World Journal of Traditional Chinese Medicine最新文献

{"title":"Rapid Discovery, Guided Isolation, and Mechanism Study of Anti-neuroinflammatory Constituents from Glycosmis craibii var. glabra Targeting 5-LOX","authors":"Hongwei Chen, M. Ding, Shizhong Chen, Wenfu Tan, Y. S. Lin, Shuo Yuan, Li Li, Xinnuo Tong, Kewu Zeng, Pengfei Tu, Yong Jiang","doi":"10.4103/wjtcm.wjtcm_23_25","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_23_25","url":null,"abstract":"Abstract Objective: In this study, we aimed to screen and identify potent 5-lipoxygenase (5-LOX) inhibitors in Glycosmis craibii var. glabra extract and elucidate the mechanisms underlying their inhibitory effects. Materials and Methods: A 95% ethanol extract of G. craibii var. glabra was analyzed using an online ultra-performance liquid chromatography–photodiode array–5-LOX–fluorescence detector (UPLC–PDA–5-LOX–FLD) system. Guided by liquid chromatography–diode array detection/mass spectrometry (LC-DAD/MS) analysis, major peaks were isolated using various chromatographic techniques, and their structures were determined using high-resolution electrospray ionization mass spectrometry (HRESIMS), one-dimensional/two-dimensional nuclear magnetic resonance (1D/2D NMR), and electronic circular dichroism (ECD) data. Molecular docking, surface plasmon resonance (SPR) assays, and enzyme activity assays were performed to evaluate the binding capacity and inhibitory effects of the isolated compounds on 5-LOX. The anti-neuroinflammatory activities and mechanisms of action of these compounds were further examined in lipopolysaccharide (LPS)-stimulated BV-2 cells. Results: Eight main peaks were detected using the online UPLC–PDA–5-LOX–FLD system: one coumarin ( 1 ), one quinoline ( 2 ), three quinolones ( 3, 5, 8 ), and three flavonoids ( 4, 6, 7 ). Among these, compounds 4 and 5 were newly characterized, while compounds 5 and 6 exhibited the strongest binding affinity for 5-LOX. Mechanistic investigations revealed that compounds 5 and 6 suppressed TNF-α and IL-6 expression in LPS-stimulated BV-2 cells in a concentration-dependent manner by modulating the 5-LOX/CysLT 1 R pathway. Conclusions: This study successfully employed an online UPLC–PDA–5-LOX–FLD system to identify two major anti-inflammatory components of G. craibii var. glabra that target 5-LOX and exert their effects by regulating the 5-LOX/CysLT 1 R pathway.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huangqi Guizhi Wuwu Decoction Alleviates Oxaliplatin-Induced Peripheral Neuropathy by Reducing the Abundance of Akkermansia Muciniphila","authors":"Xi Chen, Zhengwei Zhang, Y Wang, Peng Cao, Zhen Zhu, Yang Yang","doi":"10.4103/wjtcm.wjtcm_97_24","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_97_24","url":null,"abstract":"Objective: Oxaliplatin-induced peripheral neuropathy (OIPN) limits chemotherapy doses and impacts the patient quality of life, with no available effective preventions or treatments. The Huangqi Guizhi Wuwu decoction (HGWD), a traditional Chinese medicine remedy, has been used to treat OIPN. Previous research showed that HGWD eases OIPN symptoms by regulating gut bacteria, but the exact bacteria involved remain unknown. Methods: We used a mouse model of OIPN to study HGWD’s effects. Fresh mouse fecal samples were 16S rRNA sequencing to identify the key bacteria. Akkermansia muciniphila (AKK) was introduced into the OIPN model before HGWD administration. We evaluated mechanical allodynia, cold hyperalgesia, and intestinal mucosa integrity at set intervals. A pseudo-sterile murine model was established through antibiotic intervention, followed by the transplantation of AKK. This model was utilized to assess the effects of HGWD on nociception and the integrity of the intestinal mucosa. Results: 16S rRNA sequencing showed that oxaliplatin treatment raised AKK levels, while HGWD treatment lowered them, reducing OIPN symptoms. An OIPN model with AKK transplantation revealed that higher AKK levels counteracted HGWD’s benefits, highlighting the importance of regulating AKK levels. Histopathological analysis revealed that HGWD enhanced intestinal mucosal health by decreasing AKK levels. Moreover, antibiotic intervention experiments demonstrated that HGWD mitigated OIPN by reducing the AKK levels and ameliorating intestinal mucosal damage. Conclusions: HGWD mitigates OIPN by decreasing the abundance of AKK and ameliorating its effects on intestinal mucosa.