Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan最新文献_第4页

[Modulation of Cognitive and Psychiatric Functions by Psychostimulant-responsive Molecules]. [精神刺激剂反应分子对认知和精神功能的调节]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00179

Naotaka Izuo

{"title":"[Modulation of Cognitive and Psychiatric Functions by Psychostimulant-responsive Molecules].","authors":"Naotaka Izuo","doi":"10.1248/yakushi.24-00179","DOIUrl":"10.1248/yakushi.24-00179","url":null,"abstract":"Methamphetamine, a psychostimulant drug, acts on dopaminergic neuron terminals projecting from the ventral tegmental area to the nucleus accumbens, which constitutes the reward system in the brain. In addition to dependence triggered by excessive excitation of the reward system, methamphetamine induces various effects, including hallucinations, delusions, and cognitive dysfunction. This means that molecules responsive to methamphetamine are importantly involved in the brain function. This report reviews the functions of Shati/Nat8l and Piccolo, identified as methamphetamine-responsive molecules in the murine nucleus accumbens, in cognitive and psychiatric functions clarified by rodent studies. Shati/Nat8l is related to drug addiction and depression and participates in the synaptic function of the hippocampus to maintain cognitive function. Its upregulation suppresses cognitive disturbance in Alzheimer's disease pathology. In the nucleus accumbens, Piccolo contributes to the behavioral alteration caused by methamphetamine. Piccolo downregulation in the prefrontal cortex induced schizophrenia-like behavioral and neuronal changes in mice. These findings indicate that Shati/Nat8l and Piccolo exert important functions on the brain and are potential targets for brain disorder studies. It is anticipated that understanding of brain function will be achieved through the analysis of methamphetamine-responsive molecules.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 3","pages":"163-168"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pickering Emulsion Strategy for Multi-Catalytic Reactions]. [多催化反应的Pickering乳液策略]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00120

Kyohei Kanomata

引用次数: 0

[Next-generation Health Functional Food Research Pioneered through Collaboration between Pharmaceutical Science and Agricultural Science]. 【医药科学与农业科学合作开创下一代健康功能食品研究】。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00173-F

Kazuya Nagano, Shinsaku Nakagawa

引用次数: 0

Administration of Immune Checkpoint Inhibitors to Patients on Warfarin May Elevate PT-INR. 华法林患者使用免疫检查点抑制剂可能会升高PT-INR。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00087

Kazuya Uenoyama, Masahide Onoue, Toshiro Katayama, Katsuya Makihara, Hiroshi Yamamoto, Mari Takagi, Kazuhiko Omoto, Yoshiyuki Rikitake

引用次数: 0

[Anthracycline-Induced Cardiotoxicity and Exploration of Cardioprotective Drugs]. 蒽环类药物引起的心脏毒性及心脏保护药物的研究

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00185

Akiyoshi Hara

{"title":"[Anthracycline-Induced Cardiotoxicity and Exploration of Cardioprotective Drugs].","authors":"Akiyoshi Hara","doi":"10.1248/yakushi.24-00185","DOIUrl":"10.1248/yakushi.24-00185","url":null,"abstract":"Many anticancer drugs, including anthracycline drugs, pose a risk of cardiovascular damage as an adverse reaction. This can detrimentally impact the prognosis and quality of life of patients, potentially leading to the interruption of cancer chemotherapy and compromising cancer treatment. Recently, onco-cardiology (or cardio-oncology) has developed as a new interdisciplinary field that focuses on the prevention and treatment of cardiovascular toxicity of anticancer drugs. In this review, we explore the mechanism underlying the cardiotoxicity of anthracyclines and examine pharmacological agents that safeguard the heart from anthracycline-induced damage. Anthracycline-induced cardiotoxicity primarily involves oxidative stress, characterized by radical production in mitochondria and subsequent apoptosis in cardiomyocytes. While various antioxidant agents, such as resveratrol, vitamin E, and melatonin have demonstrated efficacy in reducing anthracycline-induced cardiotoxicity in animal models, their clinical effectiveness remains inconclusive. Alternatively, dexrazoxane, an intracellular iron chelator, along with standard heart failure medications, such as β-blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, reduce anthracycline cardiotoxicity and prevent subsequent heart failure in both animal and human studies. Additionally, statins [hydroxymethylglutaryl (HMG)-CoA reductase inhibitors] and ranolazine have emerged as potential candidates for attenuating anthracycline-induced cardiotoxicity in clinical settings. Notably, recent in vitro findings suggest that everolimus, an autophagy/mitophagy-inducing antitumor drug, may protect cardiomyocytes from anthracycline-induced toxicity without reducing the antitumor effects of anthracycline. Although promising, further clinical research is warranted to validate the potential of everolimus as a safer and more effective anthracycline chemotherapeutic strategy.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 2","pages":"121-132"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Graduation Research in Organic Chemistry: Transformation of Students' Attitude toward Research through Graduation Research]. 有机化学毕业研究：通过毕业研究转变学生的研究态度。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00167-2

