Viral immunology最新文献

筛选
英文 中文
Hepatitis B Virus Envelope Antigen and Hepatitis B Virus Surface Antigen Both Contribute to the Innate Immune Response During Persistent Hepatitis B Virus Infection. 乙型肝炎病毒包膜抗原和乙型肝炎病毒表面抗原都有助于持续性乙型肝炎病毒感染过程中的先天免疫反应。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-08-22 DOI: 10.1089/vim.2023.0018
Jie-Min Zhang, Na-Ling Kang, Lu-Ying Wu, Da-Wu Zeng
{"title":"Hepatitis B Virus Envelope Antigen and Hepatitis B Virus Surface Antigen Both Contribute to the Innate Immune Response During Persistent Hepatitis B Virus Infection.","authors":"Jie-Min Zhang,&nbsp;Na-Ling Kang,&nbsp;Lu-Ying Wu,&nbsp;Da-Wu Zeng","doi":"10.1089/vim.2023.0018","DOIUrl":"10.1089/vim.2023.0018","url":null,"abstract":"<p><p>This study aimed to investigate the changes of toll-like receptor 4 (TLR4), proinflammatory cytokine expression, hepatitis B virus surface antigen (HBsAg), and hepatitis B virus envelope antigen (HBeAg) expression as well as innate immune cell percentages in a mouse model of persistent hepatitis B virus (HBV) infection to better understand the innate immune response. Mouse models of persistent HBV infection, HBsAg expression, and HBeAg expression were developed using high-pressure tail-vein injection of recombinant adeno-associated viruses. Enzyme-linked immunosorbent assays (ELISAs) were used to determine the serum proinflammatory cytokine levels. Immunohistochemistry and western blot assays were used to detect TLR4 expression. Flow cytometric analysis was used to assess the percentage of innate immune cells in the whole blood. Persistent HBV infection, HBsAg expression, and HBeAg expression each significantly decreased the expression of TLR4. Persistent HBV infection significantly increased the percentages of T cells and monocytes, whereas it decreased the percentage of natural killer (NK) cells. Persistent HBeAg expression also decreased the percentage of NK cells, whereas persistent HBsAg expression increased the percentage of NK cells. Both persistent HBsAg and HBeAg expression increased the percentage of monocytes. However, both persistent HBsAg and HBeAg expression decreased the percentage of T cells. HBV as well as HBsAg and HBeAg showed similar effects on the expression of TLR4 and proinflammatory cytokines as well as the percentage of monocytes. Persistent HBV infection increased the percentage of T cells and decreased the percentage of NK cells, whereas only persistent HBeAg expression contributed to a decreased percentage of NK cells.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"484-493"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10651383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-4 Promotes Human Metapneumovirus Replication Through the JAK/STAT6 Pathway. 白细胞介素-4通过JAK/STAT6途径促进人肺结核病毒复制。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-07-05 DOI: 10.1089/vim.2023.0027
Yueyan Zhang, Guojin Wu, Yuting Yang, Linlin Niu, Yao Zhao
{"title":"Interleukin-4 Promotes Human Metapneumovirus Replication Through the JAK/STAT6 Pathway.","authors":"Yueyan Zhang,&nbsp;Guojin Wu,&nbsp;Yuting Yang,&nbsp;Linlin Niu,&nbsp;Yao Zhao","doi":"10.1089/vim.2023.0027","DOIUrl":"10.1089/vim.2023.0027","url":null,"abstract":"<p><p>Respiratory virus infections are the main causes of pediatric diseases. Human metapneumovirus (hMPV) is an enveloped RNA virus similar to severe acute respiratory syndrome coronavirus type 2, both of which have emerged as important new respiratory viruses. Recent studies