World Journal of Pediatrics最新文献

{"title":"Navigating the 2024 AHA guidelines for Kawasaki disease: practical insights for clinicians.","authors":"Tong Tong, Fang-Qi Gong","doi":"10.1007/s12519-025-00892-9","DOIUrl":"10.1007/s12519-025-00892-9","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"323-327"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant body composition in a randomised trial of a maternal nutritional supplement during preconception and pregnancy.","authors":"Jaz Lyons-Reid, José G B Derraik, Leigh C Ward, Timothy Kenealy, Benjamin B Albert, Jose M Ramos Nieves, Cathriona R Monnard, Mya Thway-Tint, Heidi Nield, Sheila J Barton, Sarah El-Heis, Elizabeth H Tham, Keith M Godfrey, Shiao-Yng Chan, Wayne S Cutfield","doi":"10.1007/s12519-025-00900-y","DOIUrl":"10.1007/s12519-025-00900-y","url":null,"abstract":"<p><strong>Background: </strong>In a multinational randomized controlled trial, we previously showed that maternal supplementation with myo-inositol, probiotics, and micronutrients was associated with reduced incidence of rapid infant weight gain and high body mass index (BMI) at two years among offspring. It was unclear whether these differences in weight gain and body mass were due to reduced adiposity. Therefore, we aimed to determine whether there were any differences in body composition.</p><p><strong>Methods: </strong>Body composition was measured using bioelectrical impedance spectroscopy at six weeks, six months, one year, and two years among offspring born to mothers who received a nutritional intervention (n = 268) or control (n = 264) supplement preconception and during pregnancy.</p><p><strong>Results: </strong>There were no group-level differences in body composition, except at two years, when fat-free mass was greater among control offspring [adjusted mean difference (aMD) 0.14 kg, 95% confidence interval (CI) 0.03, 0.25, P = 0.012]. However, there were no differences in mean percentage fat mass (%FM) at any time. In both groups, rapid weight gain [Δ weight > 0.67 standard deviation (SD) from birth to one year] was associated with greater %FM (aMD 2.0% at six months, 2.0% at one year, 1.4% at two years) compared with those who did not have rapid weight gain. Likewise, high BMI (≥ 95 percentile) at two years was associated with greater %FM (aMD 2.5%).</p><p><strong>Conclusions: </strong>A maternal nutritional intervention did not lead to differences in average offspring body composition in the first two years of life. However, fewer offspring from the supplemented group experienced rapid weight gain and high BMI, characterized by greater %FM.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"361-371"},"PeriodicalIF":6.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Qigong vs. routine physical exercise in school-aged children with attention-deficit hyperactivity disorder: a randomized controlled trial.","authors":"Yu Li, Yuan-Chen He, Yin Wang, Jing-Wei He, Meng-Yao Li, Wen-Qin Wang, Zhi-Heng Wu, Yun-Jia Xu, Wen-Nan He, Ya-Lan Dou, Duo-Lao Wang, Wei-Li Yan, Da-Qian Zhu","doi":"10.1007/s12519-025-00890-x","DOIUrl":"https://doi.org/10.1007/s12519-025-00890-x","url":null,"abstract":"<p><strong>Background: </strong>Increased understanding of the etiology of attention-deficit hyperactivity disorder (ADHD) emphasizes the importance of non-pharmaceutical treatments. This study compares the effects of Baduanjin exercise, a Qigong-based body therapy from traditional Chinese medicine (TCM), with routine physical exercise on school-aged children diagnosed with ADHD.</p><p><strong>Methods: </strong>In this two-arm, single-blind, randomized controlled trial, eligible school-aged children with ADHD were randomly assigned (1:1) to Baduanjin exercise or regular physical exercise using a permuted block randomization procedure. Both groups performed the designated exercise for at least 30 minutes a day and were monitored for exercise quality at least 5 days a week for 3 months. The primary outcome was a doctor-assessed hyperactivity/impulsivity score change, using the Swanson, Nolan, and Pelham rating scale (DSNAP_HYP) at the end of the third month since intervention initiation.</p><p><strong>Results: </strong>Between October 2020 and January 2023, 120 eligible children were randomly allocated to two exercise interventions. After 3 months, the DSNAP_HYP decreased by 3.67 ± 4.81 and 4.68 ± 4.44 of Baduanjin exercise and regular physical exercise, respectively, with no significant between-group difference [mean difference = 1.52; 95% confidence interval (CI) = - 0.08 to 3.13; P = 0.06]. No adverse events were reported during the whole study period.