World journal of emergency medicine最新文献

{"title":"Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis.","authors":"Wei Zhou, Maiying Fan, Xiang Li, Fang Yu, En Zhou, Xiaotong Han","doi":"10.5847/wjem.j.1920-8642.2024.016","DOIUrl":"10.5847/wjem.j.1920-8642.2024.016","url":null,"abstract":"<p><strong>Background: </strong>Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten the intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated with sepsis, but the molecular mechanisms have not been elucidated. This study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology approach.</p><p><strong>Methods: </strong>The active ingredients and targets of XBJ were retrieved from the ETCM database. Potential targets related to PLA and sepsis were retrieved from the GeneCards, PharmGKB, DisGeNet, Online Mendelian Inheritance in Man (OMIM), Therapeutic Targets Database (TTD), and DrugBank databases. The targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment targets. Protein-protein interaction networks were analyzed using the STRING database. Potential treatment targets were imported into the Metascape platform for Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Molecular docking was performed to validate the interactions between active ingredients and core targets.</p><p><strong>Results: </strong>XBJ was found to have 54 potential treatment targets for PLA complicated with sepsis. Interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF) were identified as core targets. KEGG enrichment analysis revealed important pathways, including the interleukin-17 (IL-17) signaling pathway, the TNF signaling pathway, the nuclear factor-kappa B (NF-κB) signaling pathway, and the Toll-like receptor (TLR) signaling pathway. Molecular docking experiments indicated stable binding between XBJ active ingredients and core targets.</p><p><strong>Conclusion: </strong>XBJ may exert therapeutic effects on PLA complicated with sepsis by modulating signaling pathways, such as the IL-17, TNF, NF-κB, and TLR pathways, and targeting IL-1β, IL-6, and TNF.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 1","pages":"35-40"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10765075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Glanzmann thrombasthenia encounters antithrombin deficiency: how do we balance the risk and benefit of antithrombotic therapy?","authors":"Yu Wang, Zhihao Liu, Haoyu Weng, Jianping Li","doi":"10.5847/wjem.j.1920-8642.2024.012","DOIUrl":"10.5847/wjem.j.1920-8642.2024.012","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 1","pages":"67-69"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10765076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency physicians' occupational risks in China.","authors":"Huaying Jiang, Jia Chang, Rong Huang, Xiayi Liang, Manning Song, Hejing Yuan, Shuo Wang","doi":"10.5847/wjem.j.1920-8642.2024.045","DOIUrl":"10.5847/wjem.j.1920-8642.2024.045","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"232-234"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loculated pericardial hematoma diagnosed with point-of-care ultrasound.","authors":"Joaquín Valle Alonso, Esther Montoro, Leandro Noblia","doi":"10.5847/wjem.j.1920-8642.2024.039","DOIUrl":"10.5847/wjem.j.1920-8642.2024.039","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"241-242"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplantation of a pectoralis major flap for the repair of myiasis wounds.","authors":"Yongkang Cai, Yilin He, Xiaoxing Tan, Tangchun Liu, Qingdeng Feng, Dongjing Zhang, Zhengfei Yang","doi":"10.5847/wjem.j.1920-8642.2024.038","DOIUrl":"10.5847/wjem.j.1920-8642.2024.038","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"238-240"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of alcohol consumption with aortic aneurysm and dissection risk: results from the UK Biobank cohort study.","authors":"Yaowen Liang, Guoxiang Zou, Dingchen Wang, Weiyue Zeng, Jiarui Zhang, Xiaoran Huang, Miao Lin, Cong Mai, Fei'er Song, Yuelin Zhang, Jinxiu Meng, Hongliang Feng, Yu Huang, Xin Li","doi":"10.5847/wjem.j.1920-8642.2024.096","DOIUrl":"10.5847/wjem.j.1920-8642.2024.096","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have reported inconsistent results with positive, negative, and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection (AAD). This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of AAD.</p><p><strong>Methods: </strong>The UK Biobank study is a population-based cohort study. Weekly alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score (GRS). Cox proportional hazards models were used to estimate hazard ratios (<i>HR</i>s) with 95% confidence intervals (<i>CI</i>s) for the associations between alcohol consumption and AAD. Several sensitivity analyses were performed to assess the robustness of the results.</p><p><strong>Results: </strong>Among the 388,955 participants (mean age: 57.1 years, 47.4% male), 2,895 incident AAD cases were documented during a median follow-up of 12.5 years. Compared with never-drinkers, moderate drinkers (adjusted <i>HR</i>: 0.797, 95%<i>CI</i>: 0.646-0.984, <i>P</i><0.05) and moderate-heavy drinkers (adjusted <i>HR</i>: 0.794, 95%<i>CI</i>: 0.635-0.992, <i>P</i><0.05) were significantly associated with a decreased risk of incident AAD. Interaction-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and women.