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West African journal of pharmacology and drug research最新文献

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Adenosine triphosphatase and phosphatase in some African viperine venoms 某些非洲毒蛇毒液中的腺苷三磷酸酶和磷酸酶
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V6I1.53370
P. Okonkwo
{"title":"Adenosine triphosphatase and phosphatase in some African viperine venoms","authors":"P. Okonkwo","doi":"10.4314/WAJPDR.V6I1.53370","DOIUrl":"https://doi.org/10.4314/WAJPDR.V6I1.53370","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76581182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro activity of amikacin compared with other amtimicrobials against clinically important bacteria in the Lagos Universety Teaching Hospital 拉米卡星与其他氨微生物药物对拉各斯大学附属医院临床重要细菌的体外活性比较
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V6I1.53367
A. Coker, Tolu Odugbemi, A. Onitiri
{"title":"In vitro activity of amikacin compared with other amtimicrobials against clinically important bacteria in the Lagos Universety Teaching Hospital","authors":"A. Coker, Tolu Odugbemi, A. Onitiri","doi":"10.4314/WAJPDR.V6I1.53367","DOIUrl":"https://doi.org/10.4314/WAJPDR.V6I1.53367","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"265 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77691182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the responsed of guinea pig ileum to the root extract of Calliandra protoricensis 豚鼠回肠对原花青菜根提取物的反应分析
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V11I1.53385
P. Akah, K. Gamaniel, C. Wambebe
{"title":"Analysis of the responsed of guinea pig ileum to the root extract of Calliandra protoricensis","authors":"P. Akah, K. Gamaniel, C. Wambebe","doi":"10.4314/WAJPDR.V11I1.53385","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53385","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85609371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antagonist ligands are not always reliable in the functional identification of 5-HT 2 receptor in rat aorta 拮抗剂配体对大鼠主动脉5-HT 2受体的功能鉴定并不总是可靠的
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V13I1.53395
E. Okoro, J. Marwood
{"title":"Antagonist ligands are not always reliable in the functional identification of 5-HT 2 receptor in rat aorta","authors":"E. Okoro, J. Marwood","doi":"10.4314/WAJPDR.V13I1.53395","DOIUrl":"https://doi.org/10.4314/WAJPDR.V13I1.53395","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79538258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal and physiological properties of flavonoids, coumarin derivatives and anthraqoinones of plant origin 植物源类黄酮、香豆素衍生物和蒽醌的药用生理特性
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V11I1.53394
S. Oladele, J. Ayo, A. O. Adaudi
{"title":"Medicinal and physiological properties of flavonoids, coumarin derivatives and anthraqoinones of plant origin","authors":"S. Oladele, J. Ayo, A. O. Adaudi","doi":"10.4314/WAJPDR.V11I1.53394","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53394","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89409078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
Antinutagenic and anticarcinogeic acticity of phenolic compounds: possible involvement of the structural activity 酚类化合物的抗突变和抗癌活性:可能与结构活性有关
West African journal of pharmacology and drug research Pub Date : 2010-04-06 DOI: 10.4314/WAJPDR.V11I1.53393
M. Azuine, S. Bhide
{"title":"Antinutagenic and anticarcinogeic acticity of phenolic compounds: possible involvement of the structural activity","authors":"M. Azuine, S. Bhide","doi":"10.4314/WAJPDR.V11I1.53393","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53393","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81475994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Effect of Caffeine on Amplitude of Accommodation and Near Point of Convergence 咖啡因对调节振幅和近收敛点的急性影响
West African journal of pharmacology and drug research Pub Date : 2008-10-22 DOI: 10.4314/WAJPDR.V22I1.14764
O. Ajayi, O. George
{"title":"Acute Effect of Caffeine on Amplitude of Accommodation and Near Point of Convergence","authors":"O. Ajayi, O. George","doi":"10.4314/WAJPDR.V22I1.14764","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14764","url":null,"abstract":"Caffeine is widely consumed in kola nuts and in other products in Sub-Saharan Africa. We examined the acute effect of caffeine on the amplitude of accommodation and near point of convergence of healthy Nigerians. Forty volunteers between ages of 20 and 27 years with refractive power± 0.50 DS were employed. Amplitude of accommodation (AMP) and Near point of convergence (NPC) were measured at 0, 30, 60 and 90 minutes after the ingestion of coffee by two groups of participants, namely the experimental (caffeinated coffee) and control (decaffeinated coffee) groups. The result showed that ingested caffeine increases mean AMP by almost 2.00D within 30 minutes, and the elevation, though variable across patients is sustained for several minutes. The NPC and AMP in the decaffeinated coffee was statically insignificant (P>0.05) within the 0-90minutes of ingestion. However, there was a significant increase in the AMP of the experimental group (P< 0.05). The result suggests that further studies would be most desirable with the older and larger population. Keywords: Caffeine, amplitude of accommodation, near point of convergenceWest African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 27-30","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"24 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83142170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of a Long Term Treatment by Algerian Propolis Flavonoids on Mitochondrial Antioxidant-Prooxidant Balance 阿尔及利亚蜂胶类黄酮长期处理对线粒体抗氧化-促氧化平衡的影响