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"11 3","pages":"351-361"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychosomatic thought of tibetan medicine and its treatment methods","authors":"Zijuan Zhang, Xin Li, Yasong Cheng, Amatti Jorigori, Dongzhu Renqing, Liwen Pan, Meng Mao, Xiao-Qiao Ren, Huizhen Zhao","doi":"10.4103/2311-8571.373598","DOIUrl":"https://doi.org/10.4103/2311-8571.373598","url":null,"abstract":"Objectives: Call on people to treat the causes of physical diseases is to take into account the causes of psychological factors as well as external causes. Materials and Methods: The analysis was conducted by combining the classical medical books of Tibetan medicine, as well as the traditional culture and living habits of Tibetan people, with modern research results. Results: Many of the theories mentioned in Tibetan medicine related to mind-body medicine have been confirmed by modern research. Mental and physical treatment related to psychosomatic diseases should be administered simultaneously. First, when a person is healthy, he should cultivate his mind to build a solid psychological defense against diseases. Developing both the mind and body contributes to creating a stable physical protection barrier against diseases. When a person is ill, he should realign his mind and help his body adjust and promote its early recovery with the help of medications. Conclusions: Treating related psychosomatic diseases should treat the mind and body simultaneously. And the mind and body should be cultivated before diseases to reinforce the psychological and physical defense against diseases.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"330 - 337"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45603556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer treatment in traditional chinese medicine: History, current status, and development","authors":"Hong-Sheng Lin, Ying Zhang, Chu-Chu Zhang, Su-ying Liu, Jie Liu, Peilun Yang","doi":"10.4103/2311-8571.382025","DOIUrl":"https://doi.org/10.4103/2311-8571.382025","url":null,"abstract":"Objective: This article discusses the following aspects, including the history of traditional Chinese medicine (TCM) in the treatment of lung cancer, the breakthrough in the theory of TCM in treatment of lung cancer, clinical study of TCM in treating lung cancer, microscientific interpretation of TCM treatment for lung cancer and the prospect of TCM in treating lung cancer. Materials and Methods: In this paper, through a systematic search, combing traditional Chinese medicine prevention and treatment of lung cancer ancient books and modern literature. Results: A series of large sample and multi-centered clinical studies have proved that TCM comprehensive treatment significantly improves the clinical efficacy for lung cancer. “TCM treatment system for non-small cell lung cancer” based on staged and standardized integration of TCM and Western medicine has been well developed and popularized in practice. Furthermore, in virtue of the international cooperation platform established by the National Cancer Institute of the United States, the scientific connotation of TCM in the prevention and treatment of lung cancer is systematically and deeply studied, thereby promoting the research and development of new Chinese drugs for lung cancer. Conclusions: Nowadays, TCM has realized a landmark breakthrough in treating lung cancer, bringing benefits to all lung cancer patients.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"297 - 306"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45237473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of huachansu capsules for the treatment of esophageal cancer: A systematic review and meta-analysis","authors":"Meng-Meng Wang, Xinghui Zhang, Jun-Yan Wang, Jing Xua, Ming-zhu Chen, Shuyue Wang, M. Jia, Zhiping Shen, Ling Zhang, Y. Gong, Jian Gong","doi":"10.4103/2311-8571.355009","DOIUrl":"https://doi.org/10.4103/2311-8571.355009","url":null,"abstract":"The objective of this study was to systematically evaluate the efficacy and safety of Huachansu capsules in the treatment of esophageal cancer. We searched all relevant Chinese and English documents in the Cochrane Library Clinical Controlled Trials, PubMed, EMBASE, CNKI, and VIP databases, from the time the databases were established to December 2020. The studies were selected according to the inclusion and exclusion criteria, and their quality was evaluated. We used RevMan 5.4 to conduct the meta-analysis of measurement indicators and intervention measures. Six randomized controlled trials comprising 526 patients with esophageal cancer were included in the study. Compared with radiotherapy and chemotherapy alone, oral Huachansu capsules combined with radiotherapy and chemotherapy improved the clinical efficacy (risk ratio [RR] = 1.35, 95% confidence interval [CI], 1.17–1.55, P < 0.0001), quality of life (weighted mean difference [MD] = 10.01, 95% CI [3.39–16.64], P = 0.003), and immune level (CD3+: MD = 4.99, 95% CI [3.70–6.29], P < 0.0001; CD4+: MD = 6.49, 95% CI [5.55–7.42], P < 0.0001; CD5+: MD = 0.20, 95% CI [0.11–0.28], P < 0.0001), and reduced toxic and side effects (reductions in white blood cell count: RR = 0.63, 95% CI [0.44–0.90], P = 0.01; Reductions in blood platelet: RR = 0.70, 95% CI [0.52–0.94], P = 0.02; Gastrointestinal reaction: RR = 0.73, 95% CI [0.59–0.89], P = 0.002). However, the number of included studies was small, and conclusions still need to be further verified using larger samples and high-quality randomized, double-blind controlled trials.