World Journal of Gastrointestinal Oncology最新文献

{"title":"Primary squamous cell carcinoma of the descending colon with pancreatic metastasis: A case report.","authors":"Rui-Rui Hu, Mei Liu, Hong-Yun Li","doi":"10.4251/wjgo.v17.i6.107272","DOIUrl":"10.4251/wjgo.v17.i6.107272","url":null,"abstract":"<p><strong>Background: </strong>Squamous cell carcinoma (SCC) of the colon is a rare malignant tumor with an unclear pathogenesis. Its clinical presentation is similar to that of adenocarcinoma, and there are no standard treatment guidelines. Treatment for SCC of the colon is mainly based on the protocols for colon adenocarcinoma. In advanced stages, colon SCC is highly invasive, prone to distant metastasis, and has a worse prognosis than adenocarcinoma. Furthermore, pancreatic metastasis from colon SCC is even rarer.</p><p><strong>Case summary: </strong>The patient presented with abdominal pain and was diagnosed with SCC of the descending colon following colonoscopy. Preoperative examinations did not reveal any obvious metastasis to other organs, and the patient underwent laparoscopic radical resection of the descending colon cancer. During surgery, suspicious metastases to the pancreatic body and tail, splenic vessels, and splenic hilum were found, leading to combined resection of the pancreatic body and tail along with the spleen. Postoperative pathology confirmed moderately to poorly differentiated SCC with nerve invasion. The patient developed postoperative complications, including abdominal cavity infection, acute myocardial infarction, and deep vein thrombosis in the lower limbs. Despite active symptomatic treatment and stabilization of the patient's vital signs, the patient did not undergo adjuvant chemotherapy due to an Eastern Cooperative Oncology Group score of 3. The patient passed away 3 months postoperatively due to multiple organ failure.</p><p><strong>Conclusion: </strong>This case highlights the aggressive nature of colorectal SCC with atypical metastasis and underscores the necessity for multidisciplinary perioperative management.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 6","pages":"107272"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation <i>via</i> cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling.","authors":"Ya-Tao Wang, Yu-Le Yong, Ze-Kun Liu, Yi-Xuan Shen, Xiang-Min Yang, Zhi-Nan Chen","doi":"10.4251/wjgo.v17.i6.106080","DOIUrl":"10.4251/wjgo.v17.i6.106080","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) ranks among the most prevalent and deadly malignancies, characterized by a high recurrence rate. Regulator of chromosome condensation 1 (RCC1) serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase (GTPase) and is implicated in various cancers. However, the role of RCC1 in HCC remains unexplored.</p><p><strong>Aim: </strong>To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.</p><p><strong>Methods: </strong>Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy. The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells. Furthermore, quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.</p><p><strong>Results: </strong>Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients. Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells, especially the proliferation of HCC cells, whereas RCC1 knockdown had the opposite effect. Mechanistically, we identified cell division cycle-associated (CDCA) 8 as a downstream target of RCC1 in HCC. RCC1 overexpression markedly increased CDCA8 levels, consequently enhancing cell proliferation and survival in HCC cells. Additionally, we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.</p><p><strong>Conclusion: </strong>Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 6","pages":"106080"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population.","authors":"Shashank Kumar","doi":"10.4251/wjgo.v17.i6.102687","DOIUrl":"10.4251/wjgo.v17.i6.102687","url":null,"abstract":"<p><p>Lin <i>et al</i>'s investigation on the association of activin A receptor type 1C (ACVR1C) (transforming growth factor beta type I receptor) single nucleotide polymorphisms (SNPs) with esophageal squamous cell carcinoma (ESCC) risk in the Chinese population is a scientific approach. This study explores the susceptibility of ACVR1C polymorphism towards ESCC in the Chinese population, highlighting the polymorphism's potentiality as an early diagnostic and therapeutic target. The author assessed about a thousand ESCC Chinese patients' samples for ACVR1C SNPs in a hospital-based cohort study using the ligation detection reaction method. Further, the hypothesis was tested using appropriate statistical genetic models and stratified analysis. ACVR1C SNPs can help assess ESCC susceptibility stratification and provide valuable information for individual diagnosis and treatment of ESCC patients. In order to account for confounding variables, find genuine SNP-disease relationships, boost statistical power, and make biological interpretation easier, it is imperative that genetic association studies of ESCC incorporate pertinent clinical aspects.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 6","pages":"102687"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of gastrointestinal endoscopy center care on the psychological state and pain level of colorectal cancer patients.","authors":"Yu-Hong Dai, Shi Lang Zhuo-Ma, Yu-Hua Luo","doi":"10.4251/wjgo.v17.i6.106154","DOIUrl":"10.4251/wjgo.v17.i6.106154","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) has become the third leading cancer with the third highest occurrence rate and the second highest death ratio globally. Its incidence and mortality rates have been increasing annually in recent years, posing a serious threat to global public health. Digestive endoscopy technology can not only be used for the diagnosis of CRC, but it can also be used in determining the depth of infiltration in early CRC. There are significant deficiencies in care measures in this area.