West African journal of medicine最新文献

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ATRIAL FIBRILLATION IN WEST AFRICA: LESSONS GLEANED FROM THE IBADAN AF PROJECT. 西非的心房颤动:从伊巴丹心房颤动项目中汲取的教训。
West African journal of medicine Pub Date : 2024-11-10
O S Ogah, O A Orimolade, A Adebiyi, W A Shokunbi, A Aje, M O Owolabi, A O Falase
{"title":"ATRIAL FIBRILLATION IN WEST AFRICA: LESSONS GLEANED FROM THE IBADAN AF PROJECT.","authors":"O S Ogah, O A Orimolade, A Adebiyi, W A Shokunbi, A Aje, M O Owolabi, A O Falase","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction/background: </strong>There is still little data on clinical profile and atrial fibrillation (AF) characteristics in West Africa. Traditionally the risk factor for chronic AF in the sub-region is chronic rheumatic heart disease. However, with the rapid demographic and epidemiologic transition in the sub-region, the risk factors, clinical profile, and complications of AF appear to be changing.</p><p><strong>Objective(s): </strong>The aim of this study is therefore to describe the contemporary clinical profile and characteristics of AF in Ibadan, Nigeria.</p><p><strong>Methods: </strong>This is a prospective observational study that commenced on June 1, 2016. All adults aged 18 years and above with electrocardiographic diagnoses of AF were included in the study. The case report form included sociodemographic data, clinical information, risk factors, management, and clinical outcomes.</p><p><strong>Results: </strong>Three hundred and fifty-seven (357) patients were recruited (mean age 63.4(14.6) years, males 189 (52.9%). In terms of clinical subtypes, the distribution is as follows: permanent- 219(61%), persistent - 88(25%), paroxysmal- 51(14%) There was none with lone AF in this cohort. 112 (31%) had previous AF. The common co-morbidities are hypertension, heart failure, and valvular heart disease. 318(89%) had a CHA2D2VASC score of 2 or more. In terms of management, rate control was the commonest strategy (64.4%), and beta-blockers and/or digoxin were commonly prescribed. 73(64.6%) were on anticoagulation, but only 30% achieved adequate anticoagulation.</p><p><strong>Conclusions: </strong>Non-rheumatic, non-atherosclerotic conditions are the common risk factors for AF in Ibadan, Nigeria. Measures to prevent stroke as well as control of risk factors for AF should be emphasized. Keywords: Atrial fibrillation, lessons gleaned, Ibadan AF project.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S37-S38"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLOBAL LONGITUDINAL LEFT VENTRICULAR STRAIN AND ITS CORRELATES IN BLACK NIGERIAN SICKLE CELL DISEASE (SCD) PATIENTS: PROTOCOL FOR A PILOT STUDY. 黑尼日利亚镰状细胞病(SCD)患者左心室整体纵向应变及其相关性:试验研究方案。
West African journal of medicine Pub Date : 2024-11-10
C N Ugwu, S E Antia, G A Antia, N M Chika-Igwenyi, Q U Alu, C C Ajaero, G C Isiguzo, N I Ugwu
{"title":"GLOBAL LONGITUDINAL LEFT VENTRICULAR STRAIN AND ITS CORRELATES IN BLACK NIGERIAN SICKLE CELL DISEASE (SCD) PATIENTS: PROTOCOL FOR A PILOT STUDY.","authors":"C N Ugwu, S E Antia, G A Antia, N M Chika-Igwenyi, Q U Alu, C C Ajaero, G C Isiguzo, N I Ugwu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Sickle cell cardiomyopathy is becoming a neglected tropical cardiovascular disease, yet the most common cause of death in HbSS patients. Myocardial strain using speckle tracking has recently been validated as a tool for the detection of subclinical left ventricular systolic dysfunction. Its utility in sickle cell disease in Nigeria is unknown.</p><p><strong>Objectives: </strong>The study aims to evaluate global longitudinal left ventricular (GL LV) strain pattern in black SCD patients in steady state, and correlate that with clinico-laboratory and electrocardiographic (ECG) measurements. Furthermore, we will evaluate the timeline for the earliest detectable cardiac changes in SCD detectable by ECG or speckle tracking.</p><p><strong>Method: </strong>60 sickle cell patients between ages 5 and 40 years will be matched with 60 controls. Baseline clinic-laboratory data will be collected. All participants will have electrocardiography and speckle-tracking echocardiography of the left ventricle. The primary outcome is the global LV longitudinal strain in HBSS and matched control. Secondary outcomes are the clinico-laboratory and electrocardiographic correlates of LV strain in black HBSS patients as well as tracking the earliest detectable cardiovascular change in the life spectrum from childhood to adulthood. Regression analysis and other statistical models will be used.