Xenobiotica最新文献_第5页

Tetrahydrouridine pre-treatment increases tissue exposure of ¹⁴C-decitabine in mice. 四氢吡啶预处理增加小鼠14c -地西他滨的组织暴露。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI: 10.1080/00498254.2026.2689078

Hans Helleberg, Inga Bjørnsdottir, Signe Beck Petersen, Hanne Kjær Offenberg

引用次数: 0

Exploring the clinical pharmacokinetics and pharmacodynamics of third-generation cephalosporin, a cefotaxime: a systematic review. 第三代头孢菌素-头孢噻肟的临床药代动力学和药效学研究综述。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-05-31 DOI: 10.1080/00498254.2026.2677148

Muhammad Zubair, Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Hamid Saeed, Faleh Alqahtani

{"title":"Exploring the clinical pharmacokinetics and pharmacodynamics of third-generation cephalosporin, a cefotaxime: a systematic review.","authors":"Muhammad Zubair, Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Hamid Saeed, Faleh Alqahtani","doi":"10.1080/00498254.2026.2677148","DOIUrl":"10.1080/00498254.2026.2677148","url":null,"abstract":"Cefotaxime is a third-generation cephalosporin that is used to treat susceptible bacterial infections. This systematic review provides an in-depth analysis of all pharmacokinetic (PK) and pharmacodynamic (PD) parameters of cefotaxime in humans.A systematic search was conducted using the search engines Google Scholar, PubMed, Science Direct, and Cochrane Library to identify the relevant articles on the PK of cefotaxime.The healthy populations have shown a linear increase in area under the plasma concentration vs. time curve from zero to infinity (AUC0-∞) after receiving doses ranging from 250-2000 mg. One study has reported a decrease in cefotaxime clearance (CL) in patients with renal insufficiency compared to healthy participants, i.e. 129.8 ± 9.3 ml/min vs. 272.8 ± 43.9 ml/min. Moreover, a slight increase in the maximum plasma concentration (Cmax) of about 5.6% was observed when cefotaxime is co-administered with tazobactam. Therefore, cefotaxime depicts time-dependent killing above the minimum inhibitory concentration (MIC < 2 ug/ml), this property makes it suitable for managing infections caused by susceptible pathogens.This review compiles all the relevant PK and PD parameters of cefotaxime in healthy subjects. These data may assist health practitioners in adjusting the cefotaxime dose among renal failure patients to avoid toxicity.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"453-463"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice. 小檗碱胶束的制备及其对高血糖小鼠的抗皮肤损伤作用。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-06-07 DOI: 10.1080/00498254.2026.2683638

Xingcheng Jin, Qinyang Hua, Michael Adu-Frimpong, Qingwen Li, Qilong Wang, Elmurat Toreniyazov, Xia Cao, Jiangnan Yu, Ximing Xu

{"title":"Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice.","authors":"Xingcheng Jin, Qinyang Hua, Michael Adu-Frimpong, Qingwen Li, Qilong Wang, Elmurat Toreniyazov, Xia Cao, Jiangnan Yu, Ximing Xu","doi":"10.1080/00498254.2026.2683638","DOIUrl":"10.1080/00498254.2026.2683638","url":null,"abstract":"This study aimed to prepare and evaluate berberine micelles for improving the oral bioavailability and therapeutic effect against skin injury in hyperglycaemic mice. Berberine micelles were fabricated using the film dispersion method with PLGA-PEG-PLGA and glycyrrhizic acid monoamine salt, followed by orthogonal optimisation.The optimised berberine micelles exhibited a particle size of 112.55 ± 2.48 nm, polydispersity index of 0.217 ± 0.005, zeta potential of -31.60 ± 0.23 mV, encapsulation efficiency of 95.57 ± 1.36% (w/w), and drug loading capacity of 7.06 ± 0.25% (w/w). In vitro release of berberine from micelles was higher than that of free berberine across all tested media.Pharmacokinetic studies in rats showed that berberine micelles prolonged the half-life from 5.77 h to 12.19 h and extended the mean retention time from 20.74 h to 143.31 h, with a relative bioavailability 2.64‑fold greater than that of free berberine.In a streptozotocin‑induced hyperglycaemic mouse skin injury model, the high‑dose berberine micelle group significantly accelerated wound closure compared to the free drug group on days 6 and 9, and histopathological analysis of skin, liver, spleen, and pancreas revealed superior tissue recovery. These findings suggest that berberine micelles effectively enhance the anti‑hyperglycaemic and skin‑repairing efficacy of berberine.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"476-488"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-PDA & LC-MS/MS approach of Daprodustat: forced degradation study. hplc - pda和LC-MS/MS法研究达普罗司他的强制降解。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-06-10 DOI: 10.1080/00498254.2026.2682900

