West African journal of pharmacology and drug research最新文献

{"title":"Protection against generalised seizured by Dalbergia saxatilis (Hook, F.) in the pentylenetetrazole and electroconvulsive models","authors":"O. Yemitan, O. Adeyemi","doi":"10.4314/WAJPDR.V21I1.14758","DOIUrl":"https://doi.org/10.4314/WAJPDR.V21I1.14758","url":null,"abstract":"The aqueous root decoction of Dalbergia saxatilis (DS) is used to manage convulsive disorders in African herbal medicine practice. We had previously reported the anticonvulsant effects of the aqueous root extract of DS against strychnine and picrotoxin seizures. In this study, DS was tested against pentylenetetrazole (PTZ) seizures, and electrically- induced threshold tonic extension (TTE) and kindling seizures in mice. In the PTZ model, DS (50-200 mg/kg) was administered orally to groups of mice, 30 min. before 75 mg/kg PTZ and onset to seizures noted. In the TTE test, foot shock was delivered through an electrode before treatment and 1h post- treatment. Electrical kindling was produced twice daily at 48h interval in groups of mice. Onset to tonic hind-limb extension (THE) was determined, in the kindling experiment. DS produced a dose-dependent protection against PTZ and elevated the TTE. In the electrical kindling, DS retarded the development and progression of THE, but did not produce a significant delay to THE in kindled mice. \u0000These results indicate that DS might provide protection against generalized absence and partial seizures, which further justifies its use in the management of epilepsies and convulsions in traditional African medicine.\u0000 Keywords : Dalbergia saxatilis , generalized seizure, pentylenetetrazole, kindling, electro- foot shock. West African Joural of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 43-47","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"46 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90569611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of some patients' perceptions and practices on the treatment of dental diseases – a study of the situation in Benin City, Edo State, Nigeria","authors":"E. Omogbai, E. Ehikhamenor, M. Ojo","doi":"10.4314/WAJPDR.V20I1.14745","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14745","url":null,"abstract":"In their search for relief, dental patients (especially if experiencing severe pain) use a variety of substances and visit different types of health care establishments for treatment and relief. Many patients are unaware of the proper places where routine dental care is available and this results in inappropriate management of dental diseases. This study investigated the types of drugs and substances used, the sources of treatment to which dental patients have initial recourse and the factors and constraints that influence their choices. Two orthodox (the University of Benin Teaching Hospital and the Central Hospital) and three traditional (Ebohon Traditional Health Clinic, Omon Obheaghele Herbal Home and Dr. Jibril Traditional Medical Centre) health establishments, all in Benin City, Edo State in Nigeria were used for the study. A total of 400 patients were sampled and information was obtained by means of a questionnaire. The study revealed that only 41.5% of the sampled patients visited an orthodox hospital as a first action in their search for dental treatment. Of these, female patients (54.5%) sought hospital treatment more readily than males (29.1%) as a first-line measure. The study revealed that various drugs and substances including antibiotics, analgesics and unorthodox agents such as petrol, alcohol, auto-battery acid and urine were inappropriately used prior to a visit or reference to a hospital or dentist. The study showed that only 37%of dental patients received treatment from a dentist and most of these were serious cases referred only when non-dentists had been unable to treat them. The study revealed that resort to self-medication, ignorance about availability of proper dental treatment, high cost of dental treatment, fear of the dentist and treatment by non-dental personnel militate against the effective treatment of dental patients. It is recommended that to ensure a comprehensive and effective oral health-care among Nigerians, the Federal, State and Local Governments should place emphasis on the provision of dental health awareness education and care to the populace at the community and primary school levels. Keywords : dental diseases, treatment, patients perceptions, constraints West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 44-47","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"52 1","pages":"44-47"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91245481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risks of external oculotoxicity in the usage of hydroquinone containing, cosmetic products (A