</p><p><strong>Conclusion: </strong>The simplicity of the study design is crafted to spark interest in life-threatening cardiovascular complications of sickle cell disease beyond pulmonary hypertension.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S19"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE IBADAN CHRONIC HEART FAILURE REGISTRY: RATIONALE, DESIGN AND GENDER DIFFERENCES IN THE INITIAL 1290 PARTICIPANTS. 伊巴丹慢性心力衰竭登记:最初 1290 名参与者的原理、设计和性别差异。
West African journal of medicine Pub Date : 2024-11-10
Okechukwu S Ogah, Taiwo A Adedokun, Dike B Ojji, Oni Opeyemi, Akintunde A Abiodun, Sadiq H Ringim, Sabiu M Hamza, Raphael Anakwue, Peter Mba, Ido E Ukpeh, Okezie Uba-Mgbemena, Oladipupo O Fasan, Elizabeth T Emmanuel, Muhammad N Shehu, Sanusi Garba, Taiwo Olunuga, Saheed O Adebayo, Maduka Chiedozie James, Offia E Mark, Folasade A Daniel, Ayotunde Raheem, Henry O Iheonye, Nneka Iloeje Ugoeze, Chesa Abram Mankwe, Suraj A Ogunyemi, Olumide A Akinyele, Freedom Enerho, Ejiroghene M Umuerri, Tolulope T Shogade, Aquaowo U Udosen, Emmanuel Auchi Edafe, C E Nwafor, Muhammad A Usman, Kamilu M Karaye, Adewole Adebiyi
{"title":"THE IBADAN CHRONIC HEART FAILURE REGISTRY: RATIONALE, DESIGN AND GENDER DIFFERENCES IN THE INITIAL 1290 PARTICIPANTS.","authors":"Okechukwu S Ogah, Taiwo A Adedokun, Dike B Ojji, Oni Opeyemi, Akintunde A Abiodun, Sadiq H Ringim, Sabiu M Hamza, Raphael Anakwue, Peter Mba, Ido E Ukpeh, Okezie Uba-Mgbemena, Oladipupo O Fasan, Elizabeth T Emmanuel, Muhammad N Shehu, Sanusi Garba, Taiwo Olunuga, Saheed O Adebayo, Maduka Chiedozie James, Offia E Mark, Folasade A Daniel, Ayotunde Raheem, Henry O Iheonye, Nneka Iloeje Ugoeze, Chesa Abram Mankwe, Suraj A Ogunyemi, Olumide A Akinyele, Freedom Enerho, Ejiroghene M Umuerri, Tolulope T Shogade, Aquaowo U Udosen, Emmanuel Auchi Edafe, C E Nwafor, Muhammad A Usman, Kamilu M Karaye, Adewole Adebiyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction/background: </strong>Chronic heart failure (CHF) has important gender-specific aspects, which are worthy of note, as they influence the haemodynamic state of patients the choice of therapy, aetiology, and clinical outcomes. Women are less frequently represented in CHF studies and clinical trials than males. While some published data are conflictive, more studies tailored to this critical discourse are necessary to inform patient care and improve outcomes in patients with CHF.</p><p><strong>Objectives: </strong>The study aims to describe the rationale, design and clinical presentations, profile, and 1-year outcomes of the first 1290 CHF in the Ibadan CHF project.</p><p><strong>Materials/methods: </strong>We analyzed the differences between the genders regarding the aetiology of heart disease, comorbidities, triggers, left ventricle functional state, treatment, and all cause-mortality at 1 year.</p><p><strong>Results: </strong>A total of 1290 patients (55.8% men) were included. The men were older than the women (p<.001) and had a higher prevalence of alcohol and cigarette use, comorbidities, and worse cardiac structural abnormalities (p<.001). The are also gender differences in the pattern of aetiology of HF. HHF, DCM, and pericardial diseases are more common in men. Women have higher rates of rheumatic heart disease. Mortality rates at 6- and 12 months were higher in men.</p><p><strong>Conclusions: </strong>There is a gender difference in clinical profile and outcomes of CHF in this cohort. Males appear to have a worse clinical profile, structural cardiac abnormalities as well as worse one-year outcomes.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S38"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SKATZOCHOIROPHOBIA (FEAR OF HEDGEHOGS) IS A RARE FORM OF A SPECIFIC PHOBIA. A CASE REPORT. 刺猬恐惧症(skatzochoirophobia)是一种罕见的特殊恐惧症。病例报告。
West African journal of medicine Pub Date : 2024-11-10
A T Bakare, A I Yakubu, A Abubakar, A Attahiru, H S Abdulsalam, M Ahma, E I Stephen, A Bello, H A Lawal, M A Yunusa
