Voprosy virusologii最新文献

{"title":"[Immunological properties of a chimeric protein containing the major capsid protein of echovirus 30 (Picornaviridae: <i>Enterovirus: Enterovirus betacoxsackie</i>)].","authors":"D A Melentev, D V Novikov, E V Mokhonova, N A Novikova, A Y Kashnikov, S G Selivanova, L N Golitsyna, V A Lapin, M I Tsyganova, D E Zaitsev, V V Novikov","doi":"10.36233/0507-4088-311","DOIUrl":"https://doi.org/10.36233/0507-4088-311","url":null,"abstract":"<p><strong>Introduction: </strong>Enterovirus infection, widespread in the world and in Russia, is characterized by a variety of clinical forms, one of which is serous meningitis. The most common cause of enterovirus meningitis in children is echovirus 30 (E30). Previously, we obtained a chimeric protein consisting of the S domain of norovirus VP1 protein(S_N), fused into one molecule with VP1 protein of E30 (S_N-VP1_E30), which in the future can be used to develop a vaccine for the prevention of enterovirus meningitis caused by the E30 virus. The aim of this work was to study the immunological properties of the S_N-VP1_E30 protein.</p><p><strong>Materials and methods: </strong>Balb/c mice and a guinea pig were immunized with the S_N-VP1_E30 protein. The production of IgG and IgM antibodies was studied by ELISA. The interaction of antibodies against S_N-VP1_E30 with virions of enteroviruses E30 of different genotypes was studied by electron microscopy. The reaction of neutralization of E30 by antibodies was carried out <i>in vitro </i>in RD cells.</p><p><strong>Results: </strong>In mice immunized with S_N-VP1_E30 without adjuvant, the average titers of total antibodies against E30 VP1 protein were 1 : 19,000. The use of adjuvant increased the average titer of antibodies by 3 times. The level of IgM antibodies was significantly lower and amounted to, on average, 1 : 1500. Using immunoelectron microscopy, it was shown that guinea pig antibodies against chimeric S_N-VP1_E30 are able to bind virions of E30 genotypes h and eC2. Mouse and guinea pig antibodies were able to neutralize E30 in RD cell line. Neutralizing antibody titers in mice varied from 20 to 40, and were 40 in guinea pigs.</p><p><strong>Conclusion: </strong>The immunogenicity of S_N-VP1_E30 in two animal species and the ability of antibodies to bind and neutralize enterovirus E30 allows us to propose it as an antigen in a vaccine for the prevention of diseases caused by E30.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"189-198"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Detection of the Liman tick virus (unclassified <i>Chuviridae</i>) in tick cell line HAE/CTVM8].","authors":"A G Litov, A M Shchetinin, I S Kholodilov, O A Belova, А S Kalyanova, V A Gushchin, G G Karganova","doi":"10.36233/0507-4088-283","DOIUrl":"https://doi.org/10.36233/0507-4088-283","url":null,"abstract":"<p><strong>Introduction: </strong>Tick cell lines are widely used to study the biology of ticks and tick-borne pathogens, especially viruses. Most of the cell cultures currently available have been obtained from tick embryonic cells and can be infected with viruses. The HAE/CTVM8 cell line was obtained from <i>Hyalomma anatolicum</i> ticks and is often used for isolation of novel viruses. The aim of the work is to study the HAE/CTVM8 cell line using high-throughput sequencing in order to search for viruses in it.</p><p><strong>Materials and methods: </strong>The HAE/CTVM8 cell culture fluid was ultracentrifuged. The resulting pellet was used for high-throughput sequencing after RNA extraction, reverse transcription reaction, and synthesis of the second strand. The resulting reads were filtered by length and quality in the Trimmomatic program, after which the contigs were assembled using the SPAdes program and analyzed for the presence of viral sequences. The final assembly of the virus genome was carried out in the Ugene program. Sequence alignment was performed by the MAFFT program. The phylogenetic trees were constructed using the IQ-TREE program.</p><p><strong>Results: </strong>We have identified the persistence of one virus, Liman tick virus (LMTV), in HAE/CTVM8 cell culture. Phylogenetically LMTV belongs to the <i>Chuviridae </i>- novel family, that consists of viruses detected by high-throughput sequencing, the virological characteristics of which are currently unknown.