World Journal of Traditional Chinese Medicine最新文献_第4页

Effective common chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome: A review of clinical studies in the past 10 years 常用有效中药治疗慢性胆囊炎合并肝胆湿热证10年临床研究综述

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.364414

Desmond Tee, H. Wong

{"title":"Effective common chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome: A review of clinical studies in the past 10 years","authors":"Desmond Tee, H. Wong","doi":"10.4103/2311-8571.364414","DOIUrl":"https://doi.org/10.4103/2311-8571.364414","url":null,"abstract":"The objective of the study is to identify the effective common Chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome (CCLGDHS) through reviewing relevant clinical studies published in the past 10 years. Data were collected from ScienceDirect and Chinese National Knowledge Infrastructure. Data screening was carried out for the abstracts and full texts of the data. The top 15 Chinese herbal medicines with the highest occurring frequency were selected, statistically analyzed, and classified by their medicinal properties, actions, and indications according to the Chinese Pharmacopoeia 2015 edition. The top 15 effective common Chinese herbal medicines comprise Chai Hu, Huang Qin, Jin Qian Cao, Bai Shao, Yin Chen, Yu Jin, Chuan Lian Zi, Yan Hu Suo, Zhi Shi, Ban Xia, Bai Zhu, Pu Gong Ying, Gan Cao, Zhi Zi, and Qing Pi. The predominant natures were cold, cool, and warm. This combination can clear stagnant heat, warm Yang, and regulate Qi dynamics. In addition, bitter, pungent, and sweet were the predominant flavors. They can clear dampness-heat, regulate Qi dynamics to relieve cramps and pain, as well as tonify the deficiency. Along with entering the liver and gallbladder meridians, these herbal medicines also entered the spleen, stomach, and lung meridians to prevent potential disease transmission. The combinatorial medicinal actions of the effective common Chinese herbal medicine highlight the importance of the holistic concept of traditional Chinese medicine when treating CCLGDHS. In addition, the inclusion of activating blood to promote blood circulation, relieving cramps and alleviating pain, and tonifying the spleen and stomach represents a new finding in the treatment principle for CCLGDHS.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"8 - 20"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48271867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional uses and phytochemical constituents of Cynanchum otophyllum C. K. Schneid (Qingyangshen) 青阳参的传统用途及植物化学成分

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.353189

C. Bailly, Cheng Xiang, Ji-hong Zhang

{"title":"Traditional uses and phytochemical constituents of Cynanchum otophyllum C. K. Schneid (Qingyangshen)","authors":"C. Bailly, Cheng Xiang, Ji-hong Zhang","doi":"10.4103/2311-8571.353189","DOIUrl":"https://doi.org/10.4103/2311-8571.353189","url":null,"abstract":"The roots of the plant Cynanchum otophyllum C. K. Schneid (Apocynaceae), known as Qingyangshen in Chinese, are used for a long time as a traditional medicine by different ethnic communities in the Yunnan province (China). The multiple properties and applications of this herbal medicine have been analyzed. C. otophyllum is a perennial herbal liana, nonedible, and generally wild harvested. A cultivation method has been proposed to increase the fruit set level. Qingyangshen is used essentially to treat epilepsy, rheumatism, or other inflammatory diseases. The plant can be found also in diverse polyherbal preparations used in cosmetic or as food supplement (detox products), and in phyto-preparations claimed to reduce hair loss. The plant is a rich reservoir of C-21 steroidal glycosides. Many bioactive compounds have been isolated from this plant and some of them have been pharmacologically characterized, such as otophyllosides, cynotophyllosides, cynanotins, cynotogenins, cynanchins, all briefly evocated here. The plant presents also interesting features in other domains. In particular, leave extracts of C. otophyllum C. K. Schneid contain proteases which are exploited for the local preparation of a cheese-like milk cake. Qingyangshen herbal preparation can be useful to treat epilepsy and inflammation. It has applications beyond medicine in the cosmetic and food industry.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"1 - 7"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44784108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry, pharmacology, and clinical applications of Centella asiatica (L.) Urban 积雪草的植物化学、药理及临床应用城市

