Evaluation of the toxic effect of Mansonia altisima extract after short term oral administration to rats

Abstract

The effect of ethanolic extract of Mansonia altisima on biochemical and haematological parameters was examined using the rat as animal model. Female Wistar albino rats (105.00 ± 2.30g) were distributed into control and three test groups, with ten rats in each group. The test rats were treated orally by intubations with 0.5, 1.0 and 2.0g of the extrac kg body weight of the rat respectively. Control rats were administered the same volume of distilled water. Rats administered the highest dose of the extract had a significantly higher (P 0.05) different from each other, but were significantly (P 0.05) difference was observed in plasma creatinine and urea of rats in all exposure groups. The plasma uric acid concentration of the test groups were not significantly (P>0.05) different from each other but were significantly (P Keywords : Mansonia, extract, toxicity, rats West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 53-57