World journal of emergency medicine最新文献

{"title":"Effects of probiotic treatment on the prognosis of patients with sepsis: a systematic review.","authors":"Chao Gong, Shengyong Xu, Youlong Pan, Shigong Guo, Joseph Harold Walline, Xue Wang, Xin Lu, Shiyuan Yu, Mubing Qin, Huadong Zhu, Yanxia Gao, Yi Li","doi":"10.5847/wjem.j.1920-8642.2025.018","DOIUrl":"10.5847/wjem.j.1920-8642.2025.018","url":null,"abstract":"<p><strong>Background: </strong>Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are still inconclusive. This study aimed to evaluate the overall effect of probiotics on the prognosis of patients with sepsis.</p><p><strong>Data resources: </strong>We searched several sources for published/presented studies, including PubMed, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register (www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials (RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit (ICU) mortality and other outcomes.</p><p><strong>Results: </strong>Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.</p><p><strong>Conclusion: </strong>Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"18-27"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function.","authors":"Meifang Cui, Xiaoyu Xu, Jilu Ye, Xuehua Pu, Liping Ren","doi":"10.5847/wjem.j.1920-8642.2025.010","DOIUrl":"10.5847/wjem.j.1920-8642.2025.010","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"82-84"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferior vena cava invasion by double-J stent.","authors":"Huiming Zhong, Shanxiang Xu, Mao Zhang, Yiping Feng","doi":"10.5847/wjem.j.1920-8642.2025.015","DOIUrl":"10.5847/wjem.j.1920-8642.2025.015","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"97-98"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between echocardiography utilization and prognosis in patients with cardiac arrest.","authors":"Nan Zhang, Qingting Lin, Huadong Zhu","doi":"10.5847/wjem.j.1920-8642.2025.007","DOIUrl":"10.5847/wjem.j.1920-8642.2025.007","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"63-66"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction cardiac arrest in intensive care units: the value of laboratory indicator trends.","authors":"Wentao Sang, Jiaxin Ma, Xuan Zhang, Shuo Wu, Chang Pan, Jiaqi Zheng, Wen Zheng, Qiuhuan Yuan, Jian Zhang, Jingjing Ma, Feng Xu","doi":"10.5847/wjem.j.1920-8642.2025.003","DOIUrl":"10.5847/wjem.j.1920-8642.2025.003","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"67-70"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric bronchial rupture: outcomes in four cases.","authors":"Yiyao Bao, Jing Ye, Lijun Guan, Caina Gao, Lei Hu, Linhua Tan","doi":"10.5847/wjem.j.1920-8642.2024.089","DOIUrl":"10.5847/wjem.j.1920-8642.2024.089","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"85-87"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world cost-effectiveness of targeted temperature management in out-of-hospital cardiac arrest survivors: results from an academic medical center.","authors":"Wachira Wongtanasarasin, Daniel K Nishijima, Wanrudee Isaranuwatchai, Jeffrey S Hoch","doi":"10.5847/wjem.j.1920-8642.2025.012","DOIUrl":"10.5847/wjem.j.1920-8642.2025.012","url":null,"abstract":"<p><strong>Background: </strong>Targeted temperature management (TTM) is a common therapeutic intervention, yet its cost-effectiveness remains uncertain. This study aimed to evaluate the real-world cost-effectiveness of TTM compared with that of conventional care in adult out-of-hospital cardiac arrest (OHCA) survivors using clinical patient-level data.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at an academic medical center in the USA to assess the cost-effectiveness of TTM in adult non-traumatic OHCA survivors between 1 January, 2019 and 30 June, 2023. The primary outcome was survival to hospital discharge. Incremental cost-effectiveness ratios (ICERs) were calculated and compared with various decision makers' willingness to pay. Cost-effectiveness acceptability curves were utilized to evaluate the economic attractiveness of TTM. Uncertainty about the incremental cost and effect was explored with a 95% confidence ellipse.</p><p><strong>Results: </strong>Among 925 non-traumatic OHCA survivors, only 30 (3%) received TTM. After adjusting for potential confounders, the TTM group did not demonstrate a significantly lower cost (delta cost -$5,141, 95% confidence interval [95% CI]: $-35,347 to $25,065, P=0.79) and higher survival to hospital discharge (delta effect 6%, 95% CI: -11% to 23%, P=0.41). Additionally, a 95% confidence ellipse indicated uncertainty reflected by evidence that the true value of the ICER could be in any of the quadrants of the cost-effectiveness plane.</p><p><strong>Conclusion: </strong>Although TTM did not demonstrate a clear survival benefit in this study, its potential cost-effectiveness warrants further investigation with larger sample sizes. These findings highlight the need for additional research to optimize TTM use in OHCA care and inform resource allocation decisions.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"28-34"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria and host: what does this mean for sepsis bottleneck?","authors":"Azzah S Alharbi, Raghad Hassan Sanyi, Esam I Azhar","doi":"10.5847/wjem.j.1920-8642.2025.001","DOIUrl":"10.5847/wjem.j.1920-8642.2025.001","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a life-threatening inflammatory condition in which the invading pathogen avoids the host's defense mechanisms and continuously stimulates and damages host cells. Consequently, many immune responses initially triggered for protection become harmful because of the failure to restore homeostasis, resulting in ongoing hyperinflammation and immunosuppression.</p><p><strong>Methods: </strong>A literature review was conducted to address bacterial sepsis, describe advances in understanding complex immunological reactions, critically assess diagnostic approaches, and emphasize the importance of studying bacterial bottlenecks in the detection and treatment of sepsis.</p><p><strong>Results: </strong>Diagnosing sepsis via a single laboratory test is not feasible; therefore, multiple key biomarkers are typically monitored, with a focus on trends rather than absolute values. The immediate interpretation of sepsis-associated clinical signs and symptoms, along with the use of specific and sensitive laboratory tests, is crucial for the survival of patients in the early stages. However, long-term mortality associated with sepsis is now recognized, and alongside the progression of this condition, there is an in vivo selection of adapted pathogens.</p><p><strong>Conclusion: </strong>Bacterial sepsis remains a significant cause of mortality across all ages and societies. While substantial progress has been made in understanding the immunological mechanisms underlying the inflammatory response, there is growing recognition that the ongoing host-pathogen interactions, including the emergence of adapted virulent strains, shape both the acute and long-term outcomes in sepsis. This underscores the urgent need for novel high-throughput diagnostic methods and a shift toward more pre-emptive, rather than reactive, treatment strategies in sepsis care.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"10-17"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilia and clonorchiasis presenting as fever of unknown origin in adult patients.","authors":"Jie Zhong, Xin Zhou, Wei Gu","doi":"10.5847/wjem.j.1920-8642.2024.069","DOIUrl":"10.5847/wjem.j.1920-8642.2024.069","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"91-93"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fever without source in infants aged 22-60 days: how laboratory tests perform at identifying bacterial infections and predicting the need for a lumbar puncture?","authors":"Keven Vachon, Geneviève Gravel, Samuel Leduc, Alexandra Larouche, Myriam Mallet, David Simonyan, Mahukpe Narcisse Ulrich Singbo, Julie Ouellet-Pelletier, Simon Berthelot","doi":"10.5847/wjem.j.1920-8642.2025.004","DOIUrl":"10.5847/wjem.j.1920-8642.2025.004","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"74-77"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}