case study of Warri, Del Ta State, Nigeria)","authors":"C. Asonye, Ho Ovberedjo","doi":"10.4314/WAJPDR.V20I1.14749","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14749","url":null,"abstract":"Hydroquinone, (benzene-1, 4-diol) belongs to the quinol group of compounds which are derivatives of phenols known to possess hypopigmentary effects on the skin. Among the dark skinned, it is described as a skin lightening substance when added to creams, soaps, lotions, gels and ointments. To look fair skinned has been the fancy and attraction of some female and male blacks whose major motive is for social (aesthetic) reasons so as to obtain a sense of distinction from their dark skinned contemporaries. The adverse effects of hydroquinone abuse have been of great concern to the government and people of Nigeria and the outcomes of such abuse range from skin cancers to toxicity of the external adnexia. Clinical eye examinations and questionnaires were used to investigate the oculo-toxic effects of hydroquinone among 200 respondents using hydroquinone containing products (Group A), compared to a control of 200 not using hydroquinone containing products (Group B), all residing in Warri, Delta State, Nigeria. Oculovisual disorders namely redness and itching, itching alone, redness alone and blurred vision occurred in 65% of the experimental group (group A) compared to 35% in control (group B). Among the experimental group, red eye and itching (120 respondents) followed by itching alone (90), red eye alone (47) and blurred vision (40) were the common signs and symptoms. In addition, 25% became exposed to hydroquinone-containing products through personal knowledge while (65%) were through encouragement by friends and relations and 3.0% through the prescription of dermatologists. The results indicate that there are indeed adverse oculotoxic effects of hydroquinone abuse in Nigeria. Keywords : hydroquinone, abuse, adverse effects, eye West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 62-67","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"18 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73535481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of malaria in health care facilities in Benin city, Nigeria","authors":"O. Akoria, A. Isah","doi":"10.4314/WAJPDR.V20I1.14741","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14741","url":null,"abstract":"Malaria is a leading cause of morbidity and mortality in Africa, especially in the sub-Saharan region and an assumption is that medical practitioners in this part of the world should be skilled in prescribing drugs for the treatment of malaria. This study assessed the patterns of prescriptions for antimalarial drugs by doctors. Prescriptions were collected retrospectively from the outpatient clinics of all public hospitals, and 9 randomly selected private hospitals in Benin City, Nigeria from January 2000 to July 2001. Out of the 1,970 prescriptions assessed, 32.1% (633) had antimalarials prescribed. Antimalarial prescriptions showed that the most frequently prescribed drug was chloroquine (54.8%). Other antimalarials prescribed were sulphadoxine/pyrimethamine (20.9%), quinine (12.5%), halofantrine (6.2%), sulphalene/pyri- methamine (2.7%), sulphadoxine/pyrimethamine/mefloquine (1.7%), amodiaquine (0.8%), and artesunate (0.5%). More than half of the prescriptions for chloroquine (52%) were for injections. Oral chloroquine for adults was prescribed in doses ranging from 600mg to 3g for a course of therapy. More than one antimalarial drug was prescribed in 29% of encounters, with quinine plus sulphadoxine/pyrimethamine being the most frequent combination. Co-prescription of analgesics with antimalarials occurred in 517 (82.1%) encounters with paracetamol as the most frequently prescribed analgesic. Almost all (95.8%) of dipyrone prescriptions were for injections. Antibiotics were coprescribed in 48.2% of encounters, and ampicillin/amoxicillin were the most frequently prescribed antibiotics. The values for the WHO Core Prescribing Indicators were: average number of drugs per encounter – 4.4; percentage of drugs prescribed by generic name – 50.2%; percentage of encounters with injections prescribed – 42.2%, and percentage of drugs prescribed from the Essential Drugs List – 96.7%. Vitamin/mineral supplements were co-prescribed in 323 (51.3%) encounters. The findings suggest that there is inappropriate use of parenteral chloroquine, dipyrone and antibiotics in the treatment of malaria. There is also the questionable use of vitamin and mineral supplements alongside antimalarials in the therapeutic setting Keywords : Malaria, antimalarial drugs, prescriptions, WHO indicators West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 26-30","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"1 