Vector borne and zoonotic diseases最新文献

{"title":"A Systematic Review of Zoonotic Disease Prevalence in Sri Lanka (2000-2022).","authors":"Nadeesha Athukorala, Susiji Wickramasinghe, Lalani Yatawara, Kosala Weerakoon","doi":"10.1089/vbz.2023.0141","DOIUrl":"10.1089/vbz.2023.0141","url":null,"abstract":"<p><p><b><i>Background:</i></b> The burden of zoonotic diseases in developing countries is significantly underestimated, influenced by various factors such as misdiagnosis, underreporting, natural disasters, climate change, resource limitations, rapid unplanned urbanization, poverty, animal migration, travel, ecotourism, and the tropical environmental conditions prevalent in the region. Despite Sri Lanka's provision of a publicly funded free health care system, zoonoses still contribute significantly to the burden of communicable diseases in the country. This study serves as a timely and exhaustive systematic review of zoonoses reported over the past 22 years in Sri Lanka. <b><i>Materials and Methods:</i></b> This systematic review adhered to the guidelines provided by the \"Preferred Reporting Items for Systematic Reviews and Meta-Analyses\" (PRISMA) statement. A systematic literature search was conducted between July and September 2022, utilizing the following databases and sources: Google Scholar, PubMed, Cochrane Library, Weekly Epidemiological Reports, and Rabies Statistical Bulletins published by the Ministry of Health, Sri Lanka. <b><i>Results:</i></b> From the initial database search, 1,710 articles were identified. After excluding nonzoonotic diseases, duplicated reports, inaccessible articles, and those not meeting the inclusion criteria, 570 reports were evaluated for eligibility. Of these, 91 reports were selected for data extraction, comprising 58 original research articles, 10 case reports, 16 weekly epidemiological reports, and 7 rabies statistical bulletins. Over the study period (2000-2022), 14 parasitic, 7 bacterial, and 7 viral zoonoses have been reported in Sri Lanka. Notably, leptospirosis emerged as the most reported zoonotic disease in the country. <b><i>Conclusions:</i></b> In response to these findings, we strongly recommend the implementation of a tailored, country-specific prevention and control program. To achieve this goal effectively, we emphasize the importance of adopting a country-specific \"One Health\" approach as a comprehensive framework for managing and controlling zoonotic diseases in Sri Lanka.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"453-472"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T(r)icky Environments: Higher Prevalence of Tick-Borne Zoonotic Pathogens in Rodents from Natural Areas Compared with Urban Areas.","authors":"Marieke P de Cock, Valérie O Baede, Helen J Esser, Manoj Fonville, Ankje de Vries, Willem F de Boer, Calvin Mehl, Rainer G Ulrich, Gereon Schares, Renate W Hakze-van der Honing, Wim H M van der Poel, Hein Sprong, Miriam Maas","doi":"10.1089/vbz.2023.0151","DOIUrl":"10.1089/vbz.2023.0151","url":null,"abstract":"<p><p><b><i>Background:</i></b> Urban areas are unique ecosystems with stark differences in species abundance and composition compared with natural ecosystems. These differences can affect pathogen transmission dynamics, thereby altering zoonotic pathogen prevalence and diversity. In this study, we screened small mammals from natural and urban areas in the Netherlands for up to 19 zoonotic pathogens, including viruses, bacteria, and protozoan parasites. <b><i>Materials and Methods:</i></b> In total, 578 small mammals were captured, including wood mice (<i>Apodemus sylvaticus</i>), bank voles (<i>Myodes glareolus</i>), yellow-necked mice (<i>Apodemus flavicollis</i>), house mice (<i>Mus musculus</i>), common voles (<i>Microtus arvalis</i>), and greater white-toothed shrews (<i>Crocidura russula</i>). We detected a wide variety of zoonotic pathogens in small mammals from both urban and natural areas. For a subset of these pathogens, in wood mice and bank voles, we then tested whether pathogen prevalence and diversity were associated with habitat type (<i>i.e.,</i> natural versus urban), degree of greenness, and various host characteristics. <b><i>Results:</i></b> The prevalence of tick-borne zoonotic pathogens (<i>Borrelia</i> spp. and <i>Neoehrlichia mikurensis</i>) was significantly