</p><p><strong>Aim: </strong>To investigate the effect of digestive endoscopy center nursing on the psychological state and pain level of CRC patients.</p><p><strong>Methods: </strong>A total of 120 CRC patients were randomly and equally divided into a control group and an observation group. The patients in the control group received basic routine nursing care, and the patients in the observation group received systematic digestive endoscopy center nursing care. The patients' compliance and nursing satisfaction were observed and recorded, as well as the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and Visual Analogue Scale (VAS) scores.</p><p><strong>Results: </strong>After care, the SAS and SDS scale scores of patients in both groups significantly decreased compared to before care (<i>P</i> < 0.05). The VAS scale scores significantly increased for each group compared to before examination (<i>P</i> < 0.05). The SAS, SDS and VAS scale scores of the observation group were significantly lower than those of the control group after nursing care (<i>P</i> < 0.05), and compliance and satisfaction of nursing care were significantly higher than those of the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Digestive endoscopy center nursing can effectively intervene in and improve the psychological state and pain level of CRC patients, suggesting it is a valuable approach to adopt in the clinic.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 6","pages":"106154"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevating surgical standards: The role of intraperitoneal isoperistaltic side-to-side anastomosis in colon cancer surgery.","authors":"Sung Uk Bae","doi":"10.4251/wjgo.v17.i6.106645","DOIUrl":"10.4251/wjgo.v17.i6.106645","url":null,"abstract":"<p><p>Since its introduction in 1991, laparoscopic right colectomy has been the standard surgical treatment for benign and malignant right colon diseases. Extracorporeal anastomosis (ECA) is the most commonly used anastomotic technique. However, intracorporeal anastomosis (ICA) has emerged as a promising alternative because of its potential advantages. Recently, Wu <i>et al</i> provided compelling evidence supporting superiority of ICA over ECA, demonstrating reduced blood loss, smaller incisions, and faster postoperative recovery without increased complications. Despite these benefits, ICA presents certain challenges such as longer operative times and technical difficulties. However, advances in minimally invasive surgery, including robot-assisted platforms, may facilitate broader adoption of ICA by addressing the technical limitations. Furthermore, meticulous surgical techniques and perioperative infection control strategies are essential for mitigating intra-abdominal infectious complications. Given the increasing adoption of ICA in minimally invasive right hemicolectomy, further studies, including multicenter randomized controlled trials, are necessary to confirm its oncological safety and establish standardized surgical protocols. Overall, ICA has the potential to become the preferred anastomotic approach in both laparoscopic and robotic colorectal surgeries.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 6","pages":"106645"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram-based strategy to predict relapse-free survival in patients with gastrointestinal stromal tumor using inflammatory indicators.","authors":"Shashank Kumar","doi":"10.4251/wjgo.v17.i5.103127","DOIUrl":"10.4251/wjgo.v17.i5.103127","url":null,"abstract":"<p><p>Zhao <i>et al</i>'s investigation on the assessment of inflammatory markers prognostic value for relapse-free survival in patients with gastrointestinal stromal tumor (GIST) using a nomogram-based approach is a scientific approach. This study explored the potential of an inflammatory marker-based nomograph model, highlighting the relapse-free survival-associated risk factors prognostic potential in patients with GIST. The author assessed 124 samples from patients with GIST to find an association between inflammatory markers and tumor size in a retrospective study using multivariate regression analysis. Further, a nomogram model was developed to identify the independent risk factors for the prognosis. GIST clinical treatment can use preoperative monocyte/lymphocyte ratio and platelet/lymphocyte ratio for relapse-free survival prognosis as independent factors.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 5","pages":"103127"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research status and progress of deep learning in automatic esophageal cancer detection.","authors":"Jing Chen, Xin Fan, Qiao-Liang Chen, Wei Ren, Qi Li, Dong Wang, Jian He","doi":"10.4251/wjgo.v17.i5.104410","DOIUrl":"10.4251/wjgo.v17.i5.104410","url":null,"abstract":"<p><p>Esophageal cancer (EC), a common malignant tumor of the digestive tract, requires early diagnosis and timely treatment to improve patient prognosis. Automated detection of EC using medical imaging has the potential to increase screening efficiency and diagnostic accuracy, thereby significantly improving long-term survival rates and the quality of life of patients. Recent advances in deep learning (DL), particularly convolutional neural networks, have demonstrated remarkable performance in medical imaging analysis. These techniques have shown significant progress in the automated identification of malignant tumors, quantitative analysis of lesions, and improvement in diagnostic accuracy and efficiency. This article comprehensively examines the research progress of DL in medical imaging for EC, covering various imaging modalities such as digital pathology, endoscopy, computed tomography, <i>etc.