Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie最新文献_第3页

Local and systemic opsonic adherent, hemagglutinating and rosette forming activity in mice induced by respiratory immunization with sheep red blood cells. 绵羊红细胞呼吸免疫诱导小鼠的局部和全身粘附、血凝和玫瑰结形成活性。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

S Birnabaum, M Pinto

{"title":"Local and systemic opsonic adherent, hemagglutinating and rosette forming activity in mice induced by respiratory immunization with sheep red blood cells.","authors":"S Birnabaum, M Pinto","doi":"","DOIUrl":"","url":null,"abstract":"The humoral response in mice after intranasal (IN) instillation of sheep red blood cells (SRBC) was compared to that produced by intraperitoneal route of immunization. Study of opsonic adherent (passive indirect cytophilic) and hemagglutinating antibody levels in serum and bronchial washings after repeated challenge with SRBC showed that serum antibody titers following respiratory immunization does not differ from the general pattern of a humoral antibody response. The bronchial wash antibody titer was higher than the serum titer as calculated per globulin unit. In contrast, the appearance of measurable antibodies in the bronchial washings after repeated intraperitoneal immunization was delayed and in low titer. B. pertussis vaccine administered in conjunction with SRBC was found to be an excellent adjuvant in the intranasal route of immunization. A single administration of SRBC-Pertussis evoked a considerable adjuvant effect as measured by hemagglutinating and opsonic adherent tests. Monospecific anti-mouse IgG nullified the hemagglutinating and opsonic adherent activity of the bronchial washings, while monospecific anti-mouse IgM had no effect in either activity. Lung and spleen cells capable of forming rosettes with SRBC of intranasally immunized and control mice were counted. Mean response on day 14 was 6 X 10(3) rosetes per million lung lymphoid cells in comparison with less than 10(3) in control mice. No difference was found in the number of rosette-forming cells in the spleen of control and intranasally immunized mice.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11401189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the mechanism of specific immunological unresponsiveness. II. Immunological properties of lymphoid cells from normal, immunized and immunologically unresponsive mice transferred into lethally irradiated recipients. 特异性免疫无应答机制的研究。2从正常、免疫和免疫无反应小鼠转移到致死性辐照受体的淋巴样细胞的免疫学特性。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

V Tomazic, B Vitale

{"title":"Studies on the mechanism of specific immunological unresponsiveness. II. Immunological properties of lymphoid cells from normal, immunized and immunologically unresponsive mice transferred into lethally irradiated recipients.","authors":"V Tomazic, B Vitale","doi":"","DOIUrl":"","url":null,"abstract":"The immunological capacity of lymphoid cells from mice rendered tolerant to high and low doses of BSA was investigated. The tolerance was induced by multiple injections of high and low doses of antigen through the period of 30 days. Lymph node and bone marrow cells from tolerant animals were transferred into lethally irradiated syngeneic recipients. After 10 days, when lymphoid organs of the recipients were repopulated with the injected cells, challenge injection of the same antigen incorporated into complete Freund's adjuvant was given. The immune response of the transferred cells in the recipients was evaluated by analysis of the specific antibodies in the sera. Lymphoid cells from donors rendered toloerant with high doses of antigen recovered their reactivity 20 days after the transfer to the level of reaction of normal cells. Lymphoid cells from donors receiving multiple injection of low doses of BSA remained tolerant after the transfer through the entire observation period. According to the cellular events in the donors during the period of tolerance induction, and the behaviour of the transferred lymphoid cells in the new recipients, it seems possible that tolerance induced with high doses of BSA corresponded to the B-cell tolerance, while low doses of antigen most likely induced tolerance of T-cell population. The possible cellular mechanisms of B and T-cell tolerance were discussed.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11353600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guinea pig histocompatibility antigens. III. Analysis of normal lymphocyte transfer (NLT) reactions among guinea pigs with serologically defined phenotypes (GPL-AB locus and I region). 豚鼠组织相容性抗原。3血清学定义表型(GPL-AB位点和I区)豚鼠正常淋巴细胞转移(NLT)反应分析

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

K J Tötterman, E Müller, A L de Weck

{"title":"Guinea pig histocompatibility antigens. III. Analysis of normal lymphocyte transfer (NLT) reactions among guinea pigs with serologically defined phenotypes (GPL-AB locus and I region).","authors":"K J Tötterman, E Müller, A L de Weck","doi":"","DOIUrl":"","url":null,"abstract":"The normal lymphocyte transfer (NLT) reaction occurring upon intradermal injection of lymphocytes into a normal recipient may be considered as a kind of mixed lymphocyte reaction in vivo. In previous experiments, we have defined serologically a number of guinea pig lymphocyte antigens, controlled either by a GPL-A locus (equivalent of H-2 D locus in mice) or by a so-called I region (equivalent to the I region in mice). The I region also appears to control a number of immune response genes in the guinea pig. Using guinea pig inbred strains (such as 2, 13, OM3, BE), guinea pig families homozygous for their GPL-A antigens and serologically characterized outbreds, it has been possible to show that antigens of the I region probably play a higher role in NLT reactions. No NLT reactions occur among outbred animals of a closed colony which have been bred to homozygozity for their GPL-A antigens and thereby probably possess haplotype homozygozity for their major histocompatibility complex. The NLT reaction among serologically characterized guinea pigs may become a convenient way to detect new specificities and recombinant progeny.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"78-94"},"PeriodicalIF":0.0,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11353442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A histoautoradiographic study of the localization of antigen and specific antibodies in the rabbit spleen. I. Comparison of the primary and secondary immune response. 兔脾脏抗原和特异性抗体定位的组织放射自显影研究。1 .原发性和继发性免疫反应的比较。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

