic reaction to target cells could not be demonstrated. Addition of autologous serum to the cytotoxic assay blocked the lymphocytotoxicity in patients with chronic active hepatitis. A weak potentiating effect on lymphocytotoxicity was observed in patients with hepatitis B after addition of autologous serum. It is discussed that this reaction is due to the presence of HB-antigen in the serum since addition of HB-antigen from other sources increased also the lymphocytotoxicity in hepatitis B patients. This effect was observed neither in HB-antigen positive nor in HB-antigen negative patients with chronic active hepatitis or chronic persistent hepatisis.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"435-49"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11805020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Impairment of the cation transport on Rh-pos. human red cells after incubation with IgG-anti-D (author's transl)]. Rh-pos阳离子输运的损害。用IgG-anti-D(作者译)孵育后的人红细胞]。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
H Weicker, A Ruberg, H Huster
{"title":"[Impairment of the cation transport on Rh-pos. human red cells after incubation with IgG-anti-D (author's transl)].","authors":"H Weicker,&nbsp;A Ruberg,&nbsp;H Huster","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rh-pos. human red cells sensitized with IgG-Anti-D showed at 4 degrees C an intracellular Na+-accumulation, which was amplified by an increase in the Na+-concentration in the incubation medium. This increase of the intracellular Na+-concentration may be due to a passive Na+-influx since the Na+-K+-ATPase system does not work at this temperature. At the optimal reaction-temperature of the enzyme the Na+-K+-ATPase activity of the sensitized Rh-pos. red cells was inhibited proportionally to the anti-D concentration. Both the amplified Na+-influx and the inhibition of the active Na+-transport caused an osmotic hemolysis. The hemoglobin release was significant above the anti-D titer step of 1:512. This mechanism suggests that the intravasular part of the immunohemolysis with Rh incompatibility was generated by an impaired active and passive cation transport following the antigen-antibody reaction. This suggestion is supported by the fact that IgG-Anti-D neither stimulated the complement system nor the intravascular monocyte mediated cell lysis, since the activity of the effector cells is reduced by the surplus of sensitized red cells and the presence of other inhibiting IgG immunoglobulins. The biochemical relationship of the Rh-D-antigen and the Na+-K+ATPase both located on membrane lipoproteins, may be the reason why only the antigen-antibody reaction in the Rh-D system impaired the cation transport. The antigen-antibody reaction of IgM-Anti-A and of the cold agglutinin IgM-Anti-I reacting with glycolipid and with glycoprotein membrane antigens respectively did not impair the cation transport after complement inactivation.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"412-27"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11365062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomenclature for factors of the HLA-system 1977. hla系统因子命名法1977。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
E Albert, D B Amos, W F Bodmer, R Ceppellini, J Dausset, F Kissmeyer-Nielsen, W Mayr, R Payne, J J van Rood, P I Terasaki, Z Trnka, R I Walford
{"title":"Nomenclature for factors of the HLA-system 1977.","authors":"E Albert,&nbsp;D B Amos,&nbsp;W F Bodmer,&nbsp;R Ceppellini,&nbsp;J Dausset,&nbsp;F Kissmeyer-Nielsen,&nbsp;W Mayr,&nbsp;R Payne,&nbsp;J J van Rood,&nbsp;P I Terasaki,&nbsp;Z Trnka,&nbsp;R I Walford","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"373-9"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11294096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Secretory antibodies in saliva against group G streptococci (author's transl)]. 唾液中抗G群链球菌的分泌抗体(作者译)。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
O Prokop, W Köhler, A Rackwitz, R Paunova, E Barthold
{"title":"[Secretory antibodies in saliva against group G streptococci (author's transl)].","authors":"O Prokop,&nbsp;W Köhler,&nbsp;A Rackwitz,&nbsp;R Paunova,&nbsp;E Barthold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Saliva of 310 persons were examined for their ability to agglutinate 33 streptococcal strains of the groups A-T. It was found that the saliva of persons with blood group O agglutinated significantly more often streptococci of strain G9 than the saliva of persons with blood group A (33.3%, and 18.75% resp., p less than 0.01). A statistical significant difference between persons of blood group B and O, or A and B did not exist. The agglutination reactions were caused probably by unspecific immunoglobulins because this strain G9 binds unspecifically human IgG. It is known, that some streptococcal strains of the groups A, B, C, D, and G contain receptors for the Fc-fragment of IgG and/or IgA. The results demonstrate that persons of the blood group O secrete more often immunoglobulin than those with blood group A.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"428-34"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11805019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron microscopic detection of the cryptantigen AhumHP (Friedenreich antigen) on human erythrocytes by means of gold-labelled agglutinin from Helix pomatia. 用金标记凝集素对人红细胞隐抗原AhumHP的电镜检测。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
M Wagner, B Wagner
{"title":"Electron microscopic detection of the cryptantigen AhumHP (Friedenreich antigen) on human erythrocytes by means of gold-labelled agglutinin from Helix pomatia.","authors":"M Wagner,&nbsp;B Wagner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using the gold-labelled agglutinin anti-AHP from Helix pomatia (edible snail) the ultrastructural site and distribution of the cryptantigen (Friedenreich antigen) AhumHP was revealed on neuraminidase treated human O and B erythrocytes. On A1 and A2 cells the antigen was demonstrated simultaneously with the blood group antigen A by labelling the cells with anti-AHP-ferritin followed by removing the neuraminic acid and labelling with anti-AHP-gold. The cryptantigen is focally distributed on the cell surface.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"450-6"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11805021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Relationship between haptoglobin types and group G streptococci (author's transl)]. [触珠蛋白类型与G群链球菌的关系(作者译)]。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