</p><p><strong>Conclusion: </strong>The obtained information is of significant importance when utilizing HAE/CTVM8 cell culture in scientific research and during the process of isolating new viruses. Our study shows that this cell line with persistent LMTV is a ready-to-use system for studying <i>Chuviridae</i> reproduction.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic diversity of human metapneumovirus (Pneumoviridae: <i>Metapneumovirus</i>) in Russia: results of molecular analysis].","authors":"A V Fadeev, Y V Ivanov, P A Petrova, A A Perederiy, M M Pisareva, A D Moshkin, A B Komissarov, D M Danilenko, D A Lioznov","doi":"10.36233/0507-4088-294","DOIUrl":"https://doi.org/10.36233/0507-4088-294","url":null,"abstract":"<p><strong>Introduction: </strong>Human metapneumovirus (hMPV) holds significant epidemiological importance, being a dominant cause of lower respiratory tract infections in children under two years of age and individuals over 65. Multiple infections with hMPV throughout a person's life are possible due to the antigenic and genetic variability of the virus. However, the genetic variability of hMPV circulating in Russia remains unexplored.</p><p><strong>Aim of the study: </strong>The aim of this study was to test a protocol for whole-genome sequencing of hMPV to assess the genetic diversity of metapneumoviruses circulating in certain regions of Russia.</p><p><strong>Materials and methods: </strong>Nasopharyngeal swabs were collected from patients of different ages with acute respiratory viral infections (ARVI) tested positive for hMPV using polymerase chain reaction (PCR). From some of the samples, viral isolates were obtained in cell culture. Whole-genome sequencing was performed on both swabs and isolates using the MiSeq Illumina platform, followed by phylogenetic analysis.</p><p><strong>Results: </strong>For the first time in Russia, whole-genome sequencing of 44 hMPV strains circulating from 2017 to 2024 was conducted. Their genetic group affiliation was described, with the A2b2 clade shown to dominate. It was confirmed that the greatest variability among genes encoding viral surface proteins was observed in the G gene, while changes in the F gene were minimal during the studied period.</p><p><strong>Conclusion: </strong>The study provides insights into the genetic diversity of hMPV strains circulating in various regions of the Russian Federation. Understanding the genetic variability of hMPV is crucial for comprehending viral evolution, transmission dynamics, and mechanisms of immune evasion, which influence the development of vaccines and antiviral drugs.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"164-176"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reassortant strains of <i>Rotavirus A</i> (Sedoreoviridae: <i>Rotavirus: Rotavirus A</i>): the role of animal rotaviruses in the emergence of new human rotavirus variants].","authors":"E I Velikzhanina, T A Sashina, N A Novikova","doi":"10.36233/0507-4088-306","DOIUrl":"https://doi.org/10.36233/0507-4088-306","url":null,"abstract":"<p><p>Animal rotaviruses (RV) play a significant role in the formation of new variants of epidemiologically significant human group A rotavirus (RVA) strains.A reassortant variant of genotype G3P[8] which has been shown to originate from RV in horses and cattle currently dominates on the territory of the Russian Federation. In addition, reassortant RV variants of genotypes G3P[3], G3P[9], G6P[9], similar to RV of cats and dogs, have been sporadically identified in the world for a long time. Given the relevance of this topic, a detailed study of the AU-1-like genetic group of RVAs, whose representatives are closely related to animal RVs, particularly those found in cats and dogs, is of scientific and practical interest. The aim of this review is to analyze published scientific data on human, feline and canine RV that belong to the AU-1-like genetic group and have been studied based on their complete genotypes.