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"270 - 277"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41348931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom assessment and management in patients with lung cancer undergoing conventional or traditional chinese medicine care","authors":"Baojin Han, Ya-jie Liu, Jia-Yue Jin, Hong-Kun Xu, Wenze Zhang, Si-Meng Ren, Xin Wang, Jie Liu","doi":"10.4103/2311-8571.382112","DOIUrl":"https://doi.org/10.4103/2311-8571.382112","url":null,"abstract":"Patients with lung cancer may experience various symptoms as the disease progresses, which may reduce the benefits of cancer treatment, reduce treatment compliance, delay cancer treatment, reduce the quality of life (QoL), and impact survival. This review discusses comprehensive symptom assessment and management, which are crucial for high-quality lung cancer treatment. Traditional Chinese medicine (TCM) is important in relieving cancer-related symptoms in patients with lung cancer. Including patient-reported outcomes (PROs) in clinical trials and practice can provide a better assessment of symptom burden and the effectiveness of symptom management. Patient-centered care with TCM in lung cancer patients may include six steps: Symptom screening, etiology investigation, comprehensive assessment, integrative management, reassessment, and regular symptom follow-up monitoring. PRO measures can be used to evaluate symptom intensity, the degree to which symptoms interfere with activities of daily living, and the QoL. Clearly defined and reliable PRO measures can enhance patient satisfaction and improve symptom control. Quantitative PRO measures developed from the TCM perspective should be considered one of the important outcome measurements in TCM care. A multidisciplinary collaborative symptom management model, including TCM and conventional therapy, will be the future goal for treating patients with lung cancer.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"235 - 242"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44610799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shenyi capsule prolongs postoperative survival of patients with nonsmall cell lung cancer: A multicenter, randomized, controlled trial","authors":"Dao-rui Li, W. Hou, B. Hua, Pei-tong Zhang, Lu Xiong, Hao Liu, Qi-Yuan Mao, Hong-Sheng Lin, B. Piao","doi":"10.4103/2311-8571.382023","DOIUrl":"https://doi.org/10.4103/2311-8571.382023","url":null,"abstract":"Objective: The objective of this study was to examine the effect of the postsurgical administration of Shenyi capsules on the outcome and overall survival of patients with nonsmall cell lung cancer (NSCLC). Materials and Methods: This was a multicenter, randomized, placebo-controlled, double-blind clinical trial. Patients with stages I–IIIA NSCLC were randomized to Shenyi or placebo groups (treatment duration: 6 months) and followed up for 10 years. One-year, 2-year, 5-year, and 10-year survival rates and survival times were calculated. Symptoms, quality of life, traditional Chinese medicine (TCM) syndrome, and recurrence were evaluated. Results: A total of 361 patients (treatment group, n = 185; placebo group, n = 176) were randomized and followed up for 10 years. The two groups had similar baseline demographic and clinical characteristics. Among all 361 patients, the treatment group had significantly longer median survival (31 months, respectively) than the placebo group (22.3 months, P < 0.01). In stage II or III patients, recurrence and metastasis rates in the treatment group were lower than those in the placebo group (P < 0.05). The treatment group also had significantly longer 1-year and 2-year survival rates based on the full analysis set and per-protocol set; however, there was no statistically significant difference in the 5-year and 10-year survival rates (P < 0.01 for all comparisons). Multivariate analysis of variance showed that the interaction between stage and age had a significant impact on overall survival (P < 0.05). Compared with the placebo group, the treatment group showed a significant decrease in TCM syndrome (P < 0.01) and a significant increase in the Karnofsky Performance Score (P < 0.01) and body weight (P < 0.05). Conclusions: Adjunctive therapy with Shenyi capsules significantly prolonged the 1-year and 2-year survival rates after surgery and improved the quality of life. Moreover, none of the patients experienced severe adverse effects. These results suggest that Shenyi capsules may have clinical applications in treating patients with NSCLC.