World Journal of Current Medical and Pharmaceutical Research最新文献_第3页

Green Medicine for Weight Management: Medicinal Plants as promising curative agents in the treatment of Obesity 体重管理的绿色医药:药用植物在肥胖治疗中的应用前景

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-10-12 DOI: 10.37022/wjcmpr.v5i5.298

Jeevana K, Kalpana S, Sirisha M

引用次数: 0

Daruharidra (Berberisaristata Dc.) An Important Ayurvedic Medicinal Plant - A Review Daruharidra (Berberisaristata Dc.)一种重要的阿育吠陀药用植物综述

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-10-08 DOI: 10.37022/wjcmpr.v5i5.296

Raj Patel, Sushant Priyadarshi, Ashwini Kumar Kushwaha

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PROFILING OF CLINICAL DYNAMICS OF TYPE 2 DIABETES MELLITUS IN PATIENTS: A PERSPECTIVE REVIEW 2型糖尿病患者的临床动态分析:一项前瞻性综述

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-10-05 DOI: 10.37022/wjcmpr.v5i5.294

Aloysius Obinna Ikwuka, Daniel Inioluwa Omoju, Ousainou K Mahanera

{"title":"PROFILING OF CLINICAL DYNAMICS OF TYPE 2 DIABETES MELLITUS IN PATIENTS: A PERSPECTIVE REVIEW","authors":"Aloysius Obinna Ikwuka, Daniel Inioluwa Omoju, Ousainou K Mahanera","doi":"10.37022/wjcmpr.v5i5.294","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.294","url":null,"abstract":"Type 2 diabetes mellitus (T2DM), also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM) is one of the common metabolic disorders in the world. T2DM accounts for around 90% of all cases of diabetes mellitus, afflicting millions worldwide. It is a significant global health burden with a steadily increasing prevalence. In T2DM, the response to insulin is diminished, and this is defined as insulin resistance. Risk factors for T2DM are diverse. Some are modifiable, and others are not. Modifiable risk factors include overweight/obesity, lack of exercise or physical inactivity, poor nutrition, etc. Non-modifiable risk factors include age, ethnicity/race, family history, history of gestational diabetes mellitus, etc. The starting points and mainstays of treatment for T2DM are diet and lifestyle modifications such as increased physical activity and stoppage of smoking. In addition to the diet and lifestyle modifications, drugs are also used in the management of T2DM. This study aimed to profile the clinical dynamics of type 2 diabetes mellitus in patients. Current literatures from different databases including MEDLINE, PubMed, EMBASE, CINAHL, Google Scholar, etc. on the topic were searched online and reviewed.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of opicapone use in Parkinson’s disease: review of literature and real-world safety data 阿匹卡朋治疗帕金森病的安全性:文献回顾和现实世界的安全性数据

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-10-03 DOI: 10.37022/wjcmpr.v5i5.292

Anuj Kumar Burakoti, Ram Kumar Roy, Harikesh Dubey

{"title":"Safety of opicapone use in Parkinson’s disease: review of literature and real-world safety data","authors":"Anuj Kumar Burakoti, Ram Kumar Roy, Harikesh Dubey","doi":"10.37022/wjcmpr.v5i5.292","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.292","url":null,"abstract":"Parkinson's disease (PD) presents a significant global health concern with increasing prevalence and burden. This review article examines the safety data of drug Opicapone from literature and real-world sources of safety data, highlighting the need for vigilance over anti-parkinsonian drugs. For literature review, the PubMed database was mined which concluded that Opicapone, a selective COMT inhibitor for PD, demonstrated ADR like dyskinesia, nausea, vomiting, headache, and constipation where on the other hand real-world evidence showed no safety alerts or recalls initiated by regulatory authorities for Opicapone, but known risks like dyskinesia and hallucination were identified. However, clinical trial statistics revealed hypertension as the most probable ADR, alongside constipation, dizziness, dyskinesia, headache, somnolence, and hyperhidrosis. Whereas, unlisted events, such as somnolence, hyperhidrosis, pulmonary embolism, and abdominal pain, were also observed. Most ADRs belonged to the nervous system disorders and gastrointestinal disorders class which can be attributed to the pharmacological effect of Opicapone. It was concluded from this review that there is need for continuous safety vigilance for Opicapone use as despite the presence of well-structured safety guidance, new risks can emerge.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical Analysis of the Siddha Herbal Formulation -Murungai Nei (Moringa Ghee) 悉达草药配方木伦盖内(辣木油)的生化分析