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of inactivated whole-virion concentrated purified vaccine for the prevention of COVID-19 on clinical and biochemical blood parameters of immature rats].","authors":"A A Siniugina, N A Lycheva, A A Saprykina, K L Kryshen', V D Apolokhov, A D Chernavtseva, A A Kovpak, Y Y Ivin, A N Piniaeva, M N Makarova, V G Makarov, A A Ishmukhametov","doi":"10.36233/0507-4088-303","DOIUrl":"https://doi.org/10.36233/0507-4088-303","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of new coronavirus infection (COVID-19) in 2021-2022 in the pediatric population was 9.5%, and fatal outcomes began to be recorded. In 2022-2023, the proportion of children infected with COVID-19 increased to 18%. Developing a vaccine for the pediatric population is an urgent task. The aim of the study is to explore the effect of the vaccine on the parameters of general and biochemical blood tests in immature rats.</p><p><strong>Materials and methods: </strong>The study was performed on 112 immature rats (60 females, 52 males) of the Wistar line. Animals were randomized into groups that received the CoviVac vaccine at doses of 0.125, 0.25 and 0.5 mL/animal or placebo (0.5 mL/animal), intramuscularly on days 1, 15, 29 and 43 of the experiment. General and biochemical blood tests were performed twice, on the 57th and 71st days.</p><p><strong>Results: </strong>Oligocythemia (0.25 and 0.5 mL/animal, <i>p</i> < 0.05), leukocytosis and thrombocytopenia (0.5 mL/animal, <i>p</i> < 0.05) were recorded in males. Monocytopenia (0.5 mL/animal, <i>p </i>< 0.05) and leukopenia (0.25 mL/animal, <i>p</i> < 0.05) were established in females. In males, an increase in the amount of globulins and total protein (0.5 mL/animal), a decrease in the A/G ratio (doses 0.25 and 0.5 mL/animal), a decrease in the cholesterol level (0.125 mL/animal) were detected. In females, an increase in the amount of albumin and total protein (0.5 mL/animal, <i>p</i> < 0.05), a decrease in the level of triglycerides (0.125, 0.25, 0.5 mL/animal, placebo, <i>p</i> < 0.05), a decrease in the level of lactate dehydrogenase, triglycerides and urea (0.25 mL/animal, <i>p</i> < 0.05) were recorded.</p><p><strong>Conclusion: </strong>The safety of the CociVac vaccine in relation to clinical and biochemical blood parameters has been demonstrated.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"177-188"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of the epidemic process of measles, rubella and mumps in Moscow and assessment of their seroprevalence at the present stage].","authors":"Y V Simakova, V A Gushchin, T A Semenenko, D A Ogarkova, D A Kleymenov, A V Nozdracheva, V A Manuylov, A P Tkachuk, A L Gintsburg","doi":"10.36233/0507-4088-282","DOIUrl":"https://doi.org/10.36233/0507-4088-282","url":null,"abstract":"<p><strong>Introduction: </strong>The problem of vaccine-preventable infections requires assessing the state of herd immunity through serological monitoring.</p><p><strong>The aim: </strong>To study the epidemiological features of measles, rubella and mumps and to estimate their seroprevalence in the last decade in Moscow.</p><p><strong>Materials and methods: </strong>Forms of federal statistical observation; State reports «On the state of sanitary and epidemiological well-being of the Moscow population»; official EMISS data for 2012-2023 were used to conduct a retrospective analysis of incidence. Blood serum samples (<i>n</i> = 7458) from healthy individuals stratified by age were tested for the presence of IgG antobodies to measles, rubella and mumps using the ELISA. Statistical data processing was performed using Microsoft Excel and SPSS Statistics v.27 (IBM).</p><p><strong>Results: </strong>The analysis of epidemiological situation in Moscow in 2012-2023 revealed the presence of multidirectional trends: wave-like increase in the incidence of measles, stabilization of rubella cases registration and unstable incidence of mumps with an upward trend. A high prevalence of IgG antibodies to rubella virus was determined, preventing the spread of infection among the population. The formed level of herd immunity to mumps does not allow reducing the incidence to sporadic cases. The observed trend of increasing measles incidence can be explained by the accumulation of non-immune individuals among the population.</p><p><strong>Conclusion: </strong>The significant proportion of seronegative individuals indicate the necessity to adjust vaccination prevention tactics and implement measures for mopping-up and catch-up immunization of the population against measles and mumps, especially in risk age groups.