Vector borne and zoonotic diseases最新文献

{"title":"Genetic Characterization and Zoonotic Analyses of <i>Enterocytozoon bieneusi</i> from Cats and Dogs in Shanghai in China.","authors":"Yan Zhang, Yidan Zhang, Rongsheng Mi, Luming Xia, Hongxiao Han, Tao Ma, Haiyan Gong, Yan Huang, Xiangan Han, Zhaoguo Chen","doi":"10.1089/vbz.2024.0075","DOIUrl":"https://doi.org/10.1089/vbz.2024.0075","url":null,"abstract":"<p><p><b><i>Background:</i></b> <i>Enterocytozoon bieneusi</i> is reported to be a common microsporidian of humans and animals in various countries. However, limited information on <i>E. bieneusi</i> has been recorded in cats (<i>Felis catus</i>) and dogs (<i>Canis familiaris</i>) in China. Here, we undertook molecular epidemiological investigation of <i>E. bieneusi</i> in cats and dogs in Shanghai, China. <b><i>Methods:</i></b> A total of 359 genomic DNAs were extracted from individual fecal samples from cats (<i>n</i> = 59) and dogs (<i>n</i> = 300), and then were tested using a nested PCR-based sequencing approach employing internal transcribed spacer (ITS) of nuclear ribosomal DNA as the genetic marker. <b><i>Results:</i></b> <i>Enterocytozoon bieneusi</i> was detected in 34 of 359 (9.5%) (95% confidence interval [6.7 - 13.0%]) fecal samples from cats (32.2%; 19/59) and dogs (5.0%; 15/300), including 24 stray cats and dogs (22.6%; 24/106), as well as 10 household/raised cats and dogs (4.0%; 10/253). Correlation analyses revealed that <i>E. bieneusi</i> positive rates were significantly associated with stray cats and dogs (<i>p</i> < 0.05). The analysis of ITS sequence data revealed the presence of five known genotypes, CD7, CHN-HD2, D, PtEb IX, and Type IV, and two novel genotypes, D-like1 and PtEb IX-like1. Zoonotic genotype D was the predominant type with percentage of 61.8% (21/34). Phylogenetic analysis of ITS sequence data sets showed that genotypes D, D-like1, and Type IV were clustered within Group 1, showing zoonotic potential. The others were assigned into Group 10 with host specificity. <b><i>Conclusions:</i></b> These findings suggested that cats and dogs in Shanghai harbor zoonotic genotype D of <i>E. bieneusi</i> and may have a significant risk for zoonotic transmission. Further insight into the epidemiology of <i>E. bieneusi</i> in other animals, water, and the environment from other areas in China will be important to have an informed position on the public health significance of microsporidiosis caused by this microbe.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of West Nile Virus as a Cause of Human Disease in Kansas.","authors":"Stephen Higgs, Susan M Hettenbach, Ashlie M Ake, Nicole M Ioerger, Dana L Vanlandingham","doi":"10.1089/vbz.2024.0104","DOIUrl":"https://doi.org/10.1089/vbz.2024.0104","url":null,"abstract":"<p><p><b><i>Background:</i></b> In the United States, West Nile virus (WNV) was first identified in 1999 in New York City and in Kansas in 2002. How the virus was introduced remains uncertain, although several potential methods have been hypothesized. This review presents an overview of what has occurred with WNV since 1999 and the potential for establishment of related viruses, such as Japanese encephalitis virus, if they were to be introduced in the United States. <b><i>Materials and Methods:</i></b> We have compiled human West Nile case data from Kansas over time with the purpose of illustrating how this virus has become endemic in the center of North America in a representative Midwestern state that is seasonal and does not have year-round mosquito vector activity. Case data were compiled from multiple sources including the U.S. Center for Disease Control and Prevention, the U.S. Department of Agriculture, and the Kansas Department of Health and Environment. <b><i>Results:</i></b> The annual reported numbers of human WNV infections have fluctuated widely in Kansas since the introduction in 2002. Between 2002 and 2022, there were a total of 715 reported cases in Kansas, with an average of 34 cases per year. Among the 715 cases, 73% were from 23 counties, but 4 counties accounted for 32% of this total with clusters of cases. Sedgwick County, which is the second most populous county in Kansas, represented 15% of the 715 total cases. <b><i>Conclusion:</i></b> The reasons for fluctuations in the number of cases reported each year and the distribution of these cases is uncertain, but they are most likely due to changes in the mosquito vector populations, which are influenced by environmental factors, such as seasonal rainfall, temperature, and humidity. With regards to the future, WNV is here to stay with annual fluctuations that are difficult to predict. The establishment of WNV in the U.S. and Kansas should serve as a warning for the possibility of establishment of other mosquito-vectored diseases, including Japanese Encephalitis virus.