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.376900

Hai-jun Jiang, Zhonghong Yan, X. Shi

引用次数: 0

The mechanism of total ginseng extracts in the treatment of lung cancer progression based on network pharmacology and experimental validation 基于网络药理学和实验验证的人参总提取物治疗肺癌进展的机制

3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.385513

Zhong-Hong Wei, Yang Zhao, Yin Lu, Hong-Kuan Hana, Cheng Qian, Meng-Yao Song, Teng Zhang, Chun-Mei Yang, Ren-Jun Gu, Xian Zhou

{"title":"The mechanism of total ginseng extracts in the treatment of lung cancer progression based on network pharmacology and experimental validation","authors":"Zhong-Hong Wei, Yang Zhao, Yin Lu, Hong-Kuan Hana, Cheng Qian, Meng-Yao Song, Teng Zhang, Chun-Mei Yang, Ren-Jun Gu, Xian Zhou","doi":"10.4103/2311-8571.385513","DOIUrl":"https://doi.org/10.4103/2311-8571.385513","url":null,"abstract":"Objective: The objective of this study was to investigate the mechanism by which total ginseng extract (TGE) inhibits the progression of lung cancer through network pharmacology and experimentation. Materials and Methods: A Lewis lung carcinomas (LLC) model was established by injecting cancer cells through the tail vein and through administering different doses of TGE. The infiltrated immune cells into the microenvironment of lung cancer metastasis through flow cytometry were evaluated, and the messenger RNA (mRNA) expression levels of various immune cell-related chemokines were determined using quantitative reverse transcription–polymerase chain reaction. Therapeutic targets and signaling pathways of TGE in nonsmall cell lung cancer were investigated using systematic pharmacology and virtual docking. Immunoblotting was performed to determine the impacts of TGE on migration-related proteins. Results: Flow cytometry showed that 1.82 g/kg TGE increased the infiltrated T cells and inhibited the recruitment of myeloid cells, which was caused by decreased mRNA expression of chemokines after TGE treatment. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses showed that the delayed progression of lung cancer by TGE might be related to the promotion of lung cancer cell apoptosis-associated signaling pathways. The virtual docking results indicated that the active components of ginseng are directly bound to apoptosis-related proteins. Immunoblotting showed that TGE inhibited tumor metastasis by regulating the expression of migration-related proteins. Conclusions: The study reveals the potential mechanism of ginseng extract in the treatment of lung cancer progression and provides a reliable basis for its clinical application.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135360524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing a novel single-marker-based method for the quantitative evaluation of the multiple active components in Corydalis yanhusuo W. T. Wang 开发一种新的基于单标记的延胡索多活性成分定量评价方法

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.364415

Chun-Juan Yang, Xinrong Yang, Shuang Jiang, Chun Gan, Jing-jing Huang, Fan-Shu Wei, Z. Wang, Hesong Peng, Jing Yang

{"title":"Developing a novel single-marker-based method for the quantitative evaluation of the multiple active components in Corydalis yanhusuo W. T. Wang","authors":"Chun-Juan Yang, Xinrong Yang, Shuang Jiang, Chun Gan, Jing-jing Huang, Fan-Shu Wei, Z. Wang, Hesong Peng, Jing Yang","doi":"10.4103/2311-8571.364415","DOIUrl":"https://doi.org/10.4103/2311-8571.364415","url":null,"abstract":"Objective: This study was designed to develop a method for detecting differences in the chemical composition of Corydalis yanhusuo W. T. Wang using high-performance liquid chromatography with a diode array detector technology. Materials and Methods: We established a novel quantitative evaluation method for identifying multiple components in natural extracts using a single-marker method quantitative analysis of multi-components by single marker (QAMS). This method was then validated using eight alkaloid phytochemical markers designed to evaluate C. yanhusuo quality. Results: Our evaluations revealed good linearity (R2 ≥ 0.9991) within the range of tested concentrations for all eight alkaloids, with recovery ranging from 95.5% to 101.5%. The evaluations also returned stability results that fell within the acceptable range. Cluster analysis and Heatmap analyses were applied to classify and evaluate alkaloids across 21 different production areas. These results revealed a significant difference in the component profiles between samples from different origins. Conclusions: Thus, these data suggest that in the absence of a material reference, QAMS may help facilitate the stable production of C. yanhusuo. In addition, our data suggest that this method may have value as a promising alternative to common quality evaluations for controlling C. yanhusuo composition.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"43 - 52"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44547265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and correlation analysis of negative emotions, quality of life, and chinese medicine syndromes in patients with lung cancer after surgery: A cross-sectional study 肺癌术后患者负性情绪、生活质量与中医证候特征及相关分析:一项横断面研究

