World Journal of Traditional Chinese Medicine最新文献

{"title":"Shenyi capsule prolongs postoperative survival of patients with nonsmall cell lung cancer: A multicenter, randomized, controlled trial","authors":"Dao-rui Li, W. Hou, B. Hua, Pei-tong Zhang, Lu Xiong, Hao Liu, Qi-Yuan Mao, Hong-Sheng Lin, B. Piao","doi":"10.4103/2311-8571.382023","DOIUrl":"https://doi.org/10.4103/2311-8571.382023","url":null,"abstract":"Objective: The objective of this study was to examine the effect of the postsurgical administration of Shenyi capsules on the outcome and overall survival of patients with nonsmall cell lung cancer (NSCLC). Materials and Methods: This was a multicenter, randomized, placebo-controlled, double-blind clinical trial. Patients with stages I–IIIA NSCLC were randomized to Shenyi or placebo groups (treatment duration: 6 months) and followed up for 10 years. One-year, 2-year, 5-year, and 10-year survival rates and survival times were calculated. Symptoms, quality of life, traditional Chinese medicine (TCM) syndrome, and recurrence were evaluated. Results: A total of 361 patients (treatment group, n = 185; placebo group, n = 176) were randomized and followed up for 10 years. The two groups had similar baseline demographic and clinical characteristics. Among all 361 patients, the treatment group had significantly longer median survival (31 months, respectively) than the placebo group (22.3 months, P < 0.01). In stage II or III patients, recurrence and metastasis rates in the treatment group were lower than those in the placebo group (P < 0.05). The treatment group also had significantly longer 1-year and 2-year survival rates based on the full analysis set and per-protocol set; however, there was no statistically significant difference in the 5-year and 10-year survival rates (P < 0.01 for all comparisons). Multivariate analysis of variance showed that the interaction between stage and age had a significant impact on overall survival (P < 0.05). Compared with the placebo group, the treatment group showed a significant decrease in TCM syndrome (P < 0.01) and a significant increase in the Karnofsky Performance Score (P < 0.01) and body weight (P < 0.05). Conclusions: Adjunctive therapy with Shenyi capsules significantly prolonged the 1-year and 2-year survival rates after surgery and improved the quality of life. Moreover, none of the patients experienced severe adverse effects. These results suggest that Shenyi capsules may have clinical applications in treating patients with NSCLC.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"314 - 321"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43740398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of ayurvedic medicines and extracts of medicinal plants as an alternative therapeutic treatment option for nephrolithiasis","authors":"S. Sachdeva, Jaspreet Kaur, Sanjana Mehta, Renu Saharan, Parminder Nain","doi":"10.4103/2311-8571.351512","DOIUrl":"https://doi.org/10.4103/2311-8571.351512","url":null,"abstract":"The incidence of nephrolithiasis, commonly known as kidney stone, is increasing worldwide with significant health and economic burden. Approximately 2 million people every year in India are affected by kidney stones. It affects all ages, genders, and races, but between the ages of 20 and 49 years, it affects most frequently in men than women. Different types of stones include calcium stones, cysteine stones, struvite or magnesium ammonium phosphate stones, uric acid stones, and drug-induced stones. This review article provides information about general pathophysiology, epidemiology, clinical presentation, and pharmacological treatment, which includes ayurvedic and herbal medicines for nephrolithiasis. Further understanding of the pathophysiological link between nephrolithiasis and systemic disorders is necessary for the development of new therapeutic options.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"278 - 283"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46397134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on Rodgersia and predictive analysis on its quality markers","authors":"Ling-Ling Chu, Bin Li, Jia Wu, Ling Jiang, Xudong Zhou, Wen-bing Sheng, Cai-yun Peng, Salman Zafar, Ping-an Liu, Wei Wang","doi":"10.4103/2311-8571.343650","DOIUrl":"https://doi.org/10.4103/2311-8571.343650","url":null,"abstract":"Rodgersia is a traditional Chinese medicine that contains a variety of chemical constituents, including flavonoids, terpenoids, phenylpropanoids, gallic acid derivatives, steroids, volatile oils, and tannins, with anti-inflammatory, antioxidant, antitumor, antibacterial, antivirus, hepatoprotective, and other properties. In this paper, the main chemical constituents and pharmacological effects of Rodgersia are summarized. On this basis, the quality markers of this genus were predicted based on chemical composition, traditional medicinal properties, traditional efficacy, and measurable components. This review provides the basis for in-depth research, utilization, and quality control of Rodgersia.