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 2","pages":"133-146"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19.","authors":"Y Y Chernoryzh, V M Kondratieva, А P Malkova, T E Savochkina, O V Eliseeva, O E Latyshev, D Y Yakunin, O N Zaykova, E S Sludnyakova, T V Grebennikova","doi":"10.36233/0507-4088-278","DOIUrl":"https://doi.org/10.36233/0507-4088-278","url":null,"abstract":"<p><strong>Introduction: </strong>The large-scale and prolonged pandemic of the novel coronavirus disease (COVID-19) has demonstrated the need for effective vaccination. Along with immunogenicity, safety is a critical issue for vaccines, as public trust can contribute to the success or failure of immunization programs. In preclinical studies, we assessed the safety of an intranasal Virus-like particle (VLP)-based vaccine in mice and rats. The aim of the study is to conduct preclinical acute and subchronic toxicity studies assessing local tolerability of an intranasal VLP vaccine against COVID-19 in accordance with good laboratory practice.</p><p><strong>Materials and methods: </strong>Study was performed on adult outbreed mice (30 males, 30 females) and rats (45 males, 45 females). Physiological, morphometric and histological parameters, as well as general and biochemical blood tests and urine analysis were assessed.</p><p><strong>Results: </strong>No deaths or intoxication were recorded in the acute toxicity study on mice, all parameters were within the physiological norm. In the subchronic toxicity study on rats, no changes in the general condition, behavior, or death of animals were noted. The structure of internal organs, blood and urine tests, hemostasis did not differ significantly between the groups. No local irritant effect was detected at the injection site during visual assessment, cytological and histological analysis.</p><p><strong>Conclusion: </strong>The VLP vaccine is safe, as evidenced by the results of preclinical studies, does not negatively affect the function of various organs, the level of cellular and biochemical biomarkers in the blood and urine of mice and rats. Visual assessment, cytology and histology of the vaccine injection site did not reveal any local irritant effect.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 1","pages":"35-46"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total antibodies and neutralizing ability of convalescent sera against three different strains of SARS-CoV-2.","authors":"N V Palyanova, L S Adamenko, O G Kurskaya, T A Saroyan, M V Solomatina, I A Sobolev, A M Shestopalov","doi":"10.36233/0507-4088-290","DOIUrl":"https://doi.org/10.36233/0507-4088-290","url":null,"abstract":"<p><p>The aim of the study was to assess the level of humoral immunity to SARS-CoV-2 in COVID-19 convalescents.</p><p><strong>Materials and methods: </strong>We used ELISA for antibody quantitation, microneutralization test using three SARS-CoV-2 strains for neutralizing activity measurement, Illumina MiSeq platform for NGS sequencing and NextClade resource for phylogenetic analysis.</p><p><strong>Results: </strong>The mean concentration of antibody in convalescents was 133.42 ± 7.2 BAU/mL and the value depended on neither the gender and age of the patients, nor on the time elapsed since COVID-19 infection. The studied SARS-CoV-2 strains were sequenced and deposited in the international GISAID database. According to genetic analysis: EPI_ISL_19424272 phylogenetically belongs to the B1.1 clade, EPI_ISL_19424271 - to B.1.1.397 clade, EPI_ISL_19424270 - to Delta B.1.617.2.122. There were no significant differences in the neutralizing ability of convalescent sera (those who had been ill 2-3 months before the study) for the first two variants of SARS-CoV-2 and it was significantly reduced for the Delta variant, which appeared in the Novosibirsk region later.</p><p><strong>Conclusions: </strong>The neutralizing activity of convalescent sera was the highest against those variants of the virus that the patient had recovered from, while was reduced or absent against the new variant. The antibody developed to the original variants of the SARS-CoV-2 may not be effective enough against newly emerging strains due to the emergence of mutations in the virus that allow it to evade previously developed humoral immune response.