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of Ticks and Rickettsiae in the Southwestern United States: Implications for Public Health.","authors":"Guillermo Arcega Castillo, Laura H Backus, Dawn Gouge, Lucy Li, Kathleen Walker, Janet Foley","doi":"10.1089/vbz.2024.0102","DOIUrl":"https://doi.org/10.1089/vbz.2024.0102","url":null,"abstract":"<p><p><b><i>Background:</i></b> Surveillance is important in addressing the significant public health concerns posed by tick-borne diseases. However, the southwestern U.S. presents particular challenges due to diverse tick fauna and varied ecologies. <b><i>Methods:</i></b> From 2021 to 2022, we conducted a partner-based tick surveillance program in Arizona and California to assess the presence of <i>Rickettsia</i> spp. pathogens and species composition of tick vectors. <b><i>Results:</i></b> A total of 913 ticks was collected, comprising in descending abundance <i>Rhipicephalus sanguineus</i>, <i>Dermacentor similis</i>, <i>Ixodes pacificus (I. pacificus)</i>, <i>Argas sp</i>., <i>Otobius megnini,</i> and <i>Haemaphysalis leporispalustris</i>. Arizona submitted predominantly brown dog ticks (90.05% of all ticks from Arizona), while California showed greater tick species richness with five species identified. No <i>Rickettsia rickettsii</i> was detected, but a variety of other <i>Rickettsia</i> spp. was found in ticks from both Arizona and California and included <i>Rickettsia rhipicephali (R. rhipicephali)</i>, Rickettsia <i>massiliae</i>, and <i>Rickettsia monacensis</i>-like rickettsial agents of <i>I. pacificus</i>, and two rickettsial organisms that were not identified to species: one <i>Rickettsia montanensis</i> or <i>Rickettsia raoultii</i>-like, and the other most similar to <i>Candidatus Rickettsia tarasevichiae (R.</i> tarasevichiae). <b><i>Conclusion:</i></b> This research contributes to our understanding of tickborne diseases in the southwestern U.S., and emphasizes the need for targeted surveillance and intervention initiatives in a region with complex relationships among ticks, hosts, and <i>Rickettsia</i> species. In particular, the finding of an apparently novel pairing of an unknown <i>Argas</i> sp. tick and <i>R. tarasevichiae</i>-like organism suggests that argasid species are an important target for future research. In addition, the results-both tick species submitted and resulting <i>Rickettsia</i> spp. identified-highlights the strengths and potential biases associated with a partner-based sampling method for tick surveillance.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short Communication: Analysis of the Spectrum of Glomerular Diseases in Chronic Filariasis Diagnosed in a Tertiary Care Hospital in India.","authors":"Priti Meena, Sandip Panda, Paromita Das, Anish Garg, Suvendu Purkait, Pavithra Ayyanar","doi":"10.1089/vbz.2024.0038","DOIUrl":"10.1089/vbz.2024.0038","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The study presents renal manifestations in chronic filariasis, a substantial health concern in the eastern and north-eastern regions of India. <b><i>Materials and Methods:</i></b> The study is a retrospective analysis of a renal biopsy series of patients with chronic filariasis from a tertiary care hospital in Odisha. It involves eight cases of chronic filariasis. <b><i>Results:</i></b> Common indications of biopsy were nephrotic syndrome, chyluria, and unexplained renal failure. The mean duration from the diagnosis of filariasis to the onset of glomerular diseases was 15.75 years, SD ± 4.2 years. Patients were followed up for a minimum of 6 months. Renal histopathology revealed various patterns, including membranous nephropathy, minimal change disease, IGA nephropathy, and membranoproliferative glomerulonephritis. <b><i>Conclusion:</i></b> The study fills a critical gap in the literature by elucidating renal biopsy findings in chronic filariasis. The multifaceted nature of this disease underscores the need for continued research to understand kidney diseases due to filariasis, especially in endemic regions.