Tomoyo Kamei

{"title":"[Graduation Research in Organic Chemistry: Transformation of Students' Attitude toward Research through Graduation Research].","authors":"Tomoyo Kamei","doi":"10.1248/yakushi.24-00167-2","DOIUrl":"https://doi.org/10.1248/yakushi.24-00167-2","url":null,"abstract":"Organic chemistry in pharmaceutical education is indispensable for drug discovery and the understanding of biological phenomena and plays an important role in the identity formation of pharmacists. In the Model Core Curriculum for Pharmacy Education (2022 revision), organic chemistry is one of the most fundamental subjects in basic pharmaceutical sciences and plays an important role in the study of other fields. Based on basic pharmacy, the academic goal of pharmacological research is to develop problem-finding skills and foster the problem-solving abilities necessary for research that contributes to the development of pharmacy and medicine. The author devised ways for students to become interested in their research topics and to work on them independently. Specifically, the author adopted a teaching method that respects students' independence in scheduling and selecting synthetic routes. For example, in research to determine the absolute configuration of metabolites of the antibiotic nabumetone, students managed their own schedules and became able to conduct research with a sense of conviction and responsibility. In addition, in research on the synthesis of thiophene derivatives, presenting multiple synthetic routes and allowing students to choose one enabled them to propose the direction of the experiment based on their own opinions. Therefore, it is necessary to devise and support research procedures tailored to individual students.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"411-414"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Development of Hypervalent Iodine Reagents Utilizing Functional Group Properties]. 利用官能团性质开发高价碘试剂

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00005

Akira Yoshimura

引用次数: 0

[Development of Methods for the Early Detection of Chemical Hazard and the Prevention of Pre-disease, Focusing on Environment, Food, and Health]. [以环境、食品和健康为重点的化学品危害早期检测和病前预防方法的发展]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00168

Hideko Sone

{"title":"[Development of Methods for the Early Detection of Chemical Hazard and the Prevention of Pre-disease, Focusing on Environment, Food, and Health].","authors":"Hideko Sone","doi":"10.1248/yakushi.24-00168","DOIUrl":"10.1248/yakushi.24-00168","url":null,"abstract":"Based on the perspectives of the environment, food, and health, this review reflects on previous research examining stem cells for the early detection of chemical hazards and the development of preventive health tools. The risks posed by endocrine-disrupting chemicals in the environment are investigated, including studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), phthalate esters, and bisphenol A. Building on the findings of these studies, this review identifies emerging challenges in the field of endocrine-disrupting chemical research. Moreover, this paper explores innovative testing methods aimed at accurately evaluating the impact of chemicals on human health. The key topics covered include the implementation of developmental neurotoxicity testing methods, the species-specific effects of methylmercury, nanomaterials and the application of human pluripotent cells to assess the effects of low-dose radiation. Additionally, this review highlights transformative approaches in chemical health impact assessment that integrate cell science and artificial intelligence, and addresses challenges related to the application of multi-omics technologies in environmental health and toxicology.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 3","pages":"201-221"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Modified Method for Measuring Levels of Organomercury Compounds in Household Products]. [家用产品中有机汞化合物含量的改进测量方法]。

