World Journal of Pediatrics最新文献

{"title":"Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics.","authors":"Rui-Ke Chen, Ming-Yang Li, Zhi-Yong Zhao, Hao-An Xu, Cheng-Lin Ning, Jie Lu, Qin-Feng Zhu, Yong-Quan Huang, Ruo-Ke Zhao, Ling-Xuan Zhang, Tian-Li Tao, Kai-Bo Tang, Jia-Le Cheng, Can Lai, Hong-Xi Zhang, Xiao-Hui Ma, Hosung Kim, Zhi-Hua Ren, Chun-Feng Lian, Fan Wang, Geng Chen, Min-Hui Ouyang, An-Qi Qiu, Han Zhang, Xiao-Qi Huang, Xu-Jun Duan, Gang Li, Jian Yang, Hao Huang, Kenichi Oishi, Ellen Grant, Wei-Li Lin, Duan Xu, Dan Wu","doi":"10.1007/s12519-025-00905-7","DOIUrl":"https://doi.org/10.1007/s12519-025-00905-7","url":null,"abstract":"<p><p>The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional relationship between child happiness and sleep quality and the predictive role of prenatal psychosocial support: results from U.S. and China cohort studies.","authors":"Ying Dai, Naixue Cui, Xiaopeng Ji, Adrian Raine, Therese S Richmond, Jianghong Liu","doi":"10.1007/s12519-025-00903-9","DOIUrl":"https://doi.org/10.1007/s12519-025-00903-9","url":null,"abstract":"<p><strong>Background: </strong>The relationship between daily affective states and subjective sleep measures is known to be reciprocal in both adults and children. However, its consistency across infancy to early adolescence and varying sociocultural contexts remain unclear. We investigated the bidirectional relationship between happiness and sleep quality in children from the U.S. and China and examined the predictive role of maternal prenatal psychosocial support.</p><p><strong>Methods: </strong>A total of 1300 children aged 11-12 years in the U.S. Healthy Brain and Behavior Study (HBBS) and China Jintan Child Cohort (CJCC) studies were included in the analyses. Happiness and sleep quality from infancy to early adolescence were retrospectively reported by mothers. Prenatal psychosocial factors were recalled by mothers through a structured interview. Random-intercept cross-lagged panel modeling was conducted to analyze the data.</p><p><strong>Results: </strong>Happiness and sleep quality trajectories differed significantly between U.S. adolescents in the HBBS and Chinese adolescents in the CJCC (P < 0.001). In both cohorts, cross-lagged effects showed consistent associations between happiness and subsequent sleep quality across the five time points (coefficients: 0.086-0.154, P < 0.01). The relationship between sleep quality and subsequent happiness was significant from 1-3 to 11 years. The bidirectional relationship was stronger in the Chinese cohort. Maternal prenatal psychosocial support positively predicted children's happiness (β = 0.072, P < 0.001) and sleep quality (β = 0.056, P < 0.001) trajectories.</p><p><strong>Conclusions: </strong>A bidirectional relationship exists between children's happiness and sleep quality, with potential cultural variations. Maternal prenatal psychosocial support plays a key role in fostering children's long-term emotional well-being and sleep quality.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines for acute infectious diarrhea in children in China (2024).","authors":"You-Hong Fang, Chao-Min Wan, Si-Tang Gong, Feng Fang, Mei Sun, Yuan Qian, Ying Huang, Bao-Xi Wang, Chun-Di Xu, Yu Jin, Li-Yan Ye, Sai-Nan Shu, Qing-Bin Wu, Jie Wu, Xiao-Qin Li, Jing-Fang Chen, Hong-Mei Xu, Zheng-Hong Li, Hui Yu, Ji-Kui Deng, Jie Chen","doi":"10.1007/s12519-025-00894-7","DOIUrl":"https://doi.org/10.1007/s12519-025-00894-7","url":null,"abstract":"<p><strong>Background: </strong>Some new progress and evidence have been made in the diagnosis and treatment of pediatric acute infectious diarrhea since the publication of the \"Chinese clinical practice guidelines for acute infectious diarrhea in children\" (2018 edition guidelines). The updated \"Chinese clinical practice guidelines for acute infectious diarrhea in children\" incorporates new evidence-based recommendations for managing acute infectious diarrhea in the Chinese pediatric population.</p><p><strong>Data sources: </strong>Building on the 2018 edition guidelines, expert panels reviewed clinical evidence, assessed preliminary recommendations, and conducted open-ended discussions to finalize the updated guidelines. These guidelines are founded on the latest literature and evidence-based practices. A literature review was performed in databases such as PubMed, Cochrane, EMBASE, China Biomedical Database, and the Chinese Journal Full-text Database up to June 2024. The search focused on the terms \"acute diarrhea\" or \"enteritis\", along with \"adolescent\", \"child\", \"pediatric patient\", \"baby\", or \"infant\".