哥伦比亚圣玛尔塔内华达山脉土著居民的立克次体和恙虫病血清流行率。

IF 1.8 4区 医学 Q3 INFECTIOUS DISEASES
Vector borne and zoonotic diseases Pub Date : 2024-10-01 Epub Date: 2024-05-14 DOI:10.1089/vbz.2023.0077
Regina Oakley, Simone Kann, Gustavo Concha, Michèle Plag, Sven Poppert, Stephen Graves, Daniel H Paris, Anou Dreyfus
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引用次数: 0

摘要

背景:立克次体属是病媒传播的人畜共患病原体,可导致人类发热性疾病。立克次体病未纳入哥伦比亚国家监测系统,因此预计报告不足。这项横断面研究旨在确定居住在哥伦比亚圣玛尔塔内华达山脉(Sierra Nevada de Santa Marta)的两个土著居民中立克次体属和密切相关的恙虫病Orientia的血清流行率。材料与方法:2021 年至 2022 年期间从 Wiwa 人和 Koguis 人采集了血清样本(n = 539)。使用富勒实验室立克次体 IgG IFA 试剂盒对血清样本进行斑点热组(SFG)和斑疹伤寒组(TG)立克次体筛查,并使用恙虫病 Detect™ IgG ELISA 对恙虫病进行筛查。结果:我们观察到,SFG立克次体的总血清流行率为26.2%(95%置信区间[CI] 22.5-30.1]),TG立克次体的总血清流行率为5.4%(95%置信区间[CI] 3.6-7.6),O. tsutsugamushi的总血清流行率为4.3%(95%置信区间[CI] 2.7-6.3)。对 147 名 Wiwa 参与者感染人畜共患病的常见风险因素进行了评估。观察发现,照顾牲畜(包括帮助牛分娩)的 Wiwa 参与者的 SFG 立克次体血清阳性几率增加(几率比 [OR] = 8.85;95% CI 1.54-50.90;p = 0.015),照顾山羊的 Wiwa 参与者的 SFG 立克次体血清阳性几率增加(OR = 7.60;95% CI 1.70-33.90;p = 0.008)。结论这些结果表明,在哥伦比亚农村地区存在明显的立克次体感染风险,尤其是SFG。最近有报告称,南美洲附近地区的落基山斑疹热死亡率很高,因此需要进行更详细的调查,重点是提高人们的知识和意识,并开展 "一体健康 "和 "发热原因 "研究。对立克次体属在人类、牲畜和蜱媒中的感染特征及其潜在传播途径的研究将对这些易于治疗的疾病产生重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence of Rickettsia Spp. and Orientia tsutsugamushi in Indigenous Populations from the Sierra Nevada de Santa Marta, Colombia.

Background: Rickettsia spp. are vector-borne zoonotic pathogens that cause febrile illness in humans. Rickettsioses is not included in the Colombian national surveillance system and is subsequently expected to be underreported. This cross-sectional study aimed to determine the seroprevalence of Rickettsia spp. and the closely related Orientia tsutsugamushi in two indigenous populations residing in the Sierra Nevada de Santa Marta, Colombia. Materials and Methods: Serum samples (n = 539) were collected from the Wiwa and Koguis people between 2021 and 2022. Serum samples were screened for spotted fever group (SFG) and typhus group (TG) Rickettsia spp. using the Fuller laboratories Rickettsia IgG IFA kit and for O. tsutsugamushi with the Scrub Typhus Detect™ IgG ELISA. Results: We observed an overall seroprevalence of 26.2% (95% confidence interval [CI] 22.5-30.1] for Rickettsia spp. of the SFG, 5.4% (95% CI 3.6-7.6) for Rickettsia spp. of the TG and 4.3% (95% CI 2.7-6.3) for O. tsutsugamushi. Common risk factors for zoonotic disease infections were assessed for 147 of the Wiwa participants. Increased odds of seropositivity for SFG Rickettsia spp. were observed for Wiwa participants who cared for livestock, including assisting with the birth of cattle (odds ratio [OR] = 8.85; 95% CI 1.54-50.90; p = 0.015) and goats (OR = 7.60; 95% CI 1.70-33.90; p = 0.008). Conclusions: These results highlight a notable exposure to Rickettsia spp., especially the SFG, in rural Colombia. Together with recent reports of high mortality for Rocky Mountain Spotted Fever in nearby regions of South America, more detailed investigations focusing on improving knowledge and awareness as well as "One Health" and "causes-of-fever" studies are needed. The characterization of Rickettsia spp. infections in humans, livestock, and tick vectors with their potential transmission routes could make a high impact on these easily treatable diseases.

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来源期刊
CiteScore
4.70
自引率
4.80%
发文量
73
审稿时长
3-8 weeks
期刊介绍: Vector-Borne and Zoonotic Diseases is an authoritative, peer-reviewed journal providing basic and applied research on diseases transmitted to humans by invertebrate vectors or non-human vertebrates. The Journal examines geographic, seasonal, and other risk factors that influence the transmission, diagnosis, management, and prevention of this group of infectious diseases, and identifies global trends that have the potential to result in major epidemics. Vector-Borne and Zoonotic Diseases coverage includes: -Ecology -Entomology -Epidemiology -Infectious diseases -Microbiology -Parasitology -Pathology -Public health -Tropical medicine -Wildlife biology -Bacterial, rickettsial, viral, and parasitic zoonoses
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