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 1","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the association of influenza clinical course with single nucleotide polymorphisms in genes affecting the interferon-λ3 production.","authors":"L I Nikolaeva, M D Stuchinskaya, K P Telepenina, N G Shevchenko, V V Kuprianov, K G Krasnoslobodtsev, E A Mukasheva, S V Trushakova, I N Khlopova, I S Kruzhkova, L B Kisteneva, L V Kolobukhina, E I Burtseva","doi":"10.36233/0507-4088-271","DOIUrl":"https://doi.org/10.36233/0507-4088-271","url":null,"abstract":"<p><strong>Introduction: </strong>Predisposition to different courses of the infectious process is largely associated with the polymorphisms in human genome, especially in genes encoding proteins of the immune system. In the early stages of influenza infection such components of innate immunity as interferons I (α/β) and III (λ) type play a significant role in limiting virus replication. The aim of the work was to investigate associations of single nucleotide polymorphism in <i>IFNL3</i> (rs8099917 T/G) and <i>IFNL4</i> (rs12979860 C/T) genes with different course of influenza, and identify genetic markers of influenza complicated by community-acquired pneumonia. The genes noted above affect the production of interferon-λ3, which is involved in restriction of the viral replication.</p><p><strong>Materials and methods: </strong>Samples from 456 patients with mild (<i>n </i>= 150), moderate (<i>n </i>= 173), and severe (<i>n </i>= 133) influenza were studied. The viral RNA was detected by reverse transcription and polymerase chain reaction (RT-PCR). Polymorphisms in <i>IFNL3</i> (rs8099917 T/G) and <i>IFNL4</i> (rs12979860 C/T) genes was detected by PCR. Statistical analysis was performed using SNPStats software.</p><p><strong>Results: </strong>Patients with the C/T or T/T genotype of <i>IFNL4</i> gene (rs12979860 C/T) were more likely to have pneumonia than those with the C/C genotype (OR 2.47 (1.31-4.63); <i>p </i>= 0.0044; <i>q</i> = 0.0059). The presence of one T allele increased the risk of developing pneumonia (OR 2.02 (1.05-4.02); <i>p </i>= 0.006; <i>q</i> = 0.008). In the presence of the T/T genotype, the risk increased more than twofold: OR 2.14 (1.31-3.48). Analysis of the SNP of <i>IFNL3</i> gene (rs8099917 T/G) revealed a weak association of the G allele with pneumonia (OR 1.86 (1.04-3.31); <i>p</i> = 0.03; <i>q </i>= 0.045).</p><p><strong>Conclusion: </strong>Genetic markers of increased risk of community-acquired pneumonia in influenza include the presence of the T allele in <i>IFNL4</i> gene (rs12979860 C/T) and, to a lesser extent, the G allele in <i>IFNL3</i> gene (rs8099917 T/G). Patients carrying these alleles have an increased risk of developing pneumonia, especially in old age.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 1","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Acute respiratory viral infections in monkeys].","authors":"D I Dogadov, K K Kyuregyan, A A Minosyan, A M Goncharenko, E V Shmat, M I Mikhailov","doi":"10.36233/0507-4088-293","DOIUrl":"https://doi.org/10.36233/0507-4088-293","url":null,"abstract":"<p><p>Acute respiratory viral infections (ARVI) are one of the most significant infections affecting the breeding of monkeys, especially among imported and captive primates. Respiratory diseases are also an important cause of morbidity and mortality in wild populations, and most of these infections can affect humans. Many anthropoid species, including apes, are susceptible to ARVI. Outbreaks of spontaneous respiratory infections have been described in many zoos and primatological centers around the world. Moreover, the study of spontaneous and experimental infection in laboratory primates provides an invaluable source of information on the biology and pathogenesis of ARVI and remains an indispensable tool for testing vaccines and drugs. The aim of this literature review was to summarize and analyze published data on the circulation of ARVI causative agents (parainfluenza viruses, adenoviruses, respiratory syncytial virus, influenza viruses, rhinoviruses, coronaviruses, metapneumoviruses, bocaviruses) among wild and captive primates, as well as the results of experimental modeling these infections in monkeys.</p>","PeriodicalId":23669,"journal":{"name":"Voprosy virusologii","volume":"70 1","pages":"7-24"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}