L Rodák

{"title":"A histoautoradiographic study of the localization of antigen and specific antibodies in the rabbit spleen. I. Comparison of the primary and secondary immune response.","authors":"L Rodák","doi":"","DOIUrl":"","url":null,"abstract":"The localization of antigen (chicken serum albumin) and specific antibodies in sections from the spleens of rabbits after primary and secondary immunization was studied by means of histoautoradiography. After primary immunization, both antigen and antibodies were demonstrated in the lymphoid follicles consistently between 3 and 42 days after injection. Antigen was detected in addition in the marginal zone on the 5th day, and antibody-forming cells in the marginal zone and periarteriolar lymphocyte sheaths between 3 and 9 days after immunization. After secondary immunization, follicular antigen trapping was detected as early as 2 hours after injection, reaching a peak in the follicles and marginal zone on the 3rd day after immunization. At later periods of time the presence of antigen in the follicles was less prominent than that of specific antibodies. The numbers of antibody-forming cells were 10-100-fold higher in the secondary than in the primary response. The findings are discussed in relation to the role of antigen-antibody complex in the lymphoid follicles in the development of the capacity to produce the secondary type of immune response.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"46-60"},"PeriodicalIF":0.0,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11353602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cyclophosphamide on the immune response to sheep erythrocytes in the mouse. II. A study of enzyme activities in the draining lymph node. 环磷酰胺对小鼠对绵羊红细胞免疫反应的影响。2引流淋巴结内酶活性的研究。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

S Mackiewicz, U Mackiewicz, K Burchardt, J Konys

引用次数: 0

Immunoglobulins under the influence of nonspecific factors. III. Immunoglobulins, pertussis antibodies and lysozyme in three child populations exposed to different air pollution. 免疫球蛋白受非特异性因素的影响。3暴露于不同空气污染的三个儿童群体的免疫球蛋白、百日咳抗体和溶菌酶。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1976-03-01

M Wagner, V Wagner, J Kríz, D Wokounová

{"title":"Immunoglobulins under the influence of nonspecific factors. III. Immunoglobulins, pertussis antibodies and lysozyme in three child populations exposed to different air pollution.","authors":"M Wagner, V Wagner, J Kríz, D Wokounová","doi":"","DOIUrl":"","url":null,"abstract":"The levels of IgG, IgA, IgM, lysozyme, agglutinins against B. pertussis and B. parapertussis were followed in the blood serum of 306 children 9--10 years old in 3 areas of Central Bohemian region. In children dwelling in areas with more polluted air significantly higher levels of serum lysozyme and of parapertussis antibodies were found by the t-test. The distribution of these values shows significant differences between more polluted areas in comparison with lower-pollution area also in Kolmogorov-Smirnov test. The average levels of Ig approached statistically critical values but did not reach them, but significant differences in the distribution of values of IgG and IgA were shown by the F-test and chi2-test between lightly and heavily polluted areas. The values of immunological reactions in polluted areas were always higher than in the non-polluted group. This provides evidence for a hypothesis about a stimulatory effect of polluted air on immunological mechanisms in child population. The higher values of IgM observed recently by other authors in women were shown in girls of 9--10 years.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"32-45"},"PeriodicalIF":0.0,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11400385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-synthesis and DNA-methylation in the spleen of immunized mice. 免疫小鼠脾脏dna合成和dna甲基化。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01

D Lutz, H Kröger, W Uecker, D Kubsch, E Mertens

引用次数: 0

[Calculation of the chance of paternity exclusion for the HL-A system (author's transl)]. [计算HL-A系统排除父权的可能性[作者译]。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01

W R Mayr, V Pausch

引用次数: 0

Autoimmunity as possible evoking factor of some so-called idiopathic bone marrow hypoplasias. 自身免疫可能是一些所谓特发性骨髓发育不全的诱发因素。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01

V Chudomel, J T Novák, J Pekárek, J Svejcar, M Láznicka

引用次数: 0

Collagen-induced acute synovitis in collagen-immunized rabbits. 胶原免疫兔胶原诱导的急性滑膜炎。

Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie Pub Date : 1975-11-01

C Steffen, H Ludwig, W Kovac, J Menzel

{"title":"Collagen-induced acute synovitis in collagen-immunized rabbits.","authors":"C Steffen, H Ludwig, W Kovac, J Menzel","doi":"","DOIUrl":"","url":null,"abstract":"Thirty rabbits were investigated in 3 groups: a) one consisting of non-immunized animsls which were injected intraarticularly with human soluble collagen, human gammaglobulin or saline, b) the other consisting of human gammaglobulin-immunized animals which were injected with human soluble collagen and human gammaglobulin into the knee joints, and c) the third consisting of human collagen-immunized rabbits which were injected with human soluble collagen and human gammaglobulin into the knee joints. Eighteen hours after injection animals were sacrificed, joint fluid collected, cell number in fluid determined and synovial tissue prepared for histologic investigation. Distinct acute synovitis was observed in collagen injected knees of collagen immunized rabbits, as shown by distinctly increased cell number in fluids and histologic investigation. In comparison to collagen- or gammaglobulin injected knees of non-immunized animals, increase in cell number of collagen injected knees of collagen injected animals was statistically significant with P less than 0.005 respectively with P less than 0.01, and with P less than 0.025 in comparison to gammaglobulin injected contralateral knee. Distinct acute inflammation was observed morphologically in synovial tissue of collagen injected knees of collagen immunized animals only. Acute synovitis was also observed in positive controls, i.e. gammaglobulin injected knees of gammaglobulin immunized animals. These observations show, that appearance of collagen in molecular disposable form can induce acute inflammation of joints in state of collagen immunization.","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"432-46"},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11281974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0