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82990549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the toxic effect of Mansonia altisima extract after short term oral administration to rats","authors":"S. Asagba, B. Owhe-Ureghe, A. Falodun, F. Okoko","doi":"10.4314/WAJPDR.V20I1.14747","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14747","url":null,"abstract":"The effect of ethanolic extract of Mansonia altisima on biochemical and haematological parameters was examined using the rat as animal model. Female Wistar albino rats (105.00 ± 2.30g) were distributed into control and three test groups, with ten rats in each group. The test rats were treated orally by intubations with 0.5, 1.0 and 2.0g of the extrac kg body weight of the rat respectively. Control rats were administered the same volume of distilled water. Rats administered the highest dose of the extract had a significantly higher (P 0.05) different from each other, but were significantly (P 0.05) difference was observed in plasma creatinine and urea of rats in all exposure groups. The plasma uric acid concentration of the test groups were not significantly (P>0.05) different from each other but were significantly (P Keywords : Mansonia, extract, toxicity, rats West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 53-57","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"10 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91258267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved appetite of pregnant rats and increased birth weight and survival of their neonates following feeding with probiotic lactobacilli","authors":"Eo Sazuwa, K. Anukam, R. Ozolua, G. Reid","doi":"10.4314/WAJPDR.V20I1.14746","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14746","url":null,"abstract":"Malnutrition and pathogenic colonization of the vagina are two major contributors to preterm labour, newborn survival and low birth weight babies. Hypothetically, the use of probiotics as food supplements might improve the appetite and health of the mother and their newborn babies. Sprague-Dawley albino rats were chosen as a model to test the above hypothesis. The rats were separated into two groups A and B each group comprising 10 rats. The rats in group A were the test rats and those in group B the control rats. Two probiotic strains, Lactobacillus rhaminosus GR-1 and Lactobacillus fermentum RC-14 were fed separately to the rats as supplement in drinking water for 30 days. The feed intake and bir weight of the newborns were measured. There was significant improvement in appetite for the lactobacilli fed rats with a mean feed weight of 16.81g compared with 13.16g feed weight for the control rats, P=0.006. The pups mortality rat for the control rats was 18% as opposed to 2.7% death rate for the newborns of the probiotic fed group. There was significant difference in birth weight between the 37 newborns whose mothers were fed probiotics (mean birth weight 6.5g) and the 38 newborns from the control group (mean birth weight 4.5g) at P=0.01. There was a two-log increase in total lactobacilli recovered from the stools of the probiotic fed rats. No adverse effects of the lactobacilli were noted in the rats. These findings support the nutritional benefits of probiotics in the tested rats. Keywords : probiotics, Sprague-Dawley rats, appetite, birth weight, death rate Resume La sous-alimentation et la colonization patogenique du vagin sont deux contributeurs majeurs au couchage premature a la survivance du nouveau ne, et a une baisse de poids a la naissance des bebes. Hypothetiquement, l'emploie de supplements alimentaires probiotiques pourrait ameliorer l'appetit et la sante des meres et leurs bebes. Les Sprague- Dawley rats albinos sont choisis comme modeles pour tester l'hypothese ci-dessus. Les rats etaient repartient en deux groupes: A et B; chaque groupe ayant chacun 10 rats. Les rats du groupe A sont ceux etudies alors que ceux du groupe B sont les controles. Deux especes probiotiques, le lactobacillus rhamnosus GR-1 et le Lactobacillus fermentum RC 14 ont ete administe separement comme supplement dans l'eau potable aux rats etudies pendant 30 jours. La ration et le poids a la naissance des chiots ont ete mesure. Une amelioration significative d'appetit des rats dont le lactobacilli ont ete administe est remarque avec 16.81gm moyen de poids en alimentation par rapport a 13.16g, P=0.006 moyen pour le groupe de controle. Le taux de mortalite des chiots du groupe de controle etait de 18% par rapport a 2.2% pour le groupe nourri par la probiotique. Il y avait une difference significative dans le poids a la naissance entre les 37 nouveaux-nes dont les meres etaient nourries par la probiotiques (un moyen de 6.5g) et les 38 nouveaux-nes du groupe de contr","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"118 