West African journal of medicine最新文献

{"title":"Knowledge, Perception, Barriers and Facilitators to Sleep Medicine Practice among Nigerian Paediatricians.","authors":"O E Olorunmoteni, A J Kareem, T T Oyetoke, B A Sayomi, J I Akande, O G Afeniforo, I Chinonye, M A Komolafe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to assess the knowledge and perception of Nigerian paediatricians regarding paediatric sleep disorders and their management. It also assessed the state of their current practice with screening, evaluating and treating sleep disorders in children and the perceived barriers and facilitators to the provision of quality care for sleep disorders for Nigerian children.</p><p><strong>Methods: </strong>This descriptive cross-sectional study was conducted among 153 Paediatricians who practice in Nigeria and attended the Annual Scientific Meeting of the Paediatrics Association of Nigeria (PAN) held in January 2023 at Akure, Ondo state, Nigeria. We utilized a pilot-tested, semi-structured questionnaire adapted from the Paediatrics sleep survey questionnaire. Data was analysed with the IBM SPSS software, version 20.</p><p><strong>Results: </strong>The 153 respondents were from the six geopolitical zones in Nigeria. More than two-thirds (66.7%) had a poor knowledge score (<6). The majority of the respondents rated their confidence in diagnosing sleep disorders as fair (63.4%), while 22.2% rated it as poor. Almost all (98.7%) reported the lack of sleep laboratory in their centre of practice. Also, about two-thirds (68.0%) had no paediatric sleep clinic. The main barriers to the management of paediatric sleep disorders were lack of training (119; 77.3%) and lack of sleep laboratory (102; 66.7%). Having a sleep laboratory in the centre of practice was significantly associated with the knowledge of the paediatricians (p = 0.044).</p><p><strong>Conclusion: </strong>There is a need for interventions to improve the knowledge of Nigerian paediatricians on sleep medicine and the provision of Paediatric sleep laboratory facilities in Nigeria.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 8","pages":"677-686"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willing but Unable - Exploring the Barriers to Living Kidney Donation in a Tertiary Hospital in Southeast Nigeria: A Preliminary Report.","authors":"C G Okwuonu, O D Ekwenna, I J Orji, M A Erondu, H Sylvanus-Kanu, S Alhassan, A Chuku, A K Onyebuchi, R A Balogun","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation in Nigeria has witnessed remarkable advancements. Availability of suitable and willing living donors is one of the major factors leading to its success. The aim of this study was to identify and analyze the reasons for exclusion of potential living kidney donors in a transplant program at a tertiary hospital in Southeast Nigeria. This is important in order to improve donor screening, maximize the living donor pool and ensure donor safety.</p><p><strong>Methods: </strong>This was a retrospective study of kidney transplant register and medical records at the transplant clinic of Federal Medical Center Umuahia, Southeast Nigeria. Relevant clinical data of potential living kidney donors who presented for pre-donation evaluation over a period of 8 years were collated in excel sheet and analyzed using SPSS version 23.0. Tables, charts and graphs were used to illustrate some data.</p><p><strong>Results: </strong>Pre-donation evaluation records of sixty four potential living donors were retrieved. Median age was 23 (IQR=19-39) years There were 62 males and 2 females with M:F ratio of 31:1. Majority were unskilled workers (83%) and unrelated to prospective recipients (61%). Among those related to the patients (39%), there were more second-degree relatives (22%) than first degree relatives (17%). Out of the 64 potential kidney donors, 13 (20%) eventually donated while 51(80%) did not. Factors that prevented eventual kidney donation included immunological incompatibility (32.8%), albuminuria (11%), hypertension (9%), financial motivation (9%), nephrolithiasis (4.7%), donor withdrawal from donation process (4.7%), Hepatitis B infection (3%), prediabetes (3%) and abnormal cardiac function (1.5%).</p><p><strong>Conclusion: </strong>The potential living donors evaluated were mostly young males that were unrelated to their potential recipients. Immunologic incompatibility was the leading cause of failure to donate a kidney; mainly from donor-recipient significant HLA mismatches.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 8","pages":"668-676"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Eye Syndrome Among Tertiary Institution Students in the Post-Covid Era: A Cross-Sectional Study.","authors":"S T Adepoju, A T Owolabi, G T Akande, D I Oseji, E O Fajobi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study investigates the prevalence of the symptoms and risk factors of Digital Eye Syndrome (DES) among tertiary institution students in the post-COVID era.