3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.385512

Ya-Bin Gong, Ling Xu, Cong-Meng Zhang, Yi-Feng Gu, Sheng-Ping Shen, Yi-Chao Wang, Ao Qi, Ling-Zi Su, Jia-Lin Yao, Jia-Qi Li, Wen-Xiao Yang, Qin Wang, Li-Jing Jiao, Xiong Qin

{"title":"Characteristics and correlation analysis of negative emotions, quality of life, and chinese medicine syndromes in patients with lung cancer after surgery: A cross-sectional study","authors":"Ya-Bin Gong, Ling Xu, Cong-Meng Zhang, Yi-Feng Gu, Sheng-Ping Shen, Yi-Chao Wang, Ao Qi, Ling-Zi Su, Jia-Lin Yao, Jia-Qi Li, Wen-Xiao Yang, Qin Wang, Li-Jing Jiao, Xiong Qin","doi":"10.4103/2311-8571.385512","DOIUrl":"https://doi.org/10.4103/2311-8571.385512","url":null,"abstract":"Objective: The objective of the study was to observe and analyze the characteristics of negative emotions and quality of life (QoL) in patients with nonsmall cell lung cancer (NSCLC) from 1 to 3 months after surgery, and summarize their population characteristics after surgery. Materials and Methods: The consolidation rehabilitation period was defined as 1 to 3 months after surgery. The main observation indicators were the general Hospital Anxiety and Depression Scale, the European Organization for the Research and Treatment of Cancer Core QoL Questionnaire (EORTC QLQ-C30), and EORTC QLQ-Lung Cancer-13. The secondary observation indicators were peripheral blood cytokines and immune function indicators. Statistical methods such as one-way analysis of variance and logistic regression were used to analyze the characteristics of this part of the population. Results: Among patients who underwent lung surgery, the overall incidence of anxiety during consolidation recovery was 13.66%, and that of depression was 10.38%. The scores of fatigue, pain, dyspnea, insomnia, and loss of appetite were significantly higher than those of other symptoms (P = 0.000). The presence of anxiety was associated with the site of surgery (P < 0.05) and the presence of depression was associated with emotional functioning and dyspnea (P < 0.05). Conclusions: The occurrence of negative emotions in the postoperative NSCLC population is related to gender, and the degree of emotions is negatively correlated with QoL and positively correlated with the degree of symptoms. The main relevant syndromes are the pulmonary and meridian categories.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135360512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dalbergia odorifera Essential oil protects against myocardial ischemia through upregulating nrf2 and inhibiting caspase signaling pathways in isoproterenol-induced rats 黄檗精油通过上调异丙肾上腺素诱导大鼠的nrf2和抑制caspase信号通路，对心肌缺血具有保护作用