</p><p><strong>Conclusion: </strong>Our findings support a protective effect of moderate alcohol consumption on AAD, but are limited to participants younger than 65 years and women.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 6","pages":"465-474"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in oxycodone and oxycodone-containing analgesics administration for back pain in emergency departments in the USA (2007-2018).","authors":"Jonathan Chabon, Jemer Garrido, Deanna Schreiber-Gregory, Jefferson Drapkin, Sergey Motov","doi":"10.5847/wjem.j.1920-8642.2024.002","DOIUrl":"10.5847/wjem.j.1920-8642.2024.002","url":null,"abstract":"<p><strong>Background: </strong>To describe trends in oxycodone and oxycodone-containing analgesic prescribing for the treatment of back pain among adults in emergency departments (EDs) in the USA from 2007 to 2018.</p><p><strong>Methods: </strong>Data were gathered from the National Hospital Ambulatory Medical Care Survey (NHAMCS) from 2007 to 2018. The study population included individuals of all ages presenting to USA EDs. The NHAMCS reasons for visit and oxycodone drug ID codes were used to isolate patients with back pain. The main outcome was the proportion of oxycodone and oxycodone-containing analgesics prescribed for back pain in the EDs over the specified time period.</p><p><strong>Results: </strong>There was a relative decrease in the overall administration of oxycodone for back pain in the EDs by 62.3% from 2007 (244,000 visits) to 2018 (92,000 visits). The proportion of ED patients prescribed with oxycodone-containing analgesics for back pain increased among patients aged 45 years and older (from 43.8% to 57.6%), female patients (from 54.5% to 62.0%), black patients (from 22.5% to 30.4%), and Hispanic/Latino patients (from 9.4% to 19.6%). Oxycodone/acetaminophen was most prescribed and accounted for 90.2% of all oxycodone-containing analgesics in 2007, with a decrease to 68.5% in 2018. Pure oxycodone was the second most prescribed medication, accounting for 6.1% in 2007 and 31.5% in 2018.</p><p><strong>Conclusion: </strong>The overall number of oxycodone-containing analgesics decreased significantly from 2007 to 2018. However, that number trended upward in 45-year-old and older, female, black, or Hispanic/Latino patients from 2007 to 2018. The total amount of pure oxycodone increased significantly from 2007 to 2008.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"169-174"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies.","authors":"Ji Cheng, Yulu Chen, Weidong Wang, Xueqi Zhu, Zhenluo Jiang, Peng Liu, Liwen Du","doi":"10.5847/wjem.j.1920-8642.2024.046","DOIUrl":"10.5847/wjem.j.1920-8642.2024.046","url":null,"abstract":"<p><strong>Background: </strong>Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides. Chlorfenapyr poisoning has a high mortality rate and is difficult to treat. This article aims to review the mechanisms, clinical presentations, and treatment strategies for chlorfenapyr poisoning.</p><p><strong>Data resources: </strong>We conducted a review of the literature using PubMed, Web of Science, and SpringerLink from their beginnings to the end of October 2023. The inclusion criteria were systematic reviews, clinical guidelines, retrospective studies, and case reports on chlorfenapyr poisoning that focused on its mechanisms, clinical presentations, and treatment strategies. The references in the included studies were also examined to identify additional sources.</p><p><strong>Results: </strong>We included 57 studies in this review. Chlorfenapyr can be degraded into tralopyril, which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate. High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning. Once it occurs, respiratory failure occurs immediately, ultimately leading to cardiac arrest and death. Chlorfenapyr poisoning is difficult to treat, and there is no specific antidote.</p><p><strong>Conclusion: </strong>Chlorfenapyr is a new pyrrole pesticide. Although it has been identified as a moderately toxic pesticide by the World Health Organization (WHO), the mortality rate of poisoned patients is extremely high. There is no specific antidote for chlorfenapyr poisoning. Therefore, based on the literature review, future efforts to explore rapid and effective detoxification methods, reconstitute intracellular oxidative phosphorylation couplings, identify early biomarkers of chlorfenapyr poisoning, and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"214-219"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>PEAR1</i> gene polymorphism on big endothelin-1 levels in Chinese patients with acute myocardial infarction after percutaneous coronary intervention.","authors":"Yi Yao, Na Xu, Xiaofang Tang, Ce Zhang, Sida Jia, Jingjing Xu, Ying Song, Xueyan Zhao, Runlin Gao, Jinqing Yuan","doi":"10.5847/wjem.j.1920-8642.2024.031","DOIUrl":"10.5847/wjem.j.1920-8642.2024.031","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 3","pages":"229-231"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beware of the serious harm of veterinary drug poisoning: a case report.","authors":"Ping Dai, Jin Sun, Tongyue Zhang, Zhiqiang Zhou, Zixi Wen, Tianzi Jian, Aerbusili Genjiafu, Baotian Kan, Xiangdong Jian","doi":"10.5847/wjem.j.1920-8642.2024.020","DOIUrl":"10.5847/wjem.j.1920-8642.2024.020","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"15 2","pages":"153-155"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}