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"243 - 257"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43962135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herb formulae inhibit the proliferation of human colon cancer SW480 cells by inducing cell apoptosis","authors":"Su Fu, Shaojia Qin, W. Rausch","doi":"10.4103/2311-8571.369650","DOIUrl":"https://doi.org/10.4103/2311-8571.369650","url":null,"abstract":"Objective: This study aimed to reveal the antitumor effects of Chinese herbal formulae and the underlying mechanisms in treating colorectal cancer, with a focus on developing traditional Chinese medicine (TCM) as a supplement and alternative therapeutic method for cancers. Materials and Methods: Human colon cancer SW480 cells were treated with three Chinese herbal formulae, Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction at different concentrations (50–600 μg/mL) for 24, 36, and 48 h, respectively. Cell viability was determined using the resazurin reduction assay, and cell survival rate was evaluated using a colony formation assay. After treatment with different concentrations (50–600 μg/mL) of these three formulae for 48 h, the effects of the Chinese herbal formulae on cell apoptosis were investigated using Hoechst/propidium iodide (PI) staining. The positive PI-stained cells were investigated using an EnSpire multilabel plate reader and the positive Hoechst-stained cells were observed under a fluorescence microscope for morphological changes. Results: Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction inhibited SW480 cell proliferation in a dose-and time-dependent manner and induced cell apoptosis. Conclusion: Chinese herbal formulae with a special prescription form of TCM with antitumor effects bring a new perspective in line with the principles of TCM in cancer treatment.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"348 - 354"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45649323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of wuweijiangyasan in the treatment of spontaneous hypertension based on network pharmacology","authors":"Jiangxue Zhou, Huizhen Zhao, Ai-ping Chen, Zijuan Zhang, Jingzhou Li, Ling Zuo, Yajun Cheng, D. Deng, Xue-Li Li, Xiao-yun Ma, Da Man, Ming Zheng, Jing Chen, Bo Wen, Juan Wang","doi":"10.4103/2311-8571.351793","DOIUrl":"https://doi.org/10.4103/2311-8571.351793","url":null,"abstract":"Background: Hypertension affects over 1 billion people globally and is the top risk factor of cardiovascular morbidity and mortality. Wuweijiangyasan (WWJYS), as an empirical prescription, has stable depressurization effects. This study investigated the chemical composition and pharmacodynamic effects of WWJYS in regulating the blood pressure (BP), emotion, and blood lipid of spontaneous hypertensive rats, and further explored the depressurization mechanism of WWJYS. Materials and Methods: This study used network pharmacology to identify the origins and predict targets of WWJYS, and artificial intelligence-based molecular docking is used to further predict targets and mechanisms. The chemical constituents of WWJYS were analyzed and identified by ultra high-performance liquid chromatography–mass spectrometry (MS)/MS. Results: In the WWJYS group, the systolic BP level significantly was decreased, and the HR was stable. The irritability became stable after the 5-week treatment compared with the model group (P < 0.05). Rats' rotation tolerance time increased after 2-weeks stabilization. Compared with the model group, angiotensin-converting enzyme 2 protein and mRNA of the WWJYS group increased significantly (P < 0.05). Network pharmacology collected 64 compounds and identified 22 potential targets of WWJYS for antihypertensive activity. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that WWJYS might regulate smooth muscle cells, affect inflammatory response and improve endothelial function through multiple pathways. The molecular docking study further supported that the target proteins have good combinations with the main active components of WWJYS. Conclusions: The data indicated that WWJYS had significant depressurization, analgesic, and sedative, as well as lipid-lowering effects, and the depressurization mechanism of WWJYS may function in multiple signal pathways, especially in improving blood vessel function and intervening inflammation.