{"title":"SKATZOCHOIROPHOBIA (FEAR OF HEDGEHOGS) IS A RARE FORM OF A SPECIFIC PHOBIA. A CASE REPORT.","authors":"A T Bakare, A I Yakubu, A Abubakar, A Attahiru, H S Abdulsalam, M Ahma, E I Stephen, A Bello, H A Lawal, M A Yunusa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Specific phobic anxiety disorder is characterized by severe and excessive fear that occurs constantly when exposed to one or more specific objects or situations. The fear is out of proportion to the threat, causing significant distress and impairment for the person.</p><p><strong>Methods: </strong>A thorough history was taken; a mental state examination, and physical and systematic examinations were conducted. Investigations were conducted following the biopsychosocial approach, and finally, ICD 10 was used to make the diagnosis. Treatment was also approached biopsychosocially.</p><p><strong>Result: </strong>We report a case of an adult lady who has been persistently displaying features of anxiety disorders since early childhood, specific to hedgehogs. She was diagnosed with a rare specific phobia anxiety disorder called Skatzochoirophobia and was successfully treated with systematic desensitization. Despite an extensive search, we were unable to retrieve a case of skatzochoirophobia, which makes it worthy of reporting as hedgehogs are small mammals commonly found in our environment, which in some areas are sources of protein.</p><p><strong>Conclusion: </strong>This case report may help in creating awareness and helping clinicians be on the lookout for skatzochoirophobia, which may help in early detection and prompt treatment.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S55"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NUTRITIONAL KNOWLEDGE AND NUTRITIONAL STATUS OF DIABETIC PATIENTS IN SECONDARY HEALTH FACILITIES, KADUNA METROPOLIS, NIGERIA. 尼日利亚卡杜纳市二级医疗机构糖尿病患者的营养知识和营养状况。
West African journal of medicine Pub Date : 2024-11-10
B Usman, O D Agbale, C E Esekhaigbe, N O Usman, B Bello-Ovosi
{"title":"NUTRITIONAL KNOWLEDGE AND NUTRITIONAL STATUS OF DIABETIC PATIENTS IN SECONDARY HEALTH FACILITIES, KADUNA METROPOLIS, NIGERIA.","authors":"B Usman, O D Agbale, C E Esekhaigbe, N O Usman, B Bello-Ovosi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia from deficiencies in insulin secretion, action, or both. It reduces the quality of life and life expectancy of patients26. Research shows that adequate nutritional knowledge and good nutritional status have a huge role in reducing its risk. The nutritional status of an individual is influenced by food intake and physical health8.</p><p><strong>Objectives: </strong>1. To assess the nutritional knowledge among diabetics in secondary health facilities (SHF), Kaduna metropolis. 2. To assess the nutritional status among diabetic patients in SHF, Kaduna metropolis.</p><p><strong>Methodology: </strong>A cross-sectional descriptive study was carried out with a multistage sampling technique among 184 respondents. Nutritional knowledge and Body mass index (BMI) were assessed. IBM SPSS (Version 26) was used for data analysis. Results were presented using frequency tables and charts; Chi-square/ Fisher's exact test were used to assess the relationship between dependent and independent variables (level of significance set at p<0.05).</p><p><strong>Result: </strong>The mean age was 57.3 ± 12.67 years. Only 25.5% had good nutritional knowledge while 73.9% had fair knowledge. Normal BMI was found in 36.1%, and overweight and obesity were found in 39.1% and 19.5% respectively. There was no statistically significant relationship between the BMI and the nutritional knowledge. (p = 0.876).</p><p><strong>Conclusion: </strong>Only about a quarter of the respondents had good nutritional knowledge; more than half of the respondents were found to be either overweight or obese. Thus, there should be concerted efforts to address the gap in the nutritional knowledge of diabetic patients.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S14"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
POSTPARTUM DEPRESSION AMONG PAROUS WOMEN IN IBADAN SOUTH-WEST LOCAL GOVERNMENT AREA, OYO STATE, NIGERIA. 尼日利亚奥约州伊巴丹西南地方政府地区准妈妈的产后抑郁症。
West African journal of medicine Pub Date : 2024-11-10
O S Lawal, O C Uchendu