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"220-222"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Compound AT13148 Targeting AKT Suppresses Dengue Virus 2 Replication.","authors":"Yangchao Dong, Chuantao Ye, Peijun Han, Wei Ye, Yuan Wang, Jing Yang, Zhikai Xu, Fanglin Zhang, Yingfeng Lei","doi":"10.1089/vbz.2024.0069","DOIUrl":"10.1089/vbz.2024.0069","url":null,"abstract":"<p><p><b><i>Background:</i></b> Dengue virus (DENV) infection, caused by serotypes DENV 1-4, represents a significant global public health challenge, with no antiviral drugs currently available for treatment. The host Protein kinase B (AKT) signaling pathway is crucial for DENV infection, presenting a potential target for antiviral drug development. <b><i>Objective:</i></b> This study aimed to evaluate the antiviral activity of kinase inhibitors that target the AKT pathway, focusing on the compound AT13148. Methods: A mini-screening was conducted to identify kinase inhibitors with antiviral properties against DENV-2. The effects of AT13148 on viral RNA replication and translation were assessed in a dose- and time-dependent manner following DENV-2 entry. The mechanism of action was further investigated by evaluating the impact of AT13148 on AKT kinase activity and phosphorylation status. <b><i>Results:</i></b> AT13148 exhibited potent antiviral activity against DENV-2, significantly inhibiting viral RNA replication and translation post-entry. The compound was found to inhibit AKT kinase activity through hyperphosphorylation. <b><i>Conclusion:</i></b> The findings indicate that AT13148 effectively targets the AKT pathway, demonstrating potential as an antiviral therapeutic against DENV-2 by interfering with the virus's post-entry processes. Further in vivo studies are warranted to assess the efficacy of AT13148 in controlling DENV infection.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"213-219"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Epidemiological Information Required for Lyme Disease Surveillance in a Low-Incidence State, California 2011-2017.","authors":"Sharon I Brummitt, Anne M Kjemtrup, Woutrina A Smith, Christopher M Barker, Danielle J Harvey","doi":"10.1089/vbz.2024.0043","DOIUrl":"10.1089/vbz.2024.0043","url":null,"abstract":"<p><p><b><i>Background:</i></b> Between January 1, 2011, and December 31, 2017, over 12,000 case reports of Lyme disease (LD) were submitted to the California Reportable Disease Information Exchange for further investigation. The number of case reports has tripled compared to previous years, emphasizing the need for efficient estimation and classification methods. We evaluated whether estimation procedures can be implemented in a low-incidence state such as California to correctly classify a case of LD, similar to those procedures used in high-incidence states. <b><i>Objective:</i></b> The purpose of this study was to identify whether a minimum number of variables was sufficient to reliably classify cases in California and potentially reduce workload while maintaining the ability to track LD trends in California. <b><i>Methods:</i></b> To determine the relative value of diagnostic information, we compared five candidate logistic regression models that were used to classify cases based on information that varied in its degree of difficulty for collection. <b><i>Results:</i></b> Our results using California's surveillance data showed that automatically reported data were not sufficient, additional information such as, a patient's clinical presentation and travel history were necessary in a low-incidence state to improve the overall sensitivity of the models. <b><i>Conclusion:</i></b> This study may help inform public health surveillance efforts by demonstrating that both clinical and travel information are required to accurately classify a case of LD in a low-incidence state.