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"355 - 368"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45003622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of essential oils as alternative permeation enhancers for transdermal delivery","authors":"Jayshree Mahanty, Sofi Rasheed, Sudhir Kumar, Harjeet Singh, Alok K. Sharma","doi":"10.4103/2311-8571.351508","DOIUrl":"https://doi.org/10.4103/2311-8571.351508","url":null,"abstract":"Transdermal drug delivery plays a significant part in the drug delivery system when compared to other routes of drug administration. The function of the stratum corneum (SC) is a barrier. Recently, numerous methods have been thrived to improve the perforation of drugs across the skin. The most effective method is to use enhancers since these agents enhance skin permeability. Natural penetration enhancers like essential oils demonstrate higher enhancement activity and are more widely accepted than synthetic penetration enhancers. High potential in the expansion and interaction with the SC intercellular lipids has led to an increasing interest in these oils as penetration enhancers. This article gives an overview of a few essential oils, including their mode of action and important parameters for permeation improvement. The present work can provide essential oils as alternative enhancers, and this could be useful in transdermal administration.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"258 - 269"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43940737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and duration of electro-acupuncture combined with conventional antipsychotics for schizophrenia: A meta-analysis","authors":"Zhao-han Huang, Yuan Fang, Q. Yu, Tong Wang","doi":"10.4103/2311-8571.372173","DOIUrl":"https://doi.org/10.4103/2311-8571.372173","url":null,"abstract":"Introduction: This study aimed to evaluate the effectiveness and optimal course time of electro-acupuncture (EA) combined with conventional antipsychotics in the treatment of schizophrenia (SZ) and to provide a basis for its clinical application. Methods: Relevant databases and authoritative websites were retrieved, and references were screened up to May 2021. Literature quality evaluation and data extraction were carried out according to the requirements of Cochrane version 5.1.0, and meta-analysis was conducted using Rav Man5.4 software. Results: In total, 16 randomized controlled trails comprising 1352 patients were selected. Meta-analysis revealed that the observation group showed greater improvements than the control group in total clinical efficacy (P < 0.00001, odds ratio [OR] = 3.51, 95% confidence interval [CI] = [2.51, 4.91]), as well as better effective rate of symptom relief (P = 0.02, MD = 3.08, 95% CI = [1.23, 7.71]), and an improved negative symptom score (P = 0.005, MD = −4.50, 95% CI = [−6.52, −2.48]), positive symptom score (P < 0.0001, MD = −1.41, 95% CI = [−2.25, −0.57]), total score (P = 0.001, MD = 9.25, 95% CI = [13.03, 5.47]), and general psychopathological score (P < 0.0001, MD = −2.30, 95% CI = [−4.18, −0.43]) in the Positive and Negative Syndrome Scale (PANSS). However, there was no statistically significant difference between the two groups in the effective rate of adverse reactions (P > 0.05). In the 4–6 weeks following treatment, a significant improvement in all the four components of the PANSS scores was observed in the observation group. Conclusion: The efficacy of EA combined with conventional antipsychotics for SZ is better than that of psychiatric drugs alone. In addition, the effect of a 4-to 6-week treatment course on each outcome index is more significant, and the efficacy is higher.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"212 - 223"},"PeriodicalIF":4.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42889089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-based and pharmacological evaluation of the effects of Curcumae Radix on cerebral ischemia–Reperfusion injury","authors":"Shang-Xia Zhang, Yu-Hong Wang, Hongping Long, Jian Liu, Hong Zhaoa, J. Yi, Jia Ling","doi":"10.4103/2311-8571.370154","DOIUrl":"https://doi.org/10.4103/2311-8571.370154","url":null,"abstract":"Objective: This study aimed to investigate the network pharmacology of curcumae radix (CR, Yujin) and explore the mechanism of CR in the treatment of cerebral ischemia–reperfusion injury (CIRI). Materials and Methods: Network analysis and pharmacological evaluation were performed to explore the protective role of CR to treat CIRI. The potential target genes of the active components and CIRI were identified using SwissTarget Prediction, Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine, GeneCards, and Online Mendelian Inheritance in Man. Furthermore, network analysis was performed using Cytoscape software. Gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed using the R software. In vivo experiments were performed using the water extract of CR (WECR) on PC12 cells induced by hypoxia/reoxygenation (H/R) to simulate ischemia/reperfusion injury. Results: The results exhibited that 21 active compounds identified in CR were associated with 73 targets of CIRI. Functional analysis showed that multiple pathways, including response to stress, regulation of apoptotic process, and hypoxia-inducible factor 1 signaling pathway, were significantly enriched. In addition, STAT3, IL4, HIFIA, and CTNNB1 were predicted to be the most important genes among the 36 hub genes. Furthermore, WECR treatment significantly improved PC12 cell injury and decreased apoptosis levels in cells induced by H/R, with malondialdehyde contents reduced and superoxide dismutase or glutathione peroxidase levels increased. Conclusions: Network analysis and pharmacological evaluation of CR could provide valuable directions for further research on CR and improve comprehension of CIRI.