中缝正中5 -羟色胺能神经元在正负信息加工中的作用。

IF 0.2 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hiroyuki Kawai
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引用次数: 0

摘要

血清素能神经元在处理奖励和厌恶信息中起关键作用。奖励性刺激可激活中隔背核(DRN)中的血清素能神经元,而DRN的光遗传激活可诱导奖励性效应。然而,5 -羟色胺神经传递的药理学增强并不诱导奖励或厌恶的影响。这些发现表明,在处理奖励和厌恶信息时,存在另一种血清素能神经元,其作用与DRN相反。先前的研究表明,中缝正中核(MRN)处理负性情绪刺激。为了阐明MRN 5 -羟色胺能神经元在这些过程中的功能,我们记录了小鼠在反应奖励和厌恶刺激时5 -羟色胺能活性的变化。我们还使用光遗传操作来确定这些变化是否会诱导奖励和厌恶行为。MRN - 5 -羟色胺能神经元的活性在奖励刺激后降低,在厌恶刺激后增加。光遗传抑制MRN - 5 -羟色胺能神经元诱导奖励相关行为,而光遗传刺激诱导厌恶相关行为。此外,我们发现从MRN 5 -羟色胺能神经元到脚间核的投射途径对这些过程至关重要。这些结果表明,MRN 5 -羟色胺能神经元在处理奖励和厌恶信息中起关键作用,与DRN神经元相反。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Role of Median Raphe Serotonergic Neurons in Positive and Negative Information Processing].

Serotonergic neurons play a critical role in processing reward and aversive information. Rewarding stimuli activate serotonergic neurons in the dorsal raphe nucleus (DRN), whereas optogenetic activation of DRN serotonergic neurons induces reward-like effects. However, the pharmacological enhancement of serotonin neurotransmission does not induce rewarding or aversive effects. These findings suggest the presence of another serotonergic neuron that plays a role opposite to that of the DRN in processing reward and aversion information. Previous reports suggested that the median raphe nucleus (MRN) processes negative emotional stimuli. To elucidate the function of MRN serotonergic neurons in these processes, we recorded the changes in serotonergic activity in mice in response to rewarding and aversive stimuli. We also used optogenetic manipulation to determine whether these changes could induce rewarding and aversive behaviors. The activity of MRN serotonergic neurons decreased in response to rewarding stimuli and increased after aversive stimuli. Optogenetic inhibition of MRN serotonergic neurons induced reward-related behavior, while optogenetic stimulation induced aversion-related behavior. Furthermore, we found that the projection pathway from MRN serotonergic neurons to the interpeduncular nucleus is crucial for these processes. These results indicate that MRN serotonergic neurons play a pivotal role in processing reward and aversive information, functioning oppositely to DRN neurons.

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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
169
审稿时长
1 months
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