</p><p><strong>Results: </strong>The updated guidelines address various aspects of acute infectious diarrhea, including diagnosis, etiological evaluation, dehydration assessment, fluid therapy, diet therapy, medical therapy, and prevention strategies. The main updates focused on etiological diagnosis and the use of probiotics, racecadotril, zinc, and antibiotics in treating acute infectious diarrhea.</p><p><strong>Conclusions: </strong>The updated guidelines address disputed treatments for acute infectious diarrhea through evidence-based revisions. Standardized etiological evaluations guide management. Probiotics are moderately advised for viral watery diarrhea; racecadotril remains unsupported. Zinc supplementation is recommended for children >6 months in deficient regions. Antibiotics are restricted to cases with dysenteric-like symptoms, suspected cholera with severe dehydration, or comorbidities.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of efficacy, safety and tolerability of perampanel monotherapy in children with newly-diagnosed epilepsy in routine clinical practice in China: a multicenter prospective observational study.","authors":"Tao-Yun Ji, Yi-Feng Ding, Yu-Qin Zhang, Li Jiang, Guo Zheng, Rong Luo, Dan Sun, Feng Gao, Yu-Wu Jiang, Yi Wang","doi":"10.1007/s12519-025-00914-6","DOIUrl":"https://doi.org/10.1007/s12519-025-00914-6","url":null,"abstract":"<p><strong>Background: </strong>Perampanel (PER) has gained interest as initial monotherapy for pediatric patients. Currently, there are limited studies on the PER monotherapy in treating pediatric patients with focal-onset seizures (FOS). This study aims to investigate efficacy and safety/tolerability of PER as initial monotherapy in treating pediatric patients with newly-diagnosed FOS in routine clinical practice in China.</p><p><strong>Methods: </strong>This multicenter, prospective, real-world observational study enrolled 210 antiseizure medication-naïve patients aged 4-12 years with newly-diagnosed FOS who visited one of the eight tertiary hospitals in China during March-December 2023. All patients were treated with PER monotherapy. The primary endpoint was seizure-freedom rate (SFR) during weeks 13-26 of PER monotherapy. Furthermore, 50%, 75% responder rates and retention rate were assessed. An electronic seizure diary was used. Treatment-emergent adverse events (TEAEs) were recorded.</p><p><strong>Results: </strong>The full analysis set included 203 patients. The SFR was 158/203, namely, 77.8% (95% confidence interval: 71.6%-83.0%) during weeks 13-26. The 50% and 75% responder rates were 88.2% and 85.2%, respectively, and the 26-week retention rate was 91.1%. Most patients received 2-6 mg/day maintenance PER and the 107 patients receiving 4 mg/day PER had the highest SFR (89.7%). Patients who had > 2 seizures during the three months before their enrollment were significantly less likely to be seizure free during weeks 13-26 than those who had ≤ 2 seizures. Seventy-nine (38.9%) patients had treatment-related TEAEs and most of them were mild and tolerable. Two (1.0%) patients withdrew from the study due to TEAEs. The most common TEAEs were dizziness, irritability, somnolence and fatigue.</p><p><strong>Conclusions: </strong>PER as initial monotherapy was effective and tolerable in Chinese patients aged 4-12 years with newly-diagnosed FOS. No safety issues arose in our study.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe transition of medical care: from the in utero fetus to adulthood.","authors":"Vicki L Mahan","doi":"10.1007/s12519-025-00923-5","DOIUrl":"https://doi.org/10.1007/s12519-025-00923-5","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the revised Chinese version of the Children's Sleep Habits Questionnaire (CSHQ-CH-R).","authors":"Yu-Jiao Deng, Tong Lin, Wen Li, Yan-Rui Jiang, Jing Zhang, Hui-Shan Wang, Hong Wang, Judith Owens, Guang-Hai Wang, Fan Jiang","doi":"10.1007/s12519-025-00915-5","DOIUrl":"https://doi.org/10.1007/s12519-025-00915-5","url":null,"abstract":"<p><strong>Background: </strong>The Chinese version of the Children's Sleep Habits Questionnaire (CSHQ-CH) has been widely used in clinical practice and research since it was developed in 2007. This study aimed to examine the psychometric properties of the revised version (CSHQ-CH-R) and establish cut-off values for screening for sleep disturbances in Chinese preschool-aged and school-aged children.