Importance of Drug Concentrations and Nutritional Status During Fixed-Dose Chloroquine and Sulfadoxine/Pyrimethamine Combination Treatment of Malaria

West African journal of pharmacology and drug research Pub Date : 2008-10-22 DOI:10.4314/WAJPDR.V22I1.14761

C. Obua, M. Ntale, J. Ogwal-Okeng, L. Hellgren, M. Petzold

引用次数: 1

Abstract

The importance of drug concentrations, nutritional status and other host factors were explored in uncomplicated falciparum malaria therapy with fixed-dose chloroquine+sulfadoxine/pyrimethamine (CQ+SP). A total of 83 children were treated. Younger children (6-24months) were given half-strength (HS) and older children (2-5years) full-strength (FS) CQ+SP as recommended. The concentrations of CQ and sulfadoxine (S) were determined by HPLC in 100μl of capillary blood on filter paper. Multiple logistic regressions were used to determine associations with outcomes. Stunting (height-for-age Keywords : Malaria, treatment, nutritional status, chloroquine, sulfadoxine, fixed-dose combination West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 1-9

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固定剂量氯喹与磺胺多辛/乙胺嘧啶联合治疗疟疾期间药物浓度和营养状况的重要性

探讨药物浓度、营养状况等宿主因素在固定剂量氯喹+磺胺多辛/乙胺嘧啶(CQ+SP)治疗无并发症恶性疟疾中的重要性。共有83名儿童接受了治疗。年龄较小的儿童(6-24个月)推荐给予半强度(HS)，年龄较大的儿童(2-5岁)给予全强度(FS) CQ+SP。采用高效液相色谱法测定100μl滤纸毛细管血中CQ和磺胺多辛的浓度。使用多重逻辑回归来确定与结果的关联。关键词:疟疾，治疗，营养状况，氯喹，磺胺多辛，固定剂量组合西非药理学和药物研究Vol 22/23 2007: pp. 1-9

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West African journal of pharmacology and drug research

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