{"title":"Features of RUNX1-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and international cohort (cBioPortal).","authors":"Sarah Bayat, Klaus Geissler","doi":"10.1007/s10354-025-01074-y","DOIUrl":"https://doi.org/10.1007/s10354-025-01074-y","url":null,"abstract":"<p><p>Big data collected in large international cooperations now allow validation of findings from traditional national patient cohorts for proving consistency. In this study, we compared findings in RUNX1-mutated patients of the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with the CMML cohort documented in cBioPortal. In the cBioPortal cohort, RUNX1-mutated patients had significantly inferior survival and AML-free survival as compared to nonmutated patients. In the ABCMML cohort, survival and AML-free survival were numerically shorter in RUNX1-mutated patients than in wildtype patients, but this did not reach significance. Regarding phenotype, in both cohorts, RUNX1-mutated patients had a significantly higher proportion of patients with thrombocytopenia and lower metric values for platelets as compared to wildtype patients. Validation of data, as we have done in this study in CMML patients using two independent cohorts, ensures the quality standards that are required for their use in clinical decision making.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Psychophysiological research by the East German State Security and the use of so-called lie detectors in the GDR].","authors":"Rainer Erices","doi":"10.1007/s10354-025-01078-8","DOIUrl":"https://doi.org/10.1007/s10354-025-01078-8","url":null,"abstract":"<p><p>This study is the first to describe research conducted by the GDR State Security on polygraphs and voice analyzers and their conspiratorial use. Stasi files are used to show that the so-called lie detector was also used in the GDR. Up until the late 1960s, MfS superiors considered psychophysiological tests with the polygraph to be questionable and \"ethically and morally reprehensible\". This did not prevent a few experts from conducting extensive research. In addition, own spies were trained to pass polygraph tests in the West without being recognized. With the development of voice analyzers in the early 1970s, the MfS expanded its psychophysiological research. Voice analyses were carried out in hundreds of cases - to identify informers and in criminal investigations. All of the equipment came from the West and was procured despite embargo regulations. Shortly before the end of the GDR, use and research were to be expanded. The public knew nothing about this. There were only indications in the analyzed files that the psychophysiological devices were being used for civilian purposes. The Stasi files on this subject have not yet been fully indexed.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Tchernev, D Linkwinstar, A Shine, V Broshtilova, S Kordeva
{"title":"Acquired digital periungual fibrokeratoma in a 36-year-old male: case report and an update.","authors":"G Tchernev, D Linkwinstar, A Shine, V Broshtilova, S Kordeva","doi":"10.1007/s10354-025-01073-z","DOIUrl":"https://doi.org/10.1007/s10354-025-01073-z","url":null,"abstract":"<p><p>Acquired digital fibrokeratoma (ADFK) is a rare benign mesenchymal tumor often presenting as a small, firm, hyperkeratotic lesion, typically located in the periungual or subungual regions of the digits. Though benign, ADFK can lead to significant functional or cosmetic issues and may be mistaken for more serious conditions such as squamous cell carcinoma or pyogenic granuloma. We report the case of a 36-year-old male with a 3- to 4‑year history of a progressively enlarging periungual tumor leading to nail deformity and mild pressure effects on the underlying bone. The patient's history included minor trauma, possibly contributing to the lesion's development. Dermatological and histopathological evaluations revealed a well-demarcated mesenchymal lesion with orthohyperkeratosis, irregular acanthosis, and stellate fibroblasts within a vascular stroma, consistent with ADFK. A CT scan confirmed mild deformity of the distal phalanx but no bone infiltration. Surgical excision was offered but deferred by the patient, who preferred monitoring of the lesion. This case highlights the importance of accurate diagnosis through clinical, histopathological, and imaging evaluations to distinguish ADFK from other periungual tumors and underscores the need for individualized treatment based on patient preferences and the lesion's impact.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Features of TP53-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and international cohort (cBIOPORTAL).","authors":"Magdalena Grass, Klaus Geissler","doi":"10.1007/s10354-025-01072-0","DOIUrl":"https://doi.org/10.1007/s10354-025-01072-0","url":null,"abstract":"<p><p>Big data collected in large international cooperations allow validation of findings from traditional national patient cohorts for proving consistency. In this study we analyzed outcomes and phenotypic features of TP53-mutated chronic myelomonocytic leukemia (CMML) patients in the Austrian biodatabase for CMML (ABCMML; n = 322) and in the international platform cBIOPORTAL (n = 399). The prevalences of TP53 mutations were 1.58 and 3.66, respectively. Numerically, overall survival was shorter in TP53-mutated patients in both cohorts (ABCMML 10.0 vs. 30.0 months and cBIOPORTAL 8.9 vs. 34.5 months), but this was statistically significant only in the cBIOPORTAL cohort. Decreased hemoglobin values and the presence of blast cells in peripheral blood were significantly associated with TP53 mutations in the cBIOPORTAL group but not in the ABCMML database. Our study indicates the necessity of sufficient patient numbers for the comparison of CMML patients regarding outcome and phenotype according to their molecular subtype, particularly in the case of rare mutations.