</p><p><strong>Methods: </strong>This is a cross-sectional observational study conducted in a tertiary institution. Participants included students who use digital screens for academic and recreational activities. Inclusion criteria involved students with at least ten minutes of daily screen time. A structured questionnaire was used to assess screen time, symptoms, and ergonomic practices. Data collection included self-reported symptoms of DES and potential risk factors such as screen duration, posture, and lighting conditions. The primary outcomes were the prevalence of DES symptoms, including eye strain, headaches, dryness, and blurred vision, as well as associated ergonomic and behavioral risk factors.</p><p><strong>Results: </strong>A significant proportion of students reported experiencing symptoms of DES as follows: approximately half of the respondents (49.8%) reported experiencing irritation or a gritty feeling in the eye(s), 26.5% reported a burning sensation in their eyes, eye fatigue (57.6%), sensitivity to bright light (68.7%), and a dry feeling in the eye (25.4%). Additionally, symptoms like blurring of vision (37.1%), itching (41.3%), and tearing (35.8%) were also prevalent among respondents. Statistical analysis (Chi-square test) revealed associations between prolonged screen time (8-11 hours screen time, p = 0.040) which is statistically significant; poor ergonomic practices are not statistically significant (p = 0.444 for lying down, placing the screen below the eye level, p = 0.560) and increased symptom severity.</p><p><strong>Conclusions: </strong>Symptoms of Digital Eye Syndrome are still prevalent among tertiary institution students in the post-COVID era, exacerbated by prolonged screen use and poor ergonomics. Implementing preventive strategies, such as regular breaks and optimized lighting, may mitigate symptoms. Further studies are recommended to explore the long-term ocular effects of digital devices.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 8","pages":"621-628"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Audit of Early Infant HIV Diagnosis and Protocol at Wesley Guild Hospital and Its Cost Effectiveness.","authors":"O A Oyedeji, T Ogundele, B I Oso, J B Ayinde, D K Kuti, E Agelebe, E A Adejuyigbe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The human immunodeficiency virus (HIV) screening protocol for high and low risk for HIV transmission exposed infants needs appraisal.</p><p><strong>Objective: </strong>To audit the cost effectiveness of the early HIV infant diagnosis protocol, by the 2020 (recent) and 2016 (previous) Nigerian guidelines screening protocol.</p><p><strong>Methods: </strong>All babies delivered by HIV infected mothers over 4years at the Wesley Guild Hospital, Ilesa were studied. Their HIV status, risk category and age at early infant diagnosis were analyzed.</p><p><strong>Results: </strong>Seventy-two infants and their mother were studied. Thirteen (18.1%) of the total 72 studied were HIV infected. All HIV infections were in the 21 high risk category compared to none in the 51 low risk category (P <0.01). Fifty (98.0%) low risk infants had HIV DNA Polymerase chain reaction (PCR) testing between 6 -8 weeks compared to one (4.5%) high risk between 6-8weeks. (P <0.01). The 21 (95.5%) high risk infants had their first PCR screening between 3 and 14 months. Rapid screening was conducted at 18months for all the 67 infants that survived till this age. The calculated screening cost by the current protocol is thrice as expensive, but equally sensitive for diagnosis as the year 2016 National screening protocol, for low-risk category infants. More than 95% of infants were well immunized and stopped breast feeding at 12 months.</p><p><strong>Conclusion: </strong>The year 2016 HIV screening protocol is cost effective and should be adopted for screening infants at low risk of HIV acquisition. Significantly higher rates of infection occur in the high-risk category at unknown times, thus necessitating very early screening. Rescheduling of the 9th month rapid screening to coincide with MMR vaccination at 15months is advised to allow for cessation of HIV exposure following breast feeding termination at 12 months.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 8","pages":"629-634"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Eye Diseases and Associated Factors in Calabar, Nigeria.","authors":"E D Nkanga, E B Esu, A C Nlemadim, C T Agweye, E D Nkanga, U D Nkanga, S O Ochigbo, D G Nkanga","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>To assess the pattern of eye diseases among newborn infants in newborn units in Calabar, Nigeria.