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"187-194"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short Communication: Coinfection of Japanese Encephalitis and Scrub Typhus in Acute Encephalitis Patients in North India.","authors":"Hirawati Deval, Brij Ranjan Misra, Neha Srivastava, Avinash R Deoshatwar, Mahima Mittal, Niraj Kumar, S P Behera, Kamran Zaman, Rajeev Singh, Ashok Kumar Pandey, Rajni Kant, Vijay P Bondre","doi":"10.1089/vbz.2024.0067","DOIUrl":"10.1089/vbz.2024.0067","url":null,"abstract":"<p><p><b><i>Background:</i></b> Acute encephalitis syndrome (AES) is a significant public health issue in India, attributed to various etiologies. In eastern Uttar Pradesh, Japanese encephalitis (JE) was the leading cause of AES (10-14% of total AES) until scrub typhus (ST), caused by <i>Orientia tsutsugamushi</i>, was identified in cerebrospinal fluid and blood samples of AES patients contributing more than 60% of AES cases. This study investigates the prevalence of JE-ST coinfection and compares clinical outcomes among JE mono-infection, ST mono-infection, and JE-ST coinfection. <b><i>Materials and Methods:</i></b> AES cases admitted to BRD Medical College, Gorakhpur, Uttar Pradesh, India, from January 1, 2017, to December 31, 2017, were included. JE and ST diagnosis was confirmed by serological (IgM) and molecular (PCR) tests. Statistical analysis was done to correlate clinical outcomes and infection group. <b><i>Results:</i></b> Total 1180 cases were tested positive for JE and/or ST. The prevalence of JE-ST coinfection was 8.9% among AES cases. JE mono-infection showed a mortality rate of 34.5%, ST mono-infection 13.4%, and JE-ST coinfection 9.5%. JE-ST co-infected cases experienced less severe clinical outcomes compared to mono-infected cases. <b><i>Conclusion:</i></b> JE-ST coinfection in AES cases is relatively common, with better clinical outcomes and lower mortality rates compared to JE or ST mono-infections.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"223-227"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual, Host-Vector Interactions, and Environmental Risk Factors for <i>Plasmodium knowlesi</i> Malaria Among At-Risk Communities in Peninsular Malaysia: A Case-Control Study.","authors":"Hafizah Pasi, Emma Mohamad, Arina Anis Azlan, Mohammad Rezal Hamzah, Mohd Rahim Sulong, Affendi Isa, Sivasangari Genapathy, Hazwani Damanhuri","doi":"10.1089/vbz.2024.0023","DOIUrl":"10.1089/vbz.2024.0023","url":null,"abstract":"<p><p><b><i>Background:</i></b> Highlighting the individual, host-vector interactions, and environmental risk factors for knowlesi malaria were consequential toward more focused and effective prevention and control strategies. This study aims to identify the individual, host-vector interactions, and environmental risk factors for Plasmodium knowlesi malaria among at-risk communities in Peninsular Malaysia. <b><i>Materials and Methods:</i></b> A case-control study was conducted involving laboratory-confirmed cases of P. knowlesi malaria, while a locality-matched individual with no history of fever and tested negative for malaria was taken as control. Univariate and multiple logistic regression were applied to evaluate the potential risk factors among respondents using IBM SPSS Statistics for Windows, Version 26.0. <b><i>Results:</i></b> Results showed higher cases among males as compared to females (76.1% vs. 23.9%). Multiple logistic regression analysis showed being male is 3.51 higher risk (<i>p</i> < 0.001) to become a case. Respondents whose place of work or study is near the forest edge have 44.0% lower risk (<i>p</i> = 0.030), while those living in the Orang Asli village were 56.0% lower risk as compared to the organized village to become a case (<i>p</i> = 0.035). <b><i>Conclusion:</i></b> These findings demonstrated that gender emerges as an independent individual risk factor while residing near a forest edge, in an Orang Asli village, or occupying workers' longhouses situated in hilly areas lowered the environmental risk among respondents. These findings attested that alternative directions must be considered in addressing the known risk factors associated with this type of malaria and the design of prevention and control programs should be tailored to the unique characteristics of each population.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"167-179"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic, Demographic, and Behavioral Factors Associated with Dengue Outbreak: An Observational Study from Eastern Uttar Pradesh, India.","authors":"Umaer Alam, Aman Agarwal, Hirawati Deval, Rohit Beniwal, Neha Srivastava, Ashok Kumar Pandey, Ayush Mishra, Bimla Dhiman, Tanuja Mishra, Brij Ranjan Misra, Niraj Kumar, Vijay Kumar Srivastava, Angad Singh, Rajni Kant, Manoj Murhekar","doi":"10.1089/vbz.2024.0064","DOIUrl":"10.1089/vbz.2024.0064","url":null,"abstract":"<p><p><b><i>Background:</i></b> Clinical and epidemiological aspects of dengue have extensively been studied in India. However, limited