Samir Hammoud, Kevin Tishkowski, Ahmed Hammad, Jehan Barbat, Alysse Cohen, Barry Brenner
{"title":"Identifying glass foreign bodies using conventional X-ray in a gelatinous model.","authors":"Samir Hammoud, Kevin Tishkowski, Ahmed Hammad, Jehan Barbat, Alysse Cohen, Barry Brenner","doi":"10.5847/wjem.j.1920-8642.2025.002","DOIUrl":"10.5847/wjem.j.1920-8642.2025.002","url":null,"abstract":"","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"71-73"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianpeng Hu, Yan Li, Shengtao Yan, Lichao Sun, Rui Lian, Jieqiong Yu, Jie Chen, Xiaoyu Liu, Guoqiang Zhang
{"title":"Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults.","authors":"Tianpeng Hu, Yan Li, Shengtao Yan, Lichao Sun, Rui Lian, Jieqiong Yu, Jie Chen, Xiaoyu Liu, Guoqiang Zhang","doi":"10.5847/wjem.j.1920-8642.2025.011","DOIUrl":"10.5847/wjem.j.1920-8642.2025.011","url":null,"abstract":"<p><strong>Background: </strong>Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A (MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of MxA to distinguish viral from bacterial infections.</p><p><strong>Methods: </strong>We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic (ROC) curve analysis were used to determine the diagnostic value of MxA, either alone or in combination with C-reactive protein (CRP) or procalcitonin (PCT), in patients with viral, bacterial, or co-infections.</p><p><strong>Results: </strong>The value of MxA (ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections (82.3 [24.5-182.9] vs. 16.4 [10.8-26.5], <i>P</i><0.0001) (82.3 [24.5-182.9] vs. 28.5 [10.2-106.8], <i>P</i>=0.0237). The area under the curve (AUC) of the ROC curve for distinguishing between viral and bacterial infections was 0.799 (95% confidence interval [95% <i>CI</i>] 0.696-0.903), with a sensitivity of 68.9% (95% <i>CI</i> 54.3%-80.5%) and specificity of 90.0% (95% <i>CI</i> 74.4%-96.5%) at the threshold of 50.3 ng/mL. Combining the MxA level with the CRP or PCT level improved its ability. MxA expression was low in cytomegalovirus (15.8 [9.6-47.6] ng/mL) and Epstein-Barr virus (12.9 [8.5-21.0] ng/mL) infections.</p><p><strong>Conclusion: </strong>Our study showed the diagnostic efficacy of MxA in distinguishing between viral and bacterial infections, with further enhancement when it was combined with CRP or PCT. Moreover, Epstein-Barr virus and human cytomegalovirus infections did not elicit elevated MxA expression.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"35-42"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús Jurado-Palomo, José Luis Martín-Conty, Begoña Polonio-López, Cristina Rivera Picón, Raúl López-Izquierdo, Carlos Del Pozo Vegas, Pedro Ángel de Santos Castro, Ancor Sanz-García, Francisco Martín-Rodríguez
{"title":"Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease.","authors":"Jesús Jurado-Palomo, José Luis Martín-Conty, Begoña Polonio-López, Cristina Rivera Picón, Raúl López-Izquierdo, Carlos Del Pozo Vegas, Pedro Ángel de Santos Castro, Ancor Sanz-García, Francisco Martín-Rodríguez","doi":"10.5847/wjem.j.1920-8642.2025.008","DOIUrl":"10.5847/wjem.j.1920-8642.2025.008","url":null,"abstract":"<p><strong>Background: </strong>Prehospital medication is a reality, and the role of these therapies must be explored to assess their validity, especially for acute respiratory diseases, which are usually associated with increased morbidity. The aim of this study was to examine the association of prehospital medication use with mortality in patients with acute respiratory disease.</p><p><strong>Methods: </strong>A prospective, multicenter, emergency medical service (EMS) delivery cohort study was carried out in adults with unselected respiratory diseases managed by EMS who were transferred to the emergency department. From January 1, 2019, to October 31, 2023, six advanced life support units, thirty-eight basic life support units, and four hospitals in Spain participated in the study. Demographic data, vital signs, use of mechanical ventilation, prehospital respiratory diagnosis, and prehospital medication were collected. The primary outcome was 30-day in-hospital mortality.</p><p><strong>Results: </strong>A total of 961 patients were included, with a mortality rate of 17.5% (168 patients). Age, an increasing number of comorbidities, the use of invasive mechanical ventilation (IMV), the use of major analgesics, hypnotics, and bicarbonate were risk factors. In contrast, elevated systolic blood pressure and Glasgow Coma Scale scores were found to be protective factors against mortality. The predictive capacity of the model reached an area under the curve (AUC) of 0.857 (95% confidence interval [95% <i>CI</i>] 0.827-0.888).