</p><p><strong>Materials and methods: </strong>This cross-sectional study of the eyes of newborns in 5 newborn units in Calabar, Cross River State, Nigeria was undertaken over a 10-week period extending from February 28, 2018 through May 9, 2018. Newborn whose parent gave informed consent were included, whereas those not consented for or too ill were excluded. The study was conducted with the help of a structured questionnaire and study protocol. Each newborn had basic ophthalmic examination. Ethical approval was obtained from the Health Research and Ethics Committee of the University of Calabar Teaching Hospital and the Cross River State Ministry of Health. Categorical variables were compared using Chi-Square Test and Fishers's Exact Test (FET).</p><p><strong>Results: </strong>A total of 410 newborn were studied. The male: female ratio was 1:1.2 and the mean age was 7.02 days. The most common eye disease was sub-conjunctival haemorrhage 47(11.5%). This was followed by conjunctivitis 26 (6.3%), retinal haemorrhage 24(5.9%), congenital cataracts 8(2%) and clinical anophthalmia 2(0.5%). The least frequent findings were congenital glaucoma, congenital eyelid eversion, macular oedema, at 1 (0.2%) each respectively. Eye disease was associated with an abnormal antenatal period (11.218, p-0.001) birth weight (FET: 12.423, 0.007), and or eventful labour history (FET: 26.805, <0.001).</p><p><strong>Conclusions: </strong>A significant proportion of eye disease in newborn is associated with an eventful perinatal period. Early detection of eye disease through instituted routine eye examinations may aid in preventing permanent disability from adverse sequelae, reducing the incidence of low vision or avoidable blindness.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 8","pages":"611-620"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rubella IgG Immunity: Spatial Distribution, Euclidean Distance Analysis, Correlates and Predictors among Women of Reproductive Age, Southwest Nigeria.","authors":"K A Durowade, O I Musa, M A Adeniyi, R B Mudashiru, T A Sanni, A G Salaudeen, S T Suleiman, O R Ilori, D B Parakoyi","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Rubella is a leading cause of preventable congenital abnormalities. Paucity of data exists on the national morbidity burden of rubella infection, particularly among women of reproductive age in Nigeria. Added to this is the absent immunization policy on rubella vaccination in Nigeria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To determine the spatial and Euclidean distribution, correlates and predictors of rubella immunity among women of reproductive age in Ekiti state, southwest Nigeria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A community-based cross-sectional survey for rubella IgG antibodies among women of reproductive age selected using multi-stage sampling technique. Data was collected quantitatively using interviewer-administered semi-structured questionnaire. Blood sample was collected for qualitative assay of rubella IgG. Global Positioning System (GPS) co-ordinates of sampled households were recorded. Euclidean distance tool in the ArcGIS environment analyzed the proximity to established rubella IgG negative areas. Data entry and analysis was through the use of Statistical Product and Service Solutions (SPSS) 23 and level of statistical significance was set at p-value &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;The mean age of the women was 30.5±7.9 years. A total of 482 (84.1%) had negative rubella IgG serology. There was wide spread immunity gap. Educated respondents (p=0.009), higher number of inhabitants in households (p=0.011), ever married (p&lt;0.001) and prior vaccination history (p&lt;0.001) were associated with rubella immunity. Secondary education (aOR=2.47; p=0.046) and urban location (aOR=0.45; p=0.003) were predictive of rubella immunity (p&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The rubella immunity gap cuts across both rural and urban areas with a potential for disease spread in the Euclidean-determined proximal areas. To reduce the wide spread immunity gap, increase herd immunity, the Federal Government of Nigeria needs to introduce rubella vaccination in the National Immunization. KEYWORDS: Rubella Immunity, Spatial Distribution, Correlates, Predictors, Women, Nigeria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Contexte: &lt;/strong&gt;La rubéole est une cause majeure d'anomalies congénitales évitables. Il existe une rareté de données sur la charge nationale de morbidité liée à l'infection rubéoleuse, en particulier chez les femmes en âge de procréer au Nigéria. À cela s'ajoute l'absence de politique nationale de vaccination contre la rubéole.