World Journal of Pediatrics最新文献

{"title":"Food allergy: emerging therapies in the twenty-first century.","authors":"Agnes Sze-Yin Leung, Yu-Han Xing, Gary Wing-Kin Wong","doi":"10.1007/s12519-025-00928-0","DOIUrl":"10.1007/s12519-025-00928-0","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"634-643"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines for acute infectious diarrhea in children in China (2024).","authors":"You-Hong Fang, Chao-Min Wan, Si-Tang Gong, Feng Fang, Mei Sun, Yuan Qian, Ying Huang, Bao-Xi Wang, Chun-Di Xu, Yu Jin, Li-Yan Ye, Sai-Nan Shu, Qing-Bin Wu, Jie Wu, Xiao-Qin Li, Jing-Fang Chen, Hong-Mei Xu, Zheng-Hong Li, Hui Yu, Ji-Kui Deng, Jie Chen","doi":"10.1007/s12519-025-00894-7","DOIUrl":"10.1007/s12519-025-00894-7","url":null,"abstract":"<p><strong>Background: </strong>Some new progress and evidence have been made in the diagnosis and treatment of pediatric acute infectious diarrhea since the publication of the \"Chinese clinical practice guidelines for acute infectious diarrhea in children\" (2018 edition guidelines). The updated \"Chinese clinical practice guidelines for acute infectious diarrhea in children\" incorporates new evidence-based recommendations for managing acute infectious diarrhea in the Chinese pediatric population.</p><p><strong>Data sources: </strong>Building on the 2018 edition guidelines, expert panels reviewed clinical evidence, assessed preliminary recommendations, and conducted open-ended discussions to finalize the updated guidelines. These guidelines are founded on the latest literature and evidence-based practices. A literature review was performed in databases such as PubMed, Cochrane, EMBASE, China Biomedical Database, and the Chinese Journal Full-text Database up to June 2024. The search focused on the terms \"acute diarrhea\" or \"enteritis\", along with \"adolescent\", \"child\", \"pediatric patient\", \"baby\", or \"infant\".</p><p><strong>Results: </strong>The updated guidelines address various aspects of acute infectious diarrhea, including diagnosis, etiological evaluation, dehydration assessment, fluid therapy, diet therapy, medical therapy, and prevention strategies. The main updates focused on etiological diagnosis and the use of probiotics, racecadotril, zinc, and antibiotics in treating acute infectious diarrhea.</p><p><strong>Conclusions: </strong>The updated guidelines address disputed treatments for acute infectious diarrhea through evidence-based revisions. Standardized etiological evaluations guide management. Probiotics are moderately advised for viral watery diarrhea; racecadotril remains unsupported. Zinc supplementation is recommended for children >6 months in deficient regions. Antibiotics are restricted to cases with dysenteric-like symptoms, suspected cholera with severe dehydration, or comorbidities.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"708-719"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of efficacy, safety and tolerability of perampanel monotherapy in children with newly-diagnosed epilepsy in routine clinical practice in China: a multicenter prospective observational study.","authors":"Tao-Yun Ji, Yi-Feng Ding, Yu-Qin Zhang, Li Jiang, Guo Zheng, Rong Luo, Dan Sun, Feng Gao, Yu-Wu Jiang, Yi Wang","doi":"10.1007/s12519-025-00914-6","DOIUrl":"10.1007/s12519-025-00914-6","url":null,"abstract":"<p><strong>Background: </strong>Perampanel (PER) has gained interest as initial monotherapy for pediatric patients. Currently, there are limited studies on the PER monotherapy in treating pediatric patients with focal-onset seizures (FOS). This study aims to investigate efficacy and safety/tolerability of PER as initial monotherapy in treating pediatric patients with newly-diagnosed FOS in routine clinical practice in China.</p><p><strong>Methods: </strong>This multicenter, prospective, real-world observational study enrolled 210 antiseizure medication-naïve patients aged 4-12 years with newly-diagnosed FOS who visited one of the eight tertiary hospitals in China during March-December 2023. All patients were treated with PER monotherapy. The primary endpoint was seizure-freedom rate (SFR) during weeks 13-26 of PER monotherapy. Furthermore, 50%, 75% responder rates and retention rate were assessed. An electronic seizure diary was used. Treatment-emergent adverse events (TEAEs) were recorded.</p><p><strong>Results: </strong>The full analysis set included 203 patients. The SFR was 158/203, namely, 77.8% (95% confidence interval: 71.6%-83.0%) during weeks 13-26. The 50% and 75% responder rates were 88.2% and 85.2%, respectively, and the 26-week retention rate was 91.1%. Most patients received 2-6 mg/day maintenance PER and the 107 patients receiving 4 mg/day PER had the highest SFR (89.7%). Patients who had > 2 seizures during the three months before their enrollment were significantly less likely to be seizure free during weeks 13-26 than those who had ≤ 2 seizures. Seventy-nine (38.9%) patients had treatment-related TEAEs and most of them were mild and tolerable. Two (1.0%) patients withdrew from the study due to TEAEs. The most common TEAEs were dizziness, irritability, somnolence and fatigue.