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Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie最新文献

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[Blood group specific properties of leucocyte nuclei (author's transl)]. [白细胞核的血型特异性(作者译)]。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01
V Nagel, D Giannitsis, S Pekker
{"title":"[Blood group specific properties of leucocyte nuclei (author's transl)].","authors":"V Nagel,&nbsp;D Giannitsis,&nbsp;S Pekker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The absorbing and precipitating capacity of leucocyte nuclear suspensions derived from conserved blood of various blood groups was examined with anti-A-, anti-B-, anti-H, anti-M-, anti-N-, and anti-CDE-, and anti-D-sera as well as with anti-AHP- and Evonymus-extracts. Nuclei of blood group A absorbed anti-A, but not anti-B; nuclei of blood group B absorbed anti-B, but not anti-A. Nuclei of blood group 0 absorbed anti-H, but neither anti-A nor anti-B. Anti-M-, anti-N-, anti-CDE-, and anti-D-sera showed no absorption effect after incubation with leucocyte nuclei of corresponding blood groups. A nuclei were strongly precipitated by anti-AHP; B- and 0-nuclei were markedly precipitated by Evonymus-extract. B- and 0-nuclei showed only a weak precipitation with anti-AHP-extract; A-nuclei were only slightly precipitated by Evonymus-extract. Hence, leucocyte nuclei possess blood group specific properties, which, according to the present studies, are limited to certain blood group systems.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"403-13"},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11281973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous occurrence of delayed hypersensitivity to DNA in old NZB mice. 老年NZB小鼠DNA迟发性超敏反应的自发发生。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01
J Pekárek, J Svejcar, J Rovenský, D Zitńan
{"title":"Spontaneous occurrence of delayed hypersensitivity to DNA in old NZB mice.","authors":"J Pekárek,&nbsp;J Svejcar,&nbsp;J Rovenský,&nbsp;D Zitńan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sensitivity of NZB/Bl and NZB/Swiss Fl hybride mice spleen lymphocytes to DNA was examined using the MIF production and inhibition of migration from artificial fragment. The positivity was found in the group of old mice which was considered as an indication of spontaneous autoimmune process. The possible mechanism of this process is discussed.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"384-8"},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11352492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor inhibiting capacity of spleen and lymph node cells from mice with murine sarcoma virus (MSV-M)-induced tumors. 小鼠肉瘤病毒(MSV-M)诱导肿瘤小鼠脾脏和淋巴结细胞的肿瘤抑制能力。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01
E Weiland, M Mussgay
{"title":"Tumor inhibiting capacity of spleen and lymph node cells from mice with murine sarcoma virus (MSV-M)-induced tumors.","authors":"E Weiland,&nbsp;M Mussgay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The direct tumor inhibiting capacity of spleen and lymph node cells obtained from mice in different stages of Moloney sarcoma virus (MSV-M)-induced tumor development was studied. MSV-M producing ascitic tumor cells with a tumor dosis50 of about 10(3) cells and a mean latent period--depending on the amount of transplanted cells--of6-12 days were used as target cells. They were mixed with dilutions of spleen and lymph node cells obtained from mice at various times after infection with MSV-M. The cell mixtures were incubated for 5 hours, then injected into mice, and tumor inhibiting activity was determined after an observation period of 14 days. Tumor inhibiting capacity was demonstrated with cells harvested from mice 8 days after infection with MSV-M, it was strongest with cells obtained at the stage of peak tumor size and during regression, and was still demonstrable with cells taken at the 86th day after infection. Pretreatment of the lymphoid cells with anti-0-antibodies and complement abolished the tumor inhibiting capacity. This result indicates that immune T cells abrogate the capacity of the ascitic tumor cells to induce tumor development.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"414-23"},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11399604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Autoantibodies in the ABO-Ii-system (author's transl)]. [abo - ii系统中的自身抗体(作者译)]。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01
W Graninger
{"title":"[Autoantibodies in the ABO-Ii-system (author's transl)].","authors":"W Graninger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nine cases of autoantibodies in the ABO-system, found by routine investigations, showed the following specificities by agglutination, absorption, and elution techniques: 5 anti-AI, 2 anti-(not-I)-A, I anti-BI and 1 anti-HI. Neutralization experiments by blood group substances revealed heterogeneity among the 5 anti-AI-cases. This is interpreted by different antibody specificities directed against I-antigen components. The relations between the ABO- and Ii-systems are discussed. The occurrence of these antibodies is attributed to oligosaccharides, which are common to both antigen systems. The etiology remains unknown.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"389-402"},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11352493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A micro-method for PHA-induced stimulation of human lymphocytes. I. Communication: Technical considerations (author's transl)]. 一种pha诱导的人体淋巴细胞刺激的微方法。1 .沟通:技术考虑(作者译)]。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
H Pees, A Pappas
{"title":"[A micro-method for PHA-induced stimulation of human lymphocytes. I. Communication: Technical considerations (author's transl)].","authors":"H Pees,&nbsp;A Pappas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A microculture system is described for PHA-induced stimulation of human peripheral lymphocytes. Following purification on Ficoll-Isopaque cells are incubated in microplates (Falcon 3040) for 66 hours in 5% CO2 using PHA-P (Difco) as a stimulant. DNA-synthesis is measured by labelling with 3H-thymidine (spec. act. 400 mCi/mmole) 16 hours prior to the end of the test. Using a multiple automatic sample harvester rapid evaluation is possible. Several variables were analyzed and optimal conditions defined for PHA- and cell-concentration, time dependence, thymidine dosage and buffer capacity of the medium. High variability and otherwise unexplained loss of lymphocyte stimulation in a population of \"normal donors\" are often due to acute viral infections, especially during the incubation period. On the other hand, source and concentration of serum are of equal importance since sera of healthy individuals differ greatly in their capacity to support PHA-induced stimulation of normal allogeneic lymphocytes. Using pooled or autologous serum we found the reproducibility of the technique to be good. Provided optimal conditions are employed the microtest system described herein should be ideal for in-vitro-analysis of inhibitory or stimulating factors in cancer patients' sera.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"309-17"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11349162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane associated antigens of human malignant melanoma. I. Internal labeling, detergent solubilization and characterization by homologous antisera and polyacrylamide gel electrophoresis. 人恶性黑色素瘤的膜相关抗原。1 .内部标记，洗涤剂增溶和同源抗血清和聚丙烯酰胺凝胶电泳表征。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