Venkata Divya Namala, Gowri Gollu, Jagadeesh Panda, Santosh Kumar Sahoo, Venkata Deepthi Vemuri, Nalini Mathala

{"title":"LC-PDA & LC-MS/MS approach of Daprodustat: forced degradation study.","authors":"Venkata Divya Namala, Gowri Gollu, Jagadeesh Panda, Santosh Kumar Sahoo, Venkata Deepthi Vemuri, Nalini Mathala","doi":"10.1080/00498254.2026.2682900","DOIUrl":"10.1080/00498254.2026.2682900","url":null,"abstract":"Daprodustat is a hypoxia-inducible prolyl hydroxylase inhibitor to treat anaemia in patients with Chronic Kidney Disease (CKD). A stability-indicating RP-HPLC method was developed and validated as per ICH Q2 guidelines. Chromatographic separation was performed on Zorbax SB C18 column (150 mm × 4.6 mm, 3.5 μ) detected at 235 nmusing a PDA detector. A mixture of ethanol and formic acid in a 20:80 (v/v) ratio was used as the mobile phase, with a flow rate of 1 mL/min. Forced degradation studies are conducted according to the International Council of Harmonisation (ICH) guideline Q1A (R2). The HPLC system was coupled to a SCIEX QTRAP 5500 mass spectrometer equipped with an electrospray ionisation interface to identify the plausible structures and fragmentation pattern of all the degradation products.Three degradation products were obtained from forced degradation. Based on the m/z values and molecular formula from the obtained MS spectra, the probable structures of degradation products were elucidated. Plausible degradation mechanism behind the formation of degradation productsThis method can clearly depict the stability of daprodustat under the influence of various environmental factors in less time with low cost. Further, this study also helps in impurity profiling studies.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"464-475"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AS-IV's protective potential against inflammatory injury via miR-320b/PTEN axis in acute ischaemic stroke. AS-IV通过miR-320b/PTEN轴在急性缺血性卒中中抗炎症损伤的保护潜力。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1080/00498254.2026.2672140

