使用含对苯二酚的化妆品时的外部眼毒性风险(以尼日利亚德尔塔州瓦里为例)

C. Asonye, Ho Ovberedjo
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摘要

对苯二酚,(苯- 1,4 -二醇)属于醌类化合物,醌类化合物是已知对皮肤具有低色素作用的酚类化合物的衍生物。在深色皮肤中,当添加到面霜、肥皂、乳液、凝胶和软膏中时,它被描述为一种皮肤美白物质。看起来皮肤白皙一直是一些黑人男女的幻想和吸引力,他们的主要动机是出于社会(审美)原因,以获得与他们的黑皮肤同时代人的区别感。对苯二酚滥用的不良影响一直是尼日利亚政府和人民非常关注的问题,这种滥用的后果从皮肤癌到外部附件的毒性不等。通过临床眼科检查和问卷调查,对200名使用含对苯二酚产品的受访者(A组)与200名不使用含对苯二酚产品的对照组(B组)进行对比,调查对苯二酚的眼毒性作用,这些受访者均居住在尼日利亚三角洲州瓦里。实验组(A组)65%的患者出现红肿瘙痒、单独瘙痒、单独发红和视力模糊,对照组(B组)为35%。实验组以红肿瘙痒为主(120人),其次为单独瘙痒(90人)、单独发红(47人)和视力模糊(40人)。此外,25%的人是通过个人知识接触到含对苯二酚类产品的,65%的人是通过朋友和亲戚的鼓励接触到的,3.0%的人是通过皮肤科医生的处方接触到的。结果表明,在尼日利亚滥用对苯二酚确实有不良的眼毒性作用。关键词:对苯二酚,滥用,不良反应,眼西非药理学和药物研究Vol. 20(1&2) 2005: 62-67
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The risks of external oculotoxicity in the usage of hydroquinone containing, cosmetic products (A case study of Warri, Del Ta State, Nigeria)
Hydroquinone, (benzene-1, 4-diol) belongs to the quinol group of compounds which are derivatives of phenols known to possess hypopigmentary effects on the skin. Among the dark skinned, it is described as a skin lightening substance when added to creams, soaps, lotions, gels and ointments. To look fair skinned has been the fancy and attraction of some female and male blacks whose major motive is for social (aesthetic) reasons so as to obtain a sense of distinction from their dark skinned contemporaries. The adverse effects of hydroquinone abuse have been of great concern to the government and people of Nigeria and the outcomes of such abuse range from skin cancers to toxicity of the external adnexia. Clinical eye examinations and questionnaires were used to investigate the oculo-toxic effects of hydroquinone among 200 respondents using hydroquinone containing products (Group A), compared to a control of 200 not using hydroquinone containing products (Group B), all residing in Warri, Delta State, Nigeria. Oculovisual disorders namely redness and itching, itching alone, redness alone and blurred vision occurred in 65% of the experimental group (group A) compared to 35% in control (group B). Among the experimental group, red eye and itching (120 respondents) followed by itching alone (90), red eye alone (47) and blurred vision (40) were the common signs and symptoms. In addition, 25% became exposed to hydroquinone-containing products through personal knowledge while (65%) were through encouragement by friends and relations and 3.0% through the prescription of dermatologists. The results indicate that there are indeed adverse oculotoxic effects of hydroquinone abuse in Nigeria. Keywords : hydroquinone, abuse, adverse effects, eye West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 62-67
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