have found that interleukin-4 (IL-4) is involved in the replication of a variety of viruses, and its role differs in different viruses. The purpose of this study was to investigate the effect of IL-4 on hMPV and to elucidate its mechanism of action. We found that hMPV infection promoted the expression of IL-4 in human bronchial epithelial cells. The replication of the virus was reduced using small interfering RNA knockdown of <i>IL-4</i> expression, while the addition of exogenous recombinant human IL-4 to IL-4 knockdown cells restored viral replication ability. These results demonstrate that the expression of IL-4 is closely related to the replication of hMPV; moreover, further experiments revealed that IL-4 promotes the replication of hMPV through a mechanism dependent on the Janus kinase/signal transductor and transcription activator 6 signaling pathway. Therefore, anti-IL-4 strategies may be a promising avenue for the treatment of hMPV infection, representing an important breakthrough for children at risk from hMPV infection.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"449-457"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection. 原发感染后呼吸道合胞病毒在肺树突状细胞亚群中持续存在的体内证据。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-07-31 DOI: 10.1089/vim.2023.0007
Angela M Fonceca, Jeff Lauzon-Joset, Naomi Scott, Philip A Stumbles, Deborah Strickland, Mark L Everard
{"title":"<i>In Vivo</i> Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection.","authors":"Angela M Fonceca,&nbsp;Jeff Lauzon-Joset,&nbsp;Naomi Scott,&nbsp;Philip A Stumbles,&nbsp;Deborah Strickland,&nbsp;Mark L Everard","doi":"10.1089/vim.2023.0007","DOIUrl":"10.1089/vim.2023.0007","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) causes annual epidemics of infections affecting the whole population. <i>In vitro</i>, it has been shown to infect and persist in human dendritic cells (DCs) for prolonged periods. Initially persistence is associated with low levels of replication before the virus becomes dormant. Reactivation of viral replication can be triggered many months later. Infection of DCs is likely to influence the host's ability to generate effective long-term memory responses. A well-established animal was utilized to confirm that RSV both infects and persists in pulmonary DCs <i>in vivo.</i> Mice were infected with a modified strain of RSV expressing red fluorescent protein (RSV-RFP) when replicating. Clinical symptoms of infection were monitored using weight change and inflammatory cell counts from bronchoalveolar lavage, which correlated with the RSV viral titer (quantitative polymerase chain reaction). Lung tissues were collected at 3, 5, 7, and 21 days postinfection (dpi) to assess leukocyte populations by flow cytometry. Clinical symptoms and RSV viral load peaked at 5 dpi. RSV-RFP was most prevalent in macrophages at 3 dpi and also observed in B cells and DCs. At 21 dpi, RSV-RFP remained evident in a subset of conventional DCs (CD103<sup>+</sup>CD11b<sup>+</sup>) even though both clinical symptoms and pulmonary inflammation had resolved. These results confirm that in this well-established mouse model, RSV persists in lung conventional DCs following resolution of the acute infection. Further work is required to explore whether the virus continues with low-level replication before becoming dormant <i>in vivo</i>, as has been described <i>in vitro.</i></p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"466-474"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10666589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Significance of Evaluation of Monocytic Receptors in Patients with Hepatitis C Virus Infection. 丙型肝炎病毒感染患者单核细胞受体检测的临床意义。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-07-28 DOI: 10.1089/vim.2022.0180