higher in wood mice from natural areas. In contrast, the prevalence of <i>Bartonella</i> spp. was higher in wood mice from urban areas, but this difference was not statistically significant. Pathogen diversity was higher in bank voles from natural habitats and increased with body weight for both rodent species, although this relationship depended on sex for bank voles. In addition, we detected methicillin-resistant <i>Staphylococcus aureus</i>, extended-spectrum beta-lactamase/AmpC-producing <i>Escherichia coli</i>, and lymphocytic choriomeningitis virus for the first time in rodents in the Netherlands. <b><i>Discussion:</i></b> The differences between natural and urban areas are likely related to differences in the abundance and diversity of arthropod vectors and vertebrate community composition. With increasing environmental encroachment and changes in urban land use (<i>e.g.,</i> urban greening), it is important to better understand transmission dynamics of zoonotic pathogens in urban environments to reduce potential disease risks for public health.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"478-488"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Crimean-Congo Hemorrhagic Fever Infections in Tunisia.","authors":"Syrine Rekik, Ines Hammami, Oumayma Timoumi, Dhekra Maghzaoua, Médiha Khamassi Khbou, Ansgar Schulz, Martin H Groschup, Mohamed Gharbi","doi":"10.1089/vbz.2023.0079","DOIUrl":"10.1089/vbz.2023.0079","url":null,"abstract":"<p><p>Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic tick-borne disease, caused by an arbovirus of the genus Orthonairovirus and the family Nairoviridae. Crimean-Congo hemorrhagic fever virus (CCHFV) is widespread in several regions of the world. While the virus is not pathogenic to all susceptible livestock and wild mammals, it can lead to severe hemorrhagic fever in humans. In this review, we compiled published data on CCHFV infections in humans, animals, and ticks in Tunisia. Based on that, we discussed the epidemiology and the distribution patterns of CCHFV infections highlighting the risk factors for this virus in the country. CCHF infection prevalence in humans was estimated to 2.76% (5/181) and 5% (2/38) in Tunisian febrile patients and Tunisian slaughterhouse workers, respectively. Concurrently, seroprevalence in domestic ungulates (sheep, goats, cattle, and dromedaries) ranged from zero to 89.7%, and only one <i>Hyalomma impeltatum</i> tick specimen collected from dromedaries in southern Tunisian was positive for CCHFV by reverse transcriptase-polymerase chain reaction (0.6%; 1/165). As Tunisian studies on CCHFV are geographically scattered and limited due to very small sample sizes, further studies are needed to improve the knowledge on the epidemiology of CCHF in Tunisia.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"325-337"},"PeriodicalIF":1.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Pediatric Brucellosis Cases With and Without Bacteremia.","authors":"Miray Yılmaz Çelebi, Elif Böncüoğlu, Elif Kıymet, Şahika Şahinkaya, Ela Cem, Mustafa Gülderen, Pelin Kaçar, Eda Özdağ, Aybüke Akaslan Kara, Gizem Güner Özenen, Yelda Sorguç, Fahri Yüce Ayhan, Hurşit Apa, Süleyman Nuri Bayram, İlker Devrim","doi":"10.1089/vbz.2023.0080","DOIUrl":"10.1089/vbz.2023.0080","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Brucellosis, which is among the endemic regions of Turkey, is a common zoonotic disease. The gold standard in diagnosing brucellosis is culture. We aimed to compare demographic characteristics, risk factors, and clinical and laboratory variables between cases with culture positivity and undetected in culture. <b><i>Materials and Methods:</i></b> This single-center study was conducted between January 2007 and April 2022. Clinical and laboratory data of patients with brucella growth in blood culture and patients without growth were compared. <b><i>Results:</i></b> A total of 150 patients were included in the study. The median age was 10 (1-18 years). Of the patients, 66 (44%) were female and 84 (56%) were male. Forty (26.7%) of the patients were bacteremic and 110 (73.3%) were nonbacteremic. In the bacteremic group, white blood cell count, platelet, and hemoglobin counts were lower, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values were higher. In clinical evaluation, fever, hepatomegaly, splenomegaly, and abdominal pain were more common in the bacteremic group. <b><i>Conclusion:</i></b> The distinction between bacteremic and nonbacteremic brucellosis can be predicted using laboratory values such as white blood cells, hemoglobin counts, platelet, ALT, and AST, and clinical findings such as fever, abdominal pain, hepatomegaly, and splenomegaly.