{"title":"Effect of cyclophosphamide on the immune response to sheep erythrocytes in the mouse. II. A study of enzyme activities in the draining lymph node.","authors":"S Mackiewicz, U Mackiewicz, K Burchardt, J Konys","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Young adult CFW mice, injected with sheep erythrocytes, were treated with cyclophosphamide and sacrificed at different times. The activity of acid phosphatase and for non-specific esterase was measured by semi-quantitative methods in smears prepared from cell suspension of draining lymph node. In cyclophosphamide-treated mice was noted a significant decrease in acid phosphatase activity in lymphoid cells, expressed both as average activity in single lymphoid cell and a decrease in proportion of cells exhibiting enzyme activity. Also a short-term decrease was observed in activity of non-specific esterase caused both by disappearance of highly active large lymphoid and blast cells as well as decrease in percentage of enzyme-positive small lymphocytes.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 1-2","pages":"13-21"},"PeriodicalIF":0.0000,"publicationDate":"1976-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Young adult CFW mice, injected with sheep erythrocytes, were treated with cyclophosphamide and sacrificed at different times. The activity of acid phosphatase and for non-specific esterase was measured by semi-quantitative methods in smears prepared from cell suspension of draining lymph node. In cyclophosphamide-treated mice was noted a significant decrease in acid phosphatase activity in lymphoid cells, expressed both as average activity in single lymphoid cell and a decrease in proportion of cells exhibiting enzyme activity. Also a short-term decrease was observed in activity of non-specific esterase caused both by disappearance of highly active large lymphoid and blast cells as well as decrease in percentage of enzyme-positive small lymphocytes.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