Nermine Magdi Riad, Heba Adel AbdEl Ghaffar, Reem Raied Mansour, Walaa Abdel Fattah, Ahmed Khairy, Ayman Yosry, Naglaa Ali Zayed, Mariam Onsy F Hanna
{"title":"Clinical Significance of Evaluation of Monocytic Receptors in Patients with Hepatitis C Virus Infection.","authors":"Nermine Magdi Riad,&nbsp;Heba Adel AbdEl Ghaffar,&nbsp;Reem Raied Mansour,&nbsp;Walaa Abdel Fattah,&nbsp;Ahmed Khairy,&nbsp;Ayman Yosry,&nbsp;Naglaa Ali Zayed,&nbsp;Mariam Onsy F Hanna","doi":"10.1089/vim.2022.0180","DOIUrl":"10.1089/vim.2022.0180","url":null,"abstract":"<p><p>Monocytes in hepatitis C virus (HCV) infection play a critical role in chronic liver inflammation and fibrosis. We studied circulating monocytes and monocyte receptors in patients with HCV infection who were naive to treatment and those who received direct acting antiviral therapy and achieved sustained virological response. CD64<sup>+</sup> CCR2<sup>+</sup> (M1-like) and CD206<sup>+</sup> CD163<sup>+</sup> CX3CR1<sup>+</sup> (M2-like) monocyte numbers and receptor expression were evaluated by flow cytometry. Higher expression of the monocyte chemokine receptor CCR2 predicted the severity of liver fibrosis, independent of successful treatment and viral clearance (<i>R</i><sup>2</sup> = 0.235, <i>p</i> = 0.002), whereas monocyte CX3CR1 expression was lower in both treated and untreated patients compared with controls (<i>p</i> = 0.011). The expression of the scavenger receptor CD163 was lower in patients with successful treatment (<i>p</i> = 0.005), supporting its role as a marker of treatment response. CD64<sup>+</sup> CCR2<sup>+</sup> (M1-like) and CD206<sup>+</sup> CD163<sup>+</sup> CX3CR1<sup>+</sup> (M2-like) monocyte numbers were not altered with fibrosis progression or treatment response. Our findings reflect the diverse functions of monocytes in liver inflammation, fibrosis, and therapy. However, HCV clearance did not lead to complete monocyte reconstitution. Targeting monocytes and their chemokine receptors bears therapeutic potential to reduce liver fibrosis and improve disease outcome.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"475-483"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10293733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation. AIM2和IFI16对传染病和炎症的影响。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-08-16 DOI: 10.1089/vim.2023.0044
Zhen Fan, Rui Chen, Wen Yin, Xiaomei Xie, Shan Wang, Chunbo Hao
{"title":"Effects of <i>AIM2</i> and <i>IFI16</i> on Infectious Diseases and Inflammation.","authors":"Zhen Fan,&nbsp;Rui Chen,&nbsp;Wen Yin,&nbsp;Xiaomei Xie,&nbsp;Shan Wang,&nbsp;Chunbo Hao","doi":"10.1089/vim.2023.0044","DOIUrl":"10.1089/vim.2023.0044","url":null,"abstract":"<p><p>Both absent in melanoma 2 (<i>AIM2</i>) and interferon-inducible protein 16 (<i>IFI16</i>) are intracellular innate immune receptors that recognize double-stranded DNA released during pathogenic infection, leading to the assembly of the inflammasome. The assembly of the inflammasome results in the secretion of bioactive interleukin (IL)-1<i>β</i> and IL-18 and induces cell death through an inflammatory process called pyroptosis. Although the <i>AIM2</i> inflammasome is generally harmful in the context of some aseptic inflammatory illnesses, it plays a protective role in infectious diseases. During inflammatory processes, there is competition between <i>IFI16</i> and <i>AIM2</i>. In this review, we explore the impacts of <i>IFI16</i> and <i>AIM2</i> in infectious disease and aseptic inflammation, respectively, and how they compete.