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"359-363"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of Active Orbivirus Transmission in 2016 in Kansas and Nebraska.","authors":"David Scott McVey, Greg Hanzlicek, Mark G Ruder, Dustin Loy, Barbara S Drolet","doi":"10.1089/vbz.2022.0096","DOIUrl":"10.1089/vbz.2022.0096","url":null,"abstract":"<p><p>Retrospective serological and case diagnostic data of endemic bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) provide evidence of viral transmission among livestock and wildlife from 2016 in Kansas and Nebraska. Serological testing of mature cattle in nine distinct regional zones of Kansas revealed 76% to 100% had detectable antibodies to BTV and/or EHDV. Specimens tested in the Kansas Veterinary Diagnostic Laboratory (55 submissions) were 51% test positive for antibodies to BTV and/or EHDV. Specimens tested in the Nebraska Veterinary Diagnostic Center (283 submissions) were 25% test positive for antibodies to BTV and/or EHDV. Low disease incidence in white-tailed deer and other susceptible wild ungulates was observed during 2016. However, there were no confirmed reports of disease in livestock in either state. The reasons for emergence of significant clinical disease in livestock and wildlife populations remain undefined.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"390-395"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Health Approach on <i>Ehrlichia canis</i>: Serosurvey of Owners and Dogs, Molecular Detection in Ticks, and Associated Risk Factors in Tick-Infested Households of Southern Brazil.","authors":"Natacha Sohn-Hausner, Louise Bach Kmetiuk, Warley Vieira de Freitas Paula, Luiza Gabriella Ferreira de Paula, Felipe da Silva Krawczak, Alexander Welker Biondo","doi":"10.1089/vbz.2023.0134","DOIUrl":"10.1089/vbz.2023.0134","url":null,"abstract":"<p><p><b><i>Background:</i></b> <i>Ehrlichia canis</i> has been the main hemopathogen affecting domestic dogs in Brazil. Even though tick-infested dogs may lead to household infestation and predispose human exposure and public health concern, no comprehensive study has surveyed humans, dogs, and environmental ticks altogether. <b><i>Materials and Methods:</i></b> Accordingly, the present study aimed to assess tick-infested households, identify tick species, perform serological (immunofluorescence assay) and molecular (PCR and q-PCR) detection of <i>Ehrlichia</i> in ticks, in the eighth biggest metropolitan area of Brazil. <b><i>Results:</i></b> Between 2007 and 2020, 233/5973 (3.9%) out of all complaints were from tick-infested households of 200 different addresses. Overall, 370/552 (67.0%) ticks were collected and identified as adult and 182/552 (33.0%) as immature forms of <i>Rhipicephalus sanguineus</i> s.l. complex; a single tick from one owner, a female tick of <i>Amblyomma sculptum</i>; and 395 ticks from dogs, 319/395 (80.8%) adult and 72/395 (18.2%) immature forms of <i>Rhipicephalus</i> spp., and 4/395 (1.01%) female <i>Amblyomma aureolatum</i>. Overall, 2/135 (1.5%) owners and 13/136 (9.6%) dogs were seropositive for <i>E. canis</i>. The DNA of Anaplasmataceae family was molecularly detected in 16/50 (32.0%) <i>R. sanguineus</i> s.l. As expected, the number of monthly tick infestation complaints were directly associated, and mean (<i>p</i> = 0.01), maximum (<i>p</i> = 0.011), and minimum (<i>p</i> = 0.008) temperature were statistically significant and had a low positive correlation (0.24, 0.23, and 0.24, respectively). In addition, complaints were highly associated to all socioeconomic variables (<i>p</i> < 0.001), with the exception of the presence of vacant lots. <b><i>Conclusions:</i></b> Despite low samplings and human negative results, areas with low-income with adequate temperature and urban agglomerations have been shown to be associated risks for tick infestations, predisposing tick-borne diseases. In conclusion, monitoring should always be conducted in such areas, including One Health approach with serosurvey of owners and dogs, along with identification and molecular screening of ticks.