{"title":"POSTPARTUM DEPRESSION AMONG PAROUS WOMEN IN IBADAN SOUTH-WEST LOCAL GOVERNMENT AREA, OYO STATE, NIGERIA.","authors":"O S Lawal, O C Uchendu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Post-partum depression (PPD) significantly contributes to maternal morbidity and mortality, particularly in developing countries, impacting the well-being of women, their families, and society.</p><p><strong>Objective(s): </strong>This study assessed the prevalence of PPD and its associated factors among parous women in Ibadan SouthWest LGA.</p><p><strong>Methods: </strong>The cross-sectional study utilized a multi-staged sampling technique to select 454 postpartum women from six selected primary health care centres in Ibadan. Data on socio-demographics, obstetric history, patterns of intimate partner violence (IPV), family connectedness, and PPD experiences were elicited using interviewer-administered questionnaires. Data analysis included descriptive statistics, chi-square test and logistic regression with significance level for all test sets at 5%.</p><p><strong>Results: </strong>The mean age of the women was 29.4±5.3, with the majority being married (96.3%) and in monogamous unions (88.8%). About two-fifths (41.4%) had husbands with postsecondary education and the pregnancy of respondents (76.7%) was planned and wanted. Over half (56.2%) of the women experienced emotional violence during pregnancy, and 45.2% were from dysfunctional families. Prevalence of post-partum depression was 44.6%. Husband's education level (p=0.041), family type (p=0.002), pregnancy desire (p=0.037), and family connectedness (p=0.029) were associated with PPD. Independent predictors of postpartum depression included being married (OR=0.242; 95%CI=0.06-0.92) and experiencing emotional or physical abuse (OR=3.960; 95%CI=1.787-8.796 and OR=1.764; 95%CI=1.162-2.680).</p><p><strong>Conclusions: </strong>PPD was prevalent among women; who experienced IPV, whose spouses had lower education, with unplanned or unwanted pregnancies, and dysfunctional families. Health education and social support for women are advocated to prevent the experience of postpartum depression.</p><p><strong>Key message: </strong>Postpartum depression is common among urban women in Southwest Nigeria and is significantly influenced by experience of IPV and marital status. Single women had higher odds, with additional factors including\u0000educational level, family dynamics, and pregnancy intention affecting PPD. Education, family and societal support are vital to help prevent PPD</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S48"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UNDERSTANDING THE PREVALENCE OF GAMBLING IN NIGERIA: A COMPREHENSIVE INVESTIGATION. 了解尼日利亚赌博的流行情况:全面调查。
West African journal of medicine Pub Date : 2024-11-10
N K Orjinta, V O Udenze, O K Ogunla, I C Anazodo, J E Ukpoju, A T Naibo
{"title":"UNDERSTANDING THE PREVALENCE OF GAMBLING IN NIGERIA: A COMPREHENSIVE INVESTIGATION.","authors":"N K Orjinta, V O Udenze, O K Ogunla, I C Anazodo, J E Ukpoju, A T Naibo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>There has been an increase in gambling or betting in the population, increasing the risk of gambling-related disorders. There is insufficient knowledge about the extent and determinants of this problem across Nigeria.</p><p><strong>Objective: </strong>To assess the prevalence, pattern, and sociodemographic correlates of gambling behaviour across different geopolitical zones in Nigeria.</p><p><strong>Methods: </strong>Nigerian citizens of diverse age groups were conveniently sampled from the North-Central, South-East, South-South and South-West geopolitical zones of the country. A self-paced, pre-tested gambling questionnaire designed for the study was used to collect relevant data.</p><p><strong>Results: </strong>310 Nigerians were included in this study and were mostly between the ages of 18 to 27 (44.2%) years. The study revealed a high prevalence (40.3%) of gambling behaviours among the participants. Among those engaged in gambling, \"Bet9ja\" emerged as the predominant platform. The desire to 'make money' was the most prevalent driver of gambling among participants (62.4%). A significant association was seen between respondents' knowledge and perceptions of gambling and their propensity to gamble (p < 0.001). Various sociodemographic factors (sex, marital status, socioeconomic status, and geopolitical zone) were also significantly associated with gambling.</p><p><strong>Conclusions: </strong>The study shows the notable prevalence of gambling in Nigeria and highlights its associations with sociodemographic factors, perceptions, and patterns of gambling which should be considered in strategies to mitigate gambling-related problems. This research bridges gaps by incorporating data from diverse geopolitical zones, providing a more representative population study.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S33-S34"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECT OF HAART ON OXIDATIVE DNA DAMAGE IN HIV PATIENTS AT UITH IN ILORIN. 哈特对伊洛林大学艾滋病患者 DNA 氧化损伤的影响。
