{"title":"莲藕水提物的镇痛活性研究","authors":"O. Adeyemi, O. Yemitan, O. Adeogun","doi":"10.4314/WAJPDR.V20I1.14738","DOIUrl":null,"url":null,"abstract":"Lecaniodiscus cupanioides is a medicinal plant that is widely used in folk medicine in West Africa. In Nigeria, the aqueous root extract of Lecaniodiscus cupanioides (LC) is reported to be effective against various ailments, including inflammatory conditions and hepatomegaly. Moreover, there are claims by herbal medical practitioners in Nigeria that LC is useful against acute and chronic pain, and that it is safe. This study reports the analgesic action of LC. The analgesic effect of LC (100 S 400mg/kg, p.o.) was investigated in rodents using various pain models such as hot plate, formalin-induced pain, tail immersion, tail clip and writhing tests in mice, as well as tail flick test in rats. The results showed that LC produced a significant (P Keywords : Lecaniodiscus cupanioides , Analgesic activity, rodents West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 10-14","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"178 1","pages":"10-14"},"PeriodicalIF":0.0000,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Analgesic activity of the aqueous root extract Lecaniodiscus cup anioides\",\"authors\":\"O. Adeyemi, O. Yemitan, O. Adeogun\",\"doi\":\"10.4314/WAJPDR.V20I1.14738\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lecaniodiscus cupanioides is a medicinal plant that is widely used in folk medicine in West Africa. In Nigeria, the aqueous root extract of Lecaniodiscus cupanioides (LC) is reported to be effective against various ailments, including inflammatory conditions and hepatomegaly. Moreover, there are claims by herbal medical practitioners in Nigeria that LC is useful against acute and chronic pain, and that it is safe. This study reports the analgesic action of LC. The analgesic effect of LC (100 S 400mg/kg, p.o.) was investigated in rodents using various pain models such as hot plate, formalin-induced pain, tail immersion, tail clip and writhing tests in mice, as well as tail flick test in rats. The results showed that LC produced a significant (P Keywords : Lecaniodiscus cupanioides , Analgesic activity, rodents West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 10-14\",\"PeriodicalId\":23624,\"journal\":{\"name\":\"West African journal of pharmacology and drug research\",\"volume\":\"178 1\",\"pages\":\"10-14\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-12-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"West African journal of pharmacology and drug research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/WAJPDR.V20I1.14738\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of pharmacology and drug research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/WAJPDR.V20I1.14738","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Analgesic activity of the aqueous root extract Lecaniodiscus cup anioides
Lecaniodiscus cupanioides is a medicinal plant that is widely used in folk medicine in West Africa. In Nigeria, the aqueous root extract of Lecaniodiscus cupanioides (LC) is reported to be effective against various ailments, including inflammatory conditions and hepatomegaly. Moreover, there are claims by herbal medical practitioners in Nigeria that LC is useful against acute and chronic pain, and that it is safe. This study reports the analgesic action of LC. The analgesic effect of LC (100 S 400mg/kg, p.o.) was investigated in rodents using various pain models such as hot plate, formalin-induced pain, tail immersion, tail clip and writhing tests in mice, as well as tail flick test in rats. The results showed that LC produced a significant (P Keywords : Lecaniodiscus cupanioides , Analgesic activity, rodents West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 10-14
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