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-26 DOI: 10.37022/wjcmpr.v5i5.291

Anu A, Chitra U, Anbu N

引用次数: 0

Physicochemical and Phytochemical Analysis of Siddha Polyherbal Formulation “Madhumega Nivarani Chooranam’’ Siddha复方“Madhumega Nivarani Chooranam”的理化和植物化学分析

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-26 DOI: 10.37022/wjcmpr.v5i5.293

Suresh Balaji N, Anbu N

{"title":"Physicochemical and Phytochemical Analysis of Siddha Polyherbal Formulation “Madhumega Nivarani Chooranam’’","authors":"Suresh Balaji N, Anbu N","doi":"10.37022/wjcmpr.v5i5.293","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.293","url":null,"abstract":"Aim: The aim of the study was to assess the Physicochemical and Phytochemical analysis of Siddha herbal formulation “Madhumega Nivarana Chooranam”, used for the management of Madhumegam(Type-II Diabetes mellitus) Materials and Method: The Siddha Polyherbal formulation Madhumega Nivarani Chooranam was prepared in accordance with good manufacturing practises (GMP) guidelines,], Physicochemical and phytochemicalanalyses were performed at the Tamilnadu Dr. MGR Medical University, located at no. 69, Anna salai, Guindy, Chennai32. Results and Discussion: Physicochemical analysis shows the Loss on drying(0.08%), Total ash value (7.08%), Acid insoluble ash (1.55%), Water soluble ash (2.26% ), Water soluble extraction (31.43%), Alcohol soluble extraction(19.27%)The Phytochemical analysis shows the presence of important Phytoconstituents such as Alkaloids, Carbohydrates, Saponin, Phenols, Tannins, Flavonoids, Diterpenes, QuinSiddhaones, Gum & Mucilage Conclusion: According to the results, it can be stated that the MNC has a comprehensive understanding of the presence of Physicochemical properties, Phytochemical components and has the ability to evaluate the quality profile of Madhumega nivarani Chooranam as the basis for the creation of a Pharmaceutical product, which has been standardised.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135721637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation Cholesterol and Triglycerides Levels for Type One Diabetes Patients 评估1型糖尿病患者的胆固醇和甘油三酯水平

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-19 DOI: 10.37022/wjcmpr.v5i5.289

Mohsin Aziza Mohammed, Safaa Hussein Ali, Aamir M. Abed Al-ghareebawi

引用次数: 0

General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT) 桥本甲状腺炎(HT)的危险因素、发病机制及综合治疗综述

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-18 DOI: 10.37022/wjcmpr.v5i5.290

Yash Srivastav, Akhandnath Prajapati, Kumari Meera, Kumar Madhaw

{"title":"General overview of the Risk factors, Pathogenesis, and Combined treatments for Hashimoto's Thyroiditis (HT)","authors":"Yash Srivastav, Akhandnath Prajapati, Kumari Meera, Kumar Madhaw","doi":"10.37022/wjcmpr.v5i5.290","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.290","url":null,"abstract":"In regions of the world where iodine is abundant, Hashimoto's thyroiditis, also known as Hashimoto's disease or autoimmune thyroiditis, is the most prevalent cause of hypothyroidism. It is a chronic inflammation of the thyroid gland. It is characterized by autoimmune-mediated thyroid gland destruction, which results in progressive thyroid failure, either with or without goiter formation. In young to middle-aged women, Hashimoto's thyroiditis typically starts as a painless, diffuse, firm thyroid gland enlargement that progresses to hypothyroidism. Many people don't initially exhibit hypothyroidism, and some don't even have a goiter or may have an atrophic thyroid gland. Hashimoto's thyroiditis (HT), also known as chronic autoimmune thyroiditis, is an inflammatory condition that is characterized by parenchymal atrophy, fibrosis, and diffuse lymphocytic infiltration. being the main source of primary hypothyroidism in regions with adequate iodine. With the help of various criteria, such as physical examination, blood tests for thyroid hormone levels (TSH is low, T3 and T4 are tall, for example), serum cholesterol and triglycerides, blood glucose, and radioactive iodine uptake, it is possible to distinguish between infections and clutter. According to estimates from several thyroid disease studies, 42 million persons in India are estimated to have the ailment. The pathogenesis causes, risk factors and combination therapy linked to Hashimoto's thyroiditis are discussed in this review study.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135208491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on siddha polyherbal formulation- gowthamar chooranam for the management of swasakasam (bronchial asthma) 治疗支气管哮喘的siddha复方制剂gothamar chooranam综述