L Suter, C Sorg, C Müller, R Johannsen, E Macher
{"title":"Membrane associated antigens of human malignant melanoma. I. Internal labeling, detergent solubilization and characterization by homologous antisera and polyacrylamide gel electrophoresis.","authors":"L Suter,&nbsp;C Sorg,&nbsp;C Müller,&nbsp;R Johannsen,&nbsp;E Macher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cultured melanoma cells were labeled with 3H-leucine over a period of 1-3 days. The labeled cells were mechanically disrupted and a preparation of \"extranuclear membranes\" was obtained by differential centrifugation. The membrane fragments were solubilized by the nonionic detergent NP-40 and the soluble material was double precipitated with antisera from melanoma patients and anti-human immunoglobulin sera. Because of the small quantitative differences of precipitated radiolabeled material between control and melanoma patients' sera, the precipitates were further analyzed on SDS-containing polyacrylamide gels. The labeled profiles of experimental and control gels now revealed clearcut differences usually seen in 2-3 characteristic peaks in the molecular weight range from 130,000-330,000.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"318-26"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11349163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-carbohydrate precipitins and haemagglutinins in haemolymph from Tridacna maxima (Röding). 大砗磲血淋巴中的抗碳水化合物沉淀素和血凝素(Röding)。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
G Uhlenbruck, B A Baldo, G Steinhausen
{"title":"Anti-carbohydrate precipitins and haemagglutinins in haemolymph from Tridacna maxima (Röding).","authors":"G Uhlenbruck,&nbsp;B A Baldo,&nbsp;G Steinhausen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Haemolymph from the elongate clam, Tridacna maxima (Röding) readily precipitates with H-blood group substances, pneumococcus type XIV polysaccharide, human milk and salivas, and with a number of polysaccharides which contain the O-SS-D-galactopyranosyl-(1-6)-D-galactose structure. Precipitation has been demonstrated using both gel diffusion and quantitative precipitin methods. T. maxima haemolymph strongly agglutinates human erythrocytes and haemagglutination can be inhibited by the same preparations which precipitate with the clam extract. Precipitins and haemagglutinins are inhibited by N-acetyl-D-galactosamine and by D-galactose residues preferably in ss-linkage. After agar gel immunoelectrophoresis at pH 8.6, T. maxima precipitin arcs are found in the alpha-region. Precipitation and inhibition results suggest that T. maxima extract and purified precipitin, may find widespread application in the study of many biologically important carbohydrates and glycoproteins.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"354-63"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11349166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases. 适当素因子B(富含甘氨酸的β -糖蛋白或C3促活化剂)-多态性:遗传和生化方面。首次应用于亲子关系案件。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
G Mauff, K Hummel, G Pulverer
{"title":"Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.","authors":"G Mauff,&nbsp;K Hummel,&nbsp;G Pulverer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determination of genetic properdin factor B(Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after ageing, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F,F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"327-38"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11349164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Separation of lysozyme from sera with complement or antibody activities (author's transl)]. [从具有补体或抗体活性的血清中分离溶菌酶(作者译)]。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
F Müller, C Oetting, E Beck
{"title":"[Separation of lysozyme from sera with complement or antibody activities (author's transl)].","authors":"F Müller,&nbsp;C Oetting,&nbsp;E Beck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A gel-filtration method for separating lysozyme from sera with haemolytic complement activity and/or antibody activity is described. It is shown that the gel-filtration has only a small effect, whereas bentonite absorption results in a known lost of haemolytic complement activity.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"364-9"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11349167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenesis of neural lesions in Marek's disease. II. Transmission of neural lesions by spleen cells from ill donors (author's transl) ]. 马立克病神经病变的发病机制。2来自患病供体的脾脏细胞传递神经病变[作者译]。
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-10-01
G Hoffmann-Fezer, W Schmahl, R Hoffmann
{"title":"[Pathogenesis of neural lesions in Marek's disease. II. Transmission of neural lesions by spleen cells from ill donors (author's transl) ].","authors":"G Hoffmann-Fezer,&nbsp;W Schmahl,&nbsp;R Hoffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Viable spleen lymphocytes of 13 chickens with clinical and histological signs of Marek's disease were transferred by intravenous injection to 46 chickens 4-10 days old, X-rayed 24 hours before inoculation. Histologically Marek-like neural lesions were almost regularly observed in the chickens after 6-14 days. Chickens having received destroyed spleen lymphocytes of Marek-donors were free of nerve infiltrations. There were also no neural lesions detectable within 14 days after application of pathogenic Marek's disease virus alone, or in combination with viable spleen cells from healthy donors immunized against Marek's disease. These results exclude that the formation of neural lesions 6-14 days following the spleen cell transfer is solely induced by the virus.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"300-8"},"PeriodicalIF":0.0,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11392921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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