3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.372727

Xiang-Sheng Zhao, Jian-He Wei, Can-Hong Wang, Bao Gong, Hui Meng, Yu-Lan Wu

{"title":"Dalbergia odorifera Essential oil protects against myocardial ischemia through upregulating nrf2 and inhibiting caspase signaling pathways in isoproterenol-induced rats","authors":"Xiang-Sheng Zhao, Jian-He Wei, Can-Hong Wang, Bao Gong, Hui Meng, Yu-Lan Wu","doi":"10.4103/2311-8571.372727","DOIUrl":"https://doi.org/10.4103/2311-8571.372727","url":null,"abstract":"Objective: Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular diseases. This study aimed to determine the potential myocardial protective effect and possible mechanism of action of D. odorifera essential oil (DOEO). Materials and Methods: The essential oil of D. odorifera was extracted by hydrodistillation. The cardioprotective effects of DOEO were examined by histopathological observation, myocardial enzyme detection, peroxidation, anti-oxidant level detection, and related protein expression. The compounds in the blood were identified by gas chromatography–mass spectrometry. Results: These results showed that DOEO had significant myocardial cell protection, with IC50 values ranging from 17.64 to 24.78 μg/mL in vitro. Compared to the myocardial ischemia group, the DOEO pretreatment groups had lower levels of myocardial injury, creatinine kinase, lactate dehydrogenase, alanine transaminase, aspartate transaminase, hydrogen peroxide, and nitric oxide, and higher levels of glutathione and superoxide dismutase. In addition, DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase levels. Moreover, immunohistochemical experiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2 (Nrf2) and heme oxygenase-1 (HO-1) and reduced the expression of apoptotic caspases, including caspase 3 and caspase 9. The main components of the blood were transnerolidol and nerolidol oxide. Overall, the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor- antioxidant response element (Nrf2-ARE) and caspase pathways. DOEO has a therapeutic effect on MI by inhibiting the oxidant and apoptotic effects. Conclusions: D. odorifera may be a potential candidate drug for treating myocardial ischemic injury.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhizoma drynariae improves endometrial receptivity in a Mus model of dysfunctional embryo implantation 骨碎补改善功能失调胚胎植入Mus模型的子宫内膜容受性

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/wjtcm.wjtcm_17_22

Yue Shi, Yan-feng Liu, Jia-mei Wang, Jing Jiang, Bo He, Guo-Hua Mu, Fang Liu, Ya-Hui Li, Ting Qiao, Jing-qiao Lu

{"title":"Rhizoma drynariae improves endometrial receptivity in a Mus model of dysfunctional embryo implantation","authors":"Yue Shi, Yan-feng Liu, Jia-mei Wang, Jing Jiang, Bo He, Guo-Hua Mu, Fang Liu, Ya-Hui Li, Ting Qiao, Jing-qiao Lu","doi":"10.4103/wjtcm.wjtcm_17_22","DOIUrl":"https://doi.org/10.4103/wjtcm.wjtcm_17_22","url":null,"abstract":"Background: Rhizoma drynariae is a traditional Chinese medicine used in orthopedics and traumatology, but its effect on endometrial receptivity remains unknown. Aims and Objectives: To observe effect of Rhizoma drynariae and its main components on endometrial receptivity in a mus model of dysfunctional embryo implantation. Materials and Methods: Mus models were established by the GnRHa+HMG+HCG method. Normal mus receiving saline were used as controls and the remaining six groups were: model receiving saline, progynova, aspirin, Rhizoma drynariae, osteopractic total flavone, and naringin. Pinopodes in uterine endometrium were examined by scanning electron microscopy. Stem cell factor (SCF) mRNA expressions was determined by real-time RT-PCR, and estrogen receptor α (ERα), progesterone receptor (PR) by immunohistochemistry. Results: In the model group, surface morphology of endometrium was heterogeneous, without obvious pinopodes. In the Rhizoma drynaria and progynova groups, pinopodes were abundant. Compared with the blank group, model group had lower levels of SCF (-47%), ERα (-63%) and PR (-50%) (all P<0.05). In comparison, Rhizoma drynariae group had higher levels of SCF (+73%), ERα (+118%) and PR (+101%) (all P<0.01). The individual main components of Rhizoma drynariae had variable efficacy. Conclusion: Rhizoma drynariae could improve endometrial receptivity of mouse models of dysfunctional embryo implantation as shown by increased numbers of pinopodes and higher levers of SCF, ERα, PR compared with the model group.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"94 - 100"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of SARS-CoV-2 spike protein inhibitors from Urtica dioica to develop herbal-based therapeutics against COVID-19 从荨麻疹中鉴定SARS-CoV-2刺突蛋白抑制剂以开发抗COVID-19的草药疗法