</p><p><strong>Conclusions: </strong>PER as initial monotherapy was effective and tolerable in Chinese patients aged 4-12 years with newly-diagnosed FOS. No safety issues arose in our study.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"731-743"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics.","authors":"Rui-Ke Chen, Ming-Yang Li, Zhi-Yong Zhao, Hao-An Xu, Cheng-Lin Ning, Jie Lu, Qin-Feng Zhu, Yong-Quan Huang, Ruo-Ke Zhao, Ling-Xuan Zhang, Tian-Li Tao, Kai-Bo Tang, Jia-Le Cheng, Can Lai, Hong-Xi Zhang, Xiao-Hui Ma, Hosung Kim, Zhi-Hua Ren, Chun-Feng Lian, Fan Wang, Geng Chen, Min-Hui Ouyang, An-Qi Qiu, Han Zhang, Xiao-Qi Huang, Xu-Jun Duan, Gang Li, Jian Yang, Hao Huang, Kenichi Oishi, Ellen Grant, Wei-Li Lin, Duan Xu, Dan Wu","doi":"10.1007/s12519-025-00905-7","DOIUrl":"10.1007/s12519-025-00905-7","url":null,"abstract":"<p><p>The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"652-707"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain injury and neurodevelopmental trajectory in neonates with complex congenital heart disease: current status and challenges.","authors":"Shan-Shan Shi, Qian-Nan Zhang, Qiang Shu","doi":"10.1007/s12519-025-00948-w","DOIUrl":"10.1007/s12519-025-00948-w","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"627-631"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty years' development and application of flow cytometry.","authors":"Hong-Qiang Shen","doi":"10.1007/s12519-025-00949-9","DOIUrl":"10.1007/s12519-025-00949-9","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"622-626"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal care in the twenty-first century: innovations and challenges.","authors":"Ayhan Çeri, Nazlı Dilay Gültekin, Doğukan Mustafa Keskin","doi":"10.1007/s12519-025-00927-1","DOIUrl":"10.1007/s12519-025-00927-1","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"644-651"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenital heart disease: successes and challenges over the last 20 years.","authors":"Wei-Ze Xu, Qiang Shu","doi":"10.1007/s12519-025-00934-2","DOIUrl":"10.1007/s12519-025-00934-2","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"619-621"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we sedate very young patients in the lateral position?","authors":"Chen K Pac-Soo, Daqing Ma","doi":"10.1007/s12519-025-00930-6","DOIUrl":"10.1007/s12519-025-00930-6","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"550-551"},"PeriodicalIF":6.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric lung transplantation in China, 2019-2023.","authors":"Xiao-Shan Li, Zi-Tao Wang, Bo Wu, Shu-Gao Ye, Feng Liu, Chun-Xiao Hu, Yi Lu, Wen-Jie Hua, Wei-Wei Xu, Man Huang, Jing-Yu Chen","doi":"10.1007/s12519-025-00916-4","DOIUrl":"10.1007/s12519-025-00916-4","url":null,"abstract":"<p><strong>Background: </strong>Pediatric lung transplant (pLTX) is a rare procedure globally; its characteristics and survival outcomes in China remain unknown.</p><p><strong>Methods: </strong>This retrospective study analyzed data from pLTX recipients aged ≤ 17 years between January 2019 and December 2023 from the China Lung Transplantation Registry. Pre-, intra-, and post-operative characteristics were described and compared between children aged 2-11 years and 12-17 years and between pLTX conducted in centers with high and low transplant volumes. The Kaplan‒Meier method was used to estimate the postoperative survival rates and 95% confidence intervals (CIs). One-year postoperative survival rates were compared between pediatric and adult lung transplant (LTX) patients via log-rank tests.</p><p><strong>Results: </strong>Between 2019 and 2023, 63 transplants were performed in 62 pediatric patients, accounting for 1.8% of the total LTX in China. The primary indication for pLTX was bronchiolitis obliterans syndrome (46.0%), followed by cystic fibrosis (12.7%) and idiopathic pulmonary arterial hypertension (11.1%). Infection was the most common complication after pLTX (63.9%), and the incidence of bronchial anastomotic stenosis was slightly higher among recipients aged 2-11 years than among those aged 12-17 years (14.3% vs. 2.9%, P = 0.244). High-volume hospitals had a higher incidence of infections (72.7% vs. 41.2%, P = 0.021) and primary graft failure (20.0% vs. 5.9%, P = 0.260) among pediatric recipients. However, acute rejection was exclusively observed in low-volume hospitals (0.0% vs. 17.6%, P = 0.018). The in-hospital mortality rate was 16.1% (95% CI = 6.7-25.5). The 30-day and one-year survival rates after pLTX were 93.5% (95% CI = 87.6-99.9) and 80.6% (95% CI = 71.4-91.1), respectively, and were significantly higher than those of adult recipients (82.0% and 58.7%, all P < 0.05).</p><p><strong>Conclusions: </strong>This research identified the trends, indications, donor and recipient characteristics, and complications of pLTX in China. Despite its small size, pLTX is growing gradually and has favorable outcomes. Future research on the long-term follow-up of pLTX recipients is needed to identify factors associated with the prognosis of pLTX patients.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"597-612"},"PeriodicalIF":4.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}