Analysis of Heavy metal, Aflatoxin, Pesticide Residue and Microbial Contamination of Siddha Herbal Formulation Muppirandai Chooranam

Shanthini R, Anbu N
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 Place of study: Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99.
 Methodology: The Siddha formulation Muppirandai Chooranam was prepared as per Good Manufacturing Practices(GMP) guidelines and the Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99. 
 Results: The results of Heavy metal analysis of Muppirandai Chooranam (MRC) shown the presence of Lead at 3.54 PPM and Arsenic, Cadmium, Mercury at Below Detection Limit (BDL). Aflatoxin assay of MRC shown the absence of Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. Pesticide residue analysis showed that there were no traces of Pesticide residues such as Organo chlorine, Organo phosphorus, Organo carbamates and Pyrethroids. In Microbial contamination analysis, Test for Specific Pathogen shown the absence of Organisms E-coli, Salmonella, Staphylococcus Aureus, Pseudomonas Aeruginosa and No Bacterial and fungal growth or colonies were observed in the Sterility test of MRC as per the methods of AYUSH specifications.
 Conclusion: From the results, it is concluded that the study medicine MRC has Heavy metal content below the permissible limit as per PLIM guidelines of AYUSH, and the sample were free from Aflatoxins, Pesiticides, Microbes, and Specific Pathogens which ensures that the study medicine Muppirandai Chooranam was safe therapeutically.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Current Medical and Pharmaceutical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37022/wjcmpr.v5i5.286","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract

Aim: The aim of the study was to evaluate the presence of Heavy metal, Aflatoxin, Pesiticide residue and Microbial contamination of Siddha herbal formulation Muppirandai Chooranam (MRC). Place of study: Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99. Methodology: The Siddha formulation Muppirandai Chooranam was prepared as per Good Manufacturing Practices(GMP) guidelines and the Heavy metal analysis, Aflatoxin assay, Pesiticide residue, Microbial contamination analysis were conducted at Noble Research Solutions, Kolathur, Chennai -99. Results: The results of Heavy metal analysis of Muppirandai Chooranam (MRC) shown the presence of Lead at 3.54 PPM and Arsenic, Cadmium, Mercury at Below Detection Limit (BDL). Aflatoxin assay of MRC shown the absence of Aflatoxin B1, Aflatoxin B2, Aflatoxin G1, Aflatoxin G2. Pesticide residue analysis showed that there were no traces of Pesticide residues such as Organo chlorine, Organo phosphorus, Organo carbamates and Pyrethroids. In Microbial contamination analysis, Test for Specific Pathogen shown the absence of Organisms E-coli, Salmonella, Staphylococcus Aureus, Pseudomonas Aeruginosa and No Bacterial and fungal growth or colonies were observed in the Sterility test of MRC as per the methods of AYUSH specifications. Conclusion: From the results, it is concluded that the study medicine MRC has Heavy metal content below the permissible limit as per PLIM guidelines of AYUSH, and the sample were free from Aflatoxins, Pesiticides, Microbes, and Specific Pathogens which ensures that the study medicine Muppirandai Chooranam was safe therapeutically.
中药复方木皮兰草中重金属、黄曲霉毒素、农药残留及微生物污染分析
目的:对中药复方木皮兰代朱兰(MRC)的重金属、黄曲霉毒素、农药残留及微生物污染进行评价。研究地点:重金属分析、黄曲霉毒素检测、农药残留、微生物污染分析在Noble Research Solutions, Kolathur, Chennai -99. 进行;方法学:Siddha制剂Muppirandai Chooranam按照药品生产质量管理规范(GMP)进行配制,重金属分析、黄曲霉毒素测定、农药残留、微生物污染分析在Noble Research Solutions, Kolathur, Chennai -99进行。& # x0D;结果:对木皮兰代秋拉南(MRC)进行重金属分析,铅含量为3.54 PPM,砷、镉、汞含量低于检测限(BDL)。MRC黄曲霉毒素检测显示,黄曲霉毒素B1、黄曲霉毒素B2、黄曲霉毒素G1、黄曲霉毒素G2均不存在。农药残留分析显示,未发现有机氯、有机磷、氨基甲酸酯、拟除虫菊酯等农药残留。在微生物污染分析中,特异性病原菌检验结果显示:大肠杆菌、沙门氏菌、金黄色葡萄球菌、铜绿假单胞菌未检出;MRC无菌检验未见细菌、真菌生长或菌落;结论:研究药物MRC的重金属含量低于AYUSH PLIM指南的允许限量,样品中不含黄曲霉毒素、农药、微生物和特异性病原体,保证了研究药物Muppirandai Chooranam的治疗安全性。
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