1","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83568231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological profile of Caesalpinia bonducella Flem","authors":"F. Ahmed, R. Shah, G. Rahman, M. Hossain","doi":"10.4314/WAJPDR.V20I1.14748","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14748","url":null,"abstract":"Caesalpiniabonducella Flem. (local name: natalkanta, kutum kanta) isemployed tocure various disorders such as urinary disorders, diarrhoea, dysentery, leucorrhoea, piles, wounds, indolentulcers, skind iseases, leprosy, toothache. The present study was performed to investigate the scientific basis for the traditional uses of the crude ethanolic extract of the plant Caesalpinia bonducella . The crude extract was evaluated for its anti-nociceptive, anti-diarrhoeal and phenobarbitone-induced hypnoticeffects in mice. The extractproduced moderate inhibition of acetic acid induced writhing in mice at the dose of 250 and 500mg/kg body weight which was comparable to the standard drug diclofenac sodium. It decreased frequency of defecation and increased mean latent period at the dose of 500mg/kg body weight comparable to the standard drug loperamide. It also decreased the time of onset of sleep and potentiated the phenobarbitone-induced sleeping time in mice. The results suggest that the crude ethanolic extract of the plant Caesalpinia bonducella ( C. bonducella ) might possess antinociceptive, antidiarrhoeal andcentral nervoussystem depressantactivities. Keywords : Caesalpinia bonducella , antinociceptive, antidiarrhoeal, central nervous system depressant West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 58-61","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"21 1","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88256361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activités antibactérienne et cytotoxique In vitro de différents extraits des écorces du tronc de Diospyros canaliculata (Ebenaceae)","authors":"Victor Kuete, J. G. Tangmouo, Beng V Penlap, El Nguemfo, F. Mofo, F. Etoa, D. Lontsi, Ia Samreen","doi":"10.4314/WAJPDR.V20I1.14740","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14740","url":null,"abstract":"In this study, we have evaluated the antimicrobial and cytotoxic activities of the aqueous, Hexane, ethyl acetate and methanolic extracts of Diospyros canaliculata . The study of the antimicrobial activity has been achieved by the Agar well diffusion method for the determination of the the inhibition zones and the liquide dilution method for the determination of the minimal inhibition concentraion of the different extracts on ten bacterial strains implicated in several human infections. Brine Shrimp lethality bioassay was used in the cytotoxicity investigations. The results showed a weak inhibitory activity of the aqueous extract, on 9 of the 10 microbial strains. Ethyl acetate and methanolic extracts also presented a weak inhibitory effects though active on all the tested bacterial strains. On the other hand a strong antibacterial activity of the hexane extrat was observed on all the tested pathogenic agents. Cytotoxic assay showed that the different extracts were non toxic. The LD50 has been determined only for the ethyl acetate extract. It was of 495.156 μg/ml. The results of this study indicated that this plants could be used in the control of the pathology implicated bacteria. Keywords : Diospyros canaliculata , antibacterial activity, cytotoxicity R esum e Dans cette tude, nous avons valu les activits antimicrobienne et cytotoxique des extraits l'eau, l'hexane, l'actate d'thyle et au mthanol de Diospyros canaliculata . L'tude de l'activit antimicrobienne a t ralise par les techniques de diffusion par puits sur glose pour la dtermination des diamtres des zones d'inhibition et de dilution en milieu liquide pour la dtermination des concentrations minimales inhibitrices (CMI) des diffrents extraits sur dix souches bactriennes impliques dans plusieurs infections humaines. La cytotoxicit de ces extraits a quant elle t dtermine sur les crevettes par la technique de dilution l'eau sale. Les rsultats ont montr une faible activit inhibitrice de l'extrait aqueux, actif sur 9 des 10 souches microbiennes. Les extraits l'actate d'thyle et au mthano ont galement prsent un faible effet inhibiteur bien qu'actif sur toutes les souches bactriennes testes. Par contre une forte activit de l'extrait l'hexane a t observe sur les agents pathognes. Les tudes cytotoxiques ont montres que les diffrents extraits taient non toxiques. La DL 50 n'a pu tre dtermine que pour l'extrait l'acate d'ethyle. Elle tait de 495,156 μg/ml. Les rsultats obtenus dans cette tude ont montr que cette plante pouvait tre utilise dans le contrle des pathologie lies aux bactries. Mots cls : Diospyros canaliculata , activit antibactrienne, cytotoxicit West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 