</p><p><strong>Conclusion: </strong>Our data revealed that IMV, major analgesics, hypnotics and bicarbonate administration were associated with elevated mortality. Adding prehospital drug therapy information to demographic variables and vital signs could improve EMS decision-making, allowing a better characterization of patients at risk of clinical worsening.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"43-50"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adult split liver transplantation to treat liver cancer: a single-center retrospective study.","authors":"Qiang Sun, Haoze Cao, Xuesong Bai, Xin Han, Wanlu You, Zhongquan Sun, Yixin Zhang, Xiaochang Wu, Feng Fang, Fan Wu, Lianyue Yang, Sheng Yan, Yuan Ding, Weilin Wang","doi":"10.5847/wjem.j.1920-8642.2024.098","DOIUrl":"10.5847/wjem.j.1920-8642.2024.098","url":null,"abstract":"<p><strong>Background: </strong>The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation (SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center.</p><p><strong>Methods: </strong>A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation (WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.</p><p><strong>Results: </strong>SLT and WGLT were successfully performed, with no intraoperative transplant-related mortality. Postoperatively, no significant differences in total bilirubin (TB, <i>P</i>=0.266), alanine transaminase (ALT, <i>P</i>=0.403) and aspartate transaminase (AST, <i>P</i>=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery (<i>P</i>=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery (<i>P</i>=1.000). There were no significant differences in overall survival (OS) and progress-free survival (PFS) between the SLT and WGLT groups (<i>P</i>=0.910, <i>P</i>=0.190).</p><p><strong>Conclusion: </strong>Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"57-62"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ICU-acquired weakness in critically ill patients at risk of malnutrition: risk factors, biomarkers, and early enteral nutrition impact.","authors":"Qingliu Zheng, Changyun Liu, Lingying Le, Qiqi Wu, Zhihong Xu, Jiyan Lin, Qiuyun Chen","doi":"10.5847/wjem.j.1920-8642.2025.020","DOIUrl":"10.5847/wjem.j.1920-8642.2025.020","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the risk factors associated with intensive care unit-acquired weakness (ICU-AW) in critically ill patients at risk of malnutrition and to evaluate the efficacy of early enteral nutrition (EEN) and the role of biomarkers in managing ICU-AW.</p><p><strong>Methods: </strong>This retrospective, observational cohort study included 180 patients at risk of malnutrition admitted to the emergency intensive care unit of the First Affiliated Hospital of Xiamen University Hospital from January 2022 to December 2023. Patients were divided into ICU-AW group and non-ICU-AW group according to whether they developed ICU-AW, or categorized into EEN and parenteral nutrition (PN) groups according to nutritional support. ICU-AW was diagnosed using the Medical Research Council score. The primary outcome was the occurrence of ICU-AW.</p><p><strong>Results: </strong>The significant factors associated with ICU-AW included age, sex, type of nutritional therapy, mechanical ventilation (MV), body mass index (BMI), blood urea nitrogen (BUN), and creatinine (Cr) levels (<i>P</i><0.05). The PN group developed ICU-AW earlier than did the EEN group, with a significant difference observed (log-rank <i>P</i><0.001). Among biomarkers for ICU-AW, the mean prealbumin (PAB)/C-reactive protein (CRP) ratio had the highest diagnostic accuracy (area under the curve [AUC] 0.928, 95% confidence interval [95% <i>CI</i>] 0.892-0.946), surpassing the mean Cr/BUN ratio (AUC 0.740, 95% <i>CI</i> 0.663-0.819) and mean transferrin levels (AUC 0.653, 95% <i>CI</i> 0.574-0.733).</p><p><strong>Conclusion: </strong>Independent risk factors for ICU-AW include female sex, advanced age, PN, MV, lower BMI, and elevated BUN and Cr levels. EEN may potentially delay ICU-AW onset, and the PAB/CRP ratio may be an effective diagnostic marker for this condition.</p>","PeriodicalId":23685,"journal":{"name":"World journal of emergency medicine","volume":"16 1","pages":"51-56"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}