</i> It explores the clinical value and application prospects of DL in EC screening and diagnosis. Additionally, the article addresses several critical challenges that must be overcome for the clinical translation of DL techniques, including constructing high-quality datasets, promoting multimodal feature fusion, and optimizing artificial intelligence-clinical workflow integration. By providing a detailed overview of the current state of DL in EC imaging and highlighting the key challenges and future directions, this article aims to guide future research and facilitate the clinical implementation of DL technologies in EC management, ultimately contributing to better patient outcomes.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 5","pages":"104410"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>SPDL1</i> inhibition enhances colorectal cancer progression <i>via</i> epidermal growth factor receptor/extracellular signal-regulated kinase pathways.","authors":"Peng Peng, Juan Sun, Meng-Shi Li, Ruo-Xi Cheng, Shi-Quan Liu, Meng-Bin Qin, Jin-Xiu Zhang, Jie-An Huang","doi":"10.4251/wjgo.v17.i5.104686","DOIUrl":"10.4251/wjgo.v17.i5.104686","url":null,"abstract":"<p><strong>Background: </strong>In patients with colorectal cancer (CRC), tumour metastasis is the leading cause of death. The search for key genes involved in metastasis of CRC is imperative for improved prognoses and treatments. <i>SPDL1</i> has been implicated in the development of CRC, however, its mechanism of action remains unclear.</p><p><strong>Aim: </strong>To investigate the role and mechanism of action by which SPDL1 inhibits the development and metastasis of CRC.</p><p><strong>Methods: </strong>In this study, we examined the relationship between SPDL1 expression and CRC prognosis using immunohistochemistry. Survival analyses were performed using Kaplan-Meier analysis and log-rank test. After knocking down SPDL1 in the HCT116 cancer cell line changes in cell viability, migration, invasion, and gene expression were examined using a cell counting kit 8 assay, Transwell assay, and Western blot. The effect of SPDL1 on the cell cycle was assessed using flow cytometry. RNA sequencing was used to analyse the effect of SPDL1 on gene expression of CRC cells. The mechanism of action of SPDL1 in CRC was further clarified using U0126, an inhibitor of the mitogen-activated protein kinase signaling pathway.</p><p><strong>Results: </strong>SPDL1 is expressed at low levels in tissues of patients with CRC, and this reduced expression is associated with poor prognosis. Functionally, low expression of SPDL1 in CRC promotes cell proliferation, migration, invasion, and affects the cell cycle. Mechanistically, SPDL1 affects the progression of CRC through its regulation of the process of epithelial-mesenchymal transition (EMT) and of the epidermal growth factor receptor (EGFR)/ extracellular signal-regulated kinase (ERK) signaling pathways.</p><p><strong>Conclusion: </strong>This study showed that the loss of SPDL1 may induce EMT and promote cell migration and invasion in CRC through the EGFR/ERK pathway.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 5","pages":"104686"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in diagnosis and treatment of gallbladder cancer: Current status and future directions.","authors":"Song Xu, Ming Xu","doi":"10.4251/wjgo.v17.i5.104957","DOIUrl":"10.4251/wjgo.v17.i5.104957","url":null,"abstract":"<p><p>Gallbladder cancer (GBC) is a rare but aggressive cancer that often presents subtle early symptoms, leading to late-stage diagnosis. In recent years, significant advancements have been made in early detection and treatment of GBC. These improvements are driven by a better understanding of the risk factors for this malignancy and the use of new diagnostic technologies. This review systematically examines the risk factors associated with GBC, and advancements in diagnostic techniques and treatment strategies, with an aim to enhance the early diagnosis and effective management of GBC to provide a valuable reference for clinical practice.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 5","pages":"104957"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between prognostic markers and clinical parameters in hepatocellular carcinoma: Pathophysiological aspects to therapeutic targets.","authors":"Saira Rafaqat, Iqra Noshair, Momina Shahid, Sadaf Bibi, Ramsha Hafeez, Hafsa Hamid","doi":"10.4251/wjgo.v17.i5.106278","DOIUrl":"10.4251/wjgo.v17.i5.106278","url":null,"abstract":"<p><p>One of the main causes of cancer-related morbidity and mortality globally is hepatocellular carcinoma (HCC). At every stage of the disease, HCC may now be treated using a variety of therapy techniques. Nevertheless, despite the abundance of effective therapeutic choices, the prognosis for patients with HCC is still typically dismal. Prognostic indicators are crucial when assessing prognosis and tracking tumor metastases or recurrence. There are many prognostic markers in HCC. We mainly focused on newly reported prognostic markers such as MEX3A, apolipoprotein B, alpha-fetoprotein, circulating tumor cells, SAMD13, Agrin, and Glypican-3 in the pathogenesis of HCC. Further, we highlighted how these prognostic markers correlated to clinical parameters such as tumor node metastasis, tumor diameter, differentiation, hepatocirrhosis, vascular invasion, and others in HCC. Therefore, identifying specific prognostic biomarkers of HCC helps to provide a great opportunity to improve the prognosis in patients with HCC and provide therapeutic targets.</p>","PeriodicalId":23762,"journal":{"name":"World Journal of Gastrointestinal Oncology","volume":"17 5","pages":"106278"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}