</p><p><strong>Conclusions: </strong>This study did not demonstrate the expected superiority of 3-month Baduanjin exercise in improving ADHD symptoms compared with routine physical exercise. However, the results suggest that both types of exercise may improve core symptom scores, providing preliminary evidence for Baduanjin as a potential supplementary intervention for children with ADHD.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining safety standards for animal-assisted therapy in pediatric oncology: a focus on neutropenic patients.","authors":"Gabrielle Grob, Maggie Rogers","doi":"10.1007/s12519-025-00887-6","DOIUrl":"10.1007/s12519-025-00887-6","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"213-215"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and disease burden of pediatric congenital anomalies of the kidney and urinary tract: a national cross-sectional study of hospitalized children in China.","authors":"Zhi-Han Hao, Ye-Ping Jiang, Hui Xu, Guo-Shuang Feng, Hui Wang, Xin Ni","doi":"10.1007/s12519-025-00891-w","DOIUrl":"10.1007/s12519-025-00891-w","url":null,"abstract":"<p><strong>Background: </strong>Congenital anomalies of the kidney and urinary tract (CAKUT) are among the most prevalent congenital malformations in children and a common cause of chronic kidney disease. There is currently limited documentation of the clinical epidemiology and disease burden of hospitalized CAKUT patients globally. This study reports the clinic-epidemiological characteristics and disease burden of hospitalized CAKUT children in China, and offers critical data to inform the diagnosis, treatment, and prevention of CAKUT.</p><p><strong>Methods: </strong>From January 2016 to December 2022, hospitalized patients diagnosed with CAKUT were discharged from 33 provincial and municipal hospitals across China. Demographic and clinical data were collected for statistical analysis.</p><p><strong>Results: </strong>A total of 33,621 children aged 0-18 years were hospitalized with a CAKUT diagnosis, accounting for 0.46% of the total pediatric hospitalizations during the study period. There was a male-to-female ratio of 1.88:1. The CAKUT hospitalization rate demonstrated an increasing trend from 2016 to 2022 (P < 0.001). Regional hospitalization rates were significantly higher in Eastern and Central China compared to Western and Northeastern China (P < 0.001). Most patients were diagnosed with hydronephrosis, with a hospitalization ratio of 1.28% (n = 9359). 18.00% of patients were diagnosed with multiple CAKUT. The incidence of urinary tract infections (UTIs) increased as the number of combined CAKUT conditions rose.</p><p><strong>Conclusions: </strong>The most common CAKUT subtype is hydronephrosis. The disease spectrum of CAKUT was different in different age groups, which gradually evolved from hydronephrosis to duplex collection system and renal cystic disease. UTI, associated nonurinary congenital anomalies and low birth weight are the warning factors for CAKUT. The cost burden and fatality rate of CAKUT is low. Strengthening the management of CAKUT and appropriate intervention is expected to obtain a good prognosis and improve quality of life.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"306-321"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical importance of accurate diagnosis in treatable neurometabolic disorders: insights from a large Chinese cohort with glucose transporter-1 deficiency syndrome.","authors":"Hui Xiong","doi":"10.1007/s12519-025-00885-8","DOIUrl":"10.1007/s12519-025-00885-8","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"211-212"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestations and pathogenesis of mitochondrial dysfunction in short stature.","authors":"Yue Jiang, Zhi-Qiang Wan, Xin-Yue Zhang, Han-Ze Du, Yun-Meng Yang, Hui Pan, Yi Hu","doi":"10.1007/s12519-025-00881-y","DOIUrl":"10.1007/s12519-025-00881-y","url":null,"abstract":"<p><strong>Background: </strong>Mitochondria plays a pivotal role in cellular energy production, and their dysfunction can lead to a spectrum of mitochondrial diseases, affecting various organs with a wide range of clinical symptoms. Among these, short stature is a notable manifestation, yet its pathogenesis related to mitochondrial dysfunction remains underexplored.</p><p><strong>Data sources: </strong>A comprehensive literature search was conducted in the PubMed, Medline, and EMBASE databases from inception to November 2024. Patient demographics, genetic confirmation type, clinical features associated with short stature or growth abnormalities, and any interventions or treatments alongside treatment outcomes were extracted.