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.358784

Shobha Upreti, J. Prusty, Awanish Kumar, M. Samant

{"title":"Identification of SARS-CoV-2 spike protein inhibitors from Urtica dioica to develop herbal-based therapeutics against COVID-19","authors":"Shobha Upreti, J. Prusty, Awanish Kumar, M. Samant","doi":"10.4103/2311-8571.358784","DOIUrl":"https://doi.org/10.4103/2311-8571.358784","url":null,"abstract":"Objective: The high transmission rate and mutations of SARS-CoV-2 have made it a global pandemic, and the shortage of any effective clinical treatment has created such a commotion. There are some synthetic antiviral drugs, such as remdesivir and lopinavir that are being repurposed to treat SARS-CoV-2, but all of these demonstrate extreme side effects in humans. Hence, promoting herbal-based drug development has become crucial as they are cost-effective and have lesser or no side effects. Urtica dioica is abundant in the Himalayan region and the compounds present in it have shown significant antiviral and anti-SARS activity. Therefore, molecular docking studies were performed to identify SARS-CoV-2 spike protein inhibitors from U. dioica to combat the COVID-19 disease. Materials and Methods: Compounds from U. dioica were screened using the bioinformatic approach, and subsequently, these compounds were docked with the S1 subunit of the COVID-19 spike protein (PDB ID: 6YOR). Molecular docking was carried out using the PyRx software (0.8 version) and further examined by employing the Discovery Studio Visualizer. Results: About all the selected compounds showed significant binding energy (e.g., beta-sitosterol: −10.3 kcal/mol) in contrast to the control chloroquine phosphate. This binding was observed with the spike protein residues that were common in the old strain and the more contagious newly modified B.1.1.7 strain of SARS-CoV-2. Conclusions: Thus, our study can be used in effective drug development against SARS-CoV-2 and its mutant strains also.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"61 - 70"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41536945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Elucidation of the mechanism of Gualou-Xiebai-Banxia decoction for the treatment of unstable angina based on network pharmacology and molecular docking 基于网络药理学和分子对接的瓜楼泻白半夏汤治疗不稳定型心绞痛的机制研究

IF 4.4 3区医学

World Journal of Traditional Chinese Medicine Pub Date : 2023-01-01 DOI: 10.4103/2311-8571.364411

Yu Tan, Li Chen, Hua Qu, Da-zhuo Shi, Xiao-juan Ma

{"title":"Elucidation of the mechanism of Gualou-Xiebai-Banxia decoction for the treatment of unstable angina based on network pharmacology and molecular docking","authors":"Yu Tan, Li Chen, Hua Qu, Da-zhuo Shi, Xiao-juan Ma","doi":"10.4103/2311-8571.364411","DOIUrl":"https://doi.org/10.4103/2311-8571.364411","url":null,"abstract":"Objective: The aim of this study was to identify the potential pharmacological mechanisms of Gualou-Xiebai-Banxia decoction (GLXBBX) against unstable angina (UA). Materials and Methods: The active compounds of GLXBBX were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and their targets were predicted using the SwissTargetPrediction database. The targets associated with UA were obtained from the Online Mendelian Inheritance in Man, GeneCards, and Therapeutic Target Database. Individual targets associated with UA and GLXBBX were cross-checked to identify the targets of GLXBBX involved in the treatment of UA. A protein–protein interaction network was built using the STRING online database. Cytoscape 3.7.2 software was used to screen out hub genes. Additional gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed using the clusterProfiler package in R. Results: A total of 28 bioactive compounds and 320 protein targets of GLXBBX associated with UA were screened out. Enrichment analysis indicated that the therapeutic effect of GLXBBX may be mediated through the PI3K/AKT, MAPK, and HIF-1 signaling pathways. Molecular docking suggested that the active compounds including Vitamin E, cavidine, and baicalein can bind to their protein receptors. Conclusions: This research confirmed the multifactorial effects of GLXBBX in the treatment of UA and laid the foundation for the experimental research on GLXBBX.","PeriodicalId":23692,"journal":{"name":"World Journal of Traditional Chinese Medicine","volume":"9 1","pages":"53 - 60"},"PeriodicalIF":4.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43808604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0