West African journal of medicine Pub Date : 2024-11-10
U A Hamza, A F Omolade, A B Okesina, S A Biliaminu, I M Abdul Azeez, J O Yusuff
{"title":"EFFECT OF HAART ON OXIDATIVE DNA DAMAGE IN HIV PATIENTS AT UITH IN ILORIN.","authors":"U A Hamza, A F Omolade, A B Okesina, S A Biliaminu, I M Abdul Azeez, J O Yusuff","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Human immunodeficiency virus HIV causes a well-known global disease, acquired immunodeficiency syndrome (AIDS), which has a high disease burden in Africa. HIV infection is known to be associated with oxidative stress, which may contribute to disease severity. However, the effect of HAART is equivocal, and requires more studies. 8-hydroxy-2-deoxyguanosine (8-OHdG), a useful biomarker to assess oxidative DNA damage in biological fluids, was therefore measured in this study.</p><p><strong>Objectives: </strong>The study measured 8-OHdG in HIV seronegative and seropositive participants and correlated it with the duration of HAART.</p><p><strong>Research question: </strong>Does HIV infection have an effect on oxidative DNA damage? Does HAART have an effect on oxidative DNA damage? Does HAART duration have an effect on oxidative DNA damage?</p><p><strong>Methods: </strong>This was a cross-sectional study consisting of 99 participants in 4 strata: 20 HIV seronegative, 25 HAART naïve, 26 on HAART <5 years, and 28 on HAART >5 years. Those on HAART were all on Tenofovir, Lamivudine, and Dolutegravir (TLD) combination. The questionnaires were administered, and blood samples were collected from all the participants. The serum 8-OHdG was measured with enzyme-linked immunosorbent assay in all the participants. The universal biosafety standards were strictly adhered to. The data were collected and analyzed with SPSS 2016 version.</p><p><strong>Results/discussion: </strong>The serum levels of 8-OHdG of the participants were shown below. Our findings showed higher 8-OHdG in HIV patients than the Controls and is much higher in HAART naïve when compared with those on HAART (p = 0.005). The serum 8-OHdG and HAART duration were compared and showed a statistically significant negative correlation (r = - 0.331, p= 0.014).</p><p><strong>Conclusion: </strong>This study found that HIV infection causes oxidative DNA damage which is more in patients who have not started HAART than those on HAART. This showed that the TLD-HAART regimen reduces HIV-associated oxidative stress over time, though not completely. This finding further supports a critical role of oxidative stress in HIV infection, a protective effect of HAART, and a potential role of antioxidants that requires further research.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S60"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PREVALENCE OF HYPOCALCAEMIA IN A SELECTED POPULATION IN KANO: CALL FOR METABOLOMICS AND GENETIC PROFILING FOR RISK PREDICTION. 卡诺选定人群中的低钙血症患病率:呼吁开展代谢组学和基因分析以预测风险。
West African journal of medicine Pub Date : 2024-11-10
Zainab U Ibrahim, Sherifah Sheriff, Hassan A Murtala, Usman Ali, Zainab A Mustapha, Halima Haladu, Nabila A Yau, Rabi'atu A Bichi, Aminu A Yusuf, Kabiru Abdulsalam, Aishatu L Adamu, Aisha M Nalado, Idris Y Mohammed, Mahmoud U Sani, C William Wester, Muktar H Aliyu, Hamisu M Salihu
{"title":"PREVALENCE OF HYPOCALCAEMIA IN A SELECTED POPULATION IN KANO: CALL FOR METABOLOMICS AND GENETIC PROFILING FOR RISK PREDICTION.","authors":"Zainab U Ibrahim, Sherifah Sheriff, Hassan A Murtala, Usman Ali, Zainab A Mustapha, Halima Haladu, Nabila A Yau, Rabi'atu A Bichi, Aminu A Yusuf, Kabiru Abdulsalam, Aishatu L Adamu, Aisha M Nalado, Idris Y Mohammed, Mahmoud U Sani, C William Wester, Muktar H Aliyu, Hamisu M Salihu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Severe acute symptomatic hypocalcemia, requiring emergency medical intervention, is a significant but poorly understood condition with high morbidity. In our setting, patients present to emergency rooms with painful carpo-pedal spasms that last for several hours, sometimes mimicking seizure disorders. Metabolomics and genetic profiling are innovative approaches that pinpoint molecular and genetic determinants of hypocalcemia risk which can be adopted to guide treatment in our population.