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"438-448"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Expression and Clinical Significance of Peripheral Blood IL-17A, IL-22, Tim-3, and gal-9 in Children with Infectious Mononucleosis. 感染性单核细胞增多症患儿外周血IL-17A、IL-22、Tim-3和gal-9的表达及其临床意义。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 Epub Date: 2023-08-11 DOI: 10.1089/vim.2022.0203
Mengli Xu, Yuqin Li, Meng Cao, Yuewen Su, Zhenghua Ji, Weifang Zhou
{"title":"Expression and Clinical Significance of Peripheral Blood IL-17A, IL-22, Tim-3, and gal-9 in Children with Infectious Mononucleosis.","authors":"Mengli Xu, Yuqin Li, Meng Cao, Yuewen Su, Zhenghua Ji, Weifang Zhou","doi":"10.1089/vim.2022.0203","DOIUrl":"10.1089/vim.2022.0203","url":null,"abstract":"<p><p>To investigate the expression and clinical significance of peripheral blood interleukin (IL)-17A, IL-22, T cell immunoglobulin molecule-3 (Tim-3), and galectin-9 (gal-9) in children with infectious mononucleosis (IM) caused by the Epstein-Barr virus (EBV). Peripheral blood of 54 children with IM (case group) was collected and divided into a liver damage group and a non-liver damage group. During the same period, 20 healthy children were in the control group. IL-17A and IL-22 were measured by enzyme-linked immunosorbent assay. Real-time quantitative polymerase chain reaction was used to measure the mRNA expression of Tim-3 and gal-9. Their correlation with clinical indicators was then analyzed. The IL-17A expression level was higher in the case group than in the control group, while Tim-3, gal-9, and IL-22 were lower than those in the control group. Tim-3 was positively correlated with gal-9, but negatively correlated with IL-17A. Tim-3 and gal-9 were positively correlated with CD4<sup>+</sup>/CD8<sup>+</sup> cells. Conversely, they were negatively correlated with CD3<sup>+</sup>, CD3<sup>+</sup>CD8<sup>+</sup>, white blood cell, lymphocyte (L), alanine transaminase (ALT), aspartate transaminase (AST), glutamyl transpeptidase (GGT), and lactate dehydrogenase (LDH). In the case group, IL-17A was positively correlated with L, GGT, and LDH, but negatively correlated with the natural killer (NK) cell count. IL-17A and IL-22 were positively correlated with CD3<sup>+</sup>, CD3<sup>+</sup>CD8<sup>+</sup>, ALT, and AST, but they were negatively correlated with the ratio of CD4<sup>+</sup>/CD8<sup>+</sup>. In the liver damage group, IL-17A, IL-22, CD3<sup>+</sup>, CD3<sup>+</sup>CD8<sup>+</sup>, immunoglobulin A (IgA), IgG, IgM, L, ALT, AST, GGT, LDH, and <i>α</i>-hydroxybutyrate levels were higher than those in the non-liver damage group. However, Tim-3, gal-9, the ratio of CD4<sup>+</sup>/CD8<sup>+</sup>, and NK were lower than those in the non-liver damage group. IL-17A, IL-22, Tim-3, and gal-9 are involved in the immune pathogenesis of IM caused by EBV infection in children, which may be related to immune liver injury.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"458-465"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein Barr Virus and Multiple Sclerosis: Is a Cure Possible? EB病毒与多发性硬化症:有可能治愈吗?