</p><p><strong>Results: </strong>Our article provides a comprehensive review of the clinical manifestations and delves into the molecular mechanisms of mitochondrial dysfunction that are associated with short stature. A total of 134 genetically confirmed cases with primary mitochondrial disease (PMD) associated with short stature with mtDNA (e.g., m.3243A>G, large-scale deletions) and nDNA mutations (e.g., NDUFB3, SURF1). Median age at short stature detection was 8 years, with 40% presenting earlier. Growth hormone deficiency (GHD) occurred in 15% of cases, showing variable responses to therapy. Pathogenesis involves mitochondrial dysfunction, growth plate impairment, and endocrine disorders. Early diagnosis relies on timely genetic testing. Management of PMD includes tailored dietary strategies, supplementation, and cautious GH therapy due to potential risks. Emerging gene therapy and multidisciplinary care are emphasized to address disease complexity and optimize outcomes.</p><p><strong>Conclusions: </strong>Previous reviews have described the endocrine aspects of mitochondrial diseases. Although the list of endocrine diseases is comprehensive, it is not specific for short stature. This review focuses on short stature, and it is more specific than previous reviews in terms of etiology, pathogenesis, diagnosis, treatment, and prospects.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"223-251"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic characteristics of glucose transporter 1 deficiency syndrome in a large cohort of Chinese patients.","authors":"Mei-Jiao Zhang, Shi-Min Zhang, Qing-Ping Zhang, Yong-Xin Wen, Jia-Ping Wang, Yu-Wu Jiang, Xin-Hua Bao","doi":"10.1007/s12519-025-00884-9","DOIUrl":"10.1007/s12519-025-00884-9","url":null,"abstract":"<p><strong>Background: </strong>Mutations in the SLC2A1 gene cause glucose transporter type 1 deficiency syndrome (Glut1DS). This study aimed to investigate the clinical and molecular genetics characteristics of Chinese patients with Glut1DS.</p><p><strong>Methods: </strong>The clinical data of patients with Glut1DS were analyzed retrospectively. SLC2A1 mutation analysis was performed using Sanger sequencing or next-generation sequencing (NGS). Multiplex ligation-dependent probe amplification (MLPA) was conducted in patients with negative results.</p><p><strong>Results: </strong>A total of 90 patients were diagnosed with Glut1DS, including 63 (70%) classic type and 27 (30%) non-classic type. Seizures occurred in 69 patients (77%), movement disorders were observed in 58 (68%), and episodic eye-head movements were noted in 17 (19%). Cerebrospinal fluid (CSF) glucose levels were available for 73 patients (81%), ranging from 1.0 to 2.6 mmol/L (median 1.9 mmol/L), with 90% (66/73) of patients showing levels below 2.2 mmol/L. Additionally, CSF-to-blood glucose ratios measured in 71 patients (79%) ranged from 0.20 to 0.63 (median 0.37), with 87% (62/71) of patients having ratios below 0.45. Genetic analysis identified 69 variants of the SLC2A1 gene including 39 previously reported and 30 unreported variants. The two most common variants were c.997C > T (p.Arg333Trp) and c.988C > T (p.Arg330*). Following ketogenic diet therapy, seizures were controlled in 47 of 57 patients (82%), movement disorders resolved in 18 of 47 patients (38%), and improved in 26 of 47 patients (55%).</p><p><strong>Conclusions: </strong>The clinical manifestations of Glut1DS primarily include seizures, movement disorders, and developmental delay. Most affected children had CSF glucose levels below 2.2 mmol/L, with CSF-to-blood glucose ratios under 0.45. Two of the most common SLC2A1 variants were identified in our cohort. Ketogenic diet therapy was effective in controlling seizures, improving movement disorders, and was well tolerated.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"274-283"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in children: drawing epidemiologic insights from endemic regions.","authors":"Viola Savy Dsouza, Jestina Rachel Kurian, Angela Brand","doi":"10.1007/s12519-025-00886-7","DOIUrl":"10.1007/s12519-025-00886-7","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"216-219"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human parainfluenza virus: an important but overlooked respiratory pathogen.","authors":"Zhen Zhu, Yan Zhang, Nai-Ying Mao","doi":"10.1007/s12519-025-00888-5","DOIUrl":"10.1007/s12519-025-00888-5","url":null,"abstract":"","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"220-222"},"PeriodicalIF":6.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}