O Prokop, W Köhler, G Geserick
{"title":"[Relationship between haptoglobin types and group G streptococci (author's transl)].","authors":"O Prokop,&nbsp;W Köhler,&nbsp;G Geserick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A relationship was found between the haptoglobin types of human sera and the agglutinability of some strains of group G streptococci. Sera with the haptoglobin types Hp 2-2 and Hp 2-1 agglutinate these streptococci to high titers, from 1:200 up to more than 1:6400. On the other hand, the sera with haptoglobin type Hp 1-1 agglutinate not more than up to titers of 1:16 (mostly lower). Out of 102 strains of group G streptococci only 3 showed this characteristic phenomenon. This study was undertaken in order to elucidate whether the Hp 2-2 and Hp 2-1 proteins have antibody activity. Incubation of Hp 2-2 or Hp 2-1 sera with antihaptoglobin antisera or with anti-Hp 2-antiserum did not change the agglutinating activity but the haptoglobin was eliminated from the sera. Absorption of Hp 2-2 and Hp 2-1 sera with these group G streptococci lowered the titers significantly but the haptoglobins are detectable as in the non-absorbed sera. Sera with haptoglobin 1-1 contain an inhibitor. Mixing of Hp 2-2 and Hp 2-1 sera with high agglutinating titers with Hp 1-1 sera (low titers) was followed by a significant decrease of the titer.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"457-65"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11804855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiation between various effects of cytotoxic fractions of lymphocyte culture medium. 淋巴细胞培养基中细胞毒组分的不同作用差异。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
B Wenzel, R Averdunk
{"title":"Differentiation between various effects of cytotoxic fractions of lymphocyte culture medium.","authors":"B Wenzel,&nbsp;R Averdunk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the partial characterization of supernatants derived from mitogen stimulated lymphocytes by ammonium sulfate precipitation, ultrafiltration on Hollow-Fiber beakers and gelchromatography. Fractions from these purification procedures were tested on FL-target cells and the following target cell alterations were measured: RNA- and protein synthesis, 3H-TdR incorporation, cell number and lysis of target cells. Target cell alterations of control fractions from supernatants of non-stimulated lymphocytes, from culture medium and from FCS were compared to the effects of fractions from activated lymphocytes. 3H-TdR incorporation was not only inhibited by the fractions of activated lymphocyte cultures but also by fractions of various controls. Inhibition of 3H-TdR incorporation disappeared when control fractions were serially diluted. Only fractions of supernatant from activated lymphocytes could lyse target cells. It were the same fractions which still inhibited 3H-TdR incorporation of target cells after serial dilution and which showed stimulating effects on RNA synthesis. MW of fractions which were differentiated from control fractions with respect to target cell lysis were: 90,000, 45,000 and lower than 20,000 d.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"380-94"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11805017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the chemical composition and biological properties of transfer factor. 传递因子的化学组成及生物学特性研究。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
K Krohn, A Uotila, J Väisänen, P Gröhn
{"title":"Studies on the chemical composition and biological properties of transfer factor.","authors":"K Krohn,&nbsp;A Uotila,&nbsp;J Väisänen,&nbsp;P Gröhn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dialyzable transfer factor (dTF) was fractionated on Sephadex G-10 and G-25 fine columns, and biological activity was found in 3 fractions. One of these, designated VIa, and having a tendency to adsorb to the Sephadex G-10 gel, was shown to have a therapeutic effect on certain immunological diseases. Analysis of this fraction on thin-layer and gas chromatography and with infrared and mass spectroscopy indicated that about half of this fraction was composed of uracil; additional unidentified heterocyclic and aromatic substances were present in this fraction. Adjacent fraction V contained tyrosine and a small polyribonucleotide, and fraction VII hypoxanthine and additional unidentified components. Our results suggest that the therapeutic activity of dTF is not mediated through an immunologically specific informational molecule, but is rather based on non-specific stimulation of the expression of the immune response.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"395-411"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11805018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential binding of IgA proteins of different subclasses and allotypes to Staphylococcal protein A. 不同亚类和同种异体的IgA蛋白与葡萄球菌蛋白A的差异结合。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1977-12-01
C C Patrick, G Virella, J Koistinen, H H Fudenberg
{"title":"Differential binding of IgA proteins of different subclasses and allotypes to Staphylococcal protein A.","authors":"C C Patrick,&nbsp;G Virella,&nbsp;J Koistinen,&nbsp;H H Fudenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The binding of myeloma proteins of known subclass and allotype to staphylococcal protein A has been studied using affinity chromatography with Protein A-Sepharose CL-4B. Three IgA1 proteins did not show any binding, whereas two IgA2 A2m(1) and one IgA2 A2m(2) proteins were found to bind to the column.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"153 5","pages":"466-9"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11620282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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