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-17 DOI: 10.37022/wjcmpr.v5i5.287

M. Anitha Kalaivani, Anbu N

{"title":"A review on siddha polyherbal formulation- gowthamar chooranam for the management of swasakasam (bronchial asthma)","authors":"M. Anitha Kalaivani, Anbu N","doi":"10.37022/wjcmpr.v5i5.287","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.287","url":null,"abstract":"Background: In the Siddha system of medicine Swasakasam is correlated with bronchial asthma. Bronchial asthma is a common respiratory disorder. It is a chronic inflammatory disease of the airways associated with airway hyper-responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night and in the early morning which may subside spontaneously or with treatment. This review shows the potential role of Gowthamar chooranam a Siddha polyherbal formulation from the Siddha literature the pharmacopeia of Siddha research medicine for the treatment of Swasakasam (Bronchial asthma). Aim and Objective: This review provides information on the uses, chemical components, and pharmacological properties of medicinal herbs. It also identifies research gaps and opens up new possibilities for future study of this polyherbal formulation for the treatment of Swasakasam (Bronchial asthma). Materials and Methods: The review was conducted from the primary sources called ancient Siddha literature and also the search from electronic sources called databases like Google Scholar, Pubmed, and Science Direct with keywords anti-asthmatic herbs, and pharmacological actions. The information was collected and reviewed. Result: Most of the herbs included in the Siddha formulation were found to be anti-asthmatic activity Conclusion: All the ingredients present in Siddha polyherbal formulation gowthamar chooranam are simple, easily available, inexpensive, and easy to prepare. The pharmacological properties of ingredients have a pungent taste, and hot potency and are mostly found as anti-inflammatory, immunomodulatory, anti-allergic, and anti-asthmatic. Hence it is evident that the formulation was very effective in the treatment of Swasakasam (Bronchial asthma). Further preclinical, clinical studies and statistical data analysis help in exploring this polyherbal siddha formulation.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135304194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Heavy metal, Aflatoxin, Pesticide Residue and Microbial Contamination of Siddha Herbal Formulation Muppirandai Chooranam 中药复方木皮兰草中重金属、黄曲霉毒素、农药残留及微生物污染分析

World Journal of Current Medical and Pharmaceutical Research Pub Date : 2023-09-13 DOI: 10.37022/wjcmpr.v5i5.286

Shanthini R, Anbu N

{"title":"Analysis of Heavy metal, Aflatoxin, Pesticide Residue and Microbial Contamination of Siddha Herbal Formulation Muppirandai Chooranam","authors":"Shanthini R, Anbu N","doi":"10.37022/wjcmpr.v5i5.286","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.286","url":null,"abstract":"Aim: The aim of the study was to evaluate the presence of Heavy metal, Aflatoxin, Pesiticide residue and Microbial contamination of Siddha herbal formulation Muppirandai Chooranam (MRC). Place of study: Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99. Methodology: The Siddha formulation Muppirandai Chooranam was prepared as per Good Manufacturing Practices(GMP) guidelines and the Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99.  Results: The results of Heavy metal analysis of Muppirandai Chooranam (MRC) shown the presence of Lead at 3.54 PPM and Arsenic, Cadmium, Mercury at Below Detection Limit (BDL). Aflatoxin assay of MRC shown the absence of Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. Pesticide residue analysis showed that there were no traces of Pesticide residues such as Organo chlorine, Organo phosphorus, Organo carbamates and Pyrethroids. In Microbial contamination analysis, Test for Specific Pathogen shown the absence of Organisms E-coli, Salmonella, Staphylococcus Aureus, Pseudomonas Aeruginosa and No Bacterial and fungal growth or colonies were observed in the Sterility test of MRC as per the methods of AYUSH specifications. Conclusion: From the results, it is concluded that the study medicine MRC has Heavy metal content below the permissible limit as per PLIM guidelines of AYUSH, and the sample were free from Aflatoxins, Pesiticides, Microbes, and Specific Pathogens which ensures that the study medicine Muppirandai Chooranam was safe therapeutically.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0