Xiaofen Yu, Yunjing Wang, Ting Yang, Jiancheng Lou

{"title":"AS-IV's protective potential against inflammatory injury via miR-320b/PTEN axis in acute ischaemic stroke.","authors":"Xiaofen Yu, Yunjing Wang, Ting Yang, Jiancheng Lou","doi":"10.1080/00498254.2026.2672140","DOIUrl":"10.1080/00498254.2026.2672140","url":null,"abstract":"Astragaloside IV (AS-IV) represented a promising therapeutic candidate for acute ischaemic stroke. However, its definitive molecular targets and mode of action await full elucidation.The study investigated the protective efficacy of AS-IV and delineated its underlying mechanism in regulating human brain microvascular endothelial cells (BMECs) following oxygen-glucose deprivation/reoxygenation (OGD/R) conditions.Human BMECs were exposed to OGD conditions for 4 h and AS-IV (0-100 µM) was added to the medium immediately for reoxygenating treatment. MiR-320b levels were manipulated 24 h after OGD/R by transient transfection with its inhibitor or mimic. Cell viability and apoptosis were assessed by corresponding kits. The expression level of miR-320b or PTEN was achieved by RT-qPCR. Pro-inflammatory cytokines were detected by ELISA.AS-IV rescued cells under OGD/R condition by enhancing cell viability, curbing apoptosis and pro-inflammatory signalling. This aligned with the pro-survival signature of miR-320b upregulation in OGD/R cells. Conversely, miR-320b knockdown abrogated the AS-IV efficacy. RIP and dual-luciferase reporter assay confirmed PTEN as the direct downstream target of miR-320b.AS-IV protected cells under OGD/R conditions by improving viability and inhibiting inflammation as well as apoptosis via miR-320b/PTEN axis.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"504-512"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of notoginsenoside R1 in alleviating intervertebral disc degeneration: an experimental and network pharmacological analysis based on ferroptosis and autophagy genes. 三七皂苷R1减轻椎间盘退变的机制：基于铁凋亡和自噬基因的实验和网络药理学分析。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-06-14 DOI: 10.1080/00498254.2026.2682890

Yingchao Gao, Ning Zhang, Junfei Zhang, Yan Wan, Zhengqi Fei, Wei Zhu

{"title":"Mechanism of notoginsenoside R1 in alleviating intervertebral disc degeneration: an experimental and network pharmacological analysis based on ferroptosis and autophagy genes.","authors":"Yingchao Gao, Ning Zhang, Junfei Zhang, Yan Wan, Zhengqi Fei, Wei Zhu","doi":"10.1080/00498254.2026.2682890","DOIUrl":"10.1080/00498254.2026.2682890","url":null,"abstract":"Notoginsenoside R1 (NGR1) shows therapeutic potential in intervertebral disc degeneration (IDD), but its mechanism remains unclear.An in vivo rat tail puncture model and in vitro erastin-induced nucleus pulposus (NP) cells were employed to evaluate the therapeutic effects and underlying mechanisms of NGR1 on IDD. Network pharmacology was performed to predict potential NGR1 targets, which were validated using qRT-PCR. 3-MA (an autophagy inhibitor) and colivelin (a STAT3 activator) were used for mechanistic validation.NGR1 improved disc structure and significantly increased aggrecan and collagen II levels in NP tissues. NGR1 inhibited ferroptosis, as evidenced by increased GPX4 and decreased ACSL4, Fe2+, and ROS levels. NGR1 also promoted autophagy, as indicated by increased Beclin-1 and LC3 II/I levels in NP tissues. Moreover, serum IL-1β and IL-6 were reduced by NGR1 in IDD rats. NGR1 significantly reduced the levels of predicted targets STAT3, IL1B, and MAPK3. In erastin-induced NP cells, NGR1 significantly restored cell viability, enhanced autophagy, and suppressed ferroptosis as well as STAT3, IL1B, and MAPK3 expression, all of which were partially reversed by 3-MA or colivelin.NGR1 alleviates IDD by inhibiting ferroptosis and promoting autophagy, potentially via STAT3 signalling, thereby preserving disc integrity and delaying disease progression.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"513-526"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations. 使用半机械药代动力学模型和群体模拟的口服西马鲁肽的稳态药代动力学。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-06-06 DOI: 10.1080/00498254.2026.2683901

Ayushi Tiwari, Sideequl Akbar, Anumol Joseph, Rajkumar Malayandi, Sudarshan Naidu Chilamakuri, Subramanian Natesan