</p><p><strong>Methods: </strong>A community sample of 3850 preschool and school-aged children aged 3-12 years were obtained from 6 kindergartens and 2 primary schools in Shanghai, Beijing and Chengdu, China, from December 2019 to February 2020. A clinical sample of 119 children aged 3-12 years who were diagnosed with sleep disorders were recruited from a tertiary pediatric hospital in Shanghai from September 2019 to November 2021. Caregivers completed the original 33 items of the CSHQ-CH plus an additional 15 items through an online platform. Item analysis was conducted to develop the CSHQ-CH-R, which included discriminative validity, redundancy and ambiguity. Internal consistency, interobserver reliability, test-retest reliability, concurrent validity (correlations with actigraphy) and discriminative validity were then analyzed. The cut-off values for both the full scale and subscale scores were generated by receiver operating characteristics.</p><p><strong>Results: </strong>The final version of the CSHQ-CH-R included 30 items and 8 subscales. Three subscales (bedtime resistance, sleep duration and daytime sleepiness) were revised, and the other five subscales were unchanged from those of the CSHQ-CH. The internal consistency for the full scale was 0.83 for the community sample, and 0.73 for the clinical sample. The internal consistency ranged from 0.47 (sleep duration) to 0.72 (bedtime resistance) for the community sample, and 0.38 (sleep duration) to 0.83 (sleep-disordered breathing) for the clinical sample. The interobserver reliability for the full scale was 0.55, and ranged from 0.38 (parasomnias) to 0.74 (bedtime resistance) for the subscales. The test-retest reliability was 0.70 for the full scale, and ranged from 0.54 (sleep duration) to 0.78 (bedtime resistance) for the subscales. Concurrent validities against actigraphy were 0.62 and 0.33 for \"time in bed\" and \"night sleep duration\", respectively. The clinical sample scored higher than the community sample did for the full scale and subscales (P < 0.01). A cut-off total score of 44 was determined, with an area under the curve of 0.76, a sensitivity of 0.64, and a specificity of 0.76. To facilitate cross-cultural comparisons, psychometric properties and cut-off values for the CSHQ-CH with the original 33 items were also provided.</p><p><strong>Conclusion: </strong>The CSHQ-CH-R exhibits satisfactory to good psychometric properties, indicating its suitability for identifying sleep problems among Chinese preschool- and school-aged children.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinopathy of prematurity in the era of precision neonatology: from risk stratification to targeted therapies.","authors":"Luca Filippi, Silvia Gulden, Maurizio Cammalleri, Gabriella Araimo, Giacomo Cavallaro, Eduardo Villamor","doi":"10.1007/s12519-025-00919-1","DOIUrl":"10.1007/s12519-025-00919-1","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"430-435"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac magnetic resonance and genetics in pediatric heart failure patients with nonischemia: prognostic implications.","authors":"Xue-Lian Gao, Yan Chen, Kai-Rui Bo, Wen-Hong Ding, Chen-Cheng Dai, Yan-Yan Xiao, Lei Xu, Jian-Xiu Lian, Ling Han, Hui Wang","doi":"10.1007/s12519-025-00920-8","DOIUrl":"10.1007/s12519-025-00920-8","url":null,"abstract":"<p><strong>Background: </strong>The associations among genetic variants, cardiac magnetic resonance (CMR) features, and prognostic factors of pediatric heart failure (HF) remain unknown. This study aimed to explore the relationship between genetic differences in pediatric HF and CMR findings and their impact on prognosis of HF in children.</p><p><strong>Methods: </strong>This retrospective study included children with a first-time diagnosis of HF. All patients underwent echocardiogram, CMR and genetic testing. The cohort was divided into three subgroups according to late gadolinium enhancement (LGE) on CMR: the no LGE subgroup, the subendocardial LGE subgroup, and the nonsubendocardial subgroup. The endpoint was defined as a lack of improvement in HF on echocardiography after more than six months of follow-up.