Adult split liver transplantation to treat liver cancer: a single-center retrospective study.

IF 3.2 3区医学 Q1 EMERGENCY MEDICINE

World journal of emergency medicine Pub Date : 2025-01-01 DOI:10.5847/wjem.j.1920-8642.2024.098

Qiang Sun, Haoze Cao, Xuesong Bai, Xin Han, Wanlu You, Zhongquan Sun, Yixin Zhang, Xiaochang Wu, Feng Fang, Fan Wu, Lianyue Yang, Sheng Yan, Yuan Ding, Weilin Wang

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Abstract

Background: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation (SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center.

Methods: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation (WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.

Results: SLT and WGLT were successfully performed, with no intraoperative transplant-related mortality. Postoperatively, no significant differences in total bilirubin (TB, P=0.266), alanine transaminase (ALT, P=0.403) and aspartate transaminase (AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery (P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery (P=1.000). There were no significant differences in overall survival (OS) and progress-free survival (PFS) between the SLT and WGLT groups (P=0.910, P=0.190).

Conclusion: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.

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成人裂肝移植治疗肝癌：一项单中心回顾性研究

背景：肝癌发病率的上升导致对肝移植的需求不断增长。劈裂肝移植（SLT）是一种很有希望改善器官短缺的方法。然而，SLT的安全性和有效性仍存在争议。本研究的目的是评估我们中心肝癌患者SLT的临床结果。方法：回顾性研究2019年3月至2023年7月在某三级医院接受肝移植的74例患者，其中37例接受了SLT， 37例接受了全肝移植（WGLT）。对SLT和WGLT患者的临床资料进行分析和比较。结果：SLT和WGLT均成功完成，无术中移植相关死亡。术后30 d内两组总胆红素（TB， P=0.266）、丙氨酸转氨酶（ALT， P=0.403）、天冬氨酸转氨酶（AST， P=0.160）水平比较，差异均无统计学意义。SLT组和WGLT组术后30 d内的移植相关死亡率分别为8.1%和5.4% (P=1.000)，术后90 d的移植相关死亡率分别为10.8%和8.1% （P=1.000）。SLT组和WGLT组的总生存期（OS）和无进展生存期（PFS）无显著差异（P=0.910， P=0.190）。结论：我们的研究结果表明，与WGLT相比，SLT治疗肝癌并不意味着额外的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of emergency medicine EMERGENCY MEDICINE-

CiteScore

2.50

自引率

28.60%

发文量

671

期刊介绍： The journal will cover technical, clinical and bioengineering studies related to multidisciplinary specialties of emergency medicine, such as cardiopulmonary resuscitation, acute injury, out-of-hospital emergency medical service, intensive care, injury and disease prevention, disaster management, healthy policy and ethics, toxicology, and sudden illness, including cardiology, internal medicine, anesthesiology, orthopedics, and trauma care, and more. The journal also features basic science, special reports, case reports, board review questions, and more. Editorials and communications to the editor explore controversial issues and encourage further discussion by physicians dealing with emergency medicine.