</p><p><strong>Objective: </strong>To determine the prevalence of hypocalcemia in urban Kano as a preliminary step towards identifying key risk factors.</p><p><strong>Methods: </strong>We obtained retrospective data from patients who presented to a tertiary hospital between January and December 2023. Serum calcium levels were measured on Abbott Architect c4000 autoanalyzer. We analyzed data using R statistical software (version 4.3.2). Chi-square tests were used to assess significant differences (p < 0.05).</p><p><strong>Results: </strong>A total of 1,270 samples were analyzed, consisting of 59.3% (n = 753) males, their mean age was 36.2 ± 4 years. Mean serum calcium levels were 2.05 ± 0.34 mmol/L to 2.11 ± 1.00 mmol/L. Overall prevalence of hypocalcemia (serum calcium < 2.2 mmol/L) was 52.2%. Females exhibited a significantly higher prevalence (58.8%) compared to males (p = 0.03). The highest prevalence was observed in the 40-59-year age group (p < 0.01).</p><p><strong>Conclusion: </strong>Hypocalcemia is highly prevalent in our population emphasizing the need for innovative approaches to better understand the genetic predictors, enable early intervention and prevent the long-term complications. These findings also provide a foundation for future multicenter studies and could inform public health policies targeting at risk groups. Keywords: Hypocalcaemia, Risk prediction,Metabolomics, Genetic markers.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S57"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARATIVE STUDY BETWEEN DIABETIC AND NONDIABETIC CORONARY PATIENTS IN CARDIOVASCULAR REHABILITATION IN DAKAR, SENEGAL. 塞内加尔达喀尔心血管康复治疗中糖尿病和非糖尿病冠心病患者的比较研究。
West African journal of medicine Pub Date : 2024-11-10
A A Ngaide, N D Gaye, M M Ka, J S Mingou, U S Ralaizandry, A Kane
{"title":"COMPARATIVE STUDY BETWEEN DIABETIC AND NONDIABETIC CORONARY PATIENTS IN CARDIOVASCULAR REHABILITATION IN DAKAR, SENEGAL.","authors":"A A Ngaide, N D Gaye, M M Ka, J S Mingou, U S Ralaizandry, A Kane","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac rehabilitation is crucial in managing coronary disease, particularly in type 2 diabetes, yet it remains almost non-existent in West Africa.</p><p><strong>Objectives: </strong>This study aimed to compare the profiles of diabetic and non-diabetic coronary patients undergoing cardiac rehabilitation at the Principal Hospital of Dakar, Senegal.</p><p><strong>Methodology: </strong>A comparative, descriptive, and analytical study was conducted from January 2019 to December 2022 involving two groups of coronary patients (diabetic and nondiabetic) at the rehabilitation centre. Patients who completed at least 10 sessions were included. We analysed sociodemographic, clinical, and paraclinical data before and after rehabilitation, as well as therapeutic adherence. Data analysis was performed using SPSS version 18, with a significance level set at 0.05.</p><p><strong>Results: </strong>A total of 199 coronary patients participated, including 75 diabetics and 124 non-diabetics. The average age was 61.6 ± 8.3 years for diabetics and 59.8 ± 12.4 years for non-diabetics, with a male predominance (sex ratio: 2 for diabetics and 3.9 for non-diabetics). In diabetics, the main cardiovascular risk factors were age (80%), hypertension (62.7%), physical inactivity (57.3%), dyslipidaemia (40%), and smoking (33.3%). Cardiac rehabilitation significantly improved clinical symptoms and parameters such as systolic blood pressure, heart rate, and abdominal obesity in diabetic patients. Glycated haemoglobin levels were balanced in 70.4%, an improvement of 40.8%. Rehabilitation had a greater impact on METS improvement and adherence in diabetic patients, along with reduced depression.</p><p><strong>Conclusion: </strong>Cardiac rehabilitation improves control of cardiovascular risk factors, but its availability and accessibility need improvement.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S34-S35"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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