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Scurvy-A now forgotten previously widespread disease].","authors":"Heinz Flamm","doi":"10.1007/s10354-024-01054-8","DOIUrl":"10.1007/s10354-024-01054-8","url":null,"abstract":"<p><p>From the sea voyages of the fifteenth century often lasting for years with provisions only of fish, salted meat and biscuits reports came of fatal health alterations of the seamen which were characterized by prostration, loss of teeth and bad breath.Reports on comparable endemic illnesses soon came from the Netherlands, North Germany, the Baltic area, France, Lorraine, Geneva, Bohemia, Moravia, Silesia, Swabia and Russia: the so-called land scurvy. The first medical specification was found in a letter from 1541 by Johann Echt to colleges in the area of Lower Germany, which was published four times. One of the first comprehensive considerations was prepared by the English physician James Lind. Scurvy was also mostly published under many local names, such as Skorbut, Scharbock or Scheurbuik.The pathology of scurvy is dominated by gingival necrosis with loss of teeth, hemorrhages with destruction of the cartilage-bone border especially of the ribs and by subperiosteal hemorrhages of the ribs and long bones.For treatment and prevention of scurvy eating green plants as originally Ficaria verna (lesser celandine, pilewort), Chelidonium majus (great celandine, nipplewort, tetterwort) and Cochlearia officinalis (scurvy grass) proved to be effective. Where green plants were missing decoctions of conifer needles and fresh animal innards were used. When the infantile disease originally named \"acute rachitis\" in England was diagnosed as scurvy (later Möller-Barlow disease) the treatment of cow's milk for baby food became of great interest.Finally, hexuronic acid, later called ascorbic acid or vitamin C, was found to be a drug that could easily dosed for curing and prevention of scurvy.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"75-97"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas G Nerlich, Roland Sedivy, Michael E Habicht, Francesco M Galassi, Simon Donell, Viktoria Bogner-Flatz, Oliver K Peschel
{"title":"Assassination of Elisabeth, Empress of Austria, Queen of Hungary, on 10 September 1898: further additions and minor annotations.","authors":"Andreas G Nerlich, Roland Sedivy, Michael E Habicht, Francesco M Galassi, Simon Donell, Viktoria Bogner-Flatz, Oliver K Peschel","doi":"10.1007/s10354-024-01053-9","DOIUrl":"10.1007/s10354-024-01053-9","url":null,"abstract":"<p><p>Very recently, a comprehensive re-evaluation of the medical facts and observations surrounding the death of Empress Elisabeth \"Sisi\" of Austria (1837-1898) was published. The Empress was assassinated in Geneva by the anarchist Luigi Luccheni or Lucheni (1873-1910). In parallel to this recent publication, our study group came across an almost unknown letter from Dr. Golay, who was one of the examining doctors of Empress Elisabeth. In this publication we add relevant additions based on this letter and provide further insights regarding the attempts at resuscitation.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"68-72"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alcohol and the death of Ludwig van Beethoven: comparison of general biographies to the medical literature.","authors":"Dongwon Lee, William Meredith, Benjamin Lebwohl","doi":"10.1007/s10354-023-01010-y","DOIUrl":"10.1007/s10354-023-01010-y","url":null,"abstract":"<p><p>Beethoven's autopsy findings of cirrhosis may have been due to alcoholism. This condition may have been underemphasized historically, given its stigma and the incongruence with the often heroic portrayal of Beethoven. We therefore aimed to compare how medical experts and biographers writing for a non-medical audience describe his final illness in the context of alcoholism. English-language biographies were identified using a survey of biographies of Beethoven and supplemented by the authors. English-language medical publications were identified by searching for \"Beethoven\" in the PubMed® MEDLINE database. We included studies that mentioned Beethoven's final illness and death. We recorded statements regarding alcohol consumption, alcoholism, or alcohol use disorder, and the role of alcohol in Beethoven's death. The most commonly cited final illness was liver disease. Alcohol use was more frequently mentioned in biographies, but alcoholism less so. Alcohol use was invoked as a possible cause of final illness more frequently by medical publications.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"60-67"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Edwin Klebs : Der k. k. Professor Edwin Klebs – Wegbereiter für Theodor Billroth und Robert Koch – zur 190. Wiederkehr seines Geburtstages.","authors":"Heinz Flamm","doi":"10.1007/s10354-024-01036-w","DOIUrl":"10.1007/s10354-024-01036-w","url":null,"abstract":"","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"73-74"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Grechenig, Theresa di Vora, Amir Koutp, Alexandros Andrianakis, Paul Puchwein, Gloria Hohenberger
{"title":"Course of the extensor pollicis longus tendon considering the different functional positions of the wrist and the first ray-an anatomical study.","authors":"Peter Grechenig, Theresa di Vora, Amir Koutp, Alexandros Andrianakis, Paul Puchwein, Gloria Hohenberger","doi":"10.1007/s10354-024-01052-w","DOIUrl":"10.1007/s10354-024-01052-w","url":null,"abstract":"<p><strong>Background: </strong>The aim of this anatomical study was to evaluate the course of the extensor pollicis longus (EPL) tendon, its positional relationship to adjacent structures, and the resulting clinical relevance under consideration of various functional positions.</p><p><strong>Materials and methods: </strong>Twenty upper extremities from ten adult human cadavers embalmed using Thiel's method were included in this study. The greatest possible movement/slippage of the EPL tendon, the angle at which the tendon wraps around Lister's tubercle, and its course across the extensor carpi radialis longus and brevis (ECRL and ECRB) were recorded and defined in all functional positions.</p><p><strong>Results: </strong>Our findings demonstrate a high range of motion of the tendon in relation to clinically relevant structures.</p><p><strong>Conclusion: </strong>Understanding the anatomical course of the EPL tendon, its potential extent of movement, and its resulting positional changes is essential for the diagnosis and surgical treatment of patients with complaints or injuries in the dorsoradial wrist region.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"44-49"},"PeriodicalIF":1.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}