{"title":"来自印度喀拉拉邦Alappuzha Mansonia annulifera的马来布鲁吉亚（Brugia malayi）的异种监测和分子特征。","authors":"Kiruthiga Tamilselvan, Aiswarya R Suresh, Sivalaxmi Balakrishnan, Harish Kumar Shah, Bhairavi B, Jessu Mathew, Hisham Moosan","doi":"10.1089/vbz.2025.0015","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> Lymphatic filariasis is a major public health problem known for its disfiguring and debilitating effects. Alappuzha district in Kerala has been a hotspot for Brugian and Bancroftian filariasis. The efforts to combat Brugian filariasis in this region about two decades earlier led to notable decline in vector density and interruption of disease transmission. <b><i>Materials and Method:</i></b> A cross-sectional survey was carried out in Alappuzha district and 12 wards were selected using multistage random sampling method. An entomological survey was conducted in the selected wards. <b><i>Result:</i></b> Fourteen out of 69 Ma. annulifera were positive for filarial parasites. The average infection and infectivity rate was 20% and 0%. Molecular characterization of positive samples confirmed the parasites as Brugia malayi. Phylogenetic analysis of the isolates revealed that they belong to the same clade. <b><i>Conclusion:</i></b> This study highlights the importance of continued vector surveillance and timely intervention by appropriate vector control measures to prevent transmission of the disease.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Xenomonitoring and Molecular Characterization of <i>Brugia malayi</i> from <i>Mansonia annulifera</i> in Alappuzha, Kerala, India.\",\"authors\":\"Kiruthiga Tamilselvan, Aiswarya R Suresh, Sivalaxmi Balakrishnan, Harish Kumar Shah, Bhairavi B, Jessu Mathew, Hisham Moosan\",\"doi\":\"10.1089/vbz.2025.0015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Background:</i></b> Lymphatic filariasis is a major public health problem known for its disfiguring and debilitating effects. Alappuzha district in Kerala has been a hotspot for Brugian and Bancroftian filariasis. The efforts to combat Brugian filariasis in this region about two decades earlier led to notable decline in vector density and interruption of disease transmission. <b><i>Materials and Method:</i></b> A cross-sectional survey was carried out in Alappuzha district and 12 wards were selected using multistage random sampling method. An entomological survey was conducted in the selected wards. <b><i>Result:</i></b> Fourteen out of 69 Ma. annulifera were positive for filarial parasites. The average infection and infectivity rate was 20% and 0%. Molecular characterization of positive samples confirmed the parasites as Brugia malayi. Phylogenetic analysis of the isolates revealed that they belong to the same clade. <b><i>Conclusion:</i></b> This study highlights the importance of continued vector surveillance and timely intervention by appropriate vector control measures to prevent transmission of the disease.</p>\",\"PeriodicalId\":23683,\"journal\":{\"name\":\"Vector borne and zoonotic diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vector borne and zoonotic diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1089/vbz.2025.0015\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vector borne and zoonotic diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/vbz.2025.0015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Xenomonitoring and Molecular Characterization of Brugia malayi from Mansonia annulifera in Alappuzha, Kerala, India.
Background: Lymphatic filariasis is a major public health problem known for its disfiguring and debilitating effects. Alappuzha district in Kerala has been a hotspot for Brugian and Bancroftian filariasis. The efforts to combat Brugian filariasis in this region about two decades earlier led to notable decline in vector density and interruption of disease transmission. Materials and Method: A cross-sectional survey was carried out in Alappuzha district and 12 wards were selected using multistage random sampling method. An entomological survey was conducted in the selected wards. Result: Fourteen out of 69 Ma. annulifera were positive for filarial parasites. The average infection and infectivity rate was 20% and 0%. Molecular characterization of positive samples confirmed the parasites as Brugia malayi. Phylogenetic analysis of the isolates revealed that they belong to the same clade. Conclusion: This study highlights the importance of continued vector surveillance and timely intervention by appropriate vector control measures to prevent transmission of the disease.
期刊介绍：
Vector-Borne and Zoonotic Diseases is an authoritative, peer-reviewed journal providing basic and applied research on diseases transmitted to humans by invertebrate vectors or non-human vertebrates. The Journal examines geographic, seasonal, and other risk factors that influence the transmission, diagnosis, management, and prevention of this group of infectious diseases, and identifies global trends that have the potential to result in major epidemics.
Vector-Borne and Zoonotic Diseases coverage includes:
-Ecology
-Entomology
-Epidemiology
-Infectious diseases
-Microbiology
-Parasitology
-Pathology
-Public health
-Tropical medicine
-Wildlife biology
-Bacterial, rickettsial, viral, and parasitic zoonoses
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