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectifs: &lt;/strong&gt;Déterminer la distribution spatiale et euclidienne, ainsi que les corrélats et prédicteurs de l'immunité contre la rubéole chez les femmes en âge de procréer dans l'État d'Ekiti, sud-ouest du Nigéria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Méthodes: &lt;/strong&gt;Une enquête transversale communautaire a été menée pour la recherche d'anticorps IgG anti-rubéole chez des femmes en âge de procréer sélectionnées par une technique d'échantillonnage en plusieurs étapes. Les données ont été recueillies de maniè","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 7","pages":"581-589"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic and Non-enzymatic Antioxidants as Related to Immediate Hospital Outcomes in Term Nigerian Babies with Perinatal Asphyxia.","authors":"D K Kuti, T Ogundele, B P Kuti, A O Oyelami, E A Adejuyigbe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>Antioxidants are often released to neutralise free radicals and oxidants generated in babies with perinatal asphyxia (PA). This study aims to determine the enzymatic and non-enzymatic antioxidants in babies with PA and the relationship between these antioxidants and hospital outcome at the Wesley Guild Hospital (WGH), Ilesa, Nigeria.</p><p><strong>Methods: </strong>Consecutive term babies with or without asphyxia (defined as 5th minute Apgar score <7) were consecutively recruited into a comparative cross-sectional study at the labour ward of the WGH over a nine-month period. Babies were appropriately managed and outcome of hospitalisation documented. Five ml of cord blood was collected from the babies and analysed for enzymatic and non-enzymatic antioxidants using chromatography methods (Water Incorporate, California, U.S.A). Data obtained were analysed using SPSS version 21.</p><p><strong>Results: </strong>A total of 168 babies (84 for each group) were recruited with male to female ratio of 1.2:1. Sixty-one (72.6%), 23 (27.4%) had moderate and severe PA respectively. Cord blood antioxidants were lower in babies with PA. The enzymatic [glutathione peroxidase r = -0.298, p=0.006, glutathione transferase r=-0.222, p=0.042] and non-enzymatic [TAS, r=-0.316, p=0.003] antioxidants showed negative correlation with the length of hospitalization. However, no significant relationship was observed between the antioxidants and severity of asphyxia, as well as mortality among babies with PA.</p><p><strong>Conclusion: </strong>Low cord blood antioxidants (TAS and glutathione enzymes) may be useful indicators of increased length of hospital stay in Nigerian term babies admitted with PA. KEYWORDS: ; ; ;</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 7","pages":"552-558"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors of Contrast Induced Nephropathy in Maiduguri, Northeastern Nigeria.","authors":"U Loskurima, M M Sulaiman, M Lawan, A Farate, J Shettima, A Mamza, A O Amali, A G Habibu, M M Dungus, B Bunu, I K Chiroma, M Muhammad, A D Dayar, M S Umar, I Ummate","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is the third leading cause of acute kidney injury (AKI) in developed countries. With the increase in contrast-based radiologic studies in developing countries, its contribution to the burden of AKI is increasing. However, there are few researches conducted in this part of the world on AKI due to contrast administration. This study was aimed at determining the prevalence and risk factors of CIN in a tertiary health facility in northeastern Nigeria.</p><p><strong>Methods: </strong>This prospective study was conducted at the Radiology department of the University of Maiduguri Teaching Hospital, Maiduguri, North eastern Nigeria. The study population consisted of 150 consenting adult patients referred for investigations involving contrast administration. Sociodemographic variables were obtained from each patient, and blood samples were collected before contrast administration, at 24, 48 and 72 hours after contrast administration and analyzed for creatinine. Serum creatinine obtained was used to calculate glomerular filtration rates (eGFR) using the CKD-EPI Creatinine 2012 Equation. Contrast induced nephropathy was defined as an absolute increase in serum creatinine ≥0.5mg/dl or ≥25% increase from baseline within 48 to 72 hours after administration of contrast media (CM).</p><p><strong>Results: </strong>The prevalence of CIN was 30% (45 patients), and risk factors were; advancing age (OR=1.346, p=0.009), volume of contrast (OR=2.037, p=0.001), high serum creatinine at base-line (OR=1.601, p=0.006) and low eGFR at base-line (OR=1.767, p=0.003).</p><p><strong>Conclusion: </strong>Contrast induced nephropathy is a common complication of radiologic contrast studies in Maiduguri, northeastern Nigeria. Risk factors identified were advanced age >60 years, large volume of contrast >60ml, baseline serum creatinine >150µmol/l and GFR <60ml/minute/1.73m2.