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"314 - 321"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43740398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of ayurvedic medicines and extracts of medicinal plants as an alternative therapeutic treatment option for nephrolithiasis","authors":"S. Sachdeva, Jaspreet Kaur, Sanjana Mehta, Renu Saharan, Parminder Nain","doi":"10.4103/2311-8571.351512","DOIUrl":"https://doi.org/10.4103/2311-8571.351512","url":null,"abstract":"The incidence of nephrolithiasis, commonly known as kidney stone, is increasing worldwide with significant health and economic burden. Approximately 2 million people every year in India are affected by kidney stones. It affects all ages, genders, and races, but between the ages of 20 and 49 years, it affects most frequently in men than women. Different types of stones include calcium stones, cysteine stones, struvite or magnesium ammonium phosphate stones, uric acid stones, and drug-induced stones. This review article provides information about general pathophysiology, epidemiology, clinical presentation, and pharmacological treatment, which includes ayurvedic and herbal medicines for nephrolithiasis. Further understanding of the pathophysiological link between nephrolithiasis and systemic disorders is necessary for the development of new therapeutic options.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"278 - 283"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46397134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on Rodgersia and predictive analysis on its quality markers","authors":"Ling-Ling Chu, Bin Li, Jia Wu, Ling Jiang, Xudong Zhou, Wen-bing Sheng, Cai-yun Peng, Salman Zafar, Ping-an Liu, Wei Wang","doi":"10.4103/2311-8571.343650","DOIUrl":"https://doi.org/10.4103/2311-8571.343650","url":null,"abstract":"Rodgersia is a traditional Chinese medicine that contains a variety of chemical constituents, including flavonoids, terpenoids, phenylpropanoids, gallic acid derivatives, steroids, volatile oils, and tannins, with anti-inflammatory, antioxidant, antitumor, antibacterial, antivirus, hepatoprotective, and other properties. In this paper, the main chemical constituents and pharmacological effects of Rodgersia are summarized. On this basis, the quality markers of this genus were predicted based on chemical composition, traditional medicinal properties, traditional efficacy, and measurable components. This review provides the basis for in-depth research, utilization, and quality control of Rodgersia.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"243 - 257"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43962135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herb formulae inhibit the proliferation of human colon cancer SW480 cells by inducing cell apoptosis","authors":"Su Fu, Shaojia Qin, W. Rausch","doi":"10.4103/2311-8571.369650","DOIUrl":"https://doi.org/10.4103/2311-8571.369650","url":null,"abstract":"Objective: This study aimed to reveal the antitumor effects of Chinese herbal formulae and the underlying mechanisms in treating colorectal cancer, with a focus on developing traditional Chinese medicine (TCM) as a supplement and alternative therapeutic method for cancers. Materials and Methods: Human colon cancer SW480 cells were treated with three Chinese herbal formulae, Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction at different concentrations (50–600 μg/mL) for 24, 36, and 48 h, respectively. Cell viability was determined using the resazurin reduction assay, and cell survival rate was evaluated using a colony formation assay. After treatment with different concentrations (50–600 μg/mL) of these three formulae for 48 h, the effects of the Chinese herbal formulae on cell apoptosis were investigated using Hoechst/propidium iodide (PI) staining. The positive PI-stained cells were investigated using an EnSpire multilabel plate reader and the positive Hoechst-stained cells were observed under a fluorescence microscope for morphological changes. Results: Bu Zhong Yi Qi Decoction, Fuzi Lizhong Decoction, and Pulsatilla Decoction inhibited SW480 cell proliferation in a dose-and time-dependent manner and induced cell apoptosis. Conclusion: Chinese herbal formulae with a special prescription form of TCM with antitumor effects bring a new perspective in line with the principles of TCM in cancer treatment.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"348 - 354"},"PeriodicalIF":4.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45649323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}