{"title":"Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations.","authors":"Ayushi Tiwari, Sideequl Akbar, Anumol Joseph, Rajkumar Malayandi, Sudarshan Naidu Chilamakuri, Subramanian Natesan","doi":"10.1080/00498254.2026.2683901","DOIUrl":"10.1080/00498254.2026.2683901","url":null,"abstract":"Semaglutide (SEM) is a GLP-1 analogue, administered subcutaneously or orally. Due to its large molecular structure, it has poor oral absorption and bioavailability. The reported oral bioavailability is 0.4% to 1% in the fasting state. Sodium N-[8-{2-hydroxybenzoyl} amino] caprylate (SNAC) is used as a permeation enhancer to improve gastric permeability and oral bioavailability.This study developed a semi-mechanistic pharmacokinetic (PK) model to predict the steady-state pharmacokinetics of oral SEM, primarily using published clinical data and literature-derived parameters. The present study investigated the impact of SNAC on the gastric absorption of SEM.The semi-mechanistic PK model was developed for the intravenous (IV) and oral formulations. The oral absorption model was developed for SEM at different single doses with varying amounts of SNAC. The dose, SNAC concentration, gastrointestinal permeability, and intestinal first-pass effect impact the PK of the oral SEM. Steady-state PK studies were used to validate the single-dose oral PK model. IV, single-dose, and multiple-dose oral PK models were developed and validated.The developed semi-mechanistic model could be useful for further development of mechanistic, physiologically based pharmacokinetic (PBPK) models for formulation development, drug interactions, and the influence of pharmacokinetics in special populations.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"489-503"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid dysregulation in chronic diseases: systems biology and omics perspectives. 慢性疾病中的脂质失调：系统生物学和组学观点。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-05-31 DOI: 10.1080/00498254.2026.2680076

Debashrita Majumder, Debasmita Bhattacharya, Harjot Singh Gill, Mithul Rajeev, Shubham Sharma, Shashi Prakash Dwivedi, Moupriya Nag, Dibyajit Lahiri

{"title":"Lipid dysregulation in chronic diseases: systems biology and omics perspectives.","authors":"Debashrita Majumder, Debasmita Bhattacharya, Harjot Singh Gill, Mithul Rajeev, Shubham Sharma, Shashi Prakash Dwivedi, Moupriya Nag, Dibyajit Lahiri","doi":"10.1080/00498254.2026.2680076","DOIUrl":"10.1080/00498254.2026.2680076","url":null,"abstract":"1. Lipids are fundamental regulators of cellular structure, energy balance, and signalling, while their dysregulation contributes significantly to the development of chronic diseases.2. Recent advances in multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, lipidomics, and epigenomics, have transformed the investigation of lipid metabolism by enabling high-resolution characterisation of lipid species, metabolic pathways, and regulatory networks.3. This review emphasises the significance of lipids in chronic metabolic diseases like cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, neurodegenerative disorders, cancer, and chronic kidney disease.4. The discovery of various biomarkers of disease conditions via lipidomics analysis includes lipids such as ceramides, oxidised phospholipids, acylcarnitines, and lysophospholipids, which have been implicated in causing inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis.5. Omics integration can aid in obtaining new perspectives in understanding disease pathophysiology and help in identifying novel therapeutic targets including PCSK9 (Proprotein convertase subtilisin/kexin type 9), ANGPTL3 (Angiopoietin-like 3), and inflammatory lipids. Recent lipidomics platforms like spatial lipidomics and single-cell lipidomics may add value in developing personalised medicine therapies.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"534-562"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol may mitigate the proliferation and migration of hypertrophic scars via miR-1290/ADAMTS8. 白藜芦醇可能通过miR-1290/ADAMTS8抑制增生性疤痕的增殖和迁移。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-06-01 Epub Date: 2026-06-14 DOI: 10.1080/00498254.2026.2682897