West African journal of pharmacology and drug research Pub Date : 2008-10-22 DOI: 10.4314/WAJPDR.V22I1.14763
K. Wided, Rouibah Hassiba, B. Nadia, B. Lamia, A. Mohamed, L. Mesbah
{"title":"Effect of a Long Term Treatment by Algerian Propolis Flavonoids on Mitochondrial Antioxidant-Prooxidant Balance","authors":"K. Wided, Rouibah Hassiba, B. Nadia, B. Lamia, A. Mohamed, L. Mesbah","doi":"10.4314/WAJPDR.V22I1.14763","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14763","url":null,"abstract":"Our study carried out in vivo, using liver mitochondria isolated from albinos rats, treats the effect of a long term treatment by Algerian propolis ethanolic extract and their flavonic aglycones and glycosides to the amount of 100 mg/kg on mitochondrial antioxidant-prooxidant balance. Our results showed that all extracts produced an antioxidant effect which is better than that of quercetin. They decreased superoxide anion production (O2-°) by mitochondrial respiratory chain complex III, cytosolic and mitochondrial MDA content, increased (Mn-SOD), (Cu-Zn SOD) and (CAT) enzymatic activities as well as the rate of cytosolic glutathione (GSH). Propolis flavonoids reduced free radical DPPH° in a concentration-dependent manner, inhibited PTP opening and calcium-induced mitochondrial swelling. After long term treatment, propolis flavonoids protected liver tissues from oxidative stress by protecting mitochondria and reinforcement of enzymatic and non enzymatic antioxidants. Propolis flavonoids are well tolerated and are free of any prooxidant effect. Keywords : Algerian propolis flavonoids, antioxidant-prooxidant balance, liver mitochondrion, long term effect. West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 16-26","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"65 1","pages":"16-26"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79875222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Malaria Parasite Infection and Chloroquine-Induced Pruritus: The Role of Opioid-Peptides 疟疾寄生虫感染与氯喹致瘙痒:阿片肽的作用
West African journal of pharmacology and drug research Pub Date : 2008-10-22 DOI: 10.4314/WAJPDR.V22I1.14765
O. Adeyemi, E. Iwalewa, M. Akanmu, O. Ukponmwan
{"title":"Malaria Parasite Infection and Chloroquine-Induced Pruritus: The Role of Opioid-Peptides","authors":"O. Adeyemi, E. Iwalewa, M. Akanmu, O. Ukponmwan","doi":"10.4314/WAJPDR.V22I1.14765","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14765","url":null,"abstract":"Pruritus or itch is associated with malaria infection and/or chloroquine chemotherapy. This study examined the relationship between parasitaemia and chloroquine (CQ) on body scratching (BS) in healthy (un-infected) and malaria-infected rats. The malaria parasite induced a significant (p Keywords : Rats, parasitaemia, chloroquine, opioids, antihistamine, naltrexone West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 31-38","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"32 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77839209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of Drug Concentrations and Nutritional Status During Fixed-Dose Chloroquine and Sulfadoxine/Pyrimethamine Combination Treatment of Malaria 固定剂量氯喹与磺胺多辛/乙胺嘧啶联合治疗疟疾期间药物浓度和营养状况的重要性
West African journal of pharmacology and drug research Pub Date : 2008-10-22 DOI: 10.4314/WAJPDR.V22I1.14761
C. Obua, M. Ntale, J. Ogwal-Okeng, L. Hellgren, M. Petzold
{"title":"Importance of Drug Concentrations and Nutritional Status During Fixed-Dose Chloroquine and Sulfadoxine/Pyrimethamine Combination Treatment of Malaria","authors":"C. Obua, M. Ntale, J. Ogwal-Okeng, L. Hellgren, M. Petzold","doi":"10.4314/WAJPDR.V22I1.14761","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14761","url":null,"abstract":"The importance of drug concentrations, nutritional status and other host factors were explored in uncomplicated falciparum malaria therapy with fixed-dose chloroquine+sulfadoxine/pyrimethamine (CQ+SP). A total of 83 children were treated. Younger children (6-24months) were given half-strength (HS) and older children (2-5years) full-strength (FS) CQ+SP as recommended. The concentrations of CQ and sulfadoxine (S) were determined by HPLC in 100μl of capillary blood on filter paper. Multiple logistic regressions were used to determine associations with outcomes. Stunting (height-for-age Keywords : Malaria, treatment, nutritional status, chloroquine, sulfadoxine, fixed-dose combination West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 1-9","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"32 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91061341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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