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 7","pages":"566-570"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Psychosis Spectrum Symptoms, Association with Quality of Life and Caregiver Burden in Yoruba Nigerians with Parkinson's Disease: A Matched Case Control Study.","authors":"A Ojagbemi, O Adediran, H Oyedapo-Ishola, T Olojugba, O Elugbadebo, U Imo, A K Bakare, F Taiwo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Up to 60% of persons with idiopathic Parkinson's disease (PD) will develop psychosis spectrum symptoms at some point during the course of illness. These symptoms are often undetected by attending physicians but are associated with great distress to patients and their caregivers.</p><p><strong>Objectives: </strong>To investigate the prevalence and association of positive psychosis symptoms with quality of life (QoL) and caregivers' burden among clinic attendees with PD at two tertiary general hospitals in South western Nigeria.</p><p><strong>Method: </strong>A case-control study was conducted between February 2023 to June 2024. Cases (N=150) were neurology outpatients with PD. Controls (N=150) were neurologically healthy individuals matched for age, sex, education, and outpatient status. Psychosis, QoL, and caregiver burden were assessed using the Scale for the Assessment of Positive Symptoms (SAPS), PD-QoL questionnaire (PDQ-8), and Caregivers Strain Index (CSI), respectively. Adjusted odds ratios (aO.R) and standardized coefficients (aCoeff.) were estimated using regression analyses. Estimates were within 95% confidence intervals (C.I).</p><p><strong>Results: </strong>Psychosis symptoms were present in 28% of cases. Hallucinations were the most frequent symptom (16.7%). Cases with Psychosis were more likely to be ≥60years (88.1%, p=0.020), ever users of alcohol (78.6%, p=0.012), had higher mean motor-severity scores (51.1±15.7, p<0.001), and probable dementia (21.4%, p=0.001). In unconditional logistic regression analyses, cases had approximately five-point increase in the independent odds psychosis (aOR=4.92, 95% C.I=2.20, 10.99), and two-point increase in the independent odds of requiring social support (aOR=1.95, 95% C.I=1.19, 3.21).</p><p><strong>Conclusion: </strong>The near five-point increase in the odds of psychosis spectrum symptoms in PD and their greater requirement for social support underscores the need for multidisciplinary approaches that include not only neurologists but psychiatrists, and social workers.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 7","pages":"571-580"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Rheumatic and Musculoskeletal Diseases in a Rheumatology Clinic in Nigeria: A Report of the First 5000 Patients.","authors":"O O Adelowo, A Ibrahim, E Airenakho, O Ojo, H Ahmad, O Onwualu, H Aliyu, H B Olaosebikan, A Yerima","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>Rheumatic and musculoskeletal diseases (RMDs) are important causes of morbidity, disability, and mortality worldwide, including in sub-Saharan Africa. However, the spectrum of RMDs in this region has not been well documented due to a lack of data. This is particularly true since many of the diseases observed were previously considered rare among Africans. This study aims to identify the various RMDs seen in a private rheumatology facility in Lagos, Nigeria.</p><p><strong>Method: </strong>The case records of the first 5,000 consecutive patients diagnosed with RMDs between January 2004 and May 2022 were reviewed. Diagnoses were made using standard rheumatology guidelines/consensus, societal guidelines, or clinical evaluation. Data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 26.</p><p><strong>Results: </strong>The mean ± SD age of the 5,000 patients was 52.33 ± 16.15 years, with a female-to-male ratio of 1.7:1. The frequency of the common RMDs were degenerative joint diseases (54.16%), followed by inflammatory arthritis (14.52%), soft tissue rheumatism (13.28%) and connective tissue diseases (10.32%). Females were more commonly affected in all categories except crystal arthropathies and spondyloarthropathy. Septic arthritis, metabolic bone diseases, and orphan diseases were rarely seen, at 0.26%, 0.28%, and 0.82% of the total, respectively.</p><p><strong>Conclusion: </strong>This study, which includes arguably the largest cohort of RMD patients in sub-Saharan Africa, revealed a wide spectrum of RMDs, contrary to previous assumptions that RMDs are rare among Africans. As this is a hospital-based study, large population-based studies are recommended to determine the burden of RMDs in the community to guide policy implementation and resource allocation.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"42 7","pages":"590-596"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}