</p><p><strong>Results: </strong>Ninety-five children with HF were included, of whom 64 underwent genetic testing and 89 had echocardiograms at follow-up. There were 20 patients in the no LGE group, 31 in the subendocardial group, and 44 in the nonsubendocardial group. The most common genotype was MYH7 (27.0%). RBM20 and LMNA both presented a dilated phenotype, whereas GTPBP3 uniformly presented a hypertrophic phenotype. TNNI3 showed no LGE on CMR (P = 0.003) and maintained a restrictive phenotype. The subendocardial group was more likely to have septal LGE (93.5%, P < 0.001). Multivariable regression analysis indicated that a family history of cardiomyopathy, hydropericardium, and right ventricular ejection fraction (RVEF) were independent predictors of the endpoint event (P = 0.035, P = 0.005 and P = 0.032, respectively). Notably, nonsubendocardial LGE was associated with a worse prognosis than no LGE was (P = 0.030).</p><p><strong>Conclusions: </strong>In pediatric non-ischemic HF patients, subendocardial LGE can be observed. A family history of cardiomyopathy, hydropericardium, and RVEF were predictors of HF with no improvement. The prognosis of HF is associated with the presence of LGE, particularly nonsubendocardial LGE, and less so with the genetic phenotype.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"489-501"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal depressive and anxiety symptoms in early pregnancy and offspring allergic diseases during toddlerhood.","authors":"Jia-Ying Wu, Yi-Shu Wang, Yan-Hui Hao, Chen-Chi Duan, Yan Xu, Fang-Yue Zhou, Wen Yu, Li Xia, Ting Wu, Xuan-Ping Wang, Si-Wei Zhang, Si-Yue Chen, Xian Xia, Yan-Ting Wu, He-Feng Huang","doi":"10.1007/s12519-025-00911-9","DOIUrl":"10.1007/s12519-025-00911-9","url":null,"abstract":"<p><strong>Background: </strong>While maternal psychological stress during mid-to-late pregnancy has been linked to offspring allergies, the impact of early pregnancy distress remains unclear. This study investigates the association between maternal depressive and anxiety symptoms in early pregnancy and allergic diseases in offspring.</p><p><strong>Methods: </strong>Based on a birth cohort of 5263 children, antenatal depressive and anxiety symptoms in early pregnancy were assessed via the Patient Health Questionnaire and Generalized Anxiety Disorder Questionnaire, respectively. Allergic outcomes, including asthma, atopic dermatitis (AD), and allergic rhinitis (AR), were evaluated via structured questionnaires. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated via generalized linear models, whereas restricted cubic splines were used to explore linear and non-linear associations between maternal distress and allergic outcomes.</p><p><strong>Results: </strong>Maternal depressive symptoms in early pregnancy were associated with an increased risk of AD [adjusted RR (95% CI) = 1.15 (1.03-1.29)] and AR [1.52 (1.29-1.79)]. Maternal anxiety symptoms in early pregnancy were associated with increased risks of AD [1.11 (1.02-1.21), mild anxiety] and AR [1.33 (1.04-1.68), moderate to severe anxiety]. Dose‒response analyses revealed graded relationships between distress severity and allergic outcomes. In the joint analysis, comorbid depression and anxiety in early pregnancy were associated with an increased risk of AD [1.15 (1.05-1.26)] and AR [1.42 (1.23-1.63)]. Subgroup analysis revealed a greater risk of asthma for boys born to mothers with mild anxiety [1.95 (1.20-3.15)] but not for girls.</p><p><strong>Conclusion: </strong>Maternal distress in early pregnancy is associated with an increased risk of allergic diseases in offspring during toddlerhood.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"478-488"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative therapies for childhood-onset systemic lupus erythematosus.","authors":"Dimitri Poddighe, Anh Thi Van Nguyen, Lan Tuyet Phung, Chi Quynh Le, Michelle Lynn Hermiston","doi":"10.1007/s12519-025-00913-7","DOIUrl":"10.1007/s12519-025-00913-7","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"423-429"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}