Yule Ren, Zehua Han, Xiaocheng Zhou

{"title":"Resveratrol may mitigate the proliferation and migration of hypertrophic scars via miR-1290/ADAMTS8.","authors":"Yule Ren, Zehua Han, Xiaocheng Zhou","doi":"10.1080/00498254.2026.2682897","DOIUrl":"10.1080/00498254.2026.2682897","url":null,"abstract":"Hypertrophic scars (HS) represent a common complication arising from abnormal wound healing following skin injury. Resveratrol and microRNA (miRNA) have been implicated in the formation of HS. However, the precise mechanism by which resveratrol modulates hypertrophic scarring through miRNA regulation remains unclear.Investigating the potential functional effects and molecular mechanisms of resveratrol in HS.RT-qPCR was employed to detect the levels of miR-1290 and ADAMTS8. The targeted binding relationship between miR-1290 and ADAMTS8 was validated through dual luciferase reporter assays and RIP experiments. Cell proliferation, migration capacity, and inflammatory cytokine (IL-1β, IL-6) secretion levels were assessed using CCK-8 assays, Transwell migration assays, and ELISA.MiR-1290 was overexpressed in HS tissue and HSFB cells, whereas ADAMTS8 levels were markedly downregulated, exhibiting a negative correlation between the two. Resveratrol concentration-dependently inhibited miR-1290 levels and upregulated ADAMTS8 levels. ADAMTS8 may represent a direct target gene of miR-1290. Resveratrol may suppress the proliferation, migration, inflammatory cytokine levels, and fibrosis marker levels in HSFB cells. Overexpression of miR-1290 partially reversed the effects of resveratrol, whilst overexpression of ADAMTS8 suppressed the actions induced by miR-1290.Resveratrol may suppress the malignant phenotype of HSFB cells by regulating the miR-1290/ADAMTS8 axis.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"527-533"},"PeriodicalIF":1.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of Zanthoxylum rhetsa (roxb.) DC.: a systematic review of bioactive drug-Like compounds and natural drug leads. 花椒的治疗潜力直流。生物活性类药物化合物和天然药物先导物的系统综述。

IF 1.5 4区医学

Xenobiotica Pub Date : 2026-05-01 Epub Date: 2026-05-25 DOI: 10.1080/00498254.2026.2671852

Ankur Jyoti Deka, Shounak Barua, Deepak Upadhaya, Mriganka Barman, Barnali Deka, Subhash Medhi

{"title":"Therapeutic potential of Zanthoxylum rhetsa (roxb.) DC.: a systematic review of bioactive drug-Like compounds and natural drug leads.","authors":"Ankur Jyoti Deka, Shounak Barua, Deepak Upadhaya, Mriganka Barman, Barnali Deka, Subhash Medhi","doi":"10.1080/00498254.2026.2671852","DOIUrl":"10.1080/00498254.2026.2671852","url":null,"abstract":"1. introduction: Zanthoxylum rhetsa (ZR) is a medicinal plant native to Southeast Asia, widely used in traditional medicine. Despite its medicinal importance, systematic documentation of isolated bioactive constituents and their therapeutic relevance remains scarce. This systematic review aimed to compile phytochemical profile of ZR and summarise evidence on its bioactive/drug-like phytoconstituents and compound-specific biological activities, highlighting its potential as source of natural therapeutics.2. methodology: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search of PubMed, Scopus, and Web of Science was conducted, and duplicates were removed using Rayyan software.3. result: Compounds isolated from ZR were found to confer significant cytotoxic, antimicrobial, anti-inflammatory, antioxidant, anti-photaging, antispasmodic, and antidiarrheal effects. Mechanistic investigations revealed that several compounds exhibited selective cytotoxicity against cancer only, inhibited microbial proliferation through membrane disruption, and modulated signalling pathways associated with inflammation and oxidative stress. Additionally, absorption, distribution, metabolism, excretion (ADME) analysis highlighted nitidine, dihydrochelerythrine, and hesperidin isolated from ZR as promising drug leads with favourable pharmacokinetic and safety profiles.4. conclusion: ZR constitutes a chemically diverse reservoir of bioactive metabolites, highlighting its significance as promising natural source of drug-like compounds and emphasising the need for comprehensive mechanistic, pharmacological, and clinical investigations to evaluate therapeutic translation.","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":" ","pages":"424-442"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0