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-09-01 DOI: 10.1089/vim.2023.0109
Rochelle Y Benoit, Craig S Moore
{"title":"Epstein Barr Virus and Multiple Sclerosis: Is a Cure Possible?","authors":"Rochelle Y Benoit,&nbsp;Craig S Moore","doi":"10.1089/vim.2023.0109","DOIUrl":"https://doi.org/10.1089/vim.2023.0109","url":null,"abstract":"","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 7","pages":"435-437"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the Seroprevalence of Antimeasles Immunoglobulin G Antibody in Students at Shiraz University of Medical Sciences. 设拉子医科大学学生抗麻疹免疫球蛋白G抗体血清流行率调查。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-07-01 DOI: 10.1089/vim.2023.0026
Mohammad Kia, Fatemeh Nekooei, Amir Hossein Alipour, Seyed Mohammad Ali Hashemi, Vahid Salimi, Mohammad Javad Fattahi, Kamran Bagheri Lankarani, Jamal Sarvari
{"title":"Investigation of the Seroprevalence of Antimeasles Immunoglobulin G Antibody in Students at Shiraz University of Medical Sciences.","authors":"Mohammad Kia,&nbsp;Fatemeh Nekooei,&nbsp;Amir Hossein Alipour,&nbsp;Seyed Mohammad Ali Hashemi,&nbsp;Vahid Salimi,&nbsp;Mohammad Javad Fattahi,&nbsp;Kamran Bagheri Lankarani,&nbsp;Jamal Sarvari","doi":"10.1089/vim.2023.0026","DOIUrl":"10.1089/vim.2023.0026","url":null,"abstract":"<p><p>Measles is an acute, highly contagious disease with a high mortality rate in children. Although vaccination has reduced measles incidence, outbreaks still occur. Therefore, in this study, we aimed to investigate the frequency of antimeasles immunoglobulin G (IgG) antibody (Ab) among students at Shiraz University of Medical Sciences (SUMS). Four hundred fifty SUMS students were enrolled in this cross-sectional study. Information on demographics and measles vaccination history was collected using a questionnaire. Participants were divided into two groups, including A and B, according to routine doses of measles vaccine and the national measles/rubella immunization program. The antimeasles IgG Abs were tested using a commercial Enzyme-Linked Immunosorbent Assay Kit. Participants ranged in age from 18 to 48 years, with a mean age of 22.2 (±4.3). Fifty percent of the subjects were male. Our results showed that 63.6% of the cases were positive for antimeasles IgG Abs. The seroprevalence of IgG Abs between groups A and B did not differ significantly (<i>p</i> = 0.612). There was also no significant correlation between the seroprevalence of antimeasles IgG Abs and the age (<i>p</i> = 0.43) or sex (<i>p</i> = 0.24) of the subjects. The results showed that the frequency of antimeasles IgG Abs is lower than required to prevent the measles virus from circulating. Therefore, a booster vaccination may be necessary.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 6","pages":"424-428"},"PeriodicalIF":2.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Observation of Immune Response for 23 Months in COVID-19 Convalescent Patients After Infection and Vaccination. 新冠肺炎康复患者感染和接种疫苗后23个月免疫反应的纵向观察。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-07-01 Epub Date: 2023-06-05 DOI: 10.1089/vim.2022.0111
Jingru Xu, Juan Zheng, Yan Tan, Jiaojiao Cai, Yao Xiang, Hua Ling, Zhifeng Li, Qunhua Bai
{"title":"Longitudinal Observation of Immune Response for 23 Months in COVID-19 Convalescent Patients After Infection and Vaccination.","authors":"Jingru Xu,&nbsp;Juan Zheng,&nbsp;Yan Tan,&nbsp;Jiaojiao Cai,&nbsp;Yao Xiang,&nbsp;Hua Ling,&nbsp;Zhifeng Li,&nbsp;Qunhua Bai","doi":"10.1089/vim.2022.0111","DOIUrl":"10.1089/vim.2022.0111","url":null,"abstract":"<p><p>To better understand dynamic changes of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) immune response, a prospective, single-center, cohort study was conducted on longitudinal immune response in 34 COVID-19 convalescent patients over 23 months in Chongqing. Two blood samples from convalescent patients were collected, first sample collected during 10-13 months (M10-13) after infection (pre-SARS-CoV-2 vaccination) and second sample collected during 20-23 months (M20-23) after infection (post-SARS-CoV-2 vaccination). The SARS-CoV-2-specific humoral and cellular immunity were traced by testing total antibody (Ab), anti-nucleocapsid (NP) immunoglobulin