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"201 - 211"},"PeriodicalIF":4.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43294660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and refinement of two interpretable models for coronavirus disease 2019 prognosis prediction","authors":"Xue-zhong Zhou, Kai Chang, Ting Jia, Yana Zhou, Zixin Shu, Ji-Fen Liu, Jing Sun, Qiguang Zheng, Hao-Yu Tian, Jia-Nan Xia, Kuo Yang, Ning Wang, Hai-long Sun, Xinyan Wang, Deng-Ying Yan, Taane G. Clark, Baoyi Liu, Xiao-Dong Li, Yong Peng","doi":"10.4103/2311-8571.372326","DOIUrl":"https://doi.org/10.4103/2311-8571.372326","url":null,"abstract":"Objective: To validate two proposed coronavirus disease 2019 (COVID-19) prognosis models, analyze the characteristics of different models, consider the performance of models in predicting different outcomes, and provide new insights into the development and use of artificial intelligence (AI) predictive models in clinical decision-making for COVID-19 and other diseases. Materials and Methods: We compared two proposed prediction models for COVID-19 prognosis that use a decision tree and logistic regression modeling. We evaluated the effectiveness of different model-building strategies using laboratory tests and/or clinical record data, their sensitivity and robustness to the timings of records used and the presence of missing data, and their predictive performance and capabilities in single-site and multicenter settings. Results: The predictive accuracies of the two models after retraining were improved to 93.2% and 93.9%, compared with that of the models directly used, with accuracies of 84.3% and 87.9%, indicating that the prediction models could not be used directly and require retraining based on actual data. In addition, based on the prediction model, new features obtained by model comparison and literature evidence were transferred to integrate the new models with better performance. Conclusions: Comparing the characteristics and differences of datasets used in model training, effective model verification, and a fusion of models is necessary in improving the performance of AI models.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"191 - 200"},"PeriodicalIF":4.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42578159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, purification, and anti-Inflammatory activity of steroid fraction from Physalis Alkekengi L. Var. Franchetii (Mast.) makino","authors":"Zunpeng Shu, Tianyi Xia, Yi Wang, Yanni Yang, Wuchao Wang, Zihe Ding, Renxing Zhong, Ying Chen, Wei Li, Mingming Peng, Chuan Li, Lifeng Shang, Bingchun Liu, Zhen-Yue Wang, Chong-Rong Shi","doi":"10.4103/2311-8571.372143","DOIUrl":"https://doi.org/10.4103/2311-8571.372143","url":null,"abstract":"Objective: As a traditional medicinal plant listed in the Chinese Pharmacopeia, Physalis alkekengi L. var. franchetii (Mast.) Makino (PAF) has a long medicinal history and high economic value. PAF has immunomodulatory properties and can be used to treat acute lung injury and eczema. The aim of this study is to solve the problems of extraction and purification of active components from PAF. Materials and Methods: The solvent to be used for extraction and its concentration, the solid-to-liquid ratio, and extraction duration were investigated using a single-factor experiment. An orthogonal design (L9[34]) was used to determine the optimum extraction conditions. After optimization, the sample's concentrations and flow velocity, the eluents and their velocity, adsorption time, and the removed water volume were measured. The content of the five steroids in the sample was determined by high-performance liquid chromatography (HPLC). We also investigated the anti-inflammatory property of PAF calyxes before and after purification. Results: The optimum extraction and purification processes were determined by single-factor analysis. AB-8 was identified as the best macroporous adsorption resin for enrichment. After optimization, the average total steroid content was 71.83%, and the average recovery was 90% after purification. Among the five steroid components detected by HPLC, physalin F showed the highest content. Furthermore, the sample obtained after purification could significantly inhibit paw edema by egg whites induced. Conclusions: An environmentally-sustainable, efficient, and stable process was first optimized for enriching and purifying total steroids from PAF. The process has the potential for further development and utilization in the pharmaceutical industry.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"167 - 177"},"PeriodicalIF":4.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46307561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}