22-25","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"208 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80537350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological evaluation of methanolic extract of Momordica charantia leaves in rats","authors":"O. Salawu, E. Ezekiel, A. Adaudi, H. Kwanashie","doi":"10.4314/WAJPDR.V20I1.14739","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14739","url":null,"abstract":"The acute and sub-chronic toxicity studies of the methanolic extract of the leaves of Momordica charantia were carried out in rats using the oral route. Acute toxicity study was conducted orally in two phases according to the method of Lorke (1983). Animals were observed for signs of toxicity and mortality. The sub-chronic toxicity studies were carried out at three dose levels of 1250, 2500 and 5000 mg/kg for twelve weeks. A fourth group served as the control and received normal saline. At the end of every four weeks, blood samples were collected from five rats per group by cardiac puncture for analysis of hematological and serum liver enzymes parameters. Another five rats per group were euthanized and necropsied for gross pathological lesions and body organs including the liver, heart, kidney, spleen, stomach and intestines were removed and fixed in formalin saline for histopathological examinations. The extract was not lethal to the rats dosed at 5000 mg/kg body weight. Significant (P 0.05) on PCV, TP and Hb concentration levels were observed. The liver, kidney, spleen, stomach and intestines showed mild to moderate congestion. These results suggest that the leaves of M. charantia though safe, should be used with caution in the treatment of diseases that require long term therapy. Keywords : Momordica charantia , sub-chronic, toxicity, liver enzymes, haematology, histopathology Resume \u0000L'etude de la toxicitee aigue et sub-chronique de l'extrait methanolique des feuilles du Momordica charantia ont ete entreprisent sur des souris utilisant la voix oral.l'etude de la toxicitee aigue ont ete conduite orallement en deux phases suivant la methode de lorke.(1983) les animaux etaient observe pour des signes de toxicitee et de mortalite. L'etude de toxicite sub-chronique ont ete conduite avec trios dose 1250, 2500 et 5000mg/kg pendant douze semaines Un quatrieme groupe servant de controle et recu une solution salee isotonique. A la fin de chaque quatre semaines les echantillons de sang etaient collecte sur 5 souris par groupe et ce par punction cardiaque pour analyse hemathologique et du serum pour les parametre des enzymes du foie. Cinq autre souris euthanasiees et necropsies pour les lesion macro pathologique. Et les organes incluant le foie , le Coeur, la rate, les reins l'estomach et les intest ont ete preleve et fixe a la formaline saline pour etude histopathologique. les extraits n'etait pas lethal pour les souris a la dose de 5000mg /kg du poids corporel . l'elevation significative(P,0.05)du niveau des enzymes du foie ce de meme pour des globule rouges et blancs comptee ont ete observes aucun effet significatif (P>0.05) sur l'hematocrite, TP et le taux d'Hb etait observee. Le foie ,reins ,rate, stomach, intestine ont montre une congestion d'ifinie a modere. Les resultats sugernt que les feuilles de Momordica charantia certe sauve doive etre utilise avec precaution dans le traitement des maladies qui demande une therapy a long terme. Mots cles : M","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"2 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89285683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic activity of the aqueous root extract Lecaniodiscus cup anioides","authors":"O. Adeyemi, O. Yemitan, O. Adeogun","doi":"10.4314/WAJPDR.V20I1.14738","DOIUrl":"https://doi.org/10.4314/WAJPDR.V20I1.14738","url":null,"abstract":"Lecaniodiscus cupanioides is a medicinal plant that is widely used in folk medicine in West Africa. In Nigeria, the aqueous root extract of Lecaniodiscus cupanioides (LC) is reported to be effective against various ailments, including inflammatory conditions and hepatomegaly. Moreover, there are claims by herbal medical practitioners in Nigeria that LC is useful against acute and chronic pain, and that it is safe. This study reports the analgesic action of LC. The analgesic effect of LC (100 S 400mg/kg, p.o.) was investigated in rodents using various pain models such as hot plate, formalin-induced pain, tail immersion, tail clip and writhing tests in mice, as well as tail flick test in rats. The results showed that LC produced a significant (P Keywords : Lecaniodiscus cupanioides , Analgesic activity, rodents West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 10-14","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"178 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89033534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}