M (IgM), anti-NP immunoglobulin G (IgG), and anti-spike (S) IgG Abs, lymphocyte subset count, and Th1 cytokines. Healthy donors (30) were also included in the study as the uninspected healthy controls. Our data showed significant change in mean titer of SARS-CoV-2-specific Ab response from M10-13 to M20-23 included, namely, SARS-CoV-2-specific total Ab as 219 AU/mL increasing to 750.9 AU/mL; anti-NP IgM as 3.5 AU/mL decreasing significantly (<i>p</i> < 0.001) to 0.6 AU/mL; anti-NP IgG as 7.9 AU/mL increasing to 87.1 AU/mL; and anti-S IgG as 499.0 RU/mL increasing to 1,802.3 RU/mL. Our observations suggested that one vaccine dose might have been sufficient for COVID-19 convalescent patients. Larger sample sizes are needed to compare better immune effect of protein subunit vaccine. Besides, compared to healthy donors, patients had decreased CD3+ and CD8+ T lymphocyte counts during two periods. Patients had most cytokines recovered normally within 2 years, but IL-6 level was significantly elevated; however, IL-6 was negatively correlated with IgM and positively correlated with IgG. Changes in cytokines might have been caused by SARS-CoV-2 infection or vaccination. Patients with comorbidities were associated with decreased CD3+ and CD8+ T lymphocytes and lower Ab titers following SARS-CoV-2 vaccination. Vaccination enormously increased humoral immunity beneficial in COVID-19 convalescent patients. Elderly COVID-19 convalescent patients with comorbidities needed more attention.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 6","pages":"389-400"},"PeriodicalIF":2.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Disease-Modifying Therapies on COVID-19 Vaccination Efficacy in Multiple Sclerosis Patients: A Comprehensive Review. 疾病改良疗法对多发性硬化症患者新冠肺炎疫苗接种效果的影响:综合综述。
IF 2.2 4区 医学
Viral immunology Pub Date : 2023-07-01 Epub Date: 2023-06-05 DOI: 10.1089/vim.2023.0035
Elham Jamali, Shima Shapoori, Majid Reza Farrokhi, Sina Vakili, Davoud Rostamzadeh, Farideh Iravanpour, Razieh Tavakoli Oliaee, Morteza Jafarinia
{"title":"Effect of Disease-Modifying Therapies on COVID-19 Vaccination Efficacy in Multiple Sclerosis Patients: A Comprehensive Review.","authors":"Elham Jamali,&nbsp;Shima Shapoori,&nbsp;Majid Reza Farrokhi,&nbsp;Sina Vakili,&nbsp;Davoud Rostamzadeh,&nbsp;Farideh Iravanpour,&nbsp;Razieh Tavakoli Oliaee,&nbsp;Morteza Jafarinia","doi":"10.1089/vim.2023.0035","DOIUrl":"10.1089/vim.2023.0035","url":null,"abstract":"<p><p>According to current knowledge, the etiopathogenesis of multiple sclerosis (MS) is complex, involving genetic background as well as several environmental factors that result in dysimmunity in the central nervous system (CNS). MS is an immune-mediated, inflammatory neurological disease affecting the CNS. As part of its attack on the axons of the CNS, MS witnesses varying degrees of myelin and axonal loss. A total of about 20 disease-modifying therapies (DMTs) are available today that, both in clinical trials and in real-world studies, reduce disease activity, such as relapses, magnetic resonance imaging lesions, and disability accumulation. Currently, the world is facing an outbreak of the new coronavirus disease 2019 (COVID-19), which originated in Wuhan, Hubei Province, China, in December 2019 and spread rapidly around the globe. Viral infections play an important role in triggering and maintaining neuroinflammation through direct and indirect mechanisms. There is an old association between MS and viral infections. In the context of MS-related chronic inflammatory damage within the CNS, there has been concern regarding COVID-19 worsening neurological damage. A high rate of disability and increased susceptibility to infection have made MS patients particularly vulnerable. In addition, DMTs have been a concern during the pandemic since many DMTs have immunosuppressive properties. In this article, we discuss the impact of DMTs on COVID-19 risks and the effect of DMTs on COVID-19 vaccination efficacy and outcome in MS patients.</p>","PeriodicalId":23665,"journal":{"name":"Viral immunology","volume":"36 6","pages":"368-377"},"PeriodicalIF":2.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10024246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信