IF 0.3 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.24-00203

Hiroyuki Komine, Reiji Kubota, Masao Yoshida, Toshinari Suzuki, Yoshiaki Ikarashi, Akiko Inomata, Tsuyoshi Kawakami

{"title":"[Modified Method for Measuring Levels of Organomercury Compounds in Household Products].","authors":"Hiroyuki Komine, Reiji Kubota, Masao Yoshida, Toshinari Suzuki, Yoshiaki Ikarashi, Akiko Inomata, Tsuyoshi Kawakami","doi":"10.1248/yakushi.24-00203","DOIUrl":"https://doi.org/10.1248/yakushi.24-00203","url":null,"abstract":"In Japan, the use of organomercury compounds is regulated in textile products (diapers, diaper covers, bibs, underwear, sanitary pads, sanitary panties, gloves, hosiery), adhesive, paint, wax, and shoe polish buffers. This is stated in Act No. 112 of 1973, 'Act on Control of Household Products Containing Harmful Substances'. In this study, we modified the currently used official method. The modified method uses cyclohexane/ethyl acetate (3 : 1) as the extraction solvent instead of carbon tetrachloride. The phenyl mercuric acetate as the organomercury compounds was quantified by a direct thermal decomposition mercury analyzer accurately, precisely, and safely. The calibration curves for determining the level of phenyl mercuric acetate were shown to be linear in the range of 0.12-6.0 ng mercury (Hg). The quantitation limit (Hg: 4.7 ng/g) was adequately low relative to the regulation value (Hg: 1 µg/g). The modified method exhibited a recovery rate of phenyl mercuric acetate in various household products of 38-87% with relative standard deviations of 1.5-19.5% when the standard solution (60 ng Hg) was added to the samples (1.0 g). In addition, we found that the use of suction filtration during the extraction from textile products such as thick socks provided high recovery. Thus, the modified method would be applicable for measuring levels of the organomercury compounds in various controlled household products.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 5","pages":"469-477"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pharmacotherapy Study of Ophthalmic Solutions and Their Contribution to Patients with Eye Diseases]. [眼液的药物治疗研究及其对眼病患者的贡献]。

IF 0.2 4区医学

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2025-01-01 DOI: 10.1248/yakushi.25-00035

Hiroaki Ikeda

{"title":"[Pharmacotherapy Study of Ophthalmic Solutions and Their Contribution to Patients with Eye Diseases].","authors":"Hiroaki Ikeda","doi":"10.1248/yakushi.25-00035","DOIUrl":"10.1248/yakushi.25-00035","url":null,"abstract":"Starting in 1976, I worked as a pharmacy resident in the Department of Pharmaceutical Services at Hiroshima University Hospital, starting in 1976. I simultaneously worked as a pharmaceutical researcher outside the hospital pharmacist hours. I encountered a female patient with eye disease in 1998 during drug counseling hours for an outpatient. She left for a weeklong overseas travel within 3 days. She had one bottle of ophthalmic solution for anti-inflammatory treatment; her ophthalmologist instructed her to schedule her next visit when the bottle was empty as her condition was not severe and wanted to provide a simple guideline for scheduling a follow-up. She then asked me when the ophthalmic solution bottle would be empty. I could not immediately answer her question despite my 22 years of experience as a pharmacist. I realized a gap in the field in this moment, which inspired me to become an ophthalmology research pharmacist who answered important questions such as these. In my experience, apart from me, only a few pharmacists have participated in clinical ophthalmic research over the past 50 years. Upon my retirement, and based on my experience, my message to young researchers is to remain in research in this field to help improve the outcomes and quality of life for those with eye diseases.","PeriodicalId":23810,"journal":{"name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","volume":"145 8","pages":"697-705"},"PeriodicalIF":0.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0