data are available on social and behavioral aspects of dengue outbreak. We aimed to fill this gap and wish to study socioeconomic, demographic, and behavioral factors associated with dengue outbreak in the Gorakhpur region of eastern Uttar Pradesh, India. <b><i>Methods:</i></b> This retrospective observational study was conducted among dengue patients discharged from hospital. Data on sociodemographic, economic, and behavioral factors of dengue were collected telephonically using a structured questionnaire. Continuous and categorical variables were reported as mean ± SD and numbers (%), respectively. Logistic regression analysis was done to establish association between patient's characteristics, awareness, and preventive behavior. <b><i>Results:</i></b> Age group 19-45 years 156/232, males 159/232, urban residents 142/232, residing in pucca house 187/232, and from lower-income families 149/232 were mostly affected in this outbreak. Patients spent a median of Indian national rupees 20,000 on treatment. Only 10.8% of patients had Ayushman health insurance cards. Awareness about dengue infection was found in∼43% patients. Literates, middle income group, and professionals/semiprofessionals were significantly more aware about dengue disease, mosquito bite, and treatment than their counterparts. Travel history was significantly associated with dengue infection in the males of 19-45 years age group belonging to rural areas. Use of mosquito repellent, nets, wearing full sleeve clothes were significantly less in rural residents while barefoot walking was more frequently observed in this population. Use of mosquito repellent was significantly associated with income, and these were observed more in the middle-income group. <b><i>Conclusion:</i></b> People with low education level, residing in urban areas, residing in pucca houses, who travel frequently, and who belong to lower-income groups were majorly affected by this dengue outbreak. Less dengue awareness and not following preventive practices were found in them. Targeted health education campaigns in urban setting could prevent dengue and economic burden on these vulnerable groups.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"195-204"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Incidence of Clinician-Diagnosed Lyme Disease in Manitoba, Canada 2009-2018.","authors":"Richard Rusk, Salima Gasmi, Annie-Claude Bourgeois, Mandy Whitlock, Gilles R Detillieux, Kelly Stimpert, David Buckeridge, Jules K Koffi","doi":"10.1089/vbz.2024.0088","DOIUrl":"10.1089/vbz.2024.0088","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Lyme disease (LD) surveillance yields useful information to monitor the disease trends and spatial distribution. However, due to several factors, the Manitoba Health surveillance system, as with other systems, could be subject to underreporting. <b><i>Objectives:</i></b> To estimate the number and incidence of clinician-diagnosed LD over the study period in Manitoba, describe the epidemiology of clinician-diagnosed LD, and compare the findings with Manitoba Health LD surveillance data during the same period to estimate the extent of underreporting. <b><i>Methods:</i></b> A retrospective analysis of administrative health data was performed to calculate the number and incidence of clinician-diagnosed LD from 2009 to 2018 in Manitoba and describe the epidemiological characteristics using the <i>International Classification of Diseases</i>, <i>Tenth and Ninth Revision</i> (ICD-10-CA and ICD-9-CM) codes, and antimicrobial drug prescriptions. <b><i>Conclusion:</i></b> Of the 1,629,698 registrants within the Manitoba Health Insurance Registry followed over 10 years, 1658 LD events were identified. Most of the cases occurred from May to July and corresponded to the peak activity of the nymphal stage of the blacklegged tick in the province. LD events presented a bimodal distribution with a peak in children between 5 and 9 years of age for both sexes, and a peak in adults from 65 to 84 and from 50 to 74, respectively, for males and females. We estimated that an average of 165 LD events occurred annually in Manitoba (mean annual incidence of 10.17 per 100,000 population), compared with 30 cases per year reported in the surveillance system; therefore, the LD surveillance yields an important underreporting.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"205-212"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}