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"338-350"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory Assessment of Molluscicidal Activities of <i>Cannabis sativa</i>, <i>Acacia nilotica</i>, and <i>Tinospora cordifolia</i> Against Snail Host of <i>Fasciola spp.</i>","authors":"Nilay Vishal Singh, Arundhati Singh, Vinay Kumar Singh","doi":"10.1089/vbz.2023.0073","DOIUrl":"10.1089/vbz.2023.0073","url":null,"abstract":"<p><p><b><i>Background:</i></b> The potential molluscicidal extracts, obtained from indigenous plants <i>Cannabis sativa</i>, <i>Acacia nilotica</i>, and <i>Tinospora cordifolia</i>, were tested for toxicity against freshwater pulmonate snail <i>Lymnaea acuminata</i>, an intermediate host of <i>Fasciola hepatica</i>. The organic extracts had a significant effect on young snails. <b><i>Materials and Methods:</i></b> All organic extracts and column-purified fractions gave median lethal concentrations (19-100.05 mg/L; 24 h) that fell well within the threshold level of 100 mg/L, set for a potential molluscicide by the World Health Organization. <b><i>Results:</i></b> The toxicity of <i>T. cordifolia</i> stem acetone extract (96 h LC₅₀: 16.08 mg/L) was more pronounced compared with <i>C. sativa</i> leaf ethanol extract (96 h LC₅₀: 16.32 mg/L) and <i>A. nilotica</i> leaf ethanol extract (96 h LC₅₀: 24.78 mg/L). β-caryophyllene, gallic acid, and berberine were characterized and identified as active molluscicidal components. Co-migration of β-caryophyllene (retardation factor [R<i>f</i>] 0.95), gallic acid (<i>Rf</i> 0.30), and berberine (R<i>f</i> 0.23) with column-purified parts of <i>Cannabis sativa</i>, <i>Acacia nilotica</i>, and <i>Tinospora cordifolia</i> on thin-layer chromatography demonstrates same R<i>f</i> value, that is, 0.95, 0.30, and 0.23, respectively. <b><i>Conclusion:</i></b> This study indicates that these extracts thus represent potential plant-derived molluscicides that are worthy of further investigations.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"382-389"},"PeriodicalIF":2.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fleas (Siphonaptera, Latreille, 1825) from Rio Grande do Sul State, Brazil: Species Diversity, Hosts, and One Health Approach.","authors":"Diogo Schott, Fernanda Laís Ribeiro, Fernanda Nunes Santos, Raimundo Wilson de Carvalho","doi":"10.1089/vbz.2023.0065","DOIUrl":"10.1089/vbz.2023.0065","url":null,"abstract":"<p><p><b><i>Background:</i></b> Fleas are ectoparasitic insects with holometabolous development. It has a hematophagous habit with mouthparts adapted to sting and suck its hosts. There are about 3000 species in the world, ∼61 in Brazil, and 19 in Rio Grande do Sul state. The objective of the research is to catalog the diversity of fleas recorded in the state, their respective hosts, and endosymbionts. <b><i>Materials and Methods:</i></b> To this end, a search was carried out in the scientific literature, from articles, books, to abstracts submitted to congresses. <b><i>Results:</i></b> The 19 species of fleas occurring in Rio Grande do Sul are divided into 7 families and 10 genera. These ectoparasites, in addition to being found in the environment, were associated with 10 different families of hosts in Rio Grande do Sul, and on the endosymbiont, agents found associated with fleas, there were 7 different species. The main agents researched in the state are <i>Rickettsia</i> spp. and <i>Bartonella</i> spp. The relationships between parasites, hosts, environment, and etiological agents present different scenarios, whether anthropized or conserved, but unknown. Sometimes, this overlap, a factor that aggravates the possibility of spillovers, either from cosmopolitan fleas in these conserved areas, or from their endosymbionts. <b><i>Conclusion:</i></b> Thus, it is important to characterize the environment so that the complexities of each location are known for the adoption of environmental and public health policies in each case. The challenges are extensive, but necessary in view of the One Health perspective.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"308-320"},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review on the Epidemiology of Orthobunyaviruses in Canada, in the Context of Human, Wildlife, and Domestic Animal Host Species.","authors":"Michele D Bergevin, Victoria Ng, Tara Sadeghieh, Paula Menzies, Antoinette Ludwig, Samira Mubareka, Katie M Clow","doi":"10.1089/vbz.2023.0109","DOIUrl":"10.1089/vbz.2023.0109","url":null,"abstract":"<p><p><b><i>Background:</i></b> Mosquito-borne orthobunyaviruses in Canada are a growing public health concern. Orthobunyaviral diseases are commonly underdiagnosed and in Canada, likely underreported as surveillance is passive. No vaccines or specific treatments exist for these disease agents. Further, climate change is facilitating habitat expansion for relevant reservoirs and vectors, and it is likely that the majority of the Canadian population is susceptible to these viruses. <b><i>Methods:</i></b> A scoping review was conducted to describe the current state of knowledge on orthobunyavirus epidemiology in Canada. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guideline was used. Literature searches were conducted in six databases and in gray literature. The epidemiology of orthobunyaviruses was characterized for studies focusing on host species, including spatiotemporal patterns, risk factors, and climate change impact. <b><i>Results:</i></b> A total of 172 relevant studies were identified from 1734 citations from which 95 addressed host species, including humans, wildlife, and domestic animals including livestock. The orthobunyaviruses-Cache Valley virus (CVV), Jamestown Canyon virus (JCV), Snowshoe Hare virus (SHV), and La Crosse virus (LACV)-were identified, and prevalence was widespread across vertebrate species. CVV, JCV, and SHV were detected across Canada and the United States. LACV was reported only in the United States, predominantly the Mid-Atlantic and Appalachian regions. Disease varied by orthobunyavirus and was associated with age, environment, preexisting compromised immune systems, or livestock breeding schedule. <b><i>Conclusion:</i></b> Knowledge gaps included seroprevalence data in Canada, risk factor analyses, particularly for livestock, and disease projections in the context of climate change. Additional surveillance and mitigation strategies, especially accounting for climate change, are needed to guide future public health efforts to prevent orthobunyavirus exposure and disease.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"249-264"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Serology in Persistent Q Fever Infection.","authors":"Shelly Lipman-Arens, Talya Finn, Valery Istomin, Regev Cohen, Sharon Reisfeld","doi":"10.1089/vbz.2023.0121","DOIUrl":"10.1089/vbz.2023.0121","url":null,"abstract":"<p><p><b><i>Background:</i></b> Q fever has significant consequences for patients with persistent localized infection. A combination of doxycycline with hydroxychloroquine, for at least 18-24 months, is the first-line therapy. The use of serology as a prognostic marker during therapy is controversial. <b><i>Methods:</i></b> A retrospective, observational cohort study in two outpatient clinics in northern Israel. All adults with persistent Q fever (2015-2021) were included in the study. Clinical failure was defined as relapse or death related to Q fever after end of treatment (EOT). Serological cure was defined as phase 1 IgG ≤800 or a four-fold decrease at EOT. <b><i>Results:</i></b> Twenty-two patients were included in the study, with a median follow up of 40 months (IQR = 28.5-63.5), and median treatment duration of 28.5 months (IQR = 21.8-50.5). Clinical cure occurred in 18 patients (82%), serological cure in 10 (45%). Phase 1 IgG at presentation was significantly higher in the clinical failure group (median 9600 vs. 3200 in the clinical cure group, <i>p</i> = 0.019), and at 6-12 months after EOT (median 6400 vs. 800 respectively, <i>p</i> = 0.03). Phase 1 IgG levels at 1 year and EOT were similar in both groups. Positive phase 2 IgM after one year of therapy correlated with clinical failure (<i>p</i> = 0.038), but not at EOT or after EOT. <b><i>Conclusion:</i></b> Phase 1 IgG levels at presentation, phase 2 IgM at 1 year, and